TY  - DATA
AU  - Đurđić, Slađana
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5839
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015
VL  - 11
IS  - 1
SP  - 15
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5839
ER  - 

@misc{
author = "Đurđić, Slađana and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan D. and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015",
volume = "11",
number = "1",
pages = "15",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5839"
}

Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D. D., Stanković, V., Švorc, Ľ.,& Stanković, D..Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors
MDPI., 11(1), 15.
https://hdl.handle.net/21.15107/rcub_cherry_5839

Đurđić S, Vlahović F, Markićević M, Mutić J, Manojlović DD, Stanković V, Švorc Ľ, Stanković D. Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015. in Chemosensors.11(1):15.
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

Đurđić, Slađana, Vlahović, Filip, Markićević, Milan, Mutić, Jelena, Manojlović, Dragan D., Stanković, Vesna, Švorc, Ľubomír, Stanković, Dalibor, "Supplementary material for: Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors MDPI., 11(1), 15. https://doi.org/10.3390/chemosensors11010015" in Chemosensors, 11, no. 1:15,
https://hdl.handle.net/21.15107/rcub_cherry_5839 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - JOUR
AU  - Živković, Jelena M.
AU  - Zarić, Snežana D.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6251
AB  - The recent results on fluorinated cubanes showed good electron accepting abilities of octafluorocubane. Here we did the calculation of electrostatic potentials for cubane and its fluorinated derivatives. Maps of the electrostatic potential of fluorinated cubanes show regions, in the cores of the molecules, with significant positive potential (34.5 to 45.5 kcal/mol), which is in accordance with experimentally observed electron accepting abilities of the fluorinated cubanes. The increasing number of fluorine on the cubane increases positive potentials in the core of the molecule. Maps of electrostatic potentials can also explain structural motifs in crystals of fluorinated cubanes.
PB  - Elsevier
T2  - Chemical Physics Letters
T1  - Correlation of electrostatic potentials and electron accepting properties of fluorinated cubanes
VL  - 823
SP  - 140509
DO  - 10.1016/j.cplett.2023.140509
ER  - 

@article{
author = "Živković, Jelena M. and Zarić, Snežana D.",
year = "2023",
abstract = "The recent results on fluorinated cubanes showed good electron accepting abilities of octafluorocubane. Here we did the calculation of electrostatic potentials for cubane and its fluorinated derivatives. Maps of the electrostatic potential of fluorinated cubanes show regions, in the cores of the molecules, with significant positive potential (34.5 to 45.5 kcal/mol), which is in accordance with experimentally observed electron accepting abilities of the fluorinated cubanes. The increasing number of fluorine on the cubane increases positive potentials in the core of the molecule. Maps of electrostatic potentials can also explain structural motifs in crystals of fluorinated cubanes.",
publisher = "Elsevier",
journal = "Chemical Physics Letters",
title = "Correlation of electrostatic potentials and electron accepting properties of fluorinated cubanes",
volume = "823",
pages = "140509",
doi = "10.1016/j.cplett.2023.140509"
}

Živković, J. M.,& Zarić, S. D.. (2023). Correlation of electrostatic potentials and electron accepting properties of fluorinated cubanes. in Chemical Physics Letters
Elsevier., 823, 140509.
https://doi.org/10.1016/j.cplett.2023.140509

Živković JM, Zarić SD. Correlation of electrostatic potentials and electron accepting properties of fluorinated cubanes. in Chemical Physics Letters. 2023;823:140509.
doi:10.1016/j.cplett.2023.140509 .

Živković, Jelena M., Zarić, Snežana D., "Correlation of electrostatic potentials and electron accepting properties of fluorinated cubanes" in Chemical Physics Letters, 823 (2023):140509,
https://doi.org/10.1016/j.cplett.2023.140509 . .

TY  - JOUR
AU  - Mijatović, Aleksandar
AU  - Gligorijević, Nevenka
AU  - Ćoćić, Dušan
AU  - Spasić, Snežana
AU  - Lolić, Aleksandar
AU  - Aranđelović, Sandra
AU  - Nikolić, Milan
AU  - Baošić, Rada
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6248
AB  - The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu(ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and cytotoxic activity. A significant antioxidant behavior was exhibited by complex CuAA, greater than Trolox in the Oxygen Radical Absorbance Capacity (ORAC) assay. Antibacterial assay over Gram-positive and Gram-negative pathogenic bacterial strains and some fungal pathogens were studied. Antiproliferative activity of complexes in two human tumor cell lines, breast adenocarcinoma MCF-7, colon adenocarcinoma LS-174, and normal fibroblast cells-MRC-5, examined the effect on cell cycle progression. The significant cytotoxic potential, comparable to cisplatin cytotoxicity, was determined in human breast cancer cell line-MCF-7 with IC50 values being 17.53–31.40 μM and human colon cancer cell line-LS-174 with IC50 values being 15.22–23.92 μM. All tested compounds showed nearly twice more selectivity toward cancer cell lines than normal cells. The interactions of complexes with human serum albumin (HSA), the most prominent protein in plasma, were investigated using spectroscopic fluorescence techniques. The complexes bind to human serum albumin at multiple sites (n = 0.2–1.9), displaying a moderate binding constant Ka = 4.1–12.4 × 104 M−1. The molecular docking experiment effectively showed complex binding to HSA and DNA molecular fragments.
PB  - Elsevier
T2  - Journal of Inorganic Biochemistry
T1  - In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge
VL  - 244
SP  - 112224
DO  - 10.1016/j.jinorgbio.2023.112224
ER  - 

@article{
author = "Mijatović, Aleksandar and Gligorijević, Nevenka and Ćoćić, Dušan and Spasić, Snežana and Lolić, Aleksandar and Aranđelović, Sandra and Nikolić, Milan and Baošić, Rada",
year = "2023",
abstract = "The biological activity of six structurally similar tetradentate Schiff base copper(II) complexes, namely [Cu(ethylenediamine-bis-acetylacetonate)] (CuAA) and five derivatives where two methyl groups are replaced by phenyl, (CuPP), CF3 (CuTT) or by mixed groups CH3/CF3 (CuAT), Ph/CF3 (CuPT), and Ph/CH3 (CuAP) has been investigated. The set of antioxidant assays was performed, and the results were expressed as IC50 and EC50 values. The series of complexes showed interesting bioactivity and were investigated for the determination of antioxidant, antifungal, antimicrobial, and cytotoxic activity. A significant antioxidant behavior was exhibited by complex CuAA, greater than Trolox in the Oxygen Radical Absorbance Capacity (ORAC) assay. Antibacterial assay over Gram-positive and Gram-negative pathogenic bacterial strains and some fungal pathogens were studied. Antiproliferative activity of complexes in two human tumor cell lines, breast adenocarcinoma MCF-7, colon adenocarcinoma LS-174, and normal fibroblast cells-MRC-5, examined the effect on cell cycle progression. The significant cytotoxic potential, comparable to cisplatin cytotoxicity, was determined in human breast cancer cell line-MCF-7 with IC50 values being 17.53–31.40 μM and human colon cancer cell line-LS-174 with IC50 values being 15.22–23.92 μM. All tested compounds showed nearly twice more selectivity toward cancer cell lines than normal cells. The interactions of complexes with human serum albumin (HSA), the most prominent protein in plasma, were investigated using spectroscopic fluorescence techniques. The complexes bind to human serum albumin at multiple sites (n = 0.2–1.9), displaying a moderate binding constant Ka = 4.1–12.4 × 104 M−1. The molecular docking experiment effectively showed complex binding to HSA and DNA molecular fragments.",
publisher = "Elsevier",
journal = "Journal of Inorganic Biochemistry",
title = "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge",
volume = "244",
pages = "112224",
doi = "10.1016/j.jinorgbio.2023.112224"
}

Mijatović, A., Gligorijević, N., Ćoćić, D., Spasić, S., Lolić, A., Aranđelović, S., Nikolić, M.,& Baošić, R.. (2023). In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge. in Journal of Inorganic Biochemistry
Elsevier., 244, 112224.
https://doi.org/10.1016/j.jinorgbio.2023.112224

Mijatović A, Gligorijević N, Ćoćić D, Spasić S, Lolić A, Aranđelović S, Nikolić M, Baošić R. In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge. in Journal of Inorganic Biochemistry. 2023;244:112224.
doi:10.1016/j.jinorgbio.2023.112224 .

Mijatović, Aleksandar, Gligorijević, Nevenka, Ćoćić, Dušan, Spasić, Snežana, Lolić, Aleksandar, Aranđelović, Sandra, Nikolić, Milan, Baošić, Rada, "In vitro and in silico study of the biological activity of tetradentate Schiff base copper(II) complexes with ethylenediamine-bridge" in Journal of Inorganic Biochemistry, 244 (2023):112224,
https://doi.org/10.1016/j.jinorgbio.2023.112224 . .

TY  - JOUR
AU  - Antunović, Vesna
AU  - Blagojević, Dragana
AU  - Baošić, Rada
AU  - Relić, Dubravka
AU  - Lolić, Aleksandar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6252
AB  - This study assesses heavy metal content in soil, water, and plant material from sites located around the lignite mine and the power plant “Gacko”, Bosnia and Herzegovina. The samples were collected, prepared, and analyzed for heavy metals content using the flame atomic absorption spectrophotometer. Samples were analyzed for cadmium, lead, copper, zinc, manganese, and iron. To identify the relationship among the metals in samples and their possible sources, Pearson’s correlation and principal component analysis were performed. Health risk assessment was applied to establish potential health risks posed to humans caused by contaminants in different environmental compartments. The results of our analyses show that most soil samples contain copper, and one of those samples had a copper concentration of more than 70 µg/g, which is a critical upper value for agricultural use. In the soil samples that were analyzed, cadmium was also detected, and its concentration was greater than 2 µg/g. Lead, on the other hand, had a concentration that was higher than the maximum permissible for unpolluted soils in 40% of the soil samples that were analyzed. Lead and cadmium concentrations in surface waters mostly contribute to a non-carcinogenic risk in the scenario of recreational swimming exposure. The presence of Cd, a highly toxic element in water, may be explained by the leaching of artificial fertilizers used in the study area, whereas Pb’s origin may be geological. The results of this study recommend routine heavy metal monitoring in samples of soil, water, and plants from the examined area so that, if metal concentrations continue increasing, remedial action should be advised to prevent accumulation in the food chain.
PB  - Springer
T2  - Environmental Monitoring and Assessment
T1  - Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina
VL  - 195
IS  - 5
SP  - 596
DO  - 10.1007/s10661-023-11232-7
ER  - 

@article{
author = "Antunović, Vesna and Blagojević, Dragana and Baošić, Rada and Relić, Dubravka and Lolić, Aleksandar",
year = "2023",
abstract = "This study assesses heavy metal content in soil, water, and plant material from sites located around the lignite mine and the power plant “Gacko”, Bosnia and Herzegovina. The samples were collected, prepared, and analyzed for heavy metals content using the flame atomic absorption spectrophotometer. Samples were analyzed for cadmium, lead, copper, zinc, manganese, and iron. To identify the relationship among the metals in samples and their possible sources, Pearson’s correlation and principal component analysis were performed. Health risk assessment was applied to establish potential health risks posed to humans caused by contaminants in different environmental compartments. The results of our analyses show that most soil samples contain copper, and one of those samples had a copper concentration of more than 70 µg/g, which is a critical upper value for agricultural use. In the soil samples that were analyzed, cadmium was also detected, and its concentration was greater than 2 µg/g. Lead, on the other hand, had a concentration that was higher than the maximum permissible for unpolluted soils in 40% of the soil samples that were analyzed. Lead and cadmium concentrations in surface waters mostly contribute to a non-carcinogenic risk in the scenario of recreational swimming exposure. The presence of Cd, a highly toxic element in water, may be explained by the leaching of artificial fertilizers used in the study area, whereas Pb’s origin may be geological. The results of this study recommend routine heavy metal monitoring in samples of soil, water, and plants from the examined area so that, if metal concentrations continue increasing, remedial action should be advised to prevent accumulation in the food chain.",
publisher = "Springer",
journal = "Environmental Monitoring and Assessment",
title = "Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina",
volume = "195",
number = "5",
pages = "596",
doi = "10.1007/s10661-023-11232-7"
}

Antunović, V., Blagojević, D., Baošić, R., Relić, D.,& Lolić, A.. (2023). Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina. in Environmental Monitoring and Assessment
Springer., 195(5), 596.
https://doi.org/10.1007/s10661-023-11232-7

Antunović V, Blagojević D, Baošić R, Relić D, Lolić A. Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina. in Environmental Monitoring and Assessment. 2023;195(5):596.
doi:10.1007/s10661-023-11232-7 .

Antunović, Vesna, Blagojević, Dragana, Baošić, Rada, Relić, Dubravka, Lolić, Aleksandar, "Health risk assessment of heavy metals in soil, plant, and water samples near “Gacko” power plant, in Bosnia and Herzegovina" in Environmental Monitoring and Assessment, 195, no. 5 (2023):596,
https://doi.org/10.1007/s10661-023-11232-7 . .

TY  - JOUR
AU  - Apostolović, Danijela
AU  - Grundström, Jeanette
AU  - Kiewiet, Mensiena B. Gea
AU  - Peruško, Marija
AU  - Hamsten, Carl
AU  - Starkhammar, Maria
AU  - Paulie, Staffan
AU  - Hage, Marianne van
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6244
AB  - Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.
PB  - American Society for Clinical Investigation
T2  - The Journal of Clinical Investigation
T1  - Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome
VL  - 133
IS  - 6
DO  - 10.1172/JCI158357
ER  - 

@article{
author = "Apostolović, Danijela and Grundström, Jeanette and Kiewiet, Mensiena B. Gea and Peruško, Marija and Hamsten, Carl and Starkhammar, Maria and Paulie, Staffan and Hage, Marianne van",
year = "2023",
abstract = "Tick bites have been shown to transmit a novel form of severe food allergy, the galactose-α-1,3-galactose (α-Gal) syndrome (AGS). Cellular responses to α-Gal in patients with AGS have, to date, not been thoroughly scrutinized. Therefore, we investigated T and B cell proliferation, activation, and cytokine profiles in response to tick protein extract (TE) and α-Gal-free TE in patients with AGS and in healthy controls. T and B cells from both patients and controls proliferated in response to TE, but significantly more in patients with AGS. B cell proliferation, but not T cell proliferation, in patients with AGS was reduced by removing α-Gal from the TE. In addition, TE induced a clear Th2 cytokine profile in patients with AGS. Expression of CD23 by B cells correlated only to T cell proliferation. However, both B cell proliferation and CD23 expression were reduced when CD40L and IL-4 were blocked. A large portion of the IgG1 and IgE antibodies binding TE in patients with AGS were directed against the α-Gal epitope. We have, for what we believe to be the first time, investigated T and B cell responses to α-Gal carrying tick proteins in patients with AGS, which will be essential for the understanding of the immune response against an allergenic carbohydrate transmitted by ticks.",
publisher = "American Society for Clinical Investigation",
journal = "The Journal of Clinical Investigation",
title = "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome",
volume = "133",
number = "6",
doi = "10.1172/JCI158357"
}

Apostolović, D., Grundström, J., Kiewiet, M. B. G., Peruško, M., Hamsten, C., Starkhammar, M., Paulie, S.,& Hage, M. v.. (2023). Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation
American Society for Clinical Investigation., 133(6).
https://doi.org/10.1172/JCI158357

Apostolović D, Grundström J, Kiewiet MBG, Peruško M, Hamsten C, Starkhammar M, Paulie S, Hage MV. Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome. in The Journal of Clinical Investigation. 2023;133(6).
doi:10.1172/JCI158357 .

Apostolović, Danijela, Grundström, Jeanette, Kiewiet, Mensiena B. Gea, Peruško, Marija, Hamsten, Carl, Starkhammar, Maria, Paulie, Staffan, Hage, Marianne van, "Th2-skewed T cells correlate with B cell response to α-Gal and tick antigens in α-Gal syndrome" in The Journal of Clinical Investigation, 133, no. 6 (2023),
https://doi.org/10.1172/JCI158357 . .

TY  - JOUR
AU  - Milikić, Jadranka
AU  - Knežević, Sara
AU  - Ognjanović, Miloš
AU  - Stanković, Dalibor
AU  - Rakočević, Lazar
AU  - Šljukić, Biljana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6250
AB  - Porous cobalt (III) oxide (Co3O4) and mixed cobalt (III) oxide - tin oxide (Co3O4/SnO2) were prepared by a novel template-based hydrothermal method resulting in their spherical morphology as confirmed by thorough physico-chemical characterisation. Two oxides were systematically examined as bifunctional electrocatalysts for oxygen reduction (ORR) and evolution (OER) reaction in alkaline media by voltammetry with rotating disk electrode, electrochemical impedance spectroscopy, and chronoamperometry. Low-cost Co3O4 and Co3O4/SnO2 electrocatalysts showed excellent ORR performance with low onset and half-wave potential, low Tafel slope, and the number of exchange electrons near 4, comparable to the commercial Pt/C electrocatalyst. Low OER onset potential of 1.52 and 1.57 V was observed for Co3O4 and Co3O4/SnO2, respectively, with low charge transfer resistance under anodic polarization conditions. Finally, to test bifunctional activity and durability of the two electrocatalyst, switch OER/ORR test was carried out.
PB  - Elsevier
T2  - International Journal of Hydrogen EnergyInternational Journal of Hydrogen Energy
T1  - Template-based synthesis of Co3O4 and Co3O4/SnO2 bifunctional catalysts with enhanced electrocatalytic properties for reversible oxygen evolution and reduction reaction
VL  - 48
IS  - 71
SP  - 27568
EP  - 27581
DO  - 10.1016/j.ijhydene.2023.03.433
ER  - 

@article{
author = "Milikić, Jadranka and Knežević, Sara and Ognjanović, Miloš and Stanković, Dalibor and Rakočević, Lazar and Šljukić, Biljana",
year = "2023",
abstract = "Porous cobalt (III) oxide (Co3O4) and mixed cobalt (III) oxide - tin oxide (Co3O4/SnO2) were prepared by a novel template-based hydrothermal method resulting in their spherical morphology as confirmed by thorough physico-chemical characterisation. Two oxides were systematically examined as bifunctional electrocatalysts for oxygen reduction (ORR) and evolution (OER) reaction in alkaline media by voltammetry with rotating disk electrode, electrochemical impedance spectroscopy, and chronoamperometry. Low-cost Co3O4 and Co3O4/SnO2 electrocatalysts showed excellent ORR performance with low onset and half-wave potential, low Tafel slope, and the number of exchange electrons near 4, comparable to the commercial Pt/C electrocatalyst. Low OER onset potential of 1.52 and 1.57 V was observed for Co3O4 and Co3O4/SnO2, respectively, with low charge transfer resistance under anodic polarization conditions. Finally, to test bifunctional activity and durability of the two electrocatalyst, switch OER/ORR test was carried out.",
publisher = "Elsevier",
journal = "International Journal of Hydrogen EnergyInternational Journal of Hydrogen Energy",
title = "Template-based synthesis of Co3O4 and Co3O4/SnO2 bifunctional catalysts with enhanced electrocatalytic properties for reversible oxygen evolution and reduction reaction",
volume = "48",
number = "71",
pages = "27568-27581",
doi = "10.1016/j.ijhydene.2023.03.433"
}

Milikić, J., Knežević, S., Ognjanović, M., Stanković, D., Rakočević, L.,& Šljukić, B.. (2023). Template-based synthesis of Co3O4 and Co3O4/SnO2 bifunctional catalysts with enhanced electrocatalytic properties for reversible oxygen evolution and reduction reaction. in International Journal of Hydrogen EnergyInternational Journal of Hydrogen Energy
Elsevier., 48(71), 27568-27581.
https://doi.org/10.1016/j.ijhydene.2023.03.433

Milikić J, Knežević S, Ognjanović M, Stanković D, Rakočević L, Šljukić B. Template-based synthesis of Co3O4 and Co3O4/SnO2 bifunctional catalysts with enhanced electrocatalytic properties for reversible oxygen evolution and reduction reaction. in International Journal of Hydrogen EnergyInternational Journal of Hydrogen Energy. 2023;48(71):27568-27581.
doi:10.1016/j.ijhydene.2023.03.433 .

Milikić, Jadranka, Knežević, Sara, Ognjanović, Miloš, Stanković, Dalibor, Rakočević, Lazar, Šljukić, Biljana, "Template-based synthesis of Co3O4 and Co3O4/SnO2 bifunctional catalysts with enhanced electrocatalytic properties for reversible oxygen evolution and reduction reaction" in International Journal of Hydrogen EnergyInternational Journal of Hydrogen Energy, 48, no. 71 (2023):27568-27581,
https://doi.org/10.1016/j.ijhydene.2023.03.433 . .

TY  - JOUR
AU  - Cvijetić, Ilija 
AU  - Herlah, Barbara
AU  - Marinković, Aleksandar
AU  - Perdih, Andrej
AU  - Bjelogrlić, Snežana K.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6246
AB  - Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural similarity of α-substituted thiocarbohydrazone to previously published thiosemicarbazone catalytic inhibitors targeting the ATP-binding site of human DNA topoisomerase IIα prompted us to investigate the inhibition activity on this target. Thiocarbohydrazone acted as a catalytic inhibitor and did not intercalate the DNA molecule, which validated their engagement with this cancer target. A comprehensive computational assessment of molecular recognition for a selected thiosemicarbazone and thiocarbohydrazone provided useful information for further optimization of this discovered lead compound for chemotherapeutic anticancer drug discovery.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα
VL  - 16
IS  - 3
SP  - 341
DO  - 10.3390/ph16030341
ER  - 

@article{
author = "Cvijetić, Ilija  and Herlah, Barbara and Marinković, Aleksandar and Perdih, Andrej and Bjelogrlić, Snežana K.",
year = "2023",
abstract = "Phenotypic screening of α-substituted thiocarbohydrazones revealed promising activity of 1,5-bis(salicylidene)thiocarbohydrazide against leukemia and breast cancer cells. Supplementary cell-based studies indicated an impairment of DNA replication via the ROS-independent pathway. The structural similarity of α-substituted thiocarbohydrazone to previously published thiosemicarbazone catalytic inhibitors targeting the ATP-binding site of human DNA topoisomerase IIα prompted us to investigate the inhibition activity on this target. Thiocarbohydrazone acted as a catalytic inhibitor and did not intercalate the DNA molecule, which validated their engagement with this cancer target. A comprehensive computational assessment of molecular recognition for a selected thiosemicarbazone and thiocarbohydrazone provided useful information for further optimization of this discovered lead compound for chemotherapeutic anticancer drug discovery.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα",
volume = "16",
number = "3",
pages = "341",
doi = "10.3390/ph16030341"
}

Cvijetić, I., Herlah, B., Marinković, A., Perdih, A.,& Bjelogrlić, S. K.. (2023). Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα. in Pharmaceuticals
MDPI., 16(3), 341.
https://doi.org/10.3390/ph16030341

Cvijetić I, Herlah B, Marinković A, Perdih A, Bjelogrlić SK. Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα. in Pharmaceuticals. 2023;16(3):341.
doi:10.3390/ph16030341 .

Cvijetić, Ilija , Herlah, Barbara, Marinković, Aleksandar, Perdih, Andrej, Bjelogrlić, Snežana K., "Phenotypic Discovery of Thiocarbohydrazone with Anticancer Properties and Catalytic Inhibition of Human DNA Topoisomerase IIα" in Pharmaceuticals, 16, no. 3 (2023):341,
https://doi.org/10.3390/ph16030341 . .

TY  - JOUR
AU  - Popović, Branko
AU  - Mitrović, Olga
AU  - Nikićević, Ninoslav
AU  - Tešević, Vele
AU  - Urošević, Ivan
AU  - Miletić, Nemanja
AU  - Milojević, Svetomir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6249
AB  - The aim of this study was to compare the aromatic profile of plum spirits, obtained from the Požegača and Stanley varieties, as affected by different combinations of pre-distillation steps used in traditional and six modified production methods that are common in Serbian distilleries. Traditional plum spirits (produced from spontaneously fermented mashes of crushed plums with stones distilled after two months of storage) had the highest contents of ethyl acetate, benzaldehyde, and total acids, which resulted in the occurrence of an unpleasant solvent-like and stone-like odour and acidic taste. These sensory defects were overcome by the distillation of fermented mashes immediately after the completion of alcoholic fermentation. Depending on the combination of the pre-distillation steps, plum spirits from mashes distilled immediately after alcoholic fermentation were characterized by different aromatic profiles: closer to traditional (from spontaneously fermented crushed plums with/without stones) or with a more pronounced fruity character (from pulped plums without stones regardless of the way of fermentation). These differences in aroma profiles have arisen mostly because of the significantly different contents and OAVs of ethyl esters and volatile fatty acids. The appropriate combination of the pre-distillation steps, which is adapted to the variety, can significantly improve the quality of the plum spirit compared to the traditionally produced spirit.
PB  - MDPI
T2  - Processes
T1  - Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods
VL  - 11
IS  - 3
SP  - 863
DO  - 10.3390/pr11030863
ER  - 

@article{
author = "Popović, Branko and Mitrović, Olga and Nikićević, Ninoslav and Tešević, Vele and Urošević, Ivan and Miletić, Nemanja and Milojević, Svetomir",
year = "2023",
abstract = "The aim of this study was to compare the aromatic profile of plum spirits, obtained from the Požegača and Stanley varieties, as affected by different combinations of pre-distillation steps used in traditional and six modified production methods that are common in Serbian distilleries. Traditional plum spirits (produced from spontaneously fermented mashes of crushed plums with stones distilled after two months of storage) had the highest contents of ethyl acetate, benzaldehyde, and total acids, which resulted in the occurrence of an unpleasant solvent-like and stone-like odour and acidic taste. These sensory defects were overcome by the distillation of fermented mashes immediately after the completion of alcoholic fermentation. Depending on the combination of the pre-distillation steps, plum spirits from mashes distilled immediately after alcoholic fermentation were characterized by different aromatic profiles: closer to traditional (from spontaneously fermented crushed plums with/without stones) or with a more pronounced fruity character (from pulped plums without stones regardless of the way of fermentation). These differences in aroma profiles have arisen mostly because of the significantly different contents and OAVs of ethyl esters and volatile fatty acids. The appropriate combination of the pre-distillation steps, which is adapted to the variety, can significantly improve the quality of the plum spirit compared to the traditionally produced spirit.",
publisher = "MDPI",
journal = "Processes",
title = "Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods",
volume = "11",
number = "3",
pages = "863",
doi = "10.3390/pr11030863"
}

Popović, B., Mitrović, O., Nikićević, N., Tešević, V., Urošević, I., Miletić, N.,& Milojević, S.. (2023). Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods. in Processes
MDPI., 11(3), 863.
https://doi.org/10.3390/pr11030863

Popović B, Mitrović O, Nikićević N, Tešević V, Urošević I, Miletić N, Milojević S. Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods. in Processes. 2023;11(3):863.
doi:10.3390/pr11030863 .

Popović, Branko, Mitrović, Olga, Nikićević, Ninoslav, Tešević, Vele, Urošević, Ivan, Miletić, Nemanja, Milojević, Svetomir, "Influence of Different Pre-Distillation Steps on Aromatic Profile of Plum Spirits Produced by Traditional and Modified Methods" in Processes, 11, no. 3 (2023):863,
https://doi.org/10.3390/pr11030863 . .

TY  - JOUR
AU  - Vlahović, Filip
AU  - Ognjanović, Miloš
AU  - Djurdjić, Sladjana
AU  - Kukuruzar, Andrej
AU  - Antić, Bratislav
AU  - Dojčinović, Biljana
AU  - Stanković, Dalibor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6253
AB  - We have set-up an electrochemical advanced oxidation process for ethidium bromide (1), based on the Eu-doped MnWO4 (Eu:MnWO4), obtained through a template-driven synthesis, along with developing a suitable monitoring method. Under galvanostatic conditions, Eu:MnWO4-coated graphite electrode serves as anode, applicable for removal of 1. To go further and augment the catalytic method, we have applied a modified carbon paste electrode for the monitoring of 1 with the limit of detection (LOD) of 54 nM. Enhancement of the hydrogen evolution reaction is an indication of electrocatalytic properties of the material, whereby developed method emerges as a candidate for straightforward application in electrochemical advanced oxidation processes (EAOPs). We have enriched experimental data with theoretical insights, provided by Density Functional Theory (DFT), and proposed oxidation mechanism of 1. Based on obtained results, we propose the new nanomaterial as a potent electrochemical modifier, suitable for catalytic treatment and process monitoring of the 1-polluted waters.
PB  - Elsevier
T2  - Applied Catalysis B: Environmental
T1  - Design of an ethidium bromide control circuit supported by deep theoretical insight
VL  - 334
SP  - 122819
DO  - 10.1016/j.apcatb.2023.122819
ER  - 

@article{
author = "Vlahović, Filip and Ognjanović, Miloš and Djurdjić, Sladjana and Kukuruzar, Andrej and Antić, Bratislav and Dojčinović, Biljana and Stanković, Dalibor",
year = "2023",
abstract = "We have set-up an electrochemical advanced oxidation process for ethidium bromide (1), based on the Eu-doped MnWO4 (Eu:MnWO4), obtained through a template-driven synthesis, along with developing a suitable monitoring method. Under galvanostatic conditions, Eu:MnWO4-coated graphite electrode serves as anode, applicable for removal of 1. To go further and augment the catalytic method, we have applied a modified carbon paste electrode for the monitoring of 1 with the limit of detection (LOD) of 54 nM. Enhancement of the hydrogen evolution reaction is an indication of electrocatalytic properties of the material, whereby developed method emerges as a candidate for straightforward application in electrochemical advanced oxidation processes (EAOPs). We have enriched experimental data with theoretical insights, provided by Density Functional Theory (DFT), and proposed oxidation mechanism of 1. Based on obtained results, we propose the new nanomaterial as a potent electrochemical modifier, suitable for catalytic treatment and process monitoring of the 1-polluted waters.",
publisher = "Elsevier",
journal = "Applied Catalysis B: Environmental",
title = "Design of an ethidium bromide control circuit supported by deep theoretical insight",
volume = "334",
pages = "122819",
doi = "10.1016/j.apcatb.2023.122819"
}

Vlahović, F., Ognjanović, M., Djurdjić, S., Kukuruzar, A., Antić, B., Dojčinović, B.,& Stanković, D.. (2023). Design of an ethidium bromide control circuit supported by deep theoretical insight. in Applied Catalysis B: Environmental
Elsevier., 334, 122819.
https://doi.org/10.1016/j.apcatb.2023.122819

Vlahović F, Ognjanović M, Djurdjić S, Kukuruzar A, Antić B, Dojčinović B, Stanković D. Design of an ethidium bromide control circuit supported by deep theoretical insight. in Applied Catalysis B: Environmental. 2023;334:122819.
doi:10.1016/j.apcatb.2023.122819 .

Vlahović, Filip, Ognjanović, Miloš, Djurdjić, Sladjana, Kukuruzar, Andrej, Antić, Bratislav, Dojčinović, Biljana, Stanković, Dalibor, "Design of an ethidium bromide control circuit supported by deep theoretical insight" in Applied Catalysis B: Environmental, 334 (2023):122819,
https://doi.org/10.1016/j.apcatb.2023.122819 . .

TY  - JOUR
AU  - Koračak, Ljiljana
AU  - Lupšić, Ema
AU  - Terzić-Jovanović, Nataša
AU  - Jovanović, Mirna
AU  - Novakovic, Miroslav
AU  - Nedialkov, Paraskev
AU  - Trendafilova, Antoaneta
AU  - Zlatović, Mario
AU  - Pešić, Milica
AU  - Opsenica, Igor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6245
AB  - The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.
PB  - Royal Society of Chemistry
T2  - New Journal of Chemistry
T2  - New Journal of ChemistryNew J. Chem.
T1  - Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells
VL  - 47
IS  - 14
SP  - 6844
EP  - 6855
DO  - 10.1039/D3NJ00427A
ER  - 

@article{
author = "Koračak, Ljiljana and Lupšić, Ema and Terzić-Jovanović, Nataša and Jovanović, Mirna and Novakovic, Miroslav and Nedialkov, Paraskev and Trendafilova, Antoaneta and Zlatović, Mario and Pešić, Milica and Opsenica, Igor",
year = "2023",
abstract = "The synthesis of 17 hybrid molecules, consisting of artesunate, a derivative of naturally occurring artemisinin, and synthetic 4-aryl-2-aminopyrimidines, is described. New compounds were designed to improve the parent compounds' cytotoxic properties, activity, and selectivity. The synthesized hybrid molecules (15a–f with ethylenediamine linker and 16a–k with piperazine linker), as well as their precursors – pyrimidine derivatives (13a–f and 14a–k), artemisinin, and artesunate, were tested on sensitive and multidrug-resistant (MDR) human non-small cell lung carcinoma (NSCLC) cells. All hybrid compounds with piperazine linker 16a–k were selective toward NSCLC cells and displayed IC50 values below 5 μM. Although they showed similar anticancer potency as artesunate, their selectivity against cancer cells was considerably improved. Importantly, 16h–k hybrid compounds were able to evade MDR phenotype, inhibit P-glycoprotein (P-gp) activity, and increase the sensitivity of MDR NSCLC cells to doxorubicin (DOX). The inhibition of P-gp activity induced by 16h–j was stronger than the one obtained with artesunate. Among these four hybrid compounds, 16k was the most potent anticancer agent with similar IC50 values of around 1.5 μM (for comparison – over 3.1 μM for artesunate) in sensitive and MDR NSCLC cells.",
publisher = "Royal Society of Chemistry",
journal = "New Journal of Chemistry, New Journal of ChemistryNew J. Chem.",
title = "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells",
volume = "47",
number = "14",
pages = "6844-6855",
doi = "10.1039/D3NJ00427A"
}

Koračak, L., Lupšić, E., Terzić-Jovanović, N., Jovanović, M., Novakovic, M., Nedialkov, P., Trendafilova, A., Zlatović, M., Pešić, M.,& Opsenica, I.. (2023). Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry
Royal Society of Chemistry., 47(14), 6844-6855.
https://doi.org/10.1039/D3NJ00427A

Koračak L, Lupšić E, Terzić-Jovanović N, Jovanović M, Novakovic M, Nedialkov P, Trendafilova A, Zlatović M, Pešić M, Opsenica I. Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells. in New Journal of Chemistry. 2023;47(14):6844-6855.
doi:10.1039/D3NJ00427A .

Koračak, Ljiljana, Lupšić, Ema, Terzić-Jovanović, Nataša, Jovanović, Mirna, Novakovic, Miroslav, Nedialkov, Paraskev, Trendafilova, Antoaneta, Zlatović, Mario, Pešić, Milica, Opsenica, Igor, "Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells" in New Journal of Chemistry, 47, no. 14 (2023):6844-6855,
https://doi.org/10.1039/D3NJ00427A . .

TY  - JOUR
AU  - Cavic, Milena
AU  - Nešić, Andrijana N.
AU  - Mirjacic Martinovic, Katarina
AU  - Vuletic, Ana
AU  - Besu Zizak, Irina
AU  - Tisma Miletic, Nevena
AU  - Krivokuca, Ana
AU  - Jankovic, Radmila
AU  - Gavrović-Jankulović, Marija
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6247
AB  - This study explored humoral and cellular responses to anti-SARS-CoV-2 BNT162b2 mRNA vaccine in breastfeeding women and naïve and seropositive individuals in the first six months after vaccination.Sixty-one volunteers vaccinated with two doses of the BNT162b2 mRNA vaccine were enrolled in the study. In-house developed ELISA was used for the quantification of SARS-CoV-2 RBD-specific antibodies. Cell surface marker expression and intracellular IFN-γ analysis were carried out by flow cytometry. The concentrations of IFN-γ, IL-6 and TNF were determined by ELISA. A significant rise in anti-RBD IgG antibody levels was observed 14 days after the first vaccine dose (p < 0.0001) in serum and milk. The expression of CD28 on CD4+ T cells was significantly higher compared to baseline (p < 0.05). There was a significant increase (p ≤ 0.05) in B cell lymphocyte subset after revaccination, and increased percentage of CD80+ B cells. The expression of IFN-γ in peripheral blood lymphocytes, CD3+ T cells and serum was significantly increased (p < 0.05). No significant difference in immune response was observed between breastfeeding women and other study participants. The anti-SARS-CoV-2 BNT162b2 mRNA vaccine-induced measurable and durable immune response in breastfeeding women and in naïve and previously infected individuals.
PB  - Nature Research
T2  - Scientific Reports
T1  - Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals
VL  - 13
IS  - 1
SP  - 6271
DO  - 10.1038/s41598-023-33516-1
ER  - 

@article{
author = "Cavic, Milena and Nešić, Andrijana N. and Mirjacic Martinovic, Katarina and Vuletic, Ana and Besu Zizak, Irina and Tisma Miletic, Nevena and Krivokuca, Ana and Jankovic, Radmila and Gavrović-Jankulović, Marija",
year = "2023",
abstract = "This study explored humoral and cellular responses to anti-SARS-CoV-2 BNT162b2 mRNA vaccine in breastfeeding women and naïve and seropositive individuals in the first six months after vaccination.Sixty-one volunteers vaccinated with two doses of the BNT162b2 mRNA vaccine were enrolled in the study. In-house developed ELISA was used for the quantification of SARS-CoV-2 RBD-specific antibodies. Cell surface marker expression and intracellular IFN-γ analysis were carried out by flow cytometry. The concentrations of IFN-γ, IL-6 and TNF were determined by ELISA. A significant rise in anti-RBD IgG antibody levels was observed 14 days after the first vaccine dose (p < 0.0001) in serum and milk. The expression of CD28 on CD4+ T cells was significantly higher compared to baseline (p < 0.05). There was a significant increase (p ≤ 0.05) in B cell lymphocyte subset after revaccination, and increased percentage of CD80+ B cells. The expression of IFN-γ in peripheral blood lymphocytes, CD3+ T cells and serum was significantly increased (p < 0.05). No significant difference in immune response was observed between breastfeeding women and other study participants. The anti-SARS-CoV-2 BNT162b2 mRNA vaccine-induced measurable and durable immune response in breastfeeding women and in naïve and previously infected individuals.",
publisher = "Nature Research",
journal = "Scientific Reports",
title = "Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals",
volume = "13",
number = "1",
pages = "6271",
doi = "10.1038/s41598-023-33516-1"
}

Cavic, M., Nešić, A. N., Mirjacic Martinovic, K., Vuletic, A., Besu Zizak, I., Tisma Miletic, N., Krivokuca, A., Jankovic, R.,& Gavrović-Jankulović, M.. (2023). Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals. in Scientific Reports
Nature Research., 13(1), 6271.
https://doi.org/10.1038/s41598-023-33516-1

Cavic M, Nešić AN, Mirjacic Martinovic K, Vuletic A, Besu Zizak I, Tisma Miletic N, Krivokuca A, Jankovic R, Gavrović-Jankulović M. Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals. in Scientific Reports. 2023;13(1):6271.
doi:10.1038/s41598-023-33516-1 .

Cavic, Milena, Nešić, Andrijana N., Mirjacic Martinovic, Katarina, Vuletic, Ana, Besu Zizak, Irina, Tisma Miletic, Nevena, Krivokuca, Ana, Jankovic, Radmila, Gavrović-Jankulović, Marija, "Detection of humoral and cellular immune response to anti-SARS-CoV-2 BNT162b2 vaccine in breastfeeding women and naïve and previously infected individuals" in Scientific Reports, 13, no. 1 (2023):6271,
https://doi.org/10.1038/s41598-023-33516-1 . .

TY  - THES
AU  - Ivanović, Ljubica
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9369
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31816/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130986249
UR  - https://nardus.mpn.gov.rs/handle/123456789/21930
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6239
AB  - U okviru ove doktorske disertacije proučavan je nutritivni i fitonutritivni sadržaj blitve koja je gajena u uslovima različitih režima đubrenja i navodnjavanja, pri čemu su ispitivane i funkcionalne osobine blitve u cilju utvrđivanja njenog potencijala kao funkcionalne hrane.U početnoj fazi eksperimenta određene su nutritivne, antinutritivne i fitonutritivne komponente u blitvi, kao i uticaj primjenjenih agrotehničkih mjera na pomenute komponente. Korišćenjem standardnih metoda za proksimativnu analizu (AOAC metode) utvrđeno je da svježa blitva ima sledeći sastav: voda- 89%, ukupni šećeri- 4,9%, proteini- 2,5%, pepeo- 1,8% i lipidi-0,45%. Savremenim instrumentalnim tehnikama (spektrofotometrija, ICP OES, tečna hromatografija) su kvantifikovane druge nutritivne, antinutritivne i fitonutritivne komponente u blitvi. Nađeno je da su prosječne koncentracije vitamina C, ukupnog hlorofila, karotenoida u 100 g svježe blitve su redom: 26,9 mg, 47,13 mg, 9,85 mg. Blitva ima visok sadržaj makro- i mikroelemenata od kojih su najzastupljeniji sledeći: kalijum (372,49 mg), kalcijum (178,6 mg), mangan (8,35 mg) i gvožđe (1,46 mg) izraženo na 100 g svježe blitve. Analizom ukupnog polifenolnog i flavonoidnog sadržaja pokazano je da je blitva bogata ovim fitonutrijentima, nakon čega su identifikovane i kvantifikovane četiri flavonoidne komponente: viteksin-2"-O-ksilozid, viteksin-6″-O-malonil-2″-O-ksilozid, izoramnetin-3,7-O-diglukozid i viteksin-6″-O-acetil-2″-O-ksilozid. Strukture ovih jedinjenja su potvrđene 1D i 2D NMR spektroskopijom (1H NMR,13 C NMR, COSY, HSQC, HMBC). Osim toga, određen je sadržaj nitrata u blitvi, koji je bio u granicama dozvoljenih vrijednosti.Statističkom analizom uticaja različitih režima navodnjavanja i đubrenja nađeno je da je đubrenje uticalo na prinos, morfološke karakteristike, količinu proteina, sadržaj fosfora, sadržaj izoramnetin-3,7-O-diglukozida, sadržaj hlorofila i vitamina C. Povećanjem količine primjenjene prihrane povećali su se svi pomenuti prametri, osim sadržaj fosfora i sadržaj izoramnetin-3,7-O-diglukozida, koji su bili niži sa povećanjem nivoa đubrenja. Interakcija navodnjavanja i đubrenja je značajno uticala na sadržaj Na i Cu i sadržaj viteksin-2"-O-ksilozida. Navodnjavanje nije imalo značajnog efekta na testirane parametre, osim na sadržaj nitrata, gdje je povećanjem nivoa navodnjavanja sadržaj nitrata u blitvi opadao, dok je povećanjem đubrenja rastao njihov sadržaj.Poslednja faza eksperimenta je obuhvatila ispitivanje antioksidativne, antiproliferativne i antimikrobne aktivnosti ekstrakta blitve. Rezultati su pokazali antioksidativnu aktivnost vodenog ekstrakta blitve u vrijednosti IC50=3,79 mg/ml (mjereno DPPH testom) dok je metanolni ekstrakt imao prosječni antioksidativni kapacitet od 8,0 (mjereno DPPH testom) odnosno 8,57 μmola ekvivalenta trolox-a/g (mjereno ABTS testom). Analizom antiproliferativne aktivnosti ekstrakta blitve je utvrđeno da postoji inhibicija rasta malignih MCF-7 ćelija i to 70% ćelija je inhibirano nakon 48 h inkubacije. Ispitivani ekstrakti blitve nijesu pokazali antimikrobnu aktivnost.
AB  - In this doctoral dissertation, the nutritional and phytonutrient content of Swiss chard grown under different irrigation and fertilization regimes was studied, while the functional properties of Swiss chard were also examined in order to determine its potential as a functional food.In the initial phase of the experiment, nutritional, anti-nutritive and phyto-nutritive components in Swiss chard were determined, as well as the influence of applied agrotechnical measurments on all tested parameters was monitored. Using standard methods for proximate analysis (AOAC methods), it was determined that fresh chard has the following composition: water- 89%, total sugars- 4,9 %, proteins- 2,5 %, ash- 1,8 % and lipids- 0,45%. Using modern instrumental techniques (spectrophotometry, ICP OES, liquid chromatography) other nutritional and phytonutritive components in Swiss chard were quantified. It was found that the average concentrations of vitamin C, total chlorophyll, carotenoids in 100 g of fresh chard are: 26,9 mg, 47,13 mg and 9,85 mg, respectively. Swiss chard has a high content of macro- and microelements, of which the most abundant are the following: potassium (372,49 mg), calcium (178,6 mg), followed by manganese (8,35 mg) and iron (1,46 mg) expressed per 100 g of fresh Swiss chard. The analysis of the total polyphenolic and flavonoid content showed that Swiss chard is rich in these phytonutrients, after which four flavonoid components were identified and quantified: vitexin-2"-O-xyloside, vitexin-6"-O-malonyl-2"-O-xyloside, isorhamnetin-3,7-O-diglucoside and vitexin-6″-O-acetyl-2″-O-xyloside. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy (1H NMR,13 C NMR, COSY, HSQC, HMBC). In addition, the content of nitrates in Swiss chard was determined, which was within the limits of permitted values.A statistical analysis of the effect of different irrigation and fertilization regimes found that fertilization influenced the yield, morphological characteristics, amount of protein, as well as phosphorus, isorhamnetin-3,7-O-diglucoside, chlorophyll, and vitamin C content. With increasing the amount of fertilization, values for all parameters mentioned above increased, except phosphorus and isorhamnetin-3,7-O-diglucoside content, which were found to be lower with increasing fertilization level. The interaction of irrigation and fertilization significantly affected Na and Cu content, as well as the content of vitexin-2"-O-xyloside. Irrigation had no significant effect on the studied parameters, except for the nitrate content. While the increased level of irrigation led to decreased nitrate content in Swiss chard, with increasing fertilization their content increased.The last phase of the experiment included investigation of the antioxidant, antiproliferative and antimicrobial activity of Swiss chard extract. The results showed the antioxidant activity of the aqueous extract of Swiss chard with an IC50 value of 3,79 mg/ml (measured by the DPPH test), while the methanolic extract had an average antioxidant capacity of 8,0 (measured by the DPPH test), 8,57 μmol of trolox equivalents per gram (measured by ABTS test). Analysis of the antiproliferative activity of Swiss chard extract revealed that there is an inhibition of the growth of malignant MCF-7 cells and that 70% of the cells were inhibited after 48 hours of incubation. The studied Swiss chard extracts did not show antimicrobial activity.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21930
ER  - 

@phdthesis{
author = "Ivanović, Ljubica",
year = "2023",
abstract = "U okviru ove doktorske disertacije proučavan je nutritivni i fitonutritivni sadržaj blitve koja je gajena u uslovima različitih režima đubrenja i navodnjavanja, pri čemu su ispitivane i funkcionalne osobine blitve u cilju utvrđivanja njenog potencijala kao funkcionalne hrane.U početnoj fazi eksperimenta određene su nutritivne, antinutritivne i fitonutritivne komponente u blitvi, kao i uticaj primjenjenih agrotehničkih mjera na pomenute komponente. Korišćenjem standardnih metoda za proksimativnu analizu (AOAC metode) utvrđeno je da svježa blitva ima sledeći sastav: voda- 89%, ukupni šećeri- 4,9%, proteini- 2,5%, pepeo- 1,8% i lipidi-0,45%. Savremenim instrumentalnim tehnikama (spektrofotometrija, ICP OES, tečna hromatografija) su kvantifikovane druge nutritivne, antinutritivne i fitonutritivne komponente u blitvi. Nađeno je da su prosječne koncentracije vitamina C, ukupnog hlorofila, karotenoida u 100 g svježe blitve su redom: 26,9 mg, 47,13 mg, 9,85 mg. Blitva ima visok sadržaj makro- i mikroelemenata od kojih su najzastupljeniji sledeći: kalijum (372,49 mg), kalcijum (178,6 mg), mangan (8,35 mg) i gvožđe (1,46 mg) izraženo na 100 g svježe blitve. Analizom ukupnog polifenolnog i flavonoidnog sadržaja pokazano je da je blitva bogata ovim fitonutrijentima, nakon čega su identifikovane i kvantifikovane četiri flavonoidne komponente: viteksin-2"-O-ksilozid, viteksin-6″-O-malonil-2″-O-ksilozid, izoramnetin-3,7-O-diglukozid i viteksin-6″-O-acetil-2″-O-ksilozid. Strukture ovih jedinjenja su potvrđene 1D i 2D NMR spektroskopijom (1H NMR,13 C NMR, COSY, HSQC, HMBC). Osim toga, određen je sadržaj nitrata u blitvi, koji je bio u granicama dozvoljenih vrijednosti.Statističkom analizom uticaja različitih režima navodnjavanja i đubrenja nađeno je da je đubrenje uticalo na prinos, morfološke karakteristike, količinu proteina, sadržaj fosfora, sadržaj izoramnetin-3,7-O-diglukozida, sadržaj hlorofila i vitamina C. Povećanjem količine primjenjene prihrane povećali su se svi pomenuti prametri, osim sadržaj fosfora i sadržaj izoramnetin-3,7-O-diglukozida, koji su bili niži sa povećanjem nivoa đubrenja. Interakcija navodnjavanja i đubrenja je značajno uticala na sadržaj Na i Cu i sadržaj viteksin-2"-O-ksilozida. Navodnjavanje nije imalo značajnog efekta na testirane parametre, osim na sadržaj nitrata, gdje je povećanjem nivoa navodnjavanja sadržaj nitrata u blitvi opadao, dok je povećanjem đubrenja rastao njihov sadržaj.Poslednja faza eksperimenta je obuhvatila ispitivanje antioksidativne, antiproliferativne i antimikrobne aktivnosti ekstrakta blitve. Rezultati su pokazali antioksidativnu aktivnost vodenog ekstrakta blitve u vrijednosti IC50=3,79 mg/ml (mjereno DPPH testom) dok je metanolni ekstrakt imao prosječni antioksidativni kapacitet od 8,0 (mjereno DPPH testom) odnosno 8,57 μmola ekvivalenta trolox-a/g (mjereno ABTS testom). Analizom antiproliferativne aktivnosti ekstrakta blitve je utvrđeno da postoji inhibicija rasta malignih MCF-7 ćelija i to 70% ćelija je inhibirano nakon 48 h inkubacije. Ispitivani ekstrakti blitve nijesu pokazali antimikrobnu aktivnost., In this doctoral dissertation, the nutritional and phytonutrient content of Swiss chard grown under different irrigation and fertilization regimes was studied, while the functional properties of Swiss chard were also examined in order to determine its potential as a functional food.In the initial phase of the experiment, nutritional, anti-nutritive and phyto-nutritive components in Swiss chard were determined, as well as the influence of applied agrotechnical measurments on all tested parameters was monitored. Using standard methods for proximate analysis (AOAC methods), it was determined that fresh chard has the following composition: water- 89%, total sugars- 4,9 %, proteins- 2,5 %, ash- 1,8 % and lipids- 0,45%. Using modern instrumental techniques (spectrophotometry, ICP OES, liquid chromatography) other nutritional and phytonutritive components in Swiss chard were quantified. It was found that the average concentrations of vitamin C, total chlorophyll, carotenoids in 100 g of fresh chard are: 26,9 mg, 47,13 mg and 9,85 mg, respectively. Swiss chard has a high content of macro- and microelements, of which the most abundant are the following: potassium (372,49 mg), calcium (178,6 mg), followed by manganese (8,35 mg) and iron (1,46 mg) expressed per 100 g of fresh Swiss chard. The analysis of the total polyphenolic and flavonoid content showed that Swiss chard is rich in these phytonutrients, after which four flavonoid components were identified and quantified: vitexin-2"-O-xyloside, vitexin-6"-O-malonyl-2"-O-xyloside, isorhamnetin-3,7-O-diglucoside and vitexin-6″-O-acetyl-2″-O-xyloside. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy (1H NMR,13 C NMR, COSY, HSQC, HMBC). In addition, the content of nitrates in Swiss chard was determined, which was within the limits of permitted values.A statistical analysis of the effect of different irrigation and fertilization regimes found that fertilization influenced the yield, morphological characteristics, amount of protein, as well as phosphorus, isorhamnetin-3,7-O-diglucoside, chlorophyll, and vitamin C content. With increasing the amount of fertilization, values for all parameters mentioned above increased, except phosphorus and isorhamnetin-3,7-O-diglucoside content, which were found to be lower with increasing fertilization level. The interaction of irrigation and fertilization significantly affected Na and Cu content, as well as the content of vitexin-2"-O-xyloside. Irrigation had no significant effect on the studied parameters, except for the nitrate content. While the increased level of irrigation led to decreased nitrate content in Swiss chard, with increasing fertilization their content increased.The last phase of the experiment included investigation of the antioxidant, antiproliferative and antimicrobial activity of Swiss chard extract. The results showed the antioxidant activity of the aqueous extract of Swiss chard with an IC50 value of 3,79 mg/ml (measured by the DPPH test), while the methanolic extract had an average antioxidant capacity of 8,0 (measured by the DPPH test), 8,57 μmol of trolox equivalents per gram (measured by ABTS test). Analysis of the antiproliferative activity of Swiss chard extract revealed that there is an inhibition of the growth of malignant MCF-7 cells and that 70% of the cells were inhibited after 48 hours of incubation. The studied Swiss chard extracts did not show antimicrobial activity.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21930"
}

Ivanović, L.. (2023). Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21930

Ivanović L. Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21930 .

Ivanović, Ljubica, "Nutritivna vrijednost i osnovne fitohemijske osobine blitve (Beta vulgaris ssp. cicla L. Voss) gajene u različitim uslovima navodnjavanja i prihranjivanja" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21930 .

TY  - THES
AU  - Joksimović, Kristina
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9346
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31768/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130945289
UR  - https://nardus.mpn.gov.rs/handle/123456789/21928
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6241
AB  - Cilj ove disertacije je primena MFC sistema kao obnovljivog izvora „zelene“ energije zatretman otpadnih voda. U tu svrhu je izvršena optimizacija MFC radi dobijanja struje odgovarajućegintenziteta, koja se može iskoristiti za razgradnju reaktivnih organskih boja, glavnih zagađujućihsupstanci otpadnih voda. Prvi deo istraživanja obuhvata fizičko-hemijsku i mikrobiološkukarakterizaciju rečnog sedimenta koji je dalje korišćen za konstrukciju MFC sistema. Formirane sučetiri MFC ćelije: sa sterilnim, sa originalnim, sa biostimulisanim i sabiostimulisanim/biaugmentisanim rečnim sedimentom. Merenja napona na formiranim ćelijama supokazala da MFC sistem sa biostimulisanim sedimentom daje najbolje performanse.Fokus u drugom delu eksperimenata je bio izolovanje i karakterizacija mikroorganizama kojisu dominantno zastupljeni u sedimentu, a ujedno su i zaslužni za procese oksidacije u anodnom delukoji omogućavaju generisanje struje preko MFC. Izvršena je metagenomska analiza u uzorku rečnogsedimenta i u biostimulisanom rečnom sedimentu, kako bi se uporedio profil zastupljenih zajednicamikroorganizama.Studija degradacije i dekolorizacije Reactive Black 5 (RB5) azo boje izvedena je pomoćuelektrohemijski unapređenog oksidacionog procesa i opisana je u trećem segmentu disertacije.Elektro-Fentonov proces je uspostavljen upotrebom radne elektrode od 15% Fe i dodatkom H2O2 urastvor RB5 boje, dok je set od tri paralelno vezane MFC, sa biostimulisanim sedimentom, služiokao izvor struje. Optimizacija procesa elektrohemijskog tretmana RB5 je sprovedena na koncentracijiboje od 25 mg/L. Efikasnost degradacija RB5 boje je potvrđena upotrebom analitičkih metodaUV/VIS, FTIR i HPLC-MS. Testovi za procenu ekotoksičnosti, izvedeni pomoću Aliivibrio fischeri,pokazuju da su degradacioni proizvodi nastali u ovom eksperimentu manje toksični od polazne boje
AB  - The goal of this dissertation is application of the MFC system as a renewable „green“ energysource in wasterwater treatment. For this purpose MFC was optimized in order to obtain a suitableamount of electricity that can be used to decompose reactive organic dyes, the primary pollutants ofwastewaters.The first part of the research includes physico-chemical and microbiological analysis ofthe river sediment, which was further used to construct the MFC system. Four MFC cells were formedcontaining: sterile, original, stimulated and biostimulated/bioaugmented river sediment. Voltagemeasurements on the established cells showed that the MFC with biostimulated sediment exibitedthe best performance.The focus of the second part of the study was the isolation and characterization ofmicroorganisms that are dominantly represented in the sediment, which enable the generation ofcurrent through the MFC. Metagenomic analysis was used to compare the profiles of microbialpopulations in a composite of river sediment and biostimulated river sediment.The study of degradation and decolorization of Reactive Black 5 (RB5) azo dye investigatedusing an electrochemically improved oxidation process is described in the last part of the dissertation.The Electro-Fenton process was established using a working electrode of 15% Fe and the addition ofH2O2 to the RB5 dye solution, while a set of three MFCs connected in parallel, with biostimulatedsediment, served as the current source. Optimization of the RB5 electrochemical treatment processwas carried out at a dye concentration of 25 mg/L. The efficiency of degradation of RB5 dye wasconfirmed using analytical methods UV/VIS, FTIR and HPLC-MS. Ecotoxicity assessment tests,performed using Aliivibrio fischeri, show that the degradation products formed in this experiment areless toxic than the starting dye.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Elektrohemijska degradacija reaktivnih organskih boja upotrebom mikrobnih gorivnih ćelija
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21928
ER  - 

@phdthesis{
author = "Joksimović, Kristina",
year = "2023",
abstract = "Cilj ove disertacije je primena MFC sistema kao obnovljivog izvora „zelene“ energije zatretman otpadnih voda. U tu svrhu je izvršena optimizacija MFC radi dobijanja struje odgovarajućegintenziteta, koja se može iskoristiti za razgradnju reaktivnih organskih boja, glavnih zagađujućihsupstanci otpadnih voda. Prvi deo istraživanja obuhvata fizičko-hemijsku i mikrobiološkukarakterizaciju rečnog sedimenta koji je dalje korišćen za konstrukciju MFC sistema. Formirane sučetiri MFC ćelije: sa sterilnim, sa originalnim, sa biostimulisanim i sabiostimulisanim/biaugmentisanim rečnim sedimentom. Merenja napona na formiranim ćelijama supokazala da MFC sistem sa biostimulisanim sedimentom daje najbolje performanse.Fokus u drugom delu eksperimenata je bio izolovanje i karakterizacija mikroorganizama kojisu dominantno zastupljeni u sedimentu, a ujedno su i zaslužni za procese oksidacije u anodnom delukoji omogućavaju generisanje struje preko MFC. Izvršena je metagenomska analiza u uzorku rečnogsedimenta i u biostimulisanom rečnom sedimentu, kako bi se uporedio profil zastupljenih zajednicamikroorganizama.Studija degradacije i dekolorizacije Reactive Black 5 (RB5) azo boje izvedena je pomoćuelektrohemijski unapređenog oksidacionog procesa i opisana je u trećem segmentu disertacije.Elektro-Fentonov proces je uspostavljen upotrebom radne elektrode od 15% Fe i dodatkom H2O2 urastvor RB5 boje, dok je set od tri paralelno vezane MFC, sa biostimulisanim sedimentom, služiokao izvor struje. Optimizacija procesa elektrohemijskog tretmana RB5 je sprovedena na koncentracijiboje od 25 mg/L. Efikasnost degradacija RB5 boje je potvrđena upotrebom analitičkih metodaUV/VIS, FTIR i HPLC-MS. Testovi za procenu ekotoksičnosti, izvedeni pomoću Aliivibrio fischeri,pokazuju da su degradacioni proizvodi nastali u ovom eksperimentu manje toksični od polazne boje, The goal of this dissertation is application of the MFC system as a renewable „green“ energysource in wasterwater treatment. For this purpose MFC was optimized in order to obtain a suitableamount of electricity that can be used to decompose reactive organic dyes, the primary pollutants ofwastewaters.The first part of the research includes physico-chemical and microbiological analysis ofthe river sediment, which was further used to construct the MFC system. Four MFC cells were formedcontaining: sterile, original, stimulated and biostimulated/bioaugmented river sediment. Voltagemeasurements on the established cells showed that the MFC with biostimulated sediment exibitedthe best performance.The focus of the second part of the study was the isolation and characterization ofmicroorganisms that are dominantly represented in the sediment, which enable the generation ofcurrent through the MFC. Metagenomic analysis was used to compare the profiles of microbialpopulations in a composite of river sediment and biostimulated river sediment.The study of degradation and decolorization of Reactive Black 5 (RB5) azo dye investigatedusing an electrochemically improved oxidation process is described in the last part of the dissertation.The Electro-Fenton process was established using a working electrode of 15% Fe and the addition ofH2O2 to the RB5 dye solution, while a set of three MFCs connected in parallel, with biostimulatedsediment, served as the current source. Optimization of the RB5 electrochemical treatment processwas carried out at a dye concentration of 25 mg/L. The efficiency of degradation of RB5 dye wasconfirmed using analytical methods UV/VIS, FTIR and HPLC-MS. Ecotoxicity assessment tests,performed using Aliivibrio fischeri, show that the degradation products formed in this experiment areless toxic than the starting dye.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Elektrohemijska degradacija reaktivnih organskih boja upotrebom mikrobnih gorivnih ćelija",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21928"
}

Joksimović, K.. (2023). Elektrohemijska degradacija reaktivnih organskih boja upotrebom mikrobnih gorivnih ćelija. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21928

Joksimović K. Elektrohemijska degradacija reaktivnih organskih boja upotrebom mikrobnih gorivnih ćelija. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21928 .

Joksimović, Kristina, "Elektrohemijska degradacija reaktivnih organskih boja upotrebom mikrobnih gorivnih ćelija" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21928 .

TY  - THES
AU  - Šuljagić, Marija
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9353
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31783/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130971401
UR  - https://nardus.mpn.gov.rs/handle/123456789/21929
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6240
AB  - U ovoj doktorskoj disertaciji detaljno je ispitan uticaj metoda sinteze, oblaganja sintetisanih čestica isinterovanja na magnetna i električna svojstva kako funkcionalizovanih spinelnih oksida, tako injihovih kompozita, a u cilju njihove primene, sa akcentom na biomedicinsku upotrebu. Jedan deoistraživanja posvećen je magnetnim svojstvima skrobom funkcionalizovanih kobalt-ferita (CoFe2O4)sintetisanih na pet različitih načina (metodom koprecipitacije, mehanohemijski, metodomkoprecipitacije potpomognute ultrazvukom, metodom mikroemulzije i mikrotalasno potpomognutimhidrotermalnim metodom). Dobijeni materijali su detaljno strukturno i morfološki okarakterisanistandardnim tehnikama. Utvrđeno je da metod sinteze kao i način oblaganja značajno utiče namagnetna svojstva. Prateći uspešnost oblaganja i efekat aglomeracije preko pokazanih magnetnihsvojstava, predloženi su najbolji materijali za primenu u magnetnoj rezonantnoj tomografiji. Drugideo istraživanja bio je posvećen magnetoelektričnim perovskit/spinel kompozitima. Detaljno jeispitan uticaj metoda sinteze, faznog sastava i temperature sinterovanja na električna svojstvaBaTiO3/CoFe2O4 i BaTiO3/NixZn1-xFe2O4 kompozita. Ispitana je struktura i morfologija materijalapre i posle sinterovanja. Odnos perovskit/ferit faza imao je presudan uticaj na električna svojstvasintetisanih kompozita. Ispitivanje električnih svojstava na ovim kompozitima može predstavljatidobar screening metod za odabir magnetoelektričnih materijala kao višefaznih multiferoika zasavremene primene u tehnologiji i/ili medicini.
AB  - This doctoral dissertation deals with detailed investigation of synthesis methods, coating and sinteringeffects on magnetic and electrical properties of spinel oxide-based nanomaterials for the applicationsin biomedical field. Part of the investigations included magnetic properties study of starch-coatedcobalt-ferrite (CoFe2O4) nanoparticles prepared by five different routes (coprecipitation,mechanochemical, ultrasonically assisted coprecipitation, microemulsion, and microwave-assistedhydrothermal syntheses). The synthesized materials were thoroughly characterized by standardtechniques. The general conclusion was that the way of coating alongside with chosen preparationmethod had a crucial role for magnetic properties. The magnetic measurements served as a goodplatform to monitor agglomeration and coating effects, which helped to choose materials with bestperformances for applications in magnetic resonance imaging (MRI). Another part of theinvestigations was devoted to the influence of synthetic method, phase composition and sinteringtemperature on BaTiO3/CoFe2O4 and BaTiO3/NixZn1-xFe2O4 electrical properties. The structure andmorphology of as-prepared and sintered samples were examined in detail. The optimalperovskite/spinel phase ratio is a key factor for prominent electrical properties. The electricalmeasurements performed on this type of composites might be a good screening test for choosingmagnetoelectric material for further investigations including usage in technology and/or medicine.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Strukturna i funkcionalna svojstva materijala na bazi spinelnih oksida
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21929
ER  - 

@phdthesis{
author = "Šuljagić, Marija",
year = "2023",
abstract = "U ovoj doktorskoj disertaciji detaljno je ispitan uticaj metoda sinteze, oblaganja sintetisanih čestica isinterovanja na magnetna i električna svojstva kako funkcionalizovanih spinelnih oksida, tako injihovih kompozita, a u cilju njihove primene, sa akcentom na biomedicinsku upotrebu. Jedan deoistraživanja posvećen je magnetnim svojstvima skrobom funkcionalizovanih kobalt-ferita (CoFe2O4)sintetisanih na pet različitih načina (metodom koprecipitacije, mehanohemijski, metodomkoprecipitacije potpomognute ultrazvukom, metodom mikroemulzije i mikrotalasno potpomognutimhidrotermalnim metodom). Dobijeni materijali su detaljno strukturno i morfološki okarakterisanistandardnim tehnikama. Utvrđeno je da metod sinteze kao i način oblaganja značajno utiče namagnetna svojstva. Prateći uspešnost oblaganja i efekat aglomeracije preko pokazanih magnetnihsvojstava, predloženi su najbolji materijali za primenu u magnetnoj rezonantnoj tomografiji. Drugideo istraživanja bio je posvećen magnetoelektričnim perovskit/spinel kompozitima. Detaljno jeispitan uticaj metoda sinteze, faznog sastava i temperature sinterovanja na električna svojstvaBaTiO3/CoFe2O4 i BaTiO3/NixZn1-xFe2O4 kompozita. Ispitana je struktura i morfologija materijalapre i posle sinterovanja. Odnos perovskit/ferit faza imao je presudan uticaj na električna svojstvasintetisanih kompozita. Ispitivanje električnih svojstava na ovim kompozitima može predstavljatidobar screening metod za odabir magnetoelektričnih materijala kao višefaznih multiferoika zasavremene primene u tehnologiji i/ili medicini., This doctoral dissertation deals with detailed investigation of synthesis methods, coating and sinteringeffects on magnetic and electrical properties of spinel oxide-based nanomaterials for the applicationsin biomedical field. Part of the investigations included magnetic properties study of starch-coatedcobalt-ferrite (CoFe2O4) nanoparticles prepared by five different routes (coprecipitation,mechanochemical, ultrasonically assisted coprecipitation, microemulsion, and microwave-assistedhydrothermal syntheses). The synthesized materials were thoroughly characterized by standardtechniques. The general conclusion was that the way of coating alongside with chosen preparationmethod had a crucial role for magnetic properties. The magnetic measurements served as a goodplatform to monitor agglomeration and coating effects, which helped to choose materials with bestperformances for applications in magnetic resonance imaging (MRI). Another part of theinvestigations was devoted to the influence of synthetic method, phase composition and sinteringtemperature on BaTiO3/CoFe2O4 and BaTiO3/NixZn1-xFe2O4 electrical properties. The structure andmorphology of as-prepared and sintered samples were examined in detail. The optimalperovskite/spinel phase ratio is a key factor for prominent electrical properties. The electricalmeasurements performed on this type of composites might be a good screening test for choosingmagnetoelectric material for further investigations including usage in technology and/or medicine.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Strukturna i funkcionalna svojstva materijala na bazi spinelnih oksida",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21929"
}

Šuljagić, M.. (2023). Strukturna i funkcionalna svojstva materijala na bazi spinelnih oksida. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21929

Šuljagić M. Strukturna i funkcionalna svojstva materijala na bazi spinelnih oksida. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21929 .

Šuljagić, Marija, "Strukturna i funkcionalna svojstva materijala na bazi spinelnih oksida" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21929 .

TY  - THES
AU  - Stojanović, Sanja
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9372
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31828/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130990089
UR  - https://nardus.mpn.gov.rs/handle/123456789/21932
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6242
AB  - Ova disertacija se bavi ispitivanjem mogućnosti primene izolata gljive rodaAspergillus spp. za produkciju enzima inulinaznog kompleksa u cilju dobijanjafruktooligosaharida. Razvijen je brz i pouzdan difuzioni test za detekciju proizvođačainulinaznog kompleksa korišćenog u ispitivanju 39 izolata vrste roda Aspergillus, prethodnoidentifikovanih do nivoa vrste, umnožavanjem CaM gena.Izolati su ispitani na mogućnost produkcije mikotoksina na genetskom nivouumnožavanjem biosintetskih klastera gena za fumonizin i ohratoksin, a analitičkim metodamaispitano je prisustvo mikotoksina u enzimskom preparatu. Ukrštanjem rezultata difuzionogenzimskog testa i mogućnosti produkcije mikotoksina odabran je soj identifikovan kaoAspergillus welwitschiae FAW1, koji ne produkuje mikotoksine i potencijalno je dobarproizvođač enzima za dobijanje FOS-ova, što ga čini pogodnim za upotrebu u proizvodnjihrane.Inulinazni enzimski kompleks je produkovan tokom fermentacije gljive na čvrstojpodlozi upotrebom različitih inducibilnih supstrata (tritikale, jerusalimska artičoka i pšeničnemekinje). Svi enzimi su okarakterisani i dobijene su različite aktivnosti u zavisnosti odsupstrata: egzoinulinazna – InuE (2,4 U/mL) i endoinulinazna – InuA (34 U/mL) dobijene suna tritikaleu, dok je najveća β-fruktofuranozidazna – FFase (6,3 U/mL) i fruktoziltransferazna– FTase aktivnost dobijena na podlozi sa jerusalimskom artičokom, pšeničnim mekinjama ipeptonom. Koprodukcijom inulinaznih enzimskih kompleksa pokazano je da se ista gljivamože koristiti za obe metode dobijanja FOS-ova (FOSs i FOSh) u zavisnosti od podloge nakojoj se uzgaja.Razvijena je nova zimogramska metoda za simultanu detekciju enzima InuA, InuE,FFase nakon jednog elektroforetskog razdvajanja enzima.Uspešno su prečišćeni glavni enzimi odgovorni za produkciju FOS-ova – InuA zadobijanje FOSh i FTase za dobijanje FOSs. Potvrđeno je prisustvo gena suc1 u genomu A.welwitschiae FAW1 koji se smatra odgovornim za ekspresiju enzima FTase i FFase. DobijeniFOSs i FOSh poseduju značajan antioksidativni potencijal što ih čini dobrim kandidatima zadodatak funkcionalnoj hrani.
AB  - This dissertation examines the possibility of using isolates of Aspergillus spp. for theproduction of the inulinase complex enzyme for obtaining of fructooligosaccharides. A rapidand reliable diffusion test was developed for the detection of the inulinase complex enzymeproducers used in the examination of 39 Aspergillus spp. isolates from the black aspergilligroup, previously identified to the species level, by amplification of the CaM gene.The isolates were examined for the possibility of mycotoxin production on the geneticlevel by amplifying the biosynthetic gene clusters for fumonisin and ochratoxin. Thepresence of mycotoxins in the enzyme preparation was examined using analytical methods.By crossing the results of the diffusion enzyme test and the possibility of mycotoxinproduction, a strain identified as Aspergillus welwitschiae FAW1 was selected as apotentially good producer of enzymes for obtaining FOS, which does not producemycotoxins what makes it safe for use in food production.The inulinase enzyme complex was produced during the fermentation of the fungi ona different solid inducible substrates (triticale, Jerusalem artichoke and wheat bran). Allenzymes were characterized and different activities were obtained depending on thesubstrate: exoinulinase - InuE (2.4 U/mL) and endoinulinase - InuA (34 U/mL) were obtainedon triticale, while the highest β-fructofuranosidase - FFase (6.3 U/mL) andfructosyltransferase - FTase activity were obtained on a medium with Jerusalem artichoke,wheat bran and peptone. The co-production of inulinase enzyme complexes showed that thesame fungi can be used for both methods of obtaining FOS (FOSs and FOSh), depending onthe substrate on which it was grown.A new zymographic method for the simultaneous detection of enzymes InuA, InuEand FFase after one electrophoretic separation of the enzymes was developed.The main enzymes responsible for the production of FOS were successfully purified -InuA for obtaining FOSh and FTase for obtaining FOSs. The presence of the suc1 gene in theA. welwitschiae FAW1 genome, which is considered responsible for the expression of FTaseand FFase enzymes, was confirmed. The obtained FOSs and FOSh have significantantioxidant potential, which makes them good candidates for use in functional food.
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Produkcija i karakterizacija enzima inulinaza Aspergillus spp. za dobijanje fruktooligosaharida
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21932
ER  - 

@phdthesis{
author = "Stojanović, Sanja",
year = "2023",
abstract = "Ova disertacija se bavi ispitivanjem mogućnosti primene izolata gljive rodaAspergillus spp. za produkciju enzima inulinaznog kompleksa u cilju dobijanjafruktooligosaharida. Razvijen je brz i pouzdan difuzioni test za detekciju proizvođačainulinaznog kompleksa korišćenog u ispitivanju 39 izolata vrste roda Aspergillus, prethodnoidentifikovanih do nivoa vrste, umnožavanjem CaM gena.Izolati su ispitani na mogućnost produkcije mikotoksina na genetskom nivouumnožavanjem biosintetskih klastera gena za fumonizin i ohratoksin, a analitičkim metodamaispitano je prisustvo mikotoksina u enzimskom preparatu. Ukrštanjem rezultata difuzionogenzimskog testa i mogućnosti produkcije mikotoksina odabran je soj identifikovan kaoAspergillus welwitschiae FAW1, koji ne produkuje mikotoksine i potencijalno je dobarproizvođač enzima za dobijanje FOS-ova, što ga čini pogodnim za upotrebu u proizvodnjihrane.Inulinazni enzimski kompleks je produkovan tokom fermentacije gljive na čvrstojpodlozi upotrebom različitih inducibilnih supstrata (tritikale, jerusalimska artičoka i pšeničnemekinje). Svi enzimi su okarakterisani i dobijene su različite aktivnosti u zavisnosti odsupstrata: egzoinulinazna – InuE (2,4 U/mL) i endoinulinazna – InuA (34 U/mL) dobijene suna tritikaleu, dok je najveća β-fruktofuranozidazna – FFase (6,3 U/mL) i fruktoziltransferazna– FTase aktivnost dobijena na podlozi sa jerusalimskom artičokom, pšeničnim mekinjama ipeptonom. Koprodukcijom inulinaznih enzimskih kompleksa pokazano je da se ista gljivamože koristiti za obe metode dobijanja FOS-ova (FOSs i FOSh) u zavisnosti od podloge nakojoj se uzgaja.Razvijena je nova zimogramska metoda za simultanu detekciju enzima InuA, InuE,FFase nakon jednog elektroforetskog razdvajanja enzima.Uspešno su prečišćeni glavni enzimi odgovorni za produkciju FOS-ova – InuA zadobijanje FOSh i FTase za dobijanje FOSs. Potvrđeno je prisustvo gena suc1 u genomu A.welwitschiae FAW1 koji se smatra odgovornim za ekspresiju enzima FTase i FFase. DobijeniFOSs i FOSh poseduju značajan antioksidativni potencijal što ih čini dobrim kandidatima zadodatak funkcionalnoj hrani., This dissertation examines the possibility of using isolates of Aspergillus spp. for theproduction of the inulinase complex enzyme for obtaining of fructooligosaccharides. A rapidand reliable diffusion test was developed for the detection of the inulinase complex enzymeproducers used in the examination of 39 Aspergillus spp. isolates from the black aspergilligroup, previously identified to the species level, by amplification of the CaM gene.The isolates were examined for the possibility of mycotoxin production on the geneticlevel by amplifying the biosynthetic gene clusters for fumonisin and ochratoxin. Thepresence of mycotoxins in the enzyme preparation was examined using analytical methods.By crossing the results of the diffusion enzyme test and the possibility of mycotoxinproduction, a strain identified as Aspergillus welwitschiae FAW1 was selected as apotentially good producer of enzymes for obtaining FOS, which does not producemycotoxins what makes it safe for use in food production.The inulinase enzyme complex was produced during the fermentation of the fungi ona different solid inducible substrates (triticale, Jerusalem artichoke and wheat bran). Allenzymes were characterized and different activities were obtained depending on thesubstrate: exoinulinase - InuE (2.4 U/mL) and endoinulinase - InuA (34 U/mL) were obtainedon triticale, while the highest β-fructofuranosidase - FFase (6.3 U/mL) andfructosyltransferase - FTase activity were obtained on a medium with Jerusalem artichoke,wheat bran and peptone. The co-production of inulinase enzyme complexes showed that thesame fungi can be used for both methods of obtaining FOS (FOSs and FOSh), depending onthe substrate on which it was grown.A new zymographic method for the simultaneous detection of enzymes InuA, InuEand FFase after one electrophoretic separation of the enzymes was developed.The main enzymes responsible for the production of FOS were successfully purified -InuA for obtaining FOSh and FTase for obtaining FOSs. The presence of the suc1 gene in theA. welwitschiae FAW1 genome, which is considered responsible for the expression of FTaseand FFase enzymes, was confirmed. The obtained FOSs and FOSh have significantantioxidant potential, which makes them good candidates for use in functional food.",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Produkcija i karakterizacija enzima inulinaza Aspergillus spp. za dobijanje fruktooligosaharida",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21932"
}

Stojanović, S.. (2023). Produkcija i karakterizacija enzima inulinaza Aspergillus spp. za dobijanje fruktooligosaharida. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21932

Stojanović S. Produkcija i karakterizacija enzima inulinaza Aspergillus spp. za dobijanje fruktooligosaharida. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21932 .

Stojanović, Sanja, "Produkcija i karakterizacija enzima inulinaza Aspergillus spp. za dobijanje fruktooligosaharida" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21932 .

TY  - CONF
AU  - Sokić, Katarina
AU  - Dikić, Jelena
AU  - Veljović, Đorđe
AU  - Đokić, Jovana
AU  - Anđić, Zoran
AU  - Jevtić, Sanja O.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6243
AB  - Natural zeolite is a good sorbent for many cations due to its specific porous structure. The degree of sorption efficiency depends on the cation type and the availability of exchange positions in the zeolite lattice. The aim of this work is to
examine the synthesis possibility of a new adsorbent based on natural zeolite and hydroxyapatite. The adsorbent was prepared mechanochemically by using clinoptilolite-rich zeolite tuff from the Slanci deposit (Serbia) and hydroxyapatite
obtained by the hydrothermal process. The milling process was performed in a ball mill and optimized regarding contact time and milling speed. For the synthesis of zeolite/hydroxyapatite adsorbent (ZHAp), optimal values for these two parameters were 10 min and 250 rpm, respectively. The resulting sample ZHAp was characterized by X-ray powder diffraction, thermal analysis and scanning electron microscopy. Diffraction analysis of the ZHAp confirmed the presence of the most abundant mineral in zeolite tuff - clinoptilolite and hydroxyapatite. Needle-like crystals of hydroxyapatite on the clinoptilolite surface are observed in SEM images. Zeolite/hydroxyapatite sample is thermally stable at 800 °C. Adsorption properties of ZHAp were examined for nickel and chromium ions, towards which natural zeolite shows a low affinity. The presence of hydroxyapatite on the zeolite surface led to an increase in the adsorption capacity more than two times for both tested ions compared to the initial zeolite tuff.
PB  - Association of Metallurgical Engineers of Serbia
C3  - 5th Metallurgical & Materials Engineering Congress of South-East Europe MME SEE Congress 2023, Trebinje, Bosnia and Herzegovina 7-10th June 2023
T1  - Mechanochemical synthesis and characterization of the adsorbents based on natural zeolite and hydroxyapatite
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6243
ER  - 

@conference{
author = "Sokić, Katarina and Dikić, Jelena and Veljović, Đorđe and Đokić, Jovana and Anđić, Zoran and Jevtić, Sanja O.",
year = "2023",
abstract = "Natural zeolite is a good sorbent for many cations due to its specific porous structure. The degree of sorption efficiency depends on the cation type and the availability of exchange positions in the zeolite lattice. The aim of this work is to
examine the synthesis possibility of a new adsorbent based on natural zeolite and hydroxyapatite. The adsorbent was prepared mechanochemically by using clinoptilolite-rich zeolite tuff from the Slanci deposit (Serbia) and hydroxyapatite
obtained by the hydrothermal process. The milling process was performed in a ball mill and optimized regarding contact time and milling speed. For the synthesis of zeolite/hydroxyapatite adsorbent (ZHAp), optimal values for these two parameters were 10 min and 250 rpm, respectively. The resulting sample ZHAp was characterized by X-ray powder diffraction, thermal analysis and scanning electron microscopy. Diffraction analysis of the ZHAp confirmed the presence of the most abundant mineral in zeolite tuff - clinoptilolite and hydroxyapatite. Needle-like crystals of hydroxyapatite on the clinoptilolite surface are observed in SEM images. Zeolite/hydroxyapatite sample is thermally stable at 800 °C. Adsorption properties of ZHAp were examined for nickel and chromium ions, towards which natural zeolite shows a low affinity. The presence of hydroxyapatite on the zeolite surface led to an increase in the adsorption capacity more than two times for both tested ions compared to the initial zeolite tuff.",
publisher = "Association of Metallurgical Engineers of Serbia",
journal = "5th Metallurgical & Materials Engineering Congress of South-East Europe MME SEE Congress 2023, Trebinje, Bosnia and Herzegovina 7-10th June 2023",
title = "Mechanochemical synthesis and characterization of the adsorbents based on natural zeolite and hydroxyapatite",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6243"
}

Sokić, K., Dikić, J., Veljović, Đ., Đokić, J., Anđić, Z.,& Jevtić, S. O.. (2023). Mechanochemical synthesis and characterization of the adsorbents based on natural zeolite and hydroxyapatite. in 5th Metallurgical & Materials Engineering Congress of South-East Europe MME SEE Congress 2023, Trebinje, Bosnia and Herzegovina 7-10th June 2023
Association of Metallurgical Engineers of Serbia..
https://hdl.handle.net/21.15107/rcub_cherry_6243

Sokić K, Dikić J, Veljović Đ, Đokić J, Anđić Z, Jevtić SO. Mechanochemical synthesis and characterization of the adsorbents based on natural zeolite and hydroxyapatite. in 5th Metallurgical & Materials Engineering Congress of South-East Europe MME SEE Congress 2023, Trebinje, Bosnia and Herzegovina 7-10th June 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_cherry_6243 .

Sokić, Katarina, Dikić, Jelena, Veljović, Đorđe, Đokić, Jovana, Anđić, Zoran, Jevtić, Sanja O., "Mechanochemical synthesis and characterization of the adsorbents based on natural zeolite and hydroxyapatite" in 5th Metallurgical & Materials Engineering Congress of South-East Europe MME SEE Congress 2023, Trebinje, Bosnia and Herzegovina 7-10th June 2023 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6243 .

TY  - CONF
AU  - Djokić, Jovana
AU  - Gajić, Nataša
AU  - Anđić, Dimitrije Z.
AU  - Kamberović, Željko
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6237
AB  - During the conventional roast–leach–electrolysis (RLE) zinc production process, precipitation of the jarosite-type compounds is widely used to remove iron and other metal impurities from the solution. Above mentioned compounds, with the general formula MFe3(SO4)2(OH)6, (M+=NH4, Na, K, Ag, etc.), in addition to iron, contain a high concentration of Pb, Cd, Cr, As, Zn, In, Ga, Ge as metal oxides and/or sulfates [1]. Consequently, jarosite is considered hazardous yet valuable waste [2]. In addition, every year around 6-7 million tonnes of jarosite waste is generated globally [3]. Due to large waste volumes and its chemical characteristics, jarosite requires a lot of storage space and monitoring. Unfortunately, this type of waste is often landfilled causing serious environmental problems and irreversible metal and value losses. Hence, an urgent solution for both managing and utilization/recycling is required, to face needs regarding ecological demands and circular economy goals.
In this paper, jarosite sludge, as a specific type of hazardous industrial waste, is used to investigate transformation to the targeted compounds through the comprehensive thermodynamic analysis and experimental roasting process tests. The roasting was conducted to transform iron into insoluble hematite (Fe2O3), valuable metals (Zn, Cu, and In) into water-soluble sulfates, and to keep Pb in the form of water-insoluble anglesite (PbSO4). The solid residue obtained after roasting was used in leaching tests to further evaluate the efficiency of the targeted phase transformations.
Theoretical considerations of chemical reactions and phase thermodynamics were performed using the HSC Chemistry v.9.2.3 software [4] to define potential chemical reactions, examine the feasibility of the target transformations, and set the limiting reaction parameters. Further, in the first part of the experimental work, the influence of the roasting process and reaction parameters on the transformation of jarosite sludge phases into target compounds was investigated. This included variations in the reaction time, temperature, and furnace atmosphere influence. The leaching conditions were kept constant (temperature of 25 °C, during 60 min, and solid to liquid ratio of 1/5) to determine the efficiency of phase transformations in the samples obtained by roasting. Changes in the chemical and mineralogical composition and microstructure were analyzed using different analytical methods, including XRD and SEM analysis.
According to the obtained results of the roasting process, it was determined that the phase transformation of jarosite sludge compounds into targeted insoluble hematite and water-soluble sulfates occurs at 730 °C, the time required is 60 min in the air (oxidizing) atmosphere of 1-2 [dm3/h]/kg of the input material, which is in accordance with the results of the theoretical indications. Also, it is experimentally confirmed that the introduction of sulfate into the roasting
 
atmosphere leads to the incomplete transformation of jarosite and the formation of the unwanted Fe2(SO4)3. Leaching results of the sample obtained by the abovementioned optimal roasting conditions show that only 4.5% of Fe is leached while the rest remains as solid targeted hematite. Also, more than 75% of In and more than 90% of other targeted metals (Cu and Zn) are leached, indicating the high efficiency of the roasting process. Phase transformation was confirmed by SEM analysis, showing that hexagonal crystals of jarosite, dominating in the starting material, were completely replaced with the globular microstructure of Fe2O3, in the roasted samples. SEM analysis of the leaching residue also confirmed the absence of the water-soluble sulfates and the presence of the anglesite as water-insoluble sulfate. The phase composition of the samples is confirmed by XRD analysis.
This research shows that the proposed process enables the recycling of jarosite through metal transformation and further utilization. The obtained products can be used in industry, while the metal ions can be selectively separated from the sulfate solution and returned to the production streams. This approach contributes to the utilization of jarosite, as hazardous waste, in order to obtain valuable metals, and generally reduces the negative environmental impact by decreasing the amount of disposed waste and reducing the need for primary exploitation.
PB  - Belgrade : Serbian Chemical Society
C3  - 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023
T1  - Jarosite sludge - utilization and valuable metals recovery applying roasting-leaching process
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6237
ER  - 

@conference{
author = "Djokić, Jovana and Gajić, Nataša and Anđić, Dimitrije Z. and Kamberović, Željko",
year = "2023",
abstract = "During the conventional roast–leach–electrolysis (RLE) zinc production process, precipitation of the jarosite-type compounds is widely used to remove iron and other metal impurities from the solution. Above mentioned compounds, with the general formula MFe3(SO4)2(OH)6, (M+=NH4, Na, K, Ag, etc.), in addition to iron, contain a high concentration of Pb, Cd, Cr, As, Zn, In, Ga, Ge as metal oxides and/or sulfates [1]. Consequently, jarosite is considered hazardous yet valuable waste [2]. In addition, every year around 6-7 million tonnes of jarosite waste is generated globally [3]. Due to large waste volumes and its chemical characteristics, jarosite requires a lot of storage space and monitoring. Unfortunately, this type of waste is often landfilled causing serious environmental problems and irreversible metal and value losses. Hence, an urgent solution for both managing and utilization/recycling is required, to face needs regarding ecological demands and circular economy goals.
In this paper, jarosite sludge, as a specific type of hazardous industrial waste, is used to investigate transformation to the targeted compounds through the comprehensive thermodynamic analysis and experimental roasting process tests. The roasting was conducted to transform iron into insoluble hematite (Fe2O3), valuable metals (Zn, Cu, and In) into water-soluble sulfates, and to keep Pb in the form of water-insoluble anglesite (PbSO4). The solid residue obtained after roasting was used in leaching tests to further evaluate the efficiency of the targeted phase transformations.
Theoretical considerations of chemical reactions and phase thermodynamics were performed using the HSC Chemistry v.9.2.3 software [4] to define potential chemical reactions, examine the feasibility of the target transformations, and set the limiting reaction parameters. Further, in the first part of the experimental work, the influence of the roasting process and reaction parameters on the transformation of jarosite sludge phases into target compounds was investigated. This included variations in the reaction time, temperature, and furnace atmosphere influence. The leaching conditions were kept constant (temperature of 25 °C, during 60 min, and solid to liquid ratio of 1/5) to determine the efficiency of phase transformations in the samples obtained by roasting. Changes in the chemical and mineralogical composition and microstructure were analyzed using different analytical methods, including XRD and SEM analysis.
According to the obtained results of the roasting process, it was determined that the phase transformation of jarosite sludge compounds into targeted insoluble hematite and water-soluble sulfates occurs at 730 °C, the time required is 60 min in the air (oxidizing) atmosphere of 1-2 [dm3/h]/kg of the input material, which is in accordance with the results of the theoretical indications. Also, it is experimentally confirmed that the introduction of sulfate into the roasting
 
atmosphere leads to the incomplete transformation of jarosite and the formation of the unwanted Fe2(SO4)3. Leaching results of the sample obtained by the abovementioned optimal roasting conditions show that only 4.5% of Fe is leached while the rest remains as solid targeted hematite. Also, more than 75% of In and more than 90% of other targeted metals (Cu and Zn) are leached, indicating the high efficiency of the roasting process. Phase transformation was confirmed by SEM analysis, showing that hexagonal crystals of jarosite, dominating in the starting material, were completely replaced with the globular microstructure of Fe2O3, in the roasted samples. SEM analysis of the leaching residue also confirmed the absence of the water-soluble sulfates and the presence of the anglesite as water-insoluble sulfate. The phase composition of the samples is confirmed by XRD analysis.
This research shows that the proposed process enables the recycling of jarosite through metal transformation and further utilization. The obtained products can be used in industry, while the metal ions can be selectively separated from the sulfate solution and returned to the production streams. This approach contributes to the utilization of jarosite, as hazardous waste, in order to obtain valuable metals, and generally reduces the negative environmental impact by decreasing the amount of disposed waste and reducing the need for primary exploitation.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023",
title = "Jarosite sludge - utilization and valuable metals recovery applying roasting-leaching process",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6237"
}

Djokić, J., Gajić, N., Anđić, D. Z.,& Kamberović, Ž.. (2023). Jarosite sludge - utilization and valuable metals recovery applying roasting-leaching process. in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023
Belgrade : Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_6237

Djokić J, Gajić N, Anđić DZ, Kamberović Ž. Jarosite sludge - utilization and valuable metals recovery applying roasting-leaching process. in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_cherry_6237 .

Djokić, Jovana, Gajić, Nataša, Anđić, Dimitrije Z., Kamberović, Željko, "Jarosite sludge - utilization and valuable metals recovery applying roasting-leaching process" in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6237 .

TY  - CONF
AU  - Djokić, Jovana
AU  - Štulović, Marija
AU  - Korać, Marija
AU  - Anđić, Zoran
AU  - Kamberović, Željko
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6236
AB  - More than 90% of lead produced in Europe comes from secondary lead flows, of which 85% is attributed to waste lead-acid batteries (LAB). The main technological approach for LAB processing implies pyrometallurgy by which 100–400 kg of waste slag (WS) is generated per 1 ton of produced metallic lead. Due to recycling process parameters, generated WS has great potential for releasing toxic elements contributing to environmental pollution [1]. Namely, the most common flux in the recycling process is sodium-based (Na2CO3) when alkali lead waste slag (ALWS) is generated, characterized as hazardous due to its physical-chemical characteristics: high leachability, hygroscopic and pulverized nature and, ultimately, instability [2,3]. Therefore, ALWS treatment prior to disposal should be considered an integral part of waste LAB treatment systems. Immobilization of toxic elements contained in slag is crucial and can be achieved by stabilization/solidification processes (S/S) as one of the most widely used technologies in the treatment of heavy metal-containing wastes for final disposal or utilization.
In this research, ALWS generated in the waste LAB recycling is used to determine the S/S process efficiency as a function of the added binder amount (cement, in the range of 5 – 10 %), pre-treatment (the removal of water-soluble compounds), and activator addition (MgO). The liquid to solid (L/S) ratio was 1/4 in all S/S experiments. The basic parameters for the effectiveness assessments were compressive strength (UCS) and pollutants leaching (Method 1311 Toxicity characteristic leaching procedure, TCLP).
ALWS containing 3.5 Pb, 15.5 Na, 14.0 S, and 24.7 Fe was mixed with cement and water. The results of UCS showed that all produced solidificates exceeded the required value of 0.35 MPa [4], yet the mixture containing 7.5 % of the cement has the best mechanical properties (2.1 MPa). This sample was further analyzed and the TCLP results showed that the Pb concentration exceeds the limit values for stabilized slag (10.4 and 5 ppm, respectively). In the next set, ALWS was pre-treated by continuous rinser (30 ºC, 60 min, L/S 4). Obtained results of UCS (0.4 MPa) and TCLP (53.4 ppm) were unfavorable. The last set, besides the binder, included activator addition (MgO, 7.5 %) altogether with a high content of untreated ALWS (85 %). Analysis of the produced solidificates showed favorable and acceptable results (USC - 3.3 MPa, TCLP – Pb 4.5 ppm). 
Generally, in an alkaline slag-leaching solution lead precipitates as a complex mixture (PbO, Pb(OH)2, PbO×Pb(OH)2). Lead oxides are amphoteric and dissolve in an alkaline aqueous solution, leading to poor solidification. Also, lead present in surface coatings around cement grains prevents cement hydration. Simultaneously, the migration of lead to the surrounding water is promoted. The negative effect of the pre-treatment is a consequence of the sulfate ions absence, as well as the absence of the ettringite (Ca6Al2(SO4)3(OH)12×26H2O) and sulfate- AFm phases [5], which negatively affect the strength of the product. The addition of MgO benefits the S/S process through hydrotalcite-like phase formation ([M1-
2+M 3+(OH) ][A   n-×mH O], M2+=Mg, Zn, Ni, Fe; M3+=Al, Cr, Fe; A=CO 2-,
NO -, Cl-), a compound capable of metal adsorption, hence immobilization [6].
The conclusion is that, contrary to the pre-treatment process, the addition of MgO has an overall positive effect on the S/S process of ALSW, ensuring both mechanical and chemical stability. This ALWS solidificate, obtained through the S/S process by using MgO as an activator, is safe for disposal, according to environmental regulations.
PB  - Belgrade : Serbian Chemical Society
C3  - 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023
T1  - Stabilization/solidification process of alkali lead waste slag: influence of pretreatment and addition of selected additives
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6236
ER  - 

@conference{
author = "Djokić, Jovana and Štulović, Marija and Korać, Marija and Anđić, Zoran and Kamberović, Željko",
year = "2023",
abstract = "More than 90% of lead produced in Europe comes from secondary lead flows, of which 85% is attributed to waste lead-acid batteries (LAB). The main technological approach for LAB processing implies pyrometallurgy by which 100–400 kg of waste slag (WS) is generated per 1 ton of produced metallic lead. Due to recycling process parameters, generated WS has great potential for releasing toxic elements contributing to environmental pollution [1]. Namely, the most common flux in the recycling process is sodium-based (Na2CO3) when alkali lead waste slag (ALWS) is generated, characterized as hazardous due to its physical-chemical characteristics: high leachability, hygroscopic and pulverized nature and, ultimately, instability [2,3]. Therefore, ALWS treatment prior to disposal should be considered an integral part of waste LAB treatment systems. Immobilization of toxic elements contained in slag is crucial and can be achieved by stabilization/solidification processes (S/S) as one of the most widely used technologies in the treatment of heavy metal-containing wastes for final disposal or utilization.
In this research, ALWS generated in the waste LAB recycling is used to determine the S/S process efficiency as a function of the added binder amount (cement, in the range of 5 – 10 %), pre-treatment (the removal of water-soluble compounds), and activator addition (MgO). The liquid to solid (L/S) ratio was 1/4 in all S/S experiments. The basic parameters for the effectiveness assessments were compressive strength (UCS) and pollutants leaching (Method 1311 Toxicity characteristic leaching procedure, TCLP).
ALWS containing 3.5 Pb, 15.5 Na, 14.0 S, and 24.7 Fe was mixed with cement and water. The results of UCS showed that all produced solidificates exceeded the required value of 0.35 MPa [4], yet the mixture containing 7.5 % of the cement has the best mechanical properties (2.1 MPa). This sample was further analyzed and the TCLP results showed that the Pb concentration exceeds the limit values for stabilized slag (10.4 and 5 ppm, respectively). In the next set, ALWS was pre-treated by continuous rinser (30 ºC, 60 min, L/S 4). Obtained results of UCS (0.4 MPa) and TCLP (53.4 ppm) were unfavorable. The last set, besides the binder, included activator addition (MgO, 7.5 %) altogether with a high content of untreated ALWS (85 %). Analysis of the produced solidificates showed favorable and acceptable results (USC - 3.3 MPa, TCLP – Pb 4.5 ppm). 
Generally, in an alkaline slag-leaching solution lead precipitates as a complex mixture (PbO, Pb(OH)2, PbO×Pb(OH)2). Lead oxides are amphoteric and dissolve in an alkaline aqueous solution, leading to poor solidification. Also, lead present in surface coatings around cement grains prevents cement hydration. Simultaneously, the migration of lead to the surrounding water is promoted. The negative effect of the pre-treatment is a consequence of the sulfate ions absence, as well as the absence of the ettringite (Ca6Al2(SO4)3(OH)12×26H2O) and sulfate- AFm phases [5], which negatively affect the strength of the product. The addition of MgO benefits the S/S process through hydrotalcite-like phase formation ([M1-
2+M 3+(OH) ][A   n-×mH O], M2+=Mg, Zn, Ni, Fe; M3+=Al, Cr, Fe; A=CO 2-,
NO -, Cl-), a compound capable of metal adsorption, hence immobilization [6].
The conclusion is that, contrary to the pre-treatment process, the addition of MgO has an overall positive effect on the S/S process of ALSW, ensuring both mechanical and chemical stability. This ALWS solidificate, obtained through the S/S process by using MgO as an activator, is safe for disposal, according to environmental regulations.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023",
title = "Stabilization/solidification process of alkali lead waste slag: influence of pretreatment and addition of selected additives",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6236"
}

Djokić, J., Štulović, M., Korać, M., Anđić, Z.,& Kamberović, Ž.. (2023). Stabilization/solidification process of alkali lead waste slag: influence of pretreatment and addition of selected additives. in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023
Belgrade : Serbian Chemical Society..
https://hdl.handle.net/21.15107/rcub_cherry_6236

Djokić J, Štulović M, Korać M, Anđić Z, Kamberović Ž. Stabilization/solidification process of alkali lead waste slag: influence of pretreatment and addition of selected additives. in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023. 2023;.
https://hdl.handle.net/21.15107/rcub_cherry_6236 .

Djokić, Jovana, Štulović, Marija, Korać, Marija, Anđić, Zoran, Kamberović, Željko, "Stabilization/solidification process of alkali lead waste slag: influence of pretreatment and addition of selected additives" in 9th Symposium Chemistry and Environmental Protection EnviroChem2023 with International Participation, Book of Abstracts, Kladovo, June 4-7, 2023 (2023),
https://hdl.handle.net/21.15107/rcub_cherry_6236 .

TY  - JOUR
AU  - Nikolić, Vesna D.
AU  - Đokić, Jovana M.
AU  - Dinić, Denis P.
AU  - Marinković, Aleksandar M.
AU  - Jevtić, Sanja O.
AU  - Anđić, Zoran M.
AU  - Kamberović, Željko J.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6235
AB  - Porozna keramika sa industrijskog aspekta predstavlja značajan materijal, međutim, za njenu pripremu se još uvek traže ekonomski i tehnološki prihvatljiva rešenja. Kontrola poroznosti predstavlja ključan korak u postizanju željenih svojstava za određenu primenu. U cilju dobijanja multiporozne keramike u ovom radu korišćena je kaolinska glina i polistirenske perle kao organska žrtvena faza. Uzorci su nakon mešanja sinterovani na 1050 oC tokom 1 h. Karakterizacija je obuhvatila infracrvenu spektroskopiju sa Furijeovom transformacijom (FTIR), 
 kenirajuću elektronsku mikroskopiju (SEM), rendgensku difrakcionu analizu (XRPD), elementnu CHNS analizu i ispitivanje pritisne čvrstoće. Analiza dobijenih rezultata pokazala je da se hijerarhijski uređena, multiporozna keramika, odgovarajućih mehaničkih svojstava može pripremiti u prisustvu organske komponente čijim sagorevanjem tokom sinterovanja zaostaju pore različitih dimenzija.
AB  - From an industrial point of view, porous ceramics represent an important material, however, economically and technologically acceptable solutions are still being sought for its preparation. Porosity control is a key step in achieving the desired properties for a specific application. In order to obtain multiporous ceramics, in this work, kaolin clay and polystyrene beads were used as organic sacrificial phase. After mixing, the samples were sintered at 1050 oC for 1 h. Characterization included Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction analysis (XRPD), elemental CHNS analysis and compressive strength investigations. The analysis of the obtained results showed that hierarchically ordered, multiporous ceramics, with appropriate mechanical properties can be prepared in the presence of an organic component whose burnout during sintering leaves behind pores of different dimensions.
PB  - Beograd : Savez inženjera i tehničara Srbije
T2  - Tehnika - Novi materijali
T1  - Sinteza inovativnih keramičkih sorbenata i nosača katalizatora hijerarhijske poroznosti
VL  - 32
IS  - 3
SP  - 269
EP  - 273
DO  - 10.5937/tehnika2303269K
ER  - 

@article{
author = "Nikolić, Vesna D. and Đokić, Jovana M. and Dinić, Denis P. and Marinković, Aleksandar M. and Jevtić, Sanja O. and Anđić, Zoran M. and Kamberović, Željko J.",
year = "2023",
abstract = "Porozna keramika sa industrijskog aspekta predstavlja značajan materijal, međutim, za njenu pripremu se još uvek traže ekonomski i tehnološki prihvatljiva rešenja. Kontrola poroznosti predstavlja ključan korak u postizanju željenih svojstava za određenu primenu. U cilju dobijanja multiporozne keramike u ovom radu korišćena je kaolinska glina i polistirenske perle kao organska žrtvena faza. Uzorci su nakon mešanja sinterovani na 1050 oC tokom 1 h. Karakterizacija je obuhvatila infracrvenu spektroskopiju sa Furijeovom transformacijom (FTIR), 
 kenirajuću elektronsku mikroskopiju (SEM), rendgensku difrakcionu analizu (XRPD), elementnu CHNS analizu i ispitivanje pritisne čvrstoće. Analiza dobijenih rezultata pokazala je da se hijerarhijski uređena, multiporozna keramika, odgovarajućih mehaničkih svojstava može pripremiti u prisustvu organske komponente čijim sagorevanjem tokom sinterovanja zaostaju pore različitih dimenzija., From an industrial point of view, porous ceramics represent an important material, however, economically and technologically acceptable solutions are still being sought for its preparation. Porosity control is a key step in achieving the desired properties for a specific application. In order to obtain multiporous ceramics, in this work, kaolin clay and polystyrene beads were used as organic sacrificial phase. After mixing, the samples were sintered at 1050 oC for 1 h. Characterization included Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction analysis (XRPD), elemental CHNS analysis and compressive strength investigations. The analysis of the obtained results showed that hierarchically ordered, multiporous ceramics, with appropriate mechanical properties can be prepared in the presence of an organic component whose burnout during sintering leaves behind pores of different dimensions.",
publisher = "Beograd : Savez inženjera i tehničara Srbije",
journal = "Tehnika - Novi materijali",
title = "Sinteza inovativnih keramičkih sorbenata i nosača katalizatora hijerarhijske poroznosti",
volume = "32",
number = "3",
pages = "269-273",
doi = "10.5937/tehnika2303269K"
}

Nikolić, V. D., Đokić, J. M., Dinić, D. P., Marinković, A. M., Jevtić, S. O., Anđić, Z. M.,& Kamberović, Ž. J.. (2023). Sinteza inovativnih keramičkih sorbenata i nosača katalizatora hijerarhijske poroznosti. in Tehnika - Novi materijali
Beograd : Savez inženjera i tehničara Srbije., 32(3), 269-273.
https://doi.org/10.5937/tehnika2303269K

Nikolić VD, Đokić JM, Dinić DP, Marinković AM, Jevtić SO, Anđić ZM, Kamberović ŽJ. Sinteza inovativnih keramičkih sorbenata i nosača katalizatora hijerarhijske poroznosti. in Tehnika - Novi materijali. 2023;32(3):269-273.
doi:10.5937/tehnika2303269K .

Nikolić, Vesna D., Đokić, Jovana M., Dinić, Denis P., Marinković, Aleksandar M., Jevtić, Sanja O., Anđić, Zoran M., Kamberović, Željko J., "Sinteza inovativnih keramičkih sorbenata i nosača katalizatora hijerarhijske poroznosti" in Tehnika - Novi materijali, 32, no. 3 (2023):269-273,
https://doi.org/10.5937/tehnika2303269K . .

TY  - THES
AU  - Mitrović, Jelena
PY  - 2023
UR  - https://eteze.bg.ac.rs/application/showtheses?thesesId=9381
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:31851/bdef:Content/download
UR  - https://plus.cobiss.net/cobiss/sr/sr/bib/130953737
UR  - https://nardus.mpn.gov.rs/handle/123456789/21933
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6238
AB  - U okviru ove disertacije ispitivani su uticaji koncentracije dopanta i parametara sinterovanja nastrukturu i svojstva keramičkih uzoraka barijum-stanata dopiranog antimonom, BaSn1-xSbxO3(BSSO, x = 0,00; 0,04; 0,06; 0,08 i 0,10) u cilju dobijanja provodne elektrokeramike sa linearnomstrujno-naponskom (I-U) karakteristikom...
AB  - The main goal of this doctoral thesis was to investigate the influence of different dopantconcentrations and sintering parameters on the structure and properties of antimony-doped bariumstannate, BaSn1-xSbxO3 (BSSO, x = 0,00; 0,04; 0,06; 0,08 and 0,10) to obtain conductiveelectroceramic samples with linear current-voltage (I-U) characteristics...
PB  - Универзитет у Београду, Хемијски факултет
T2  - Универзитет у Београду
T1  - Dobijanje provodne elektrokeramike na bazi barijum-stanata dopiranog antimonom sa linearnom strujno-naponskom karakteristikom
UR  - https://hdl.handle.net/21.15107/rcub_nardus_21933
ER  - 

@phdthesis{
author = "Mitrović, Jelena",
year = "2023",
abstract = "U okviru ove disertacije ispitivani su uticaji koncentracije dopanta i parametara sinterovanja nastrukturu i svojstva keramičkih uzoraka barijum-stanata dopiranog antimonom, BaSn1-xSbxO3(BSSO, x = 0,00; 0,04; 0,06; 0,08 i 0,10) u cilju dobijanja provodne elektrokeramike sa linearnomstrujno-naponskom (I-U) karakteristikom..., The main goal of this doctoral thesis was to investigate the influence of different dopantconcentrations and sintering parameters on the structure and properties of antimony-doped bariumstannate, BaSn1-xSbxO3 (BSSO, x = 0,00; 0,04; 0,06; 0,08 and 0,10) to obtain conductiveelectroceramic samples with linear current-voltage (I-U) characteristics...",
publisher = "Универзитет у Београду, Хемијски факултет",
journal = "Универзитет у Београду",
title = "Dobijanje provodne elektrokeramike na bazi barijum-stanata dopiranog antimonom sa linearnom strujno-naponskom karakteristikom",
url = "https://hdl.handle.net/21.15107/rcub_nardus_21933"
}

Mitrović, J.. (2023). Dobijanje provodne elektrokeramike na bazi barijum-stanata dopiranog antimonom sa linearnom strujno-naponskom karakteristikom. in Универзитет у Београду
Универзитет у Београду, Хемијски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_21933

Mitrović J. Dobijanje provodne elektrokeramike na bazi barijum-stanata dopiranog antimonom sa linearnom strujno-naponskom karakteristikom. in Универзитет у Београду. 2023;.
https://hdl.handle.net/21.15107/rcub_nardus_21933 .

Mitrović, Jelena, "Dobijanje provodne elektrokeramike na bazi barijum-stanata dopiranog antimonom sa linearnom strujno-naponskom karakteristikom" in Универзитет у Београду (2023),
https://hdl.handle.net/21.15107/rcub_nardus_21933 .

TY  - JOUR
AU  - Mutić, Tijana
AU  - Ognjanović, Miloš
AU  - Kodranov, Igor D.
AU  - Robić, Marko
AU  - Savić, Sladjana
AU  - Krehula, Stjepko
AU  - Stanković, Dalibor M.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6234
AB  - In this work, we investigated the morphological and electrochemical properties of gallium/bismuth mixed oxide. The bismuth
concentration was varied from 0 to 100%. The correct ratio was determined with inductively coupled plasma-optical emission spectroscopy (ICP-OES), while surface characteristics were determined using scanning electron microscopy (SEM)
and X-ray difraction (XRD) measurement. Electrochemical characteristics were studied using electrochemical impedance
spectroscopy (EIS) in the Fe2+/3+ couple. The obtained materials were tested for adrenaline detection. After square wave
voltammetry (SWV) optimization, the best electrode showed a wide linear working range from 7 to 100 µM at pH 6 of the
Britton–Robinson bufer solution (BRBS) supporting electrolyte. The limit of detection (LOD) for the proposed method
was calculated as 1.9 µM, with a limit of quantifcation (LOQ) of 5.8 µM. The excellent selectivity of the proposed method,
with good repeatability and reproducibility, strongly suggests the possible application of the procedure for the determination
of adrenaline in artifcially prepared real samples. The practical applicability with good recovery values indicates that the
morphology of the materials is closely connected with other parameters, which further suggests that the developed approach
can ofer a low-cost, rapid, selective, and sensitive method for adrenaline monitoring.
PB  - Springer
T2  - Analytical and Bioanalytical Chemistry
T1  - Correction to: The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline
VL  - 415
IS  - 18
SP  - 4629
DO  - 10.1007/s00216-023-04674-y
ER  - 

@article{
author = "Mutić, Tijana and Ognjanović, Miloš and Kodranov, Igor D. and Robić, Marko and Savić, Sladjana and Krehula, Stjepko and Stanković, Dalibor M.",
year = "2023",
abstract = "In this work, we investigated the morphological and electrochemical properties of gallium/bismuth mixed oxide. The bismuth
concentration was varied from 0 to 100%. The correct ratio was determined with inductively coupled plasma-optical emission spectroscopy (ICP-OES), while surface characteristics were determined using scanning electron microscopy (SEM)
and X-ray difraction (XRD) measurement. Electrochemical characteristics were studied using electrochemical impedance
spectroscopy (EIS) in the Fe2+/3+ couple. The obtained materials were tested for adrenaline detection. After square wave
voltammetry (SWV) optimization, the best electrode showed a wide linear working range from 7 to 100 µM at pH 6 of the
Britton–Robinson bufer solution (BRBS) supporting electrolyte. The limit of detection (LOD) for the proposed method
was calculated as 1.9 µM, with a limit of quantifcation (LOQ) of 5.8 µM. The excellent selectivity of the proposed method,
with good repeatability and reproducibility, strongly suggests the possible application of the procedure for the determination
of adrenaline in artifcially prepared real samples. The practical applicability with good recovery values indicates that the
morphology of the materials is closely connected with other parameters, which further suggests that the developed approach
can ofer a low-cost, rapid, selective, and sensitive method for adrenaline monitoring.",
publisher = "Springer",
journal = "Analytical and Bioanalytical Chemistry",
title = "Correction to: The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline",
volume = "415",
number = "18",
pages = "4629",
doi = "10.1007/s00216-023-04674-y"
}

Mutić, T., Ognjanović, M., Kodranov, I. D., Robić, M., Savić, S., Krehula, S.,& Stanković, D. M.. (2023). Correction to: The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline. in Analytical and Bioanalytical Chemistry
Springer., 415(18), 4629.
https://doi.org/10.1007/s00216-023-04674-y

Mutić T, Ognjanović M, Kodranov ID, Robić M, Savić S, Krehula S, Stanković DM. Correction to: The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline. in Analytical and Bioanalytical Chemistry. 2023;415(18):4629.
doi:10.1007/s00216-023-04674-y .

Mutić, Tijana, Ognjanović, Miloš, Kodranov, Igor D., Robić, Marko, Savić, Sladjana, Krehula, Stjepko, Stanković, Dalibor M., "Correction to: The influence of bismuth participation on the morphological and electrochemical characteristics of gallium oxide for the detection of adrenaline" in Analytical and Bioanalytical Chemistry, 415, no. 18 (2023):4629,
https://doi.org/10.1007/s00216-023-04674-y . .

TY  - JOUR
AU  - Ognjanović, Miloš
AU  - Jaćimović, Željko
AU  - Kosović-Perutović, Milica
AU  - Besu Žižak, Irina
AU  - Stanojković, Tatjana
AU  - Žižak, Željko
AU  - Dojčinović, Biljana
AU  - Stanković, Dalibor
AU  - Antić, Bratislav
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6184
AB  - Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.
PB  - MDPI
T2  - Nanomaterials
T1  - Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity
VL  - 13
IS  - 5
SP  - 870
DO  - 10.3390/nano13050870
ER  - 

@article{
author = "Ognjanović, Miloš and Jaćimović, Željko and Kosović-Perutović, Milica and Besu Žižak, Irina and Stanojković, Tatjana and Žižak, Željko and Dojčinović, Biljana and Stanković, Dalibor and Antić, Bratislav",
year = "2023",
abstract = "Partial cation substitution can significantly change the physical properties of parent compounds. By controlling the chemical composition and knowing the mutual relationship between composition and physical properties, it is possible to tailor the properties of materials to those that are superior for desired technological application. Using the polyol synthesis procedure, a series of yttrium-substituted iron oxide nanoconstructs, γ-Fe2−xYxO3 (YIONs), was prepared. It was found that Y3+ could substitute Fe3+ in the crystal structures of maghemite (γ-Fe2O3) up to a limited concentration of ~1.5% (γ-Fe1.969Y0.031O3). Analysis of TEM micrographs showed that crystallites or particles were aggregated in flower-like structures with diameters from 53.7 ± 6.2 nm to 97.3 ± 37.0 nm, depending on yttrium concentration. To be investigated for potential applications as magnetic hyperthermia agents, YIONs were tested twice: their heating efficiency was tested and their toxicity was investigated. The Specific Absorption Rate (SAR) values were in the range of 32.6 W/g to 513 W/g and significantly decreased with increased yttrium concentration in the samples. Intrinsic loss power (ILP) for γ-Fe2O3 and γ-Fe1.995Y0.005O3 were ~8–9 nH·m2/Kg, which pointed to their excellent heating efficiency. IC50 values of investigated samples against cancer (HeLa) and normal (MRC-5) cells decreased with increased yttrium concentration and were higher than ~300 μg/mL. The samples of γ-Fe2−xYxO3 did not show a genotoxic effect. The results of toxicity studies show that YIONs are suitable for further in vitro/in vivo studies toward to their potential medical applications, while results of heat generation point to their potential use in magnetic hyperthermia cancer treatment or use as self-heating systems for other technological applications such as catalysis.",
publisher = "MDPI",
journal = "Nanomaterials",
title = "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity",
volume = "13",
number = "5",
pages = "870",
doi = "10.3390/nano13050870"
}

Ognjanović, M., Jaćimović, Ž., Kosović-Perutović, M., Besu Žižak, I., Stanojković, T., Žižak, Ž., Dojčinović, B., Stanković, D.,& Antić, B.. (2023). Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials
MDPI., 13(5), 870.
https://doi.org/10.3390/nano13050870

Ognjanović M, Jaćimović Ž, Kosović-Perutović M, Besu Žižak I, Stanojković T, Žižak Ž, Dojčinović B, Stanković D, Antić B. Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity. in Nanomaterials. 2023;13(5):870.
doi:10.3390/nano13050870 .

Ognjanović, Miloš, Jaćimović, Željko, Kosović-Perutović, Milica, Besu Žižak, Irina, Stanojković, Tatjana, Žižak, Željko, Dojčinović, Biljana, Stanković, Dalibor, Antić, Bratislav, "Self-Heating Flower-like Nanoconstructs with Limited Incorporation of Yttrium in Maghemite: Effect of Chemical Composition on Heating Efficiency, Cytotoxicity and Genotoxicity" in Nanomaterials, 13, no. 5 (2023):870,
https://doi.org/10.3390/nano13050870 . .

TY  - JOUR
AU  - Đurđić, Slađana
AU  - Vlahović, Filip
AU  - Markićević, Milan
AU  - Mutić, Jelena
AU  - Manojlović, Dragan D.
AU  - Stanković, Vesna
AU  - Švorc, Ľubomír
AU  - Stanković, Dalibor
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5812
AB  - Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.
PB  - MDPI
T2  - Chemosensors
T1  - Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory
VL  - 11
IS  - 1
SP  - 15
DO  - 10.3390/chemosensors11010015
ER  - 

@article{
author = "Đurđić, Slađana and Vlahović, Filip and Markićević, Milan and Mutić, Jelena and Manojlović, Dragan D. and Stanković, Vesna and Švorc, Ľubomír and Stanković, Dalibor",
year = "2023",
abstract = "Herein, a screen–printed diamond electrode (SPDE) coupled with a “point-of-care” platform (30 µL-drop concepts, single-drop-detection approach) was successfully applied for the electrochemical determination of pterostilbene (PTS). Cyclic voltammetry identified irreversible oxidation of PTS, where oxidation peak was shown to be strongly dependent on the pH of the working environmental. Although the proposition of the detailed electrochemical oxidation mechanism of PTS goes out of the scope of the present research, we have determined the most probable reactive site of our analyte, by utilizing DFT-based reactivity descriptors (Fukui functions). For electrochemical quantification of PTS, oxidation peak at 0.32 V (vs. Ag/AgCl) was followed in presence of 0.5 mol L−1 of Briton–Robinson buffer solution (pH = 9). Coupled with the optimized parameters of differential pulse voltammetry (DPV), SPDE detected PTS in two linear ranges (first range was from 0.011 to 0.912 µmol L−1; second range was from 0.912 to 4.420 µmol L−1), providing the LOD and LOQ on a nanomolar level (3.1 nmol L−1 and 10.0 nmol L−1, respectively). The selectivity of the optimized DPV method was found to be excellent, with the current changes of less than 7%, in the presence of ten times higher concentrations of the certain interferences. The practical applicability of the SPDE and single-drop-detection approach in dietary supplements (with a declared PTS content of 50 mg/tablet), with the recovery values ranging from 95 to 102%, shows that the developed method has high potential for precise and accurate PTS detection, as well as exceptional miniaturization possibilities of relevant equipment for on-site sensing.",
publisher = "MDPI",
journal = "Chemosensors",
title = "Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory",
volume = "11",
number = "1",
pages = "15",
doi = "10.3390/chemosensors11010015"
}

Đurđić, S., Vlahović, F., Markićević, M., Mutić, J., Manojlović, D. D., Stanković, V., Švorc, Ľ.,& Stanković, D.. (2023). Application of Screen Printed Diamond Electrode, Coupled with “Point-of-Care” Platform, for Nanomolar Quantification of Phytonutrient Pterostilbene in Dietary Supplements: An Experimental Study Supported by Theory. in Chemosensors
MDPI., 11(1), 15.
https://doi.org/10.3390/chemosensors11010015

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