TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - DATA
AU  - Đurđić, Slađana Z.
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5839
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015
VL  - 11
IS  - 1
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5839
ER  - 

@misc{
author = "Đurđić, Slađana Z. and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan D. and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015",
volume = "11",
number = "1",
pages = "15",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5839"
}

Đurđić, S. Z., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D. D., Stanković, V., Švorc, Ľ.,& Stanković, D..Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors
MDPI., 11(1), 15.
https://hdl.handle.net/21.15107/rcub_cherry_5839

Đurđić SZ, Vlahović F, Markićević M, Mutić J, Manojlović DD, Stanković V, Švorc Ľ, Stanković D. Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors.11(1):15.
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

Đurđić, Slađana Z., Vlahović, Filip, Markićević, Milan, Mutić, Jelena, Manojlović, Dragan D., Stanković, Vesna, Švorc, Ľubomír, Stanković, Dalibor, "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015" in Chemosensors, 11, no. 1:15,
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - JOUR
AU  - Sakan, Sanja M.
AU  - Mihajlidi-Zelić, Aleksandra
AU  - Ašković, Ksenija
AU  - Sakan, Nenad
AU  - Trifunović, Snežana S.
AU  - Đorđević, Dragana S.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5889
AB  - The optimized three-step sequential extraction procedure for the fractionation of micro- and macroelements, was conducted
to determine fractional characteristics of PTEs (potentially toxic elements) in surface sediments of rivers in the Vlasina
watershed. The sequential extraction results, which enable the evaluation of mobility of the studied elements, have indicated
that Zn, Ni, Cu, Cr, and As can be considered slightly mobile, whereas Pb, Mn, Cd, and Co were regarded as possibly mobile
elements. Lead was dominantly bounded (specifcally adsorbed or co-precipitated) to iron and manganese oxides (up to 80%)
and may be released by reduction. Since the content of the exchangeable fraction (F1) is an indicator for anthropogenic impact
on the aquatic environment, a low percentage (0–8%) of studied toxic elements in this fraction indicated that these elements
have lithogenic origin in most sampling locations in the area of study. Except for Pb, the substantial positive correlations
between Al and other elements showed that studied elements came primarily from terrigenous sources. Although the values
obtained for the risk assessment code (RAC) indicated a slightly increased mobility of some elements (up to 22.44%), the
values of the modifed risk assessment code (mRAC), which include toxic efects on the environment, showed there is no
danger of pollution by studied elements (all values were<1%). Our recommendation is to use mRAC instead of RAC in
ecochemical studies and assessment of the degree of sediment and soil pollution, because mRAC includes toxic efects of
elements. Based on ATI values, river sediments show no toxic to a low toxic degree. Even though obtained results indicate
that there was no considerable risk for river water contamination, the ecological risk for Fe and Pb should be monitored in
the future.
PB  - Springer
T2  - Environmental Science and Pollution Research
T1  - The significance of applying different factors for the evaluation of sediment contamination by toxic elements and estimation of the ecological risk
VL  - 30
IS  - 18
SP  - 53461
EP  - 53477
DO  - 10.1007/s11356-023-26111-4
ER  - 

@article{
author = "Sakan, Sanja M. and Mihajlidi-Zelić, Aleksandra and Ašković, Ksenija and Sakan, Nenad and Trifunović, Snežana S. and Đorđević, Dragana S.",
year = "2023",
abstract = "The optimized three-step sequential extraction procedure for the fractionation of micro- and macroelements, was conducted
to determine fractional characteristics of PTEs (potentially toxic elements) in surface sediments of rivers in the Vlasina
watershed. The sequential extraction results, which enable the evaluation of mobility of the studied elements, have indicated
that Zn, Ni, Cu, Cr, and As can be considered slightly mobile, whereas Pb, Mn, Cd, and Co were regarded as possibly mobile
elements. Lead was dominantly bounded (specifcally adsorbed or co-precipitated) to iron and manganese oxides (up to 80%)
and may be released by reduction. Since the content of the exchangeable fraction (F1) is an indicator for anthropogenic impact
on the aquatic environment, a low percentage (0–8%) of studied toxic elements in this fraction indicated that these elements
have lithogenic origin in most sampling locations in the area of study. Except for Pb, the substantial positive correlations
between Al and other elements showed that studied elements came primarily from terrigenous sources. Although the values
obtained for the risk assessment code (RAC) indicated a slightly increased mobility of some elements (up to 22.44%), the
values of the modifed risk assessment code (mRAC), which include toxic efects on the environment, showed there is no
danger of pollution by studied elements (all values were<1%). Our recommendation is to use mRAC instead of RAC in
ecochemical studies and assessment of the degree of sediment and soil pollution, because mRAC includes toxic efects of
elements. Based on ATI values, river sediments show no toxic to a low toxic degree. Even though obtained results indicate
that there was no considerable risk for river water contamination, the ecological risk for Fe and Pb should be monitored in
the future.",
publisher = "Springer",
journal = "Environmental Science and Pollution Research",
title = "The significance of applying different factors for the evaluation of sediment contamination by toxic elements and estimation of the ecological risk",
volume = "30",
number = "18",
pages = "53461-53477",
doi = "10.1007/s11356-023-26111-4"
}

Sakan, S. M., Mihajlidi-Zelić, A., Ašković, K., Sakan, N., Trifunović, S. S.,& Đorđević, D. S.. (2023). The significance of applying different factors for the evaluation of sediment contamination by toxic elements and estimation of the ecological risk. in Environmental Science and Pollution Research
Springer., 30(18), 53461-53477.
https://doi.org/10.1007/s11356-023-26111-4

Sakan SM, Mihajlidi-Zelić A, Ašković K, Sakan N, Trifunović SS, Đorđević DS. The significance of applying different factors for the evaluation of sediment contamination by toxic elements and estimation of the ecological risk. in Environmental Science and Pollution Research. 2023;30(18):53461-53477.
doi:10.1007/s11356-023-26111-4 .

Sakan, Sanja M., Mihajlidi-Zelić, Aleksandra, Ašković, Ksenija, Sakan, Nenad, Trifunović, Snežana S., Đorđević, Dragana S., "The significance of applying different factors for the evaluation of sediment contamination by toxic elements and estimation of the ecological risk" in Environmental Science and Pollution Research, 30, no. 18 (2023):53461-53477,
https://doi.org/10.1007/s11356-023-26111-4 . .

TY  - JOUR
AU  - Štrbac, Snežana
AU  - Veselinović, Gorica
AU  - Antić, Nevena
AU  - Mijatović, Nevenka
AU  - Stojadinović, Sanja
AU  - Jovančićević, Branimir
AU  - Kašanin-Grubin, Milica
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6187
AB  - The main objective of this study was to analyze the capacity of Cedrus atlantica (Endl.) Manetti ex Carrière 1855 to accumulate macro- and microelements in order to assess the environmental status. The element concentrations were measured using X-ray Fluorescence (XRF) analysis. The obtained pH values in this study show that the urban soils are neutral to slightly alkaline with low OM content. Macroelements with the highest mean concentrations in soil are Si, Al, Fe, K, Mg, and Ca. The ratio > 2 was determined for mean concentrations of Ca in the soil and Mg in needles from the Zvezdara forest, and for mean concentrations of Cl, Ti, and Fe in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the macroelements based on the Biological Concentration Factor (BCF) values > 1 for needles is for P, S, Cl, and Ca. Microelements with the highest mean values in soil are Ba, Zr, Ce, Cr, Zn, Rb, Sr, V, and La. Microelements with the highest mean values in Atlas cedar needles are Ce, La, Ba, and Cs. The ratio > 2 was determined for Cr and V concentrations in the needles from the Byford’s and Zvezdara forests and for Cu concentrations in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the microelements based on the BCF for needles is higher for I, Cs, Mo, Ag, Cd, In, Sn, Sb, and Tl. Since differences in the concentrations of macro- and microelements in the urban areas and the reference site can be identified C. atlantica can be recommended for assessing the environmental status.
PB  - Springer
T2  - Trees
T1  - The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status
VL  - 37
IS  - 4
SP  - 1013
EP  - 1025
DO  - 10.1007/s00468-023-02401-9
ER  - 

@article{
author = "Štrbac, Snežana and Veselinović, Gorica and Antić, Nevena and Mijatović, Nevenka and Stojadinović, Sanja and Jovančićević, Branimir and Kašanin-Grubin, Milica",
year = "2023",
abstract = "The main objective of this study was to analyze the capacity of Cedrus atlantica (Endl.) Manetti ex Carrière 1855 to accumulate macro- and microelements in order to assess the environmental status. The element concentrations were measured using X-ray Fluorescence (XRF) analysis. The obtained pH values in this study show that the urban soils are neutral to slightly alkaline with low OM content. Macroelements with the highest mean concentrations in soil are Si, Al, Fe, K, Mg, and Ca. The ratio > 2 was determined for mean concentrations of Ca in the soil and Mg in needles from the Zvezdara forest, and for mean concentrations of Cl, Ti, and Fe in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the macroelements based on the Biological Concentration Factor (BCF) values > 1 for needles is for P, S, Cl, and Ca. Microelements with the highest mean values in soil are Ba, Zr, Ce, Cr, Zn, Rb, Sr, V, and La. Microelements with the highest mean values in Atlas cedar needles are Ce, La, Ba, and Cs. The ratio > 2 was determined for Cr and V concentrations in the needles from the Byford’s and Zvezdara forests and for Cu concentrations in needles from the Byford’s forest in relation to the reference site. The accumulation pattern of the microelements based on the BCF for needles is higher for I, Cs, Mo, Ag, Cd, In, Sn, Sb, and Tl. Since differences in the concentrations of macro- and microelements in the urban areas and the reference site can be identified C. atlantica can be recommended for assessing the environmental status.",
publisher = "Springer",
journal = "Trees",
title = "The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status",
volume = "37",
number = "4",
pages = "1013-1025",
doi = "10.1007/s00468-023-02401-9"
}

Štrbac, S., Veselinović, G., Antić, N., Mijatović, N., Stojadinović, S., Jovančićević, B.,& Kašanin-Grubin, M.. (2023). The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status. in Trees
Springer., 37(4), 1013-1025.
https://doi.org/10.1007/s00468-023-02401-9

Štrbac S, Veselinović G, Antić N, Mijatović N, Stojadinović S, Jovančićević B, Kašanin-Grubin M. The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status. in Trees. 2023;37(4):1013-1025.
doi:10.1007/s00468-023-02401-9 .

Štrbac, Snežana, Veselinović, Gorica, Antić, Nevena, Mijatović, Nevenka, Stojadinović, Sanja, Jovančićević, Branimir, Kašanin-Grubin, Milica, "The macro- and microelements content in Cedrus atlantica (Endl.) Manetti ex Carrière (Pinaceae) needles as an indicator for assessing the environmental status" in Trees, 37, no. 4 (2023):1013-1025,
https://doi.org/10.1007/s00468-023-02401-9 . .

TY  - JOUR
AU  - Korać Jačić, Jelena
AU  - Dimitrijević, Milena S.
AU  - Bajuk-Bogdanović, Danica V.
AU  - Stanković, Dalibor
AU  - Savić, Slađana D.
AU  - Spasojević, Ivan B.
AU  - MIlenković, Milica R.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6043
AB  - The interactions of drugs with iron are of interest in relation to the potential effects of iron-rich foods and iron supplements on sorption and bioavailability. Doxycycline (DOX), a member of the tetracycline class of broad-spectrum antibiotics, is frequently administered by oral route. In the digestive tract, DOX can be exposed to iron at different pH values (stomach pH 1.5–4, duodenum pH 5–6, distal jejunum and ileum pH 7–8). In relation to this, we analyzed the impact of pH on Fe3+-DOX complex formation. The optimal conditions for Fe3+-DOX complex formation are pH = 4 and [Fe3+]/[DOX] = 6 molar ratio. HESI-MS showed that Fe3+-DOX complex has 1:1 stoichiometry. Raman spectra of Fe3+-DOX complex indicate the presence of two Fe3+-binding sites in DOX structure: tricarbonylamide group of ring A and phenolic-diketone oxygens of BCD rings. The Fe3+-DOX complex formed at pH = 4 is less susceptible to oxidation than DOX at this pH. The increase of pH induces the decomposition of Fe3+-DOX complex without oxidative degradation of DOX. The pH dependence of Fe3+-DOX complex formation may promote unwanted effects of DOX, impeding the absorption that mainly takes place in duodenum. This could further result in higher concentrations in the digestive tract and to pronounced impact on gut microbiota.
PB  - Springer
T2  - Journal of Biological Inorganic Chemistry
T1  - The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability
VL  - 28
SP  - 679
EP  - 687
DO  - 10.1007/s00775-023-02018-w
ER  - 

@article{
author = "Korać Jačić, Jelena and Dimitrijević, Milena S. and Bajuk-Bogdanović, Danica V. and Stanković, Dalibor and Savić, Slađana D. and Spasojević, Ivan B. and MIlenković, Milica R.",
year = "2023",
abstract = "The interactions of drugs with iron are of interest in relation to the potential effects of iron-rich foods and iron supplements on sorption and bioavailability. Doxycycline (DOX), a member of the tetracycline class of broad-spectrum antibiotics, is frequently administered by oral route. In the digestive tract, DOX can be exposed to iron at different pH values (stomach pH 1.5–4, duodenum pH 5–6, distal jejunum and ileum pH 7–8). In relation to this, we analyzed the impact of pH on Fe3+-DOX complex formation. The optimal conditions for Fe3+-DOX complex formation are pH = 4 and [Fe3+]/[DOX] = 6 molar ratio. HESI-MS showed that Fe3+-DOX complex has 1:1 stoichiometry. Raman spectra of Fe3+-DOX complex indicate the presence of two Fe3+-binding sites in DOX structure: tricarbonylamide group of ring A and phenolic-diketone oxygens of BCD rings. The Fe3+-DOX complex formed at pH = 4 is less susceptible to oxidation than DOX at this pH. The increase of pH induces the decomposition of Fe3+-DOX complex without oxidative degradation of DOX. The pH dependence of Fe3+-DOX complex formation may promote unwanted effects of DOX, impeding the absorption that mainly takes place in duodenum. This could further result in higher concentrations in the digestive tract and to pronounced impact on gut microbiota.",
publisher = "Springer",
journal = "Journal of Biological Inorganic Chemistry",
title = "The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability",
volume = "28",
pages = "679-687",
doi = "10.1007/s00775-023-02018-w"
}

Korać Jačić, J., Dimitrijević, M. S., Bajuk-Bogdanović, D. V., Stanković, D., Savić, S. D., Spasojević, I. B.,& MIlenković, M. R.. (2023). The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability. in Journal of Biological Inorganic Chemistry
Springer., 28, 679-687.
https://doi.org/10.1007/s00775-023-02018-w

Korać Jačić J, Dimitrijević MS, Bajuk-Bogdanović DV, Stanković D, Savić SD, Spasojević IB, MIlenković MR. The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability. in Journal of Biological Inorganic Chemistry. 2023;28:679-687.
doi:10.1007/s00775-023-02018-w .

Korać Jačić, Jelena, Dimitrijević, Milena S., Bajuk-Bogdanović, Danica V., Stanković, Dalibor, Savić, Slađana D., Spasojević, Ivan B., MIlenković, Milica R., "The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability" in Journal of Biological Inorganic Chemistry, 28 (2023):679-687,
https://doi.org/10.1007/s00775-023-02018-w . .

TY  - JOUR
AU  - Korać Jačić, Jelena
AU  - Dimitrijević, Milena S.
AU  - Bajuk-Bogdanović, Danica V.
AU  - Stanković, Dalibor
AU  - Savić, Slađana D.
AU  - Spasojević, Ivan B.
AU  - MIlenković, Milica R.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6044
AB  - The interactions of drugs with iron are of interest in relation to the potential effects of iron-rich foods and iron supplements on sorption and bioavailability. Doxycycline (DOX), a member of the tetracycline class of broad-spectrum antibiotics, is frequently administered by oral route. In the digestive tract, DOX can be exposed to iron at different pH values (stomach pH 1.5–4, duodenum pH 5–6, distal jejunum and ileum pH 7–8). In relation to this, we analyzed the impact of pH on Fe3+-DOX complex formation. The optimal conditions for Fe3+-DOX complex formation are pH = 4 and [Fe3+]/[DOX] = 6 molar ratio. HESI-MS showed that Fe3+-DOX complex has 1:1 stoichiometry. Raman spectra of Fe3+-DOX complex indicate the presence of two Fe3+-binding sites in DOX structure: tricarbonylamide group of ring A and phenolic-diketone oxygens of BCD rings. The Fe3+-DOX complex formed at pH = 4 is less susceptible to oxidation than DOX at this pH. The increase of pH induces the decomposition of Fe3+-DOX complex without oxidative degradation of DOX. The pH dependence of Fe3+-DOX complex formation may promote unwanted effects of DOX, impeding the absorption that mainly takes place in duodenum. This could further result in higher concentrations in the digestive tract and to pronounced impact on gut microbiota.
PB  - Springer
T2  - Journal of Biological Inorganic Chemistry
T1  - The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability
VL  - 28
SP  - 679
EP  - 687
DO  - 10.1007/s00775-023-02018-w
ER  - 

@article{
author = "Korać Jačić, Jelena and Dimitrijević, Milena S. and Bajuk-Bogdanović, Danica V. and Stanković, Dalibor and Savić, Slađana D. and Spasojević, Ivan B. and MIlenković, Milica R.",
year = "2023",
abstract = "The interactions of drugs with iron are of interest in relation to the potential effects of iron-rich foods and iron supplements on sorption and bioavailability. Doxycycline (DOX), a member of the tetracycline class of broad-spectrum antibiotics, is frequently administered by oral route. In the digestive tract, DOX can be exposed to iron at different pH values (stomach pH 1.5–4, duodenum pH 5–6, distal jejunum and ileum pH 7–8). In relation to this, we analyzed the impact of pH on Fe3+-DOX complex formation. The optimal conditions for Fe3+-DOX complex formation are pH = 4 and [Fe3+]/[DOX] = 6 molar ratio. HESI-MS showed that Fe3+-DOX complex has 1:1 stoichiometry. Raman spectra of Fe3+-DOX complex indicate the presence of two Fe3+-binding sites in DOX structure: tricarbonylamide group of ring A and phenolic-diketone oxygens of BCD rings. The Fe3+-DOX complex formed at pH = 4 is less susceptible to oxidation than DOX at this pH. The increase of pH induces the decomposition of Fe3+-DOX complex without oxidative degradation of DOX. The pH dependence of Fe3+-DOX complex formation may promote unwanted effects of DOX, impeding the absorption that mainly takes place in duodenum. This could further result in higher concentrations in the digestive tract and to pronounced impact on gut microbiota.",
publisher = "Springer",
journal = "Journal of Biological Inorganic Chemistry",
title = "The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability",
volume = "28",
pages = "679-687",
doi = "10.1007/s00775-023-02018-w"
}

Korać Jačić, J., Dimitrijević, M. S., Bajuk-Bogdanović, D. V., Stanković, D., Savić, S. D., Spasojević, I. B.,& MIlenković, M. R.. (2023). The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability. in Journal of Biological Inorganic Chemistry
Springer., 28, 679-687.
https://doi.org/10.1007/s00775-023-02018-w

Korać Jačić J, Dimitrijević MS, Bajuk-Bogdanović DV, Stanković D, Savić SD, Spasojević IB, MIlenković MR. The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability. in Journal of Biological Inorganic Chemistry. 2023;28:679-687.
doi:10.1007/s00775-023-02018-w .

Korać Jačić, Jelena, Dimitrijević, Milena S., Bajuk-Bogdanović, Danica V., Stanković, Dalibor, Savić, Slađana D., Spasojević, Ivan B., MIlenković, Milica R., "The formation of Fe3+-doxycycline complex is pH dependent: implications to doxycycline bioavailability" in Journal of Biological Inorganic Chemistry, 28 (2023):679-687,
https://doi.org/10.1007/s00775-023-02018-w . .

TY  - JOUR
AU  - Koračak, Ljiljana
AU  - Lupšić, Ema
AU  - Terzić-Jovanović, Nataša
AU  - Jovanović, Mirna
AU  - Novaković, Miroslav M.
AU  - Nedialkov, Paraskev
AU  - Trendafilova, Antoaneta
AU  - Zlatović, Mario
AU  - Pešić, Milica
AU  - Opsenica, Igor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6245
AB  - The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T2  - New Journal of ChemistryNew J. Chem.
T1  - Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells
VL  - 47
IS  - 14
SP  - 6844
EP  - 6855
DO  - 10.1039/D3NJ00427A
ER  - 

@article{
author = "Koračak, Ljiljana and Lupšić, Ema and Terzić-Jovanović, Nataša and Jovanović, Mirna and Novaković, Miroslav M. and Nedialkov, Paraskev and Trendafilova, Antoaneta and Zlatović, Mario and Pešić, Milica and Opsenica, Igor",
year = "2023",
abstract = "The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry, New Journal of ChemistryNew J. Chem.",
title = "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells",
volume = "47",
number = "14",
pages = "6844-6855",
doi = "10.1039/D3NJ00427A"
}

Koračak, L., Lupšić, E., Terzić-Jovanović, N., Jovanović, M., Novaković, M. M., Nedialkov, P., Trendafilova, A., Zlatović, M., Pešić, M.,& Opsenica, I.. (2023). Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry
Royal Society of Chemistry., 47(14), 6844-6855.
https://doi.org/10.1039/D3NJ00427A

Koračak L, Lupšić E, Terzić-Jovanović N, Jovanović M, Novaković MM, Nedialkov P, Trendafilova A, Zlatović M, Pešić M, Opsenica I. Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry. 2023;47(14):6844-6855.
doi:10.1039/D3NJ00427A .

Koračak, Ljiljana, Lupšić, Ema, Terzić-Jovanović, Nataša, Jovanović, Mirna, Novaković, Miroslav M., Nedialkov, Paraskev, Trendafilova, Antoaneta, Zlatović, Mario, Pešić, Milica, Opsenica, Igor, "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells" in New Journal of Chemistry, 47, no. 14 (2023):6844-6855,
https://doi.org/10.1039/D3NJ00427A . .

TY  - JOUR
AU  - Milićević, Tijana
AU  - Relić, Dubravka
AU  - Urošević, Mira Aničić
AU  - Castanheiro, Ana
AU  - Roganović, Jovana
AU  - Samson, Roeland
AU  - Popović, Aleksandar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6267
AB  - The concentration of magnetic particulate matter (PM) on the leaf surface (an indicator of current pollution) and topsoil (an indicator of magnetic PMs which have geogenic natural signal or historical pollution origin) was assessed in agricultural areas (conventional and organic vineyards). The main aim of this study was to explore whether magnetic parameters such as saturation isothermal remanent magnetization (SIRM) and mass-specific magnetic susceptibility (χ) can be a proxy for magnetic particulate matter (PM) pollution and associated potentially toxic elements (PTEs) in agricultural areas. Besides, wavelength dispersive X-ray fluorescence spectroscopy (WD-XRF) was investigated as a screening method for total PTE content in soil and leaf samples. Both magnetic parameters (SIRM and χ) pinpoint soil pollution, while SIRM was more suitable for evaluating magnetic PM accumulated on leaves. The values of both magnetic parameters were significantly (p < 0.01) correlated within the same type of sample (soil-soil or leaf-leaf), but not between different matrixes (soil-leaf). Differences between magnetic particles’ grain sizes among vegetation seasons in vineyards were obtained by observing the SIRM/χ ratio. WD-XRF was revealed to be an appropriate screening method for soil and leaf total element contents in agricultural ambient. For a more precise application of WD-XRF leaf measurements, specific calibration using a similar matrix to plant material is required. In parallel, measurements of SIRM, χ, and element content (by WD-XRF) can be recommended as user-friendly, fast, and eco-sustainable techniques for determining magnetic PM and PTE pollution hotspots in agricultural ambient.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Environmental Monitoring and Assessment
T1  - Non-destructive techniques for the determination of magnetic particle and element contents in grapevine leaves and soil as an eco-sustainable tool for environmental pollution assessment in the agricultural areas
VL  - 195
IS  - 7
SP  - 858
DO  - 10.1007/s10661-023-11402-7
ER  - 

@article{
author = "Milićević, Tijana and Relić, Dubravka and Urošević, Mira Aničić and Castanheiro, Ana and Roganović, Jovana and Samson, Roeland and Popović, Aleksandar",
year = "2023",
abstract = "The concentration of magnetic particulate matter (PM) on the leaf surface (an indicator of current pollution) and topsoil (an indicator of magnetic PMs which have geogenic natural signal or historical pollution origin) was assessed in agricultural areas (conventional and organic vineyards). The main aim of this study was to explore whether magnetic parameters such as saturation isothermal remanent magnetization (SIRM) and mass-specific magnetic susceptibility (χ) can be a proxy for magnetic particulate matter (PM) pollution and associated potentially toxic elements (PTEs) in agricultural areas. Besides, wavelength dispersive X-ray fluorescence spectroscopy (WD-XRF) was investigated as a screening method for total PTE content in soil and leaf samples. Both magnetic parameters (SIRM and χ) pinpoint soil pollution, while SIRM was more suitable for evaluating magnetic PM accumulated on leaves. The values of both magnetic parameters were significantly (p < 0.01) correlated within the same type of sample (soil-soil or leaf-leaf), but not between different matrixes (soil-leaf). Differences between magnetic particles’ grain sizes among vegetation seasons in vineyards were obtained by observing the SIRM/χ ratio. WD-XRF was revealed to be an appropriate screening method for soil and leaf total element contents in agricultural ambient. For a more precise application of WD-XRF leaf measurements, specific calibration using a similar matrix to plant material is required. In parallel, measurements of SIRM, χ, and element content (by WD-XRF) can be recommended as user-friendly, fast, and eco-sustainable techniques for determining magnetic PM and PTE pollution hotspots in agricultural ambient.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Environmental Monitoring and Assessment",
title = "Non-destructive techniques for the determination of magnetic particle and element contents in grapevine leaves and soil as an eco-sustainable tool for environmental pollution assessment in the agricultural areas",
volume = "195",
number = "7",
pages = "858",
doi = "10.1007/s10661-023-11402-7"
}

Milićević, T., Relić, D., Urošević, M. A., Castanheiro, A., Roganović, J., Samson, R.,& Popović, A.. (2023). Non-destructive techniques for the determination of magnetic particle and element contents in grapevine leaves and soil as an eco-sustainable tool for environmental pollution assessment in the agricultural areas. in Environmental Monitoring and Assessment
Springer Science and Business Media Deutschland GmbH., 195(7), 858.
https://doi.org/10.1007/s10661-023-11402-7

Milićević T, Relić D, Urošević MA, Castanheiro A, Roganović J, Samson R, Popović A. Non-destructive techniques for the determination of magnetic particle and element contents in grapevine leaves and soil as an eco-sustainable tool for environmental pollution assessment in the agricultural areas. in Environmental Monitoring and Assessment. 2023;195(7):858.
doi:10.1007/s10661-023-11402-7 .

Milićević, Tijana, Relić, Dubravka, Urošević, Mira Aničić, Castanheiro, Ana, Roganović, Jovana, Samson, Roeland, Popović, Aleksandar, "Non-destructive techniques for the determination of magnetic particle and element contents in grapevine leaves and soil as an eco-sustainable tool for environmental pollution assessment in the agricultural areas" in Environmental Monitoring and Assessment, 195, no. 7 (2023):858,
https://doi.org/10.1007/s10661-023-11402-7 . .

TY  - JOUR
AU  - Smiljanić, Katarina
AU  - Prodić, Ivana
AU  - Trifunović, Sara
AU  - Krstić-Ristivojević, Maja
AU  - Aćimović, Milica G.
AU  - Stanković Jeremić, Jovana
AU  - Lončar, Biljana
AU  - Tešević, Vele
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6203
AB  - As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10–30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.
PB  - MDPI
T2  - Antioxidants
T1  - Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts
VL  - 12
IS  - 11
DO  - 10.3390/antiox12111988
ER  - 

@article{
author = "Smiljanić, Katarina and Prodić, Ivana and Trifunović, Sara and Krstić-Ristivojević, Maja and Aćimović, Milica G. and Stanković Jeremić, Jovana and Lončar, Biljana and Tešević, Vele",
year = "2023",
abstract = "As byproducts of essential oil distillation, hydrolates are used in natural cosmetics/biomedicine due to their beneficial skin effects. However, data on their safety with relevant biological targets, such as human skin cells, are scarce. Therefore, we have tested nine hydrolates from the Lamiaceae family with skin fibroblasts that are responsible for extracellular collagenous matrix builds. Thyme, oregano, and winter savoury hydrolates showed several times higher total phenolics, which correlated strongly with their radical scavenging and antioxidative capacity; there was no correlation between their viability profiles and the reducing sugar levels. No proteins/peptides were detected. All hydrolates appeared safe for prolonged skin exposure except for 10-fold diluted lavender, which showed cytotoxicity (~20%), as well as rosemary and lavandin (~10%) using viability, DNA synthesis, and cell count testing. Clary sage, oregano, lemon balm, and thyme hydrolates (10-fold diluted) increased fibroblast viability and/or proliferation by 10–30% compared with the control, while their viability remained unaffected by Mentha and winter savoury. In line with the STITCH database, increased viability could be attributed to thymol presence in oregano and thyme hydrolates in lemon balm, which is most likely attributable to neral and geranial. The proliferative effect of clary sage could be supported by alpha-terpineol, not linalool. The major volatile organic compounds (VOCs) associated with cytotoxic effects on fibroblasts were borneol, 1,8-cineole, and terpinene-4-ol. Further research with pure compounds is warranted to confirm the roles of VOCs in the observed effects that are relevant to cosmetic and wound healing aspects.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts",
volume = "12",
number = "11",
doi = "10.3390/antiox12111988"
}

Smiljanić, K., Prodić, I., Trifunović, S., Krstić-Ristivojević, M., Aćimović, M. G., Stanković Jeremić, J., Lončar, B.,& Tešević, V.. (2023). Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts. in Antioxidants
MDPI., 12(11).
https://doi.org/10.3390/antiox12111988

Smiljanić K, Prodić I, Trifunović S, Krstić-Ristivojević M, Aćimović MG, Stanković Jeremić J, Lončar B, Tešević V. Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts. in Antioxidants. 2023;12(11).
doi:10.3390/antiox12111988 .

Smiljanić, Katarina, Prodić, Ivana, Trifunović, Sara, Krstić-Ristivojević, Maja, Aćimović, Milica G., Stanković Jeremić, Jovana, Lončar, Biljana, Tešević, Vele, "Multistep Approach Points to Compounds Responsible for the Biological Activity and Safety of Hydrolates from Nine Lamiaceae Medicinal Plants on Human Skin Fibroblasts" in Antioxidants, 12, no. 11 (2023),
https://doi.org/10.3390/antiox12111988 . .

TY  - JOUR
AU  - Maletić, Marina
AU  - Kalijadis, Ana
AU  - Lazović, Vladimir
AU  - Trifunović, Snežana S.
AU  - Babić, Biljana
AU  - Dapčević, Aleksandra
AU  - Kovač, Janez
AU  - Vukčević, Marija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6177
AB  - N-doped TiO2/carbon composites (TiO2/CN) with different nitrogen content, were obtained starting from titanium isopropoxide and glucose, and by varying the amount of melamine, added to starting reaction mixture. For com­parison, an undoped sample (TiO2/C) was also prepared. Structural and surface characteristics were determined through scanning electron microscopy, thermo­gravimetric analysis, elemental analysis, Fourier transform infrared spectro­scopy, X-ray photoelectron spectroscopy, X-ray diffraction and nitrogen ads­orption–desorption isotherms. The photocatalytic activity of TiO2/CN com­posites was examined via photocatalytic degradation of methylene blue and multiclass pharmaceuticals from water solution. It was found that N doping of TiO2/carbon composites induced changes in structural and surface character­istics of TiO2/CN composites, improving their adsorption, but decreasing photocatalytic efficiency. Nevertheless, TiO2/CN0.05 composite obtained by the hydrothermal synthesis in the presence of glucose and 0.05 g melamine showed the highest efficiency for removing selected pharmaceuticals and methylene blue from aqueous solutions through the combined processes of adsorption in the dark, and photocatalytic degradation under UV and visible irradiation.
T2  - Journal of the Serbian Chemical Society
T1  - Influence of N doping on structural and photocatalytic properties of hydrothermally synthesized TiO2/carbon composites: Scientific paper
VL  - 88
IS  - 2
SP  - 183
EP  - 197
DO  - 10.2298/JSC220608079M
ER  - 

@article{
author = "Maletić, Marina and Kalijadis, Ana and Lazović, Vladimir and Trifunović, Snežana S. and Babić, Biljana and Dapčević, Aleksandra and Kovač, Janez and Vukčević, Marija",
year = "2023",
abstract = "N-doped TiO2/carbon composites (TiO2/CN) with different nitrogen content, were obtained starting from titanium isopropoxide and glucose, and by varying the amount of melamine, added to starting reaction mixture. For com­parison, an undoped sample (TiO2/C) was also prepared. Structural and surface characteristics were determined through scanning electron microscopy, thermo­gravimetric analysis, elemental analysis, Fourier transform infrared spectro­scopy, X-ray photoelectron spectroscopy, X-ray diffraction and nitrogen ads­orption–desorption isotherms. The photocatalytic activity of TiO2/CN com­posites was examined via photocatalytic degradation of methylene blue and multiclass pharmaceuticals from water solution. It was found that N doping of TiO2/carbon composites induced changes in structural and surface character­istics of TiO2/CN composites, improving their adsorption, but decreasing photocatalytic efficiency. Nevertheless, TiO2/CN0.05 composite obtained by the hydrothermal synthesis in the presence of glucose and 0.05 g melamine showed the highest efficiency for removing selected pharmaceuticals and methylene blue from aqueous solutions through the combined processes of adsorption in the dark, and photocatalytic degradation under UV and visible irradiation.",
journal = "Journal of the Serbian Chemical Society",
title = "Influence of N doping on structural and photocatalytic properties of hydrothermally synthesized TiO2/carbon composites: Scientific paper",
volume = "88",
number = "2",
pages = "183-197",
doi = "10.2298/JSC220608079M"
}

Maletić, M., Kalijadis, A., Lazović, V., Trifunović, S. S., Babić, B., Dapčević, A., Kovač, J.,& Vukčević, M.. (2023). Influence of N doping on structural and photocatalytic properties of hydrothermally synthesized TiO2/carbon composites: Scientific paper. in Journal of the Serbian Chemical Society, 88(2), 183-197.
https://doi.org/10.2298/JSC220608079M

Maletić M, Kalijadis A, Lazović V, Trifunović SS, Babić B, Dapčević A, Kovač J, Vukčević M. Influence of N doping on structural and photocatalytic properties of hydrothermally synthesized TiO2/carbon composites: Scientific paper. in Journal of the Serbian Chemical Society. 2023;88(2):183-197.
doi:10.2298/JSC220608079M .

Maletić, Marina, Kalijadis, Ana, Lazović, Vladimir, Trifunović, Snežana S., Babić, Biljana, Dapčević, Aleksandra, Kovač, Janez, Vukčević, Marija, "Influence of N doping on structural and photocatalytic properties of hydrothermally synthesized TiO2/carbon composites: Scientific paper" in Journal of the Serbian Chemical Society, 88, no. 2 (2023):183-197,
https://doi.org/10.2298/JSC220608079M . .

TY  - JOUR
AU  - Šokarda Slavić, Marinela
AU  - Kojić, Milan
AU  - Margetić, Aleksandra
AU  - Ristović, Marina
AU  - Pavlović, Marija
AU  - Nikolić, Stefan
AU  - Vujčić, Zoran
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6008
AB  - The combination ofb-oligosaccharides from enzymatically hydrolysed barleyb-glucan has attracted inter-est recently due to its positive effects on human health. This study aimed to assess the impact of theendo-b-1,3-1,4-glucanase enzyme fromBacillus  subtilis168 on improving the nutritional and bioactiveproperties of barleyb-glucan. A new procedure for the isolation ofb-glucan was developed, at a lowertemperature (45°C), enabling purity from starch contamination, without affecting the yield (6 gb-glucanfrom 100 g of barley flour). The endo-b-1,3-1,4-glucanase is cloned intoE. colipQE_Ek enables the highproduction and purification (82% yield, 1.8 mg mL 1and 440 U mg 1) of an enzyme identical to thenatural one (25.5 kDa). The enzymatic reaction showed high efficiency ofb-glucan degradation by recom-binant enzyme, giving a mixture of products (of which 3-O-b-cellobiosyl-D-glucose and 3-O-b-cellotriosyl-D-glucose are the most abundant), the reduction of viscosity (17%) and increase in antioxidant capacitiesby 15.2%, 30.9% and 44.0% assessed by ABTS, DPPH and ORAC, respectively. These results indicatethe possible application of endo-b-1,3-1,4-glucanase enzyme in improving the properties of barleyb-glucan used as functional foods.
PB  - Wiley
T2  - International Journal of Food Science and Technology
T1  - Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase
VL  - 58
IS  - 12
SP  - 6825
EP  - 6835
DO  - 10.1111/ijfs.16647
ER  - 

@article{
author = "Šokarda Slavić, Marinela and Kojić, Milan and Margetić, Aleksandra and Ristović, Marina and Pavlović, Marija and Nikolić, Stefan and Vujčić, Zoran",
year = "2023",
abstract = "The combination ofb-oligosaccharides from enzymatically hydrolysed barleyb-glucan has attracted inter-est recently due to its positive effects on human health. This study aimed to assess the impact of theendo-b-1,3-1,4-glucanase enzyme fromBacillus  subtilis168 on improving the nutritional and bioactiveproperties of barleyb-glucan. A new procedure for the isolation ofb-glucan was developed, at a lowertemperature (45°C), enabling purity from starch contamination, without affecting the yield (6 gb-glucanfrom 100 g of barley flour). The endo-b-1,3-1,4-glucanase is cloned intoE. colipQE_Ek enables the highproduction and purification (82% yield, 1.8 mg mL 1and 440 U mg 1) of an enzyme identical to thenatural one (25.5 kDa). The enzymatic reaction showed high efficiency ofb-glucan degradation by recom-binant enzyme, giving a mixture of products (of which 3-O-b-cellobiosyl-D-glucose and 3-O-b-cellotriosyl-D-glucose are the most abundant), the reduction of viscosity (17%) and increase in antioxidant capacitiesby 15.2%, 30.9% and 44.0% assessed by ABTS, DPPH and ORAC, respectively. These results indicatethe possible application of endo-b-1,3-1,4-glucanase enzyme in improving the properties of barleyb-glucan used as functional foods.",
publisher = "Wiley",
journal = "International Journal of Food Science and Technology",
title = "Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase",
volume = "58",
number = "12",
pages = "6825-6835",
doi = "10.1111/ijfs.16647"
}

Šokarda Slavić, M., Kojić, M., Margetić, A., Ristović, M., Pavlović, M., Nikolić, S.,& Vujčić, Z.. (2023). Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase. in International Journal of Food Science and Technology
Wiley., 58(12), 6825-6835.
https://doi.org/10.1111/ijfs.16647

Šokarda Slavić M, Kojić M, Margetić A, Ristović M, Pavlović M, Nikolić S, Vujčić Z. Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase. in International Journal of Food Science and Technology. 2023;58(12):6825-6835.
doi:10.1111/ijfs.16647 .

Šokarda Slavić, Marinela, Kojić, Milan, Margetić, Aleksandra, Ristović, Marina, Pavlović, Marija, Nikolić, Stefan, Vujčić, Zoran, "Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase" in International Journal of Food Science and Technology, 58, no. 12 (2023):6825-6835,
https://doi.org/10.1111/ijfs.16647 . .

TY  - JOUR
AU  - Šokarda Slavić, Marinela
AU  - Kojić, Milan
AU  - Margetić, Aleksandra
AU  - Ristović, Marina
AU  - Pavlović, Marija
AU  - Nikolić, Stefan
AU  - Vujčić, Zoran
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5992
AB  - The combination ofb-oligosaccharides from enzymatically hydrolysed barleyb-glucan has attracted inter-est recently due to its positive effects on human health. This study aimed to assess the impact of theendo-b-1,3-1,4-glucanase enzyme fromBacillus  subtilis168 on improving the nutritional and bioactiveproperties of barleyb-glucan. A new procedure for the isolation ofb-glucan was developed, at a lowertemperature (45°C), enabling purity from starch contamination, without affecting the yield (6 gb-glucanfrom 100 g of barley flour). The endo-b-1,3-1,4-glucanase is cloned intoE. colipQE_Ek enables the highproduction and purification (82% yield, 1.8 mg mL 1and 440 U mg 1) of an enzyme identical to thenatural one (25.5 kDa). The enzymatic reaction showed high efficiency ofb-glucan degradation by recom-binant enzyme, giving a mixture of products (of which 3-O-b-cellobiosyl-D-glucose and 3-O-b-cellotriosyl-D-glucose are the most abundant), the reduction of viscosity (17%) and increase in antioxidant capacitiesby 15.2%, 30.9% and 44.0% assessed by ABTS, DPPH and ORAC, respectively. These results indicatethe possible application of endo-b-1,3-1,4-glucanase enzyme in improving the properties of barleyb-glucan used as functional foods.
PB  - Wiley
T2  - International Journal of Food Science and Technology
T1  - Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase
VL  - 58
IS  - 12
SP  - 6825
EP  - 6835
DO  - 10.1111/ijfs.16647
ER  - 

@article{
author = "Šokarda Slavić, Marinela and Kojić, Milan and Margetić, Aleksandra and Ristović, Marina and Pavlović, Marija and Nikolić, Stefan and Vujčić, Zoran",
year = "2023",
abstract = "The combination ofb-oligosaccharides from enzymatically hydrolysed barleyb-glucan has attracted inter-est recently due to its positive effects on human health. This study aimed to assess the impact of theendo-b-1,3-1,4-glucanase enzyme fromBacillus  subtilis168 on improving the nutritional and bioactiveproperties of barleyb-glucan. A new procedure for the isolation ofb-glucan was developed, at a lowertemperature (45°C), enabling purity from starch contamination, without affecting the yield (6 gb-glucanfrom 100 g of barley flour). The endo-b-1,3-1,4-glucanase is cloned intoE. colipQE_Ek enables the highproduction and purification (82% yield, 1.8 mg mL 1and 440 U mg 1) of an enzyme identical to thenatural one (25.5 kDa). The enzymatic reaction showed high efficiency ofb-glucan degradation by recom-binant enzyme, giving a mixture of products (of which 3-O-b-cellobiosyl-D-glucose and 3-O-b-cellotriosyl-D-glucose are the most abundant), the reduction of viscosity (17%) and increase in antioxidant capacitiesby 15.2%, 30.9% and 44.0% assessed by ABTS, DPPH and ORAC, respectively. These results indicatethe possible application of endo-b-1,3-1,4-glucanase enzyme in improving the properties of barleyb-glucan used as functional foods.",
publisher = "Wiley",
journal = "International Journal of Food Science and Technology",
title = "Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase",
volume = "58",
number = "12",
pages = "6825-6835",
doi = "10.1111/ijfs.16647"
}

Šokarda Slavić, M., Kojić, M., Margetić, A., Ristović, M., Pavlović, M., Nikolić, S.,& Vujčić, Z.. (2023). Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase. in International Journal of Food Science and Technology
Wiley., 58(12), 6825-6835.
https://doi.org/10.1111/ijfs.16647

Šokarda Slavić M, Kojić M, Margetić A, Ristović M, Pavlović M, Nikolić S, Vujčić Z. Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase. in International Journal of Food Science and Technology. 2023;58(12):6825-6835.
doi:10.1111/ijfs.16647 .

Šokarda Slavić, Marinela, Kojić, Milan, Margetić, Aleksandra, Ristović, Marina, Pavlović, Marija, Nikolić, Stefan, Vujčić, Zoran, "Improvement of nutritional and bioactive properties of barleyb-glucan-based food products usingBacillus subtilis168endo-b-1,3-1,4-glucanase" in International Journal of Food Science and Technology, 58, no. 12 (2023):6825-6835,
https://doi.org/10.1111/ijfs.16647 . .

TY  - JOUR
AU  - Antunović, Vesna
AU  - Blagojević, Dragana
AU  - Baošić, Rada
AU  - Relić, Dubravka
AU  - Lolić, Aleksandar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6252
AB  - This study assesses heavy metal content in soil, water, and plant material from sites located around the lignite mine and the power plant “Gacko”, Bosnia and Herzegovina. The samples were collected, prepared, and analyzed for heavy metals content using the flame atomic absorption spectrophotometer. Samples were analyzed for cadmium, lead, copper, zinc, manganese, and iron. To identify the relationship among the metals in samples and their possible sources, Pearson’s correlation and principal component analysis were performed. Health risk assessment was applied to establish potential health risks posed to humans caused by contaminants in different environmental compartments. The results of our analyses show that most soil samples contain copper, and one of those samples had a copper concentration of more than 70 µg/g, which is a critical upper value for agricultural use. In the soil samples that were analyzed, cadmium was also detected, and its concentration was greater than 2 µg/g. Lead, on the other hand, had a concentration that was higher than the maximum permissible for unpolluted soils in 40% of the soil samples that were analyzed. Lead and cadmium concentrations in surface waters mostly contribute to a non-carcinogenic risk in the scenario of recreational swimming exposure. The presence of Cd, a highly toxic element in water, may be explained by the leaching of artificial fertilizers used in the study area, whereas Pb’s origin may be geological. The results of this study recommend routine heavy metal monitoring in samples of soil, water, and plants from the examined area so that, if metal concentrations continue increasing, remedial action should be advised to prevent accumulation in the food chain.
PB  - Springer
T2  - Environmental Monitoring and Assessment
T1  - Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina
VL  - 195
IS  - 5
SP  - 596
DO  - 10.1007/s10661-023-11232-7
ER  - 

@article{
author = "Antunović, Vesna and Blagojević, Dragana and Baošić, Rada and Relić, Dubravka and Lolić, Aleksandar",
year = "2023",
abstract = "This study assesses heavy metal content in soil, water, and plant material from sites located around the lignite mine and the power plant “Gacko”, Bosnia and Herzegovina. The samples were collected, prepared, and analyzed for heavy metals content using the flame atomic absorption spectrophotometer. Samples were analyzed for cadmium, lead, copper, zinc, manganese, and iron. To identify the relationship among the metals in samples and their possible sources, Pearson’s correlation and principal component analysis were performed. Health risk assessment was applied to establish potential health risks posed to humans caused by contaminants in different environmental compartments. The results of our analyses show that most soil samples contain copper, and one of those samples had a copper concentration of more than 70 µg/g, which is a critical upper value for agricultural use. In the soil samples that were analyzed, cadmium was also detected, and its concentration was greater than 2 µg/g. Lead, on the other hand, had a concentration that was higher than the maximum permissible for unpolluted soils in 40% of the soil samples that were analyzed. Lead and cadmium concentrations in surface waters mostly contribute to a non-carcinogenic risk in the scenario of recreational swimming exposure. The presence of Cd, a highly toxic element in water, may be explained by the leaching of artificial fertilizers used in the study area, whereas Pb’s origin may be geological. The results of this study recommend routine heavy metal monitoring in samples of soil, water, and plants from the examined area so that, if metal concentrations continue increasing, remedial action should be advised to prevent accumulation in the food chain.",
publisher = "Springer",
journal = "Environmental Monitoring and Assessment",
title = "Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina",
volume = "195",
number = "5",
pages = "596",
doi = "10.1007/s10661-023-11232-7"
}

Antunović, V., Blagojević, D., Baošić, R., Relić, D.,& Lolić, A.. (2023). Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina. in Environmental Monitoring and Assessment
Springer., 195(5), 596.
https://doi.org/10.1007/s10661-023-11232-7

Antunović V, Blagojević D, Baošić R, Relić D, Lolić A. Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina. in Environmental Monitoring and Assessment. 2023;195(5):596.
doi:10.1007/s10661-023-11232-7 .

Antunović, Vesna, Blagojević, Dragana, Baošić, Rada, Relić, Dubravka, Lolić, Aleksandar, "Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina" in Environmental Monitoring and Assessment, 195, no. 5 (2023):596,
https://doi.org/10.1007/s10661-023-11232-7 . .

TY  - JOUR
AU  - Lazović, Mila
AU  - Cvijetić, Ilija
AU  - Trifković, Jelena
AU  - Agatonović‑Kuštrin, Snežana
AU  - Morton, David
AU  - Ristivojević, Petar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6231
AB  - Owing to the use of large volumes of toxic solvents and reagents, green analytical methods have gained increasing importance in natural product research. Herein, a green approach is proposed using the natural deep eutectic solvents (NADES) for the extraction and separation of phenols from Teucrium chamaedrys by use of an ecofriendly high-performance thin-layer chromatography (HPTLC) method. Principal component analysis was used to classify NADES extracts based on HPTLC data. The method’s greenness was assessed using two different tools: the National Environmental Methods Index (NEMI) and the analytical eco-scale. This method can also find application in routine quality control analysis of the investigated medicinal herb with minimal harm to the environment or human health.
PB  - Springer
T2  - JPC – Journal of Planar Chromatography – Modern TLC
T1  - Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: a greenness assessment by the National Environmental Methods Index and analytical eco‑scale
VL  - n/a
DO  - 10.1007/s00764-023-00250-3
ER  - 

@article{
author = "Lazović, Mila and Cvijetić, Ilija and Trifković, Jelena and Agatonović‑Kuštrin, Snežana and Morton, David and Ristivojević, Petar",
year = "2023",
abstract = "Owing to the use of large volumes of toxic solvents and reagents, green analytical methods have gained increasing importance in natural product research. Herein, a green approach is proposed using the natural deep eutectic solvents (NADES) for the extraction and separation of phenols from Teucrium chamaedrys by use of an ecofriendly high-performance thin-layer chromatography (HPTLC) method. Principal component analysis was used to classify NADES extracts based on HPTLC data. The method’s greenness was assessed using two different tools: the National Environmental Methods Index (NEMI) and the analytical eco-scale. This method can also find application in routine quality control analysis of the investigated medicinal herb with minimal harm to the environment or human health.",
publisher = "Springer",
journal = "JPC – Journal of Planar Chromatography – Modern TLC",
title = "Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: a greenness assessment by the National Environmental Methods Index and analytical eco‑scale",
volume = "n/a",
doi = "10.1007/s00764-023-00250-3"
}

Lazović, M., Cvijetić, I., Trifković, J., Agatonović‑Kuštrin, S., Morton, D.,& Ristivojević, P.. (2023). Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: a greenness assessment by the National Environmental Methods Index and analytical eco‑scale. in JPC – Journal of Planar Chromatography – Modern TLC
Springer., n/a.
https://doi.org/10.1007/s00764-023-00250-3

Lazović M, Cvijetić I, Trifković J, Agatonović‑Kuštrin S, Morton D, Ristivojević P. Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: a greenness assessment by the National Environmental Methods Index and analytical eco‑scale. in JPC – Journal of Planar Chromatography – Modern TLC. 2023;n/a.
doi:10.1007/s00764-023-00250-3 .

Lazović, Mila, Cvijetić, Ilija, Trifković, Jelena, Agatonović‑Kuštrin, Snežana, Morton, David, Ristivojević, Petar, "Green analytical profiling of Teucrium chamaedrys L. using natural deep eutectic solvents and planar chromatography: a greenness assessment by the National Environmental Methods Index and analytical eco‑scale" in JPC – Journal of Planar Chromatography – Modern TLC, n/a (2023),
https://doi.org/10.1007/s00764-023-00250-3 . .

TY  - JOUR
AU  - Nedić, Olgica
AU  - Penezić, Ana
AU  - Minić, Simeon
AU  - Radomirović, Mirjana Ž.
AU  - Nikolić, Milan
AU  - Ćirković-Veličković, Tanja
AU  - Gligorijević, Nikola
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6028
AB  - Common to all biological systems and living organisms are molecular interactions, which
may lead to specific physiological events. Most often, a cascade of events occurs, establishing an equilibrium between possibly competing and/or synergistic processes. Biochemical pathways that sustain life depend on multiple intrinsic and extrinsic factors contributing to aging and/or diseases. This article deals with food antioxidants and human proteins from the circulation, their interaction, their effect on the structure, properties, and function of antioxidant-bound proteins, and the possible impact of complex formation on antioxidants. An overview of studies examining interactions between individual antioxidant compounds and major blood proteins is presented with findings. Investigating antioxidant/protein interactions at the level of the human organism and determining antioxidant distribution between proteins and involvement in the particular physiological role is a very complex and challenging task. However, by knowing the role of a particular protein in certain pathology or aging, and the effect exerted by a particular antioxidant bound to it, it is possible to recommend specific food intake or resistance to it to improve the condition or slow down the process.
PB  - MDPI
T2  - Antioxidants
T1  - Food Antioxidants and Their Interaction with Human Proteins
VL  - 12
IS  - 4
SP  - 815
DO  - 10.3390/antiox12040815
ER  - 

@article{
author = "Nedić, Olgica and Penezić, Ana and Minić, Simeon and Radomirović, Mirjana Ž. and Nikolić, Milan and Ćirković-Veličković, Tanja and Gligorijević, Nikola",
year = "2023",
abstract = "Common to all biological systems and living organisms are molecular interactions, which
may lead to specific physiological events. Most often, a cascade of events occurs, establishing an equilibrium between possibly competing and/or synergistic processes. Biochemical pathways that sustain life depend on multiple intrinsic and extrinsic factors contributing to aging and/or diseases. This article deals with food antioxidants and human proteins from the circulation, their interaction, their effect on the structure, properties, and function of antioxidant-bound proteins, and the possible impact of complex formation on antioxidants. An overview of studies examining interactions between individual antioxidant compounds and major blood proteins is presented with findings. Investigating antioxidant/protein interactions at the level of the human organism and determining antioxidant distribution between proteins and involvement in the particular physiological role is a very complex and challenging task. However, by knowing the role of a particular protein in certain pathology or aging, and the effect exerted by a particular antioxidant bound to it, it is possible to recommend specific food intake or resistance to it to improve the condition or slow down the process.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Food Antioxidants and Their Interaction with Human Proteins",
volume = "12",
number = "4",
pages = "815",
doi = "10.3390/antiox12040815"
}

Nedić, O., Penezić, A., Minić, S., Radomirović, M. Ž., Nikolić, M., Ćirković-Veličković, T.,& Gligorijević, N.. (2023). Food Antioxidants and Their Interaction with Human Proteins. in Antioxidants
MDPI., 12(4), 815.
https://doi.org/10.3390/antiox12040815

Nedić O, Penezić A, Minić S, Radomirović MŽ, Nikolić M, Ćirković-Veličković T, Gligorijević N. Food Antioxidants and Their Interaction with Human Proteins. in Antioxidants. 2023;12(4):815.
doi:10.3390/antiox12040815 .

Nedić, Olgica, Penezić, Ana, Minić, Simeon, Radomirović, Mirjana Ž., Nikolić, Milan, Ćirković-Veličković, Tanja, Gligorijević, Nikola, "Food Antioxidants and Their Interaction with Human Proteins" in Antioxidants, 12, no. 4 (2023):815,
https://doi.org/10.3390/antiox12040815 . .

TY  - JOUR
AU  - Rosenthal, R. G.
AU  - Diana Zhang, X.
AU  - Ilić Đurđić, Karla
AU  - Collins, J. J.
AU  - Weitz, D. A.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6255
AB  - Enzymes are highly specific catalysts delivering improved drugs and greener industrial processes. Naturally occurring enzymes must typically be optimized which is often accomplished through directed evolution; however, this is still a labor- and capital-intensive process, due in part to multiple molecular biology steps including DNA extraction, in vitro library generation, transformation, and limited screening throughput. We present an effective and broadly applicable continuous evolution platform that enables controlled exploration of fitness landscape to evolve enzymes at ultrahigh throughput based on direct measurement of enzymatic activity. This drop-based microfluidics platform cycles cells between growth and mutagenesis followed by screening with minimal human intervention, relying on the nCas9 chimera with mutagenesis polymerase to produce in vivo gene diversification using sgRNAs tiled along the gene. We evolve alditol oxidase to change its substrate specificity towards glycerol, turning a waste product into a valuable feedstock. We identify a variant with a 10.5-fold catalytic efficiency.
PB  - John Wiley and Sons Inc
T2  - Angewandte Chemie International Edition
T1  - Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop-Based Microfluidics
VL  - 62
IS  - 24
SP  - e202303112
DO  - 10.1002/anie.202303112
ER  - 

@article{
author = "Rosenthal, R. G. and Diana Zhang, X. and Ilić Đurđić, Karla and Collins, J. J. and Weitz, D. A.",
year = "2023",
abstract = "Enzymes are highly specific catalysts delivering improved drugs and greener industrial processes. Naturally occurring enzymes must typically be optimized which is often accomplished through directed evolution; however, this is still a labor- and capital-intensive process, due in part to multiple molecular biology steps including DNA extraction, in vitro library generation, transformation, and limited screening throughput. We present an effective and broadly applicable continuous evolution platform that enables controlled exploration of fitness landscape to evolve enzymes at ultrahigh throughput based on direct measurement of enzymatic activity. This drop-based microfluidics platform cycles cells between growth and mutagenesis followed by screening with minimal human intervention, relying on the nCas9 chimera with mutagenesis polymerase to produce in vivo gene diversification using sgRNAs tiled along the gene. We evolve alditol oxidase to change its substrate specificity towards glycerol, turning a waste product into a valuable feedstock. We identify a variant with a 10.5-fold catalytic efficiency.",
publisher = "John Wiley and Sons Inc",
journal = "Angewandte Chemie International Edition",
title = "Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop-Based Microfluidics",
volume = "62",
number = "24",
pages = "e202303112",
doi = "10.1002/anie.202303112"
}

Rosenthal, R. G., Diana Zhang, X., Ilić Đurđić, K., Collins, J. J.,& Weitz, D. A.. (2023). Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop-Based Microfluidics. in Angewandte Chemie International Edition
John Wiley and Sons Inc., 62(24), e202303112.
https://doi.org/10.1002/anie.202303112

Rosenthal RG, Diana Zhang X, Ilić Đurđić K, Collins JJ, Weitz DA. Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop-Based Microfluidics. in Angewandte Chemie International Edition. 2023;62(24):e202303112.
doi:10.1002/anie.202303112 .

Rosenthal, R. G., Diana Zhang, X., Ilić Đurđić, Karla, Collins, J. J., Weitz, D. A., "Controlled Continuous Evolution of Enzymatic Activity Screened at Ultrahigh Throughput Using Drop-Based Microfluidics" in Angewandte Chemie International Edition, 62, no. 24 (2023):e202303112,
https://doi.org/10.1002/anie.202303112 . .

TY  - CHAP
AU  - Rabrenović, Biljana B.
AU  - Natić, Maja
AU  - Dabić Zagorac, Dragana
AU  - Meland, Mekjell
AU  - Fotirić Akšić, Milica
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6192
AB  - Persian walnut (or English walnut) growing dates back to 7000 BC in Persia, a gene center of Juglans regia L. The top leading countries in walnut production are China, the USA, and Iran accounting for ~75% of world production. Nuts are an essential component in human nutrition because their consumption provides the required amount of energy (720 kcal per 100 g of fruits), unsaturated fatty acids, carbohydrates, proteins, fibers, sterols, tocopherols, minerals (K, P, Ca, Mg, and Na), volatiles, and other bioactive constituents. In addition, walnut kernels are rich in oil (50–70%) and protein, depending on the cultivar, location, and irrigation rate. Although mostly consumed raw, walnut kernels are increasingly processed by cold pressing into light yellow edible oil used in foods as flavoring, like salad dressings or cooking. Walnut oil is especially valued for its high content of essential fatty acids (linoleic and linolenic acids) and micronutrients such as phytosterols, squalene, and other tree nut oils polyphenols, and tocopherols. As by-products, both shell and cold-pressed cake from walnut that remains after the cold pressing process of oil can be used in various ways (food, cosmetics, pharmaceutical products, or textile industry). Especially residual walnut press cake is practical when used in food and in pharmacy, mostly integrated into other products. The reason for treating residual cake as a value-added product lies in the fact that defatted cake is generally rich in polar phenolic compounds and, as a source of natural antioxidants, is expected to show significant antioxidant activity. The most abundant polyphenols found in walnut oil cake are hydrolyzable tannins. In addition, press cake is rich in dietary fiber, protein, residual oil, polyunsaturated fatty acids, and tocopherol, all considered health-enhancing components. Therefore, by using walnut oil cake as a low-cost product, many aspects connected with the valorization of food wastes are covered, such as consumers' dietary habits, economy, and environmental protection. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PB  - Springer
T2  - Reference Series in Phytochemistry
T1  - Bioactive Phytochemicals from Walnut (Juglans spp.) Oil Processing By-products
SP  - 537
EP  - 557
DO  - 10.1007/978-3-030-91381-6_25
ER  - 

@inbook{
author = "Rabrenović, Biljana B. and Natić, Maja and Dabić Zagorac, Dragana and Meland, Mekjell and Fotirić Akšić, Milica",
year = "2023",
abstract = "Persian walnut (or English walnut) growing dates back to 7000 BC in Persia, a gene center of Juglans regia L. The top leading countries in walnut production are China, the USA, and Iran accounting for ~75% of world production. Nuts are an essential component in human nutrition because their consumption provides the required amount of energy (720 kcal per 100 g of fruits), unsaturated fatty acids, carbohydrates, proteins, fibers, sterols, tocopherols, minerals (K, P, Ca, Mg, and Na), volatiles, and other bioactive constituents. In addition, walnut kernels are rich in oil (50–70%) and protein, depending on the cultivar, location, and irrigation rate. Although mostly consumed raw, walnut kernels are increasingly processed by cold pressing into light yellow edible oil used in foods as flavoring, like salad dressings or cooking. Walnut oil is especially valued for its high content of essential fatty acids (linoleic and linolenic acids) and micronutrients such as phytosterols, squalene, and other tree nut oils polyphenols, and tocopherols. As by-products, both shell and cold-pressed cake from walnut that remains after the cold pressing process of oil can be used in various ways (food, cosmetics, pharmaceutical products, or textile industry). Especially residual walnut press cake is practical when used in food and in pharmacy, mostly integrated into other products. The reason for treating residual cake as a value-added product lies in the fact that defatted cake is generally rich in polar phenolic compounds and, as a source of natural antioxidants, is expected to show significant antioxidant activity. The most abundant polyphenols found in walnut oil cake are hydrolyzable tannins. In addition, press cake is rich in dietary fiber, protein, residual oil, polyunsaturated fatty acids, and tocopherol, all considered health-enhancing components. Therefore, by using walnut oil cake as a low-cost product, many aspects connected with the valorization of food wastes are covered, such as consumers' dietary habits, economy, and environmental protection. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.",
publisher = "Springer",
journal = "Reference Series in Phytochemistry",
booktitle = "Bioactive Phytochemicals from Walnut (Juglans spp.) Oil Processing By-products",
pages = "537-557",
doi = "10.1007/978-3-030-91381-6_25"
}

Rabrenović, B. B., Natić, M., Dabić Zagorac, D., Meland, M.,& Fotirić Akšić, M.. (2023). Bioactive Phytochemicals from Walnut (Juglans spp.) Oil Processing By-products. in Reference Series in Phytochemistry
Springer., 537-557.
https://doi.org/10.1007/978-3-030-91381-6_25

Rabrenović BB, Natić M, Dabić Zagorac D, Meland M, Fotirić Akšić M. Bioactive Phytochemicals from Walnut (Juglans spp.) Oil Processing By-products. in Reference Series in Phytochemistry. 2023;:537-557.
doi:10.1007/978-3-030-91381-6_25 .

Rabrenović, Biljana B., Natić, Maja, Dabić Zagorac, Dragana, Meland, Mekjell, Fotirić Akšić, Milica, "Bioactive Phytochemicals from Walnut (Juglans spp.) Oil Processing By-products" in Reference Series in Phytochemistry (2023):537-557,
https://doi.org/10.1007/978-3-030-91381-6_25 . .

TY  - JOUR
AU  - Glušač, Ksenija D.
AU  - Saičić, Radomir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6193
AB  - Does the pursuit of scientific research based on a well-defined technological outcome hamper our ability to be creative? And does it limit opportunities to explore and develop fundamental areas of science that may ultimately lead to applications we hadn’t even thought of yet?
PB  - Nature Research
T2  - Nature Chemistry
T1  - Are science and technology friends or foes?
VL  - 15
IS  - 4
SP  - 439
EP  - 442
DO  - 10.1038/s41557-023-01171-8
ER  - 

@article{
author = "Glušač, Ksenija D. and Saičić, Radomir",
year = "2023",
abstract = "Does the pursuit of scientific research based on a well-defined technological outcome hamper our ability to be creative? And does it limit opportunities to explore and develop fundamental areas of science that may ultimately lead to applications we hadn’t even thought of yet?",
publisher = "Nature Research",
journal = "Nature Chemistry",
title = "Are science and technology friends or foes?",
volume = "15",
number = "4",
pages = "439-442",
doi = "10.1038/s41557-023-01171-8"
}

Glušač, K. D.,& Saičić, R.. (2023). Are science and technology friends or foes?. in Nature Chemistry
Nature Research., 15(4), 439-442.
https://doi.org/10.1038/s41557-023-01171-8

Glušač KD, Saičić R. Are science and technology friends or foes?. in Nature Chemistry. 2023;15(4):439-442.
doi:10.1038/s41557-023-01171-8 .

Glušač, Ksenija D., Saičić, Radomir, "Are science and technology friends or foes?" in Nature Chemistry, 15, no. 4 (2023):439-442,
https://doi.org/10.1038/s41557-023-01171-8 . .

TY  - JOUR
AU  - Prodić, Ivana
AU  - Krstić-Ristivojević, Maja
AU  - Smiljanić, Katarina
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5952
AB  - Thermally processed peanuts are ideal plant models for studying the relationship between allergenicity and antioxidant capacity of protein-rich foods, besides lipids, carbohydrates and phytochemicals. Peanut is highly praised in the human diet; however, it is rich in allergens (>75% of total proteins). One-third of peanut allergens belong to the products of genes responsible for the defence of plants against stress conditions. The proximate composition of major peanut macromolecules and polyphenols is reviewed, focusing on the identity and relative abundance of all peanut proteins derived from recent proteomic studies. The importance of thermal processing, gastrointestinal digestion (performed by INFOGEST protocol) and their influence on allergenicity and antioxidant properties of protein-rich plant food matrices is elaborated. Antioxidant properties of bioactive peptides from nuts were also considered. Moreover, there are no studies dealing simultaneously with the antioxidant and allergenic properties of protein- and polyphenol-rich foods, considering all the molecules that can significantly contribute to the antioxidant capacity during and after gastrointestinal digestion. In summary, proteins and carbohydrates are underappreciated sources of antioxidant power released during the gastrointestinal digestion of protein-rich plant foods, and it is crucial to decipher their antioxidant contribution in addition to polyphenols and vitamins before and after gastrointestinal digestion.
PB  - MDPI
T2  - Antioxidants
T1  - Antioxidant Properties of Protein-Rich Plant Foods in Gastrointestinal Digestion-Peanuts as Our Antioxidant Friend or Foe in Allergies
VL  - 12
IS  - 4
SP  - 886
DO  - 10.3390/antiox12040886
ER  - 

@article{
author = "Prodić, Ivana and Krstić-Ristivojević, Maja and Smiljanić, Katarina",
year = "2023",
abstract = "Thermally processed peanuts are ideal plant models for studying the relationship between allergenicity and antioxidant capacity of protein-rich foods, besides lipids, carbohydrates and phytochemicals. Peanut is highly praised in the human diet; however, it is rich in allergens (>75% of total proteins). One-third of peanut allergens belong to the products of genes responsible for the defence of plants against stress conditions. The proximate composition of major peanut macromolecules and polyphenols is reviewed, focusing on the identity and relative abundance of all peanut proteins derived from recent proteomic studies. The importance of thermal processing, gastrointestinal digestion (performed by INFOGEST protocol) and their influence on allergenicity and antioxidant properties of protein-rich plant food matrices is elaborated. Antioxidant properties of bioactive peptides from nuts were also considered. Moreover, there are no studies dealing simultaneously with the antioxidant and allergenic properties of protein- and polyphenol-rich foods, considering all the molecules that can significantly contribute to the antioxidant capacity during and after gastrointestinal digestion. In summary, proteins and carbohydrates are underappreciated sources of antioxidant power released during the gastrointestinal digestion of protein-rich plant foods, and it is crucial to decipher their antioxidant contribution in addition to polyphenols and vitamins before and after gastrointestinal digestion.",
publisher = "MDPI",
journal = "Antioxidants",
title = "Antioxidant Properties of Protein-Rich Plant Foods in Gastrointestinal Digestion-Peanuts as Our Antioxidant Friend or Foe in Allergies",
volume = "12",
number = "4",
pages = "886",
doi = "10.3390/antiox12040886"
}

Prodić, I., Krstić-Ristivojević, M.,& Smiljanić, K.. (2023). Antioxidant Properties of Protein-Rich Plant Foods in Gastrointestinal Digestion-Peanuts as Our Antioxidant Friend or Foe in Allergies. in Antioxidants
MDPI., 12(4), 886.
https://doi.org/10.3390/antiox12040886

Prodić I, Krstić-Ristivojević M, Smiljanić K. Antioxidant Properties of Protein-Rich Plant Foods in Gastrointestinal Digestion-Peanuts as Our Antioxidant Friend or Foe in Allergies. in Antioxidants. 2023;12(4):886.
doi:10.3390/antiox12040886 .

Prodić, Ivana, Krstić-Ristivojević, Maja, Smiljanić, Katarina, "Antioxidant Properties of Protein-Rich Plant Foods in Gastrointestinal Digestion-Peanuts as Our Antioxidant Friend or Foe in Allergies" in Antioxidants, 12, no. 4 (2023):886,
https://doi.org/10.3390/antiox12040886 . .

TY  - JOUR
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
AU  - Miladinović, Zoran P.
AU  - Pastor, Ferenc
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6090
AB  - Zero-current cell potential measurements were used to determine the solution activity coefficient in a ternary system {yKCl + (1 – y) KH2PO4}(aq) at temperature T = 298.15 K. The cell of the type K–ISE|KCl(mKCl), KH2PO4(mKH2PO4)|Ag|AgCl was used in the total ionic strength range, Im = 0.0886–1.0046 mol kg–1. In order to generate a set of parameters that can be applied in a wide range of mixed solution ionic strengths, the Pitzer, Scatchard, and Clegg–Pitzer–Brimblecombe models were used to fit all available experimental data, including cell potential and isopiestic measurements from the literature. The experimental and calculated values of thermodynamic properties for the studied system are in excellent agreement. Potential interactions and solution structure were discussed by means of the excess free energy of mixing via potential pairs, triplets, or quads for the investigated solution using the Scatchard model mixing parameters.
T2  - Journal of Chemical & Engineering Data
T1  - Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements
VL  - 68
IS  - 2
SP  - 405
EP  - 415
DO  - 10.1021/acs.jced.2c00704
ER  - 

@article{
author = "Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena and Miladinović, Zoran P. and Pastor, Ferenc",
year = "2023",
abstract = "Zero-current cell potential measurements were used to determine the solution activity coefficient in a ternary system {yKCl + (1 – y) KH2PO4}(aq) at temperature T = 298.15 K. The cell of the type K–ISE|KCl(mKCl), KH2PO4(mKH2PO4)|Ag|AgCl was used in the total ionic strength range, Im = 0.0886–1.0046 mol kg–1. In order to generate a set of parameters that can be applied in a wide range of mixed solution ionic strengths, the Pitzer, Scatchard, and Clegg–Pitzer–Brimblecombe models were used to fit all available experimental data, including cell potential and isopiestic measurements from the literature. The experimental and calculated values of thermodynamic properties for the studied system are in excellent agreement. Potential interactions and solution structure were discussed by means of the excess free energy of mixing via potential pairs, triplets, or quads for the investigated solution using the Scatchard model mixing parameters.",
journal = "Journal of Chemical & Engineering Data",
title = "Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements",
volume = "68",
number = "2",
pages = "405-415",
doi = "10.1021/acs.jced.2c00704"
}

Ivanović, T., Popović, D. Ž., Miladinović, J., Miladinović, Z. P.,& Pastor, F.. (2023). Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements. in Journal of Chemical & Engineering Data, 68(2), 405-415.
https://doi.org/10.1021/acs.jced.2c00704

Ivanović T, Popović DŽ, Miladinović J, Miladinović ZP, Pastor F. Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements. in Journal of Chemical & Engineering Data. 2023;68(2):405-415.
doi:10.1021/acs.jced.2c00704 .

Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, Miladinović, Zoran P., Pastor, Ferenc, "Activity Coefficients of the System {yKCl + (1 – y)KH2PO4}(aq) at T = 298.15 K Determined by Cell Potential Measurements" in Journal of Chemical & Engineering Data, 68, no. 2 (2023):405-415,
https://doi.org/10.1021/acs.jced.2c00704 . .

TY  - JOUR
AU  - Šoštarić, Tatjana
AU  - Simić, Marija
AU  - Lopičić, Zorica
AU  - Zlatanović, Snežana
AU  - Pastor, Ferenc
AU  - Antanasković, Anja
AU  - Gorjanović, Stanislava
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6265
AB  - This article presents studies, whose main goal was to minimize food waste. To achieve this goal, it is necessary to expand the scope of their application, for example, for the purification of polluted water from heavy metals. Millions of tons of waste from the fruit and vegetable industry, including pomace of apples and beetroots, are thrown into landfills, posing a danger to the environment. In order to solve the problems with the disposal of these wastes, the authors investigated their sorption potential for the removal of lead from wastewater. The sorbents, dried apple (AP), and beetroots (BR) pomaces were characterized by various methods (study of composition, zeta potential, FTIR-ATR, and SEM-EDX). Various models of sorption kinetics and sorption isotherms were analyzed. Kinetical studies under optimal conditions showed that the sorption process occurs through complexation and ion exchange and the determining stage limiting the rate of sorption is the diffusion of lead ions in the sorbent. The maximum sorption capacity was 31.7 and 79.8 mg/g for AP and BR, respectively. The thermodynamic data revealed the spontaneous sorption of lead ions by sorbents. The temperature rise contributes to the sorption increase by the AP sorbent, while for the BR sorbent, the opposite effect is observed. The obtained results showed that apple and beetroots pomaces can serve as effective renewable materials for the preparation of sorbents, contributing to the solution of complex environmental problems.
PB  - MDPI
T2  - Processes
T1  - Food Waste (Beetroot and Apple Pomace) as Sorbent for Lead from Aqueous Solutions—Alternative to Landfill Disposal
VL  - 11
IS  - 5
SP  - 1343
DO  - 10.3390/pr11051343
ER  - 

@article{
author = "Šoštarić, Tatjana and Simić, Marija and Lopičić, Zorica and Zlatanović, Snežana and Pastor, Ferenc and Antanasković, Anja and Gorjanović, Stanislava",
year = "2023",
abstract = "This article presents studies, whose main goal was to minimize food waste. To achieve this goal, it is necessary to expand the scope of their application, for example, for the purification of polluted water from heavy metals. Millions of tons of waste from the fruit and vegetable industry, including pomace of apples and beetroots, are thrown into landfills, posing a danger to the environment. In order to solve the problems with the disposal of these wastes, the authors investigated their sorption potential for the removal of lead from wastewater. The sorbents, dried apple (AP), and beetroots (BR) pomaces were characterized by various methods (study of composition, zeta potential, FTIR-ATR, and SEM-EDX). Various models of sorption kinetics and sorption isotherms were analyzed. Kinetical studies under optimal conditions showed that the sorption process occurs through complexation and ion exchange and the determining stage limiting the rate of sorption is the diffusion of lead ions in the sorbent. The maximum sorption capacity was 31.7 and 79.8 mg/g for AP and BR, respectively. The thermodynamic data revealed the spontaneous sorption of lead ions by sorbents. The temperature rise contributes to the sorption increase by the AP sorbent, while for the BR sorbent, the opposite effect is observed. The obtained results showed that apple and beetroots pomaces can serve as effective renewable materials for the preparation of sorbents, contributing to the solution of complex environmental problems.",
publisher = "MDPI",
journal = "Processes",
title = "Food Waste (Beetroot and Apple Pomace) as Sorbent for Lead from Aqueous Solutions—Alternative to Landfill Disposal",
volume = "11",
number = "5",
pages = "1343",
doi = "10.3390/pr11051343"
}

Šoštarić, T., Simić, M., Lopičić, Z., Zlatanović, S., Pastor, F., Antanasković, A.,& Gorjanović, S.. (2023). Food Waste (Beetroot and Apple Pomace) as Sorbent for Lead from Aqueous Solutions—Alternative to Landfill Disposal. in Processes
MDPI., 11(5), 1343.
https://doi.org/10.3390/pr11051343

Šoštarić T, Simić M, Lopičić Z, Zlatanović S, Pastor F, Antanasković A, Gorjanović S. Food Waste (Beetroot and Apple Pomace) as Sorbent for Lead from Aqueous Solutions—Alternative to Landfill Disposal. in Processes. 2023;11(5):1343.
doi:10.3390/pr11051343 .

Šoštarić, Tatjana, Simić, Marija, Lopičić, Zorica, Zlatanović, Snežana, Pastor, Ferenc, Antanasković, Anja, Gorjanović, Stanislava, "Food Waste (Beetroot and Apple Pomace) as Sorbent for Lead from Aqueous Solutions—Alternative to Landfill Disposal" in Processes, 11, no. 5 (2023):1343,
https://doi.org/10.3390/pr11051343 . .

TY  - JOUR
AU  - Novakovic, Miroslav
AU  - Todorovic, Nina
AU  - Jadranin, Milka
AU  - Đorđevic, Iris
AU  - Milosavljevic, Slobodan
AU  - Mandic, Boris
AU  - Tesevic, Vele
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6264
AB  - A new auronolignan, named cotinignan B, was isolated from Cotinus coggygria Scop. Structure elucidation was performed on the basis of 1H, 13C NMR, COSY, NOESY, HSQC, and HMBC experiments, supported with HR-ESI-MS, IR and UV. Additional J-HMBC NMR experiment was essential to resolve the configuration of the trisubstituted double bond. This compound represents the secondly discovered natural compound belonging to the rare auronolignan type.
PB  - Springer
T2  - Chemistry of Natural Compounds
T1  - A New Auronolignan from the Cotinus coggygria Heartwood
VL  - 59
IS  - 3
SP  - 428
EP  - 430
DO  - 10.1007/s10600-023-04016-5
ER  - 

@article{
author = "Novakovic, Miroslav and Todorovic, Nina and Jadranin, Milka and Đorđevic, Iris and Milosavljevic, Slobodan and Mandic, Boris and Tesevic, Vele",
year = "2023",
abstract = "A new auronolignan, named cotinignan B, was isolated from Cotinus coggygria Scop. Structure elucidation was performed on the basis of 1H, 13C NMR, COSY, NOESY, HSQC, and HMBC experiments, supported with HR-ESI-MS, IR and UV. Additional J-HMBC NMR experiment was essential to resolve the configuration of the trisubstituted double bond. This compound represents the secondly discovered natural compound belonging to the rare auronolignan type.",
publisher = "Springer",
journal = "Chemistry of Natural Compounds",
title = "A New Auronolignan from the Cotinus coggygria Heartwood",
volume = "59",
number = "3",
pages = "428-430",
doi = "10.1007/s10600-023-04016-5"
}

Novakovic, M., Todorovic, N., Jadranin, M., Đorđevic, I., Milosavljevic, S., Mandic, B.,& Tesevic, V.. (2023). A New Auronolignan from the Cotinus coggygria Heartwood. in Chemistry of Natural Compounds
Springer., 59(3), 428-430.
https://doi.org/10.1007/s10600-023-04016-5

Novakovic M, Todorovic N, Jadranin M, Đorđevic I, Milosavljevic S, Mandic B, Tesevic V. A New Auronolignan from the Cotinus coggygria Heartwood. in Chemistry of Natural Compounds. 2023;59(3):428-430.
doi:10.1007/s10600-023-04016-5 .

Novakovic, Miroslav, Todorovic, Nina, Jadranin, Milka, Đorđevic, Iris, Milosavljevic, Slobodan, Mandic, Boris, Tesevic, Vele, "A New Auronolignan from the Cotinus coggygria Heartwood" in Chemistry of Natural Compounds, 59, no. 3 (2023):428-430,
https://doi.org/10.1007/s10600-023-04016-5 . .

TY  - JOUR
AU  - Haššo, Marek
AU  - Sarakhman, Olha
AU  - Đurđić, Slađana
AU  - Stanković, Dalibor
AU  - Švorc, Ľubomír
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6263
AB  - In this work, an advanced electrochemical platform was developed for the simple, rapid and sensitive determination of the polyphenolic compound tannic acid in various beverages using the combination of batch injection analysis with amperometric detection on a screen-printed carbon electrode. Several experimental parameters (pH of supporting electrolyte, detection potential, dispensing rate, injected volume, stirring) were consistently evaluated. The most favorable analytical performance in terms of sensitivity, selectivity, repeatability and sampling frequency was obtained in Britton-Robinson buffer pH 5.0 at a detection potential of +0.6 V vs. Ag/AgCl, a dispensing rate of 204 µL/s and an injected volume of 80 µL under stirring condition (1500 r.p.m.). The presented platform has advantages for routine analysis including portable and small-scale experimental setup, low sample consumption (∼100 µL), simple sample preparation (dilution in supporting electrolyte), high sampling frequency (180 injections per hour), low limit of detection (80 nM) and suitable precision (RSD = 4.2% for 10 μM tannic acid, n = 20). The applicability of the method was verified by analyzing several beverage samples (tea, wine) in spike-recovery assay with the recovery values for tannic acid ranging from 94 to 101 %.
PB  - Elsevier
T2  - Journal of Electroanalytical Chemistry
T1  - Advanced electrochemical platform for simple and rapid quantification of tannic acid in beverages using batch injection analysis with amperometric detection
VL  - 942
SP  - 117578
DO  - 10.1016/j.jelechem.2023.117578
ER  - 

@article{
author = "Haššo, Marek and Sarakhman, Olha and Đurđić, Slađana and Stanković, Dalibor and Švorc, Ľubomír",
year = "2023",
abstract = "In this work, an advanced electrochemical platform was developed for the simple, rapid and sensitive determination of the polyphenolic compound tannic acid in various beverages using the combination of batch injection analysis with amperometric detection on a screen-printed carbon electrode. Several experimental parameters (pH of supporting electrolyte, detection potential, dispensing rate, injected volume, stirring) were consistently evaluated. The most favorable analytical performance in terms of sensitivity, selectivity, repeatability and sampling frequency was obtained in Britton-Robinson buffer pH 5.0 at a detection potential of +0.6 V vs. Ag/AgCl, a dispensing rate of 204 µL/s and an injected volume of 80 µL under stirring condition (1500 r.p.m.). The presented platform has advantages for routine analysis including portable and small-scale experimental setup, low sample consumption (∼100 µL), simple sample preparation (dilution in supporting electrolyte), high sampling frequency (180 injections per hour), low limit of detection (80 nM) and suitable precision (RSD = 4.2% for 10 μM tannic acid, n = 20). The applicability of the method was verified by analyzing several beverage samples (tea, wine) in spike-recovery assay with the recovery values for tannic acid ranging from 94 to 101 %.",
publisher = "Elsevier",
journal = "Journal of Electroanalytical Chemistry",
title = "Advanced electrochemical platform for simple and rapid quantification of tannic acid in beverages using batch injection analysis with amperometric detection",
volume = "942",
pages = "117578",
doi = "10.1016/j.jelechem.2023.117578"
}

Haššo, M., Sarakhman, O., Đurđić, S., Stanković, D.,& Švorc, Ľ.. (2023). Advanced electrochemical platform for simple and rapid quantification of tannic acid in beverages using batch injection analysis with amperometric detection. in Journal of Electroanalytical Chemistry
Elsevier., 942, 117578.
https://doi.org/10.1016/j.jelechem.2023.117578

Haššo M, Sarakhman O, Đurđić S, Stanković D, Švorc Ľ. Advanced electrochemical platform for simple and rapid quantification of tannic acid in beverages using batch injection analysis with amperometric detection. in Journal of Electroanalytical Chemistry. 2023;942:117578.
doi:10.1016/j.jelechem.2023.117578 .

Haššo, Marek, Sarakhman, Olha, Đurđić, Slađana, Stanković, Dalibor, Švorc, Ľubomír, "Advanced electrochemical platform for simple and rapid quantification of tannic acid in beverages using batch injection analysis with amperometric detection" in Journal of Electroanalytical Chemistry, 942 (2023):117578,
https://doi.org/10.1016/j.jelechem.2023.117578 . .

TY  - JOUR
AU  - Simić, Katarina
AU  - Miladinović, Zoran
AU  - Todorović, Nina
AU  - Trifunović, Snežana
AU  - Avramović, Nataša
AU  - Gavrilović, Aleksandra
AU  - Jovanović, Silvana
AU  - Gođevac, Dejan
AU  - Vujisić, Ljubodrag
AU  - Tešević, Vele
AU  - Tasic, Ljubica
AU  - Mandić, Boris
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6261
AB  - Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.
PB  - MDPI
T2  - Metabolites
T1  - Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients
VL  - 13
IS  - 5
SP  - 607
DO  - 10.3390/metabo13050607
ER  - 

@article{
author = "Simić, Katarina and Miladinović, Zoran and Todorović, Nina and Trifunović, Snežana and Avramović, Nataša and Gavrilović, Aleksandra and Jovanović, Silvana and Gođevac, Dejan and Vujisić, Ljubodrag and Tešević, Vele and Tasic, Ljubica and Mandić, Boris",
year = "2023",
abstract = "Bipolar disorder (BD) is a brain disorder that causes changes in a person’s mood, energy, and ability to function. It has a prevalence of 60 million people worldwide, and it is among the top 20 diseases with the highest global burden. The complexity of this disease, including diverse genetic, environmental, and biochemical factors, and diagnoses based on the subjective recognition of symptoms without any clinical test of biomarker identification create significant difficulties in understanding and diagnosing BD. A 1H-NMR-based metabolomic study applying chemometrics of serum samples of Serbian patients with BD (33) and healthy controls (39) was explored, providing the identification of 22 metabolites for this disease. A biomarker set including threonine, aspartate, gamma-aminobutyric acid, 2-hydroxybutyric acid, serine, and mannose was established for the first time in BD serum samples by an NMR-based metabolomics study. Six identified metabolites (3-hydroxybutyric acid, arginine, lysine, tyrosine, phenylalanine, and glycerol) are in agreement with the previously determined NMR-based sets of serum biomarkers in Brazilian and/or Chinese patient samples. The same established metabolites (lactate, alanine, valine, leucine, isoleucine, glutamine, glutamate, glucose, and choline) in three different ethnic and geographic origins (Serbia, Brazil, and China) might have a crucial role in the realization of a universal set of NMR biomarkers for BD.",
publisher = "MDPI",
journal = "Metabolites",
title = "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients",
volume = "13",
number = "5",
pages = "607",
doi = "10.3390/metabo13050607"
}

Simić, K., Miladinović, Z., Todorović, N., Trifunović, S., Avramović, N., Gavrilović, A., Jovanović, S., Gođevac, D., Vujisić, L., Tešević, V., Tasic, L.,& Mandić, B.. (2023). Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites
MDPI., 13(5), 607.
https://doi.org/10.3390/metabo13050607

Simić K, Miladinović Z, Todorović N, Trifunović S, Avramović N, Gavrilović A, Jovanović S, Gođevac D, Vujisić L, Tešević V, Tasic L, Mandić B. Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients. in Metabolites. 2023;13(5):607.
doi:10.3390/metabo13050607 .

Simić, Katarina, Miladinović, Zoran, Todorović, Nina, Trifunović, Snežana, Avramović, Nataša, Gavrilović, Aleksandra, Jovanović, Silvana, Gođevac, Dejan, Vujisić, Ljubodrag, Tešević, Vele, Tasic, Ljubica, Mandić, Boris, "Metabolomic Profiling of Bipolar Disorder by 1H-NMR in Serbian Patients" in Metabolites, 13, no. 5 (2023):607,
https://doi.org/10.3390/metabo13050607 . .