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Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636

Penjišević, Jelena ; Šukalović, Vladimir ; Dukić-Stefanović, Slađana; Deuther-Conrad, Winnie; Andrić, Deana ; Kostić-Rajačić, Slađana

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 
@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}
Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845
Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .
Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination

Pastor, Ferenc T.; Dojčinović, Biljana P.; Kodranov, Igor D.; Gorjanović, Stanislava; Ivanović, Tijana; Popović, Daniela Ž.; Miladinović, Jelena

TY  - JOUR
AU  - Pastor, Ferenc T.
AU  - Dojčinović, Biljana P.
AU  - Kodranov, Igor D.
AU  - Gorjanović, Stanislava
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6390
AB  - Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.
PB  - Wiley
T2  - Electroanalysis
T1  - 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination
VL  - n/a
IS  - n/a
SP  - e202300259
DO  - 10.1002/elan.202300259
ER  - 
@article{
author = "Pastor, Ferenc T. and Dojčinović, Biljana P. and Kodranov, Igor D. and Gorjanović, Stanislava and Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena",
abstract = "Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.",
publisher = "Wiley",
journal = "Electroanalysis",
title = "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination",
volume = "n/a",
number = "n/a",
pages = "e202300259",
doi = "10.1002/elan.202300259"
}
Pastor, F. T., Dojčinović, B. P., Kodranov, I. D., Gorjanović, S., Ivanović, T., Popović, D. Ž.,& Miladinović, J..2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis
Wiley., n/a(n/a), e202300259.
https://doi.org/10.1002/elan.202300259
Pastor FT, Dojčinović BP, Kodranov ID, Gorjanović S, Ivanović T, Popović DŽ, Miladinović J. 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis.n/a(n/a):e202300259.
doi:10.1002/elan.202300259 .
Pastor, Ferenc T., Dojčinović, Biljana P., Kodranov, Igor D., Gorjanović, Stanislava, Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination" in Electroanalysis, n/a, no. n/a:e202300259,
https://doi.org/10.1002/elan.202300259 . .
1

Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry Royal Society of Chemistry., 21(6), 1187-1205. https://doi.org/10.1039/D2OB02119F

Aleksić, Jovana; Stojanović, Milovan; Bošković, Jakša; Baranac-Stojanović, Marija

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 
@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}
Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846
Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .
Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

Ćurčić, Vladimir; Olszewski, Mateusz; Maciejewska, Natalia; Višnjevac, Aleksandar; Srdić-Rajić, Tatjana; Dobričić, Vladimir; García-Sosa, Alfonso T.; Kokanov, Sanja B.; Araškov, Jovana; Silvestri, Romano; Schüle, Roland; Jung, Manfred; Nikolić, Milan; Filipović, Nenad R.

TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 
@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}
Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426
Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .
Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .
1
1

Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment

Đukić, Teodora; Khulal, Urmila; Smiljanić, Katarina; Vasović, Tamara; Aćimović, Jelena; Rajković, Andreja; Ćirković Veličković, Tanja

(University of Belgrade – Faculty of Chemistry, 2024)

TY  - CONF
AU  - Đukić, Teodora
AU  - Khulal, Urmila
AU  - Smiljanić, Katarina
AU  - Vasović, Tamara
AU  - Aćimović, Jelena
AU  - Rajković, Andreja
AU  - Ćirković Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6539
AB  - Protein modifications (PMs) are covalent changes occurring on amino acid (AA) side chains of
proteins via enzymatic action or spontaneously. They increase the protein structure complexity
from the level of the genome to the proteome, and can determine their activity and, interactions1.
It has been shown, on myofibrillar fish proteins that oxidative modifications depending on their
saturation can decrease or enhance protein digestability2. Thus in this study shellfish meat samples
were subjected to cooking followed by simulated INFOGEST in vitro gastrointestinal digestion
protocol. Mass Spectrometry and in gel based proteomics, were used to detect PMs and digestion
resistan peptides of raw and cooked shellfish meat samples with a foucs on major shellfish allergens:
sarcoplasmic calcium-binding protein (SBP) and tropomyosin (TPM). Lastly, identified PMs
were marked on TPM alignment from shrimp, oyster and abalone species, to gain insight into their
pattern on the known IgE binding epitopes. Focusing on oxidative PMs, mostly on oxidation of Met,
it was confirmed that, in all shellfish samples, PMs on TPM and SBP were more predominant after
cooking. For instance in abalone, double oxidation of Met was only detected in cooked samples
(sulfone M68 and M81). Another indicator of oxidative stress, 4-hydroxynonenal (HNE), was identified
on shrimp TPM and, notably HNE was 21 times more abundant in the cooked sample. Study
highlights the susceptibility of immunodominant epitopes in major shellfish allergens to oxidative
PMs, which could impact interactions with the immune system in sensitive individuals. Significant
resistance to digestion was demonstrated by paramyosin fragments in abalone and oyster suggesting
the need for further analysis of their allergenicity. SBP of raw shrimp was strikingly resistant
to both gastric and intestinal digestion. Moreover, our results indicate that oxidative modifications
may decrease the stability of proteins like shrimp TPM, making them more digestible in thermally
treated samples, highlighting a potential strategy for reducing allergenicity.
PB  - University of Belgrade – Faculty of Chemistry
C3  - VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
T1  - Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment
SP  - 10
EP  - 10
ER  - 
@conference{
author = "Đukić, Teodora and Khulal, Urmila and Smiljanić, Katarina and Vasović, Tamara and Aćimović, Jelena and Rajković, Andreja and Ćirković Veličković, Tanja",
year = "2024",
abstract = "Protein modifications (PMs) are covalent changes occurring on amino acid (AA) side chains of
proteins via enzymatic action or spontaneously. They increase the protein structure complexity
from the level of the genome to the proteome, and can determine their activity and, interactions1.
It has been shown, on myofibrillar fish proteins that oxidative modifications depending on their
saturation can decrease or enhance protein digestability2. Thus in this study shellfish meat samples
were subjected to cooking followed by simulated INFOGEST in vitro gastrointestinal digestion
protocol. Mass Spectrometry and in gel based proteomics, were used to detect PMs and digestion
resistan peptides of raw and cooked shellfish meat samples with a foucs on major shellfish allergens:
sarcoplasmic calcium-binding protein (SBP) and tropomyosin (TPM). Lastly, identified PMs
were marked on TPM alignment from shrimp, oyster and abalone species, to gain insight into their
pattern on the known IgE binding epitopes. Focusing on oxidative PMs, mostly on oxidation of Met,
it was confirmed that, in all shellfish samples, PMs on TPM and SBP were more predominant after
cooking. For instance in abalone, double oxidation of Met was only detected in cooked samples
(sulfone M68 and M81). Another indicator of oxidative stress, 4-hydroxynonenal (HNE), was identified
on shrimp TPM and, notably HNE was 21 times more abundant in the cooked sample. Study
highlights the susceptibility of immunodominant epitopes in major shellfish allergens to oxidative
PMs, which could impact interactions with the immune system in sensitive individuals. Significant
resistance to digestion was demonstrated by paramyosin fragments in abalone and oyster suggesting
the need for further analysis of their allergenicity. SBP of raw shrimp was strikingly resistant
to both gastric and intestinal digestion. Moreover, our results indicate that oxidative modifications
may decrease the stability of proteins like shrimp TPM, making them more digestible in thermally
treated samples, highlighting a potential strategy for reducing allergenicity.",
publisher = "University of Belgrade – Faculty of Chemistry",
journal = "VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024",
title = "Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment",
pages = "10-10"
}
Đukić, T., Khulal, U., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković Veličković, T.. (2024). Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
University of Belgrade – Faculty of Chemistry., 10-10.
Đukić T, Khulal U, Smiljanić K, Vasović T, Aćimović J, Rajković A, Ćirković Veličković T. Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024. 2024;:10-10..
Đukić, Teodora, Khulal, Urmila, Smiljanić, Katarina, Vasović, Tamara, Aćimović, Jelena, Rajković, Andreja, Ćirković Veličković, Tanja, "Insights into oxidative protein modifications in shellfish allergens: Impact of GI digestion following thermal treatment" in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024 (2024):10-10.

Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052

Smiljanić, Katarina

(Univerzitet u Beogradu - Hemijski fakultet, 2024)

TY  - DATA
AU  - Smiljanić, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6462
AB  - This research dataset encompasess the post-translational and protein modificatrion profiles of raw and roasted shrimpts done with tandem mass spectroscopy (Orbitrap Exploris 240) and processed with PEAKS X pro Studio, with its PTM engine. From these level of results (PEAKS PTM) an ptm profiling was extracted and presented here. An .rar file was created containing ptm profile of raw shirmp and prtm profile of the roasted shrimp in an excel format.
PB  - Univerzitet u Beogradu - Hemijski fakultet
T2  - Journal of Functional Foods
T1  - Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052
VL  - 113
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6462
ER  - 
@misc{
author = "Smiljanić, Katarina",
year = "2024",
abstract = "This research dataset encompasess the post-translational and protein modificatrion profiles of raw and roasted shrimpts done with tandem mass spectroscopy (Orbitrap Exploris 240) and processed with PEAKS X pro Studio, with its PTM engine. From these level of results (PEAKS PTM) an ptm profiling was extracted and presented here. An .rar file was created containing ptm profile of raw shirmp and prtm profile of the roasted shrimp in an excel format.",
publisher = "Univerzitet u Beogradu - Hemijski fakultet",
journal = "Journal of Functional Foods",
title = "Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052",
volume = "113",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6462"
}
Smiljanić, K.. (2024). Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052. in Journal of Functional Foods
Univerzitet u Beogradu - Hemijski fakultet., 113.
https://hdl.handle.net/21.15107/rcub_cherry_6462
Smiljanić K. Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052. in Journal of Functional Foods. 2024;113.
https://hdl.handle.net/21.15107/rcub_cherry_6462 .
Smiljanić, Katarina, "Research data for: Khulal, U., Đukić, T., Smiljanić, K., Vasović, T., Aćimović, J., Rajković, A.,& Ćirković-Veličković, T.. (2024). Protein modifications screening of raw and thermally treated meat gastrointestinal digesta. in Journal of Functional Foods Elsevier., 113, 106052. https://doi.org/10.1016/j.jff.2024.106052" in Journal of Functional Foods, 113 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6462 .

Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation

Trmčić, Milena; Vulović, Bojan; Zlatar, Matija; Saičić, Radomir N.

(ARKAT USA, Inc., 2024)

TY  - JOUR
AU  - Trmčić, Milena
AU  - Vulović, Bojan
AU  - Zlatar, Matija
AU  - Saičić, Radomir N.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6536
AB  - Hemiacetals of cyclopropanone can be isolated and stocked, contrary to their highly reactive parent ketone.  However, they are not readily converted to cyclopropanone, which limits their use as its synthetic equivalents.  2,2,2-trifluoroethoxy hemiacetals are expected to be better cyclopropanone surrogates, however, they have  never been prepared, so far. We show that oxyallyl cations with a heteroatom in the -position can be  intercepted with 2,2,2-trifluoroethanol, with formation of cyclopropanone trifluoroethoxy hemiacetals stable  enough to be isolated, purified and characterized. These species can serve as synthetic equivalents of  cyclopropanone under mild conditions.
PB  - ARKAT USA, Inc.
T2  - ARKIVOC - Online Journal of Organic Chemistry
T1  - Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation
VL  - 2024
IS  - 2
DO  - 10.24820/ark.5550190.p012.123
ER  - 
@article{
author = "Trmčić, Milena and Vulović, Bojan and Zlatar, Matija and Saičić, Radomir N.",
year = "2024",
abstract = "Hemiacetals of cyclopropanone can be isolated and stocked, contrary to their highly reactive parent ketone.  However, they are not readily converted to cyclopropanone, which limits their use as its synthetic equivalents.  2,2,2-trifluoroethoxy hemiacetals are expected to be better cyclopropanone surrogates, however, they have  never been prepared, so far. We show that oxyallyl cations with a heteroatom in the -position can be  intercepted with 2,2,2-trifluoroethanol, with formation of cyclopropanone trifluoroethoxy hemiacetals stable  enough to be isolated, purified and characterized. These species can serve as synthetic equivalents of  cyclopropanone under mild conditions.",
publisher = "ARKAT USA, Inc.",
journal = "ARKIVOC - Online Journal of Organic Chemistry",
title = "Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation",
volume = "2024",
number = "2",
doi = "10.24820/ark.5550190.p012.123"
}
Trmčić, M., Vulović, B., Zlatar, M.,& Saičić, R. N.. (2024). Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation. in ARKIVOC - Online Journal of Organic Chemistry
ARKAT USA, Inc.., 2024(2).
https://doi.org/10.24820/ark.5550190.p012.123
Trmčić M, Vulović B, Zlatar M, Saičić RN. Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation. in ARKIVOC - Online Journal of Organic Chemistry. 2024;2024(2).
doi:10.24820/ark.5550190.p012.123 .
Trmčić, Milena, Vulović, Bojan, Zlatar, Matija, Saičić, Radomir N., "Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation" in ARKIVOC - Online Journal of Organic Chemistry, 2024, no. 2 (2024),
https://doi.org/10.24820/ark.5550190.p012.123 . .

Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach

Selaković, Snežana; Rodić, Marko V.; Novaković, Irena T.; Matić, Ivana Z.; Stanojković, Tatjana; Pirković, Andrea; Živković, Lada; Spremo-Potparević, Biljana; Milčić, Miloš; Medaković, Vesna; Dimiza, Filitsa; Psomas, George; Anđelković, Katarina K.; Šumar-Ristović, Maja

(Royal Society of Chemistry, 2024)

TY  - JOUR
AU  - Selaković, Snežana
AU  - Rodić, Marko V.
AU  - Novaković, Irena T.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Milčić, Miloš
AU  - Medaković, Vesna
AU  - Dimiza, Filitsa
AU  - Psomas, George
AU  - Anđelković, Katarina K.
AU  - Šumar-Ristović, Maja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6537
AB  - Copper(II) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(II) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf–thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.
PB  - Royal Society of Chemistry
T2  - Dalton Transactions
T2  - Dalton TransactionsDalton Trans.
T1  - Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach
VL  - 53
IS  - 6
SP  - 2770
EP  - 2788
DO  - 10.1039/D3DT03862A
ER  - 
@article{
author = "Selaković, Snežana and Rodić, Marko V. and Novaković, Irena T. and Matić, Ivana Z. and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Milčić, Miloš and Medaković, Vesna and Dimiza, Filitsa and Psomas, George and Anđelković, Katarina K. and Šumar-Ristović, Maja",
year = "2024",
abstract = "Copper(II) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(II) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf–thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.",
publisher = "Royal Society of Chemistry",
journal = "Dalton Transactions, Dalton TransactionsDalton Trans.",
title = "Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach",
volume = "53",
number = "6",
pages = "2770-2788",
doi = "10.1039/D3DT03862A"
}
Selaković, S., Rodić, M. V., Novaković, I. T., Matić, I. Z., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Milčić, M., Medaković, V., Dimiza, F., Psomas, G., Anđelković, K. K.,& Šumar-Ristović, M.. (2024). Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions
Royal Society of Chemistry., 53(6), 2770-2788.
https://doi.org/10.1039/D3DT03862A
Selaković S, Rodić MV, Novaković IT, Matić IZ, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Milčić M, Medaković V, Dimiza F, Psomas G, Anđelković KK, Šumar-Ristović M. Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions. 2024;53(6):2770-2788.
doi:10.1039/D3DT03862A .
Selaković, Snežana, Rodić, Marko V., Novaković, Irena T., Matić, Ivana Z., Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Milčić, Miloš, Medaković, Vesna, Dimiza, Filitsa, Psomas, George, Anđelković, Katarina K., Šumar-Ristović, Maja, "Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach" in Dalton Transactions, 53, no. 6 (2024):2770-2788,
https://doi.org/10.1039/D3DT03862A . .

Novel cinnamic acid-based PET derivatives as quorum sensing modulators

Škaro Bogojević, Sanja; Perminova, D; Jakšić, Jovana; Milčić, Miloš K.; Medaković, Vesna; Milovanović, Jelena; Nikodinović-Runić, Jasmina; Maslak, V

(Elsevier, 2024)

TY  - JOUR
AU  - Škaro Bogojević, Sanja
AU  - Perminova, D
AU  - Jakšić, Jovana
AU  - Milčić, Miloš K.
AU  - Medaković, Vesna
AU  - Milovanović, Jelena
AU  - Nikodinović-Runić, Jasmina
AU  - Maslak, V
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6476
AB  - Poly(ethylene terephthalate) (PET) is widely used material in the healthcare due to its mechanical properties including resistance to chemicals and abrasion. However, it is susceptible to bacterial attachment and contamination. This study addresses some newly designed model compounds of PET with antimicrobial properties that could potentially be incorporated into PET materials. All compounds were synthesized for the first time by labeling an integral part of PET with chromophores in the form of esters of cinnamic and ferulic acids. After complete structural characterization, the effect of new compounds on microbial growth and communication (quorum sensing, QS) was analyzed and further investigated using molecular docking. The obtained results indicate that the introduction of chromophores that have one part of cinnamic acid enriched with a methoxy functional group in them acts as QS modulators. Moreover, compounds exhibited dose-dependent selectivity toward QS signaling pathways and the highest tested concentration of compounds showed Pseudomonas Quinolone Signal (PQS) inhibitory activity suggesting that these compounds have a potential effect on pyocyanin production. Docking studies demonstrated that compounds hold binding power to all four QS protein targets (LuxP, periplasmatic protein that binds AI-2 inducer and forms a complex able to transduce the autoinducer signal, RhIR protein that is a key QS transcriptional regulator that activates the genes involved in the synthesis of rhamnolipids and pyocyanin, AbaI protein that has a role in QS signal transduction, and LasR protein which is a key QS transcriptional regulator that activates transcription of genes coding for some virulence-associated traits) while the highest binding strength is observed with compounds 2 and 6 containing single cinnamic acid fragment, suggesting their further biomedical application.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Novel cinnamic acid-based PET derivatives as quorum sensing modulators
VL  - 1300
SP  - 137291
DO  - 10.1016/j.molstruc.2023.137291
ER  - 
@article{
author = "Škaro Bogojević, Sanja and Perminova, D and Jakšić, Jovana and Milčić, Miloš K. and Medaković, Vesna and Milovanović, Jelena and Nikodinović-Runić, Jasmina and Maslak, V",
year = "2024",
abstract = "Poly(ethylene terephthalate) (PET) is widely used material in the healthcare due to its mechanical properties including resistance to chemicals and abrasion. However, it is susceptible to bacterial attachment and contamination. This study addresses some newly designed model compounds of PET with antimicrobial properties that could potentially be incorporated into PET materials. All compounds were synthesized for the first time by labeling an integral part of PET with chromophores in the form of esters of cinnamic and ferulic acids. After complete structural characterization, the effect of new compounds on microbial growth and communication (quorum sensing, QS) was analyzed and further investigated using molecular docking. The obtained results indicate that the introduction of chromophores that have one part of cinnamic acid enriched with a methoxy functional group in them acts as QS modulators. Moreover, compounds exhibited dose-dependent selectivity toward QS signaling pathways and the highest tested concentration of compounds showed Pseudomonas Quinolone Signal (PQS) inhibitory activity suggesting that these compounds have a potential effect on pyocyanin production. Docking studies demonstrated that compounds hold binding power to all four QS protein targets (LuxP, periplasmatic protein that binds AI-2 inducer and forms a complex able to transduce the autoinducer signal, RhIR protein that is a key QS transcriptional regulator that activates the genes involved in the synthesis of rhamnolipids and pyocyanin, AbaI protein that has a role in QS signal transduction, and LasR protein which is a key QS transcriptional regulator that activates transcription of genes coding for some virulence-associated traits) while the highest binding strength is observed with compounds 2 and 6 containing single cinnamic acid fragment, suggesting their further biomedical application.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Novel cinnamic acid-based PET derivatives as quorum sensing modulators",
volume = "1300",
pages = "137291",
doi = "10.1016/j.molstruc.2023.137291"
}
Škaro Bogojević, S., Perminova, D., Jakšić, J., Milčić, M. K., Medaković, V., Milovanović, J., Nikodinović-Runić, J.,& Maslak, V.. (2024). Novel cinnamic acid-based PET derivatives as quorum sensing modulators. in Journal of Molecular Structure
Elsevier., 1300, 137291.
https://doi.org/10.1016/j.molstruc.2023.137291
Škaro Bogojević S, Perminova D, Jakšić J, Milčić MK, Medaković V, Milovanović J, Nikodinović-Runić J, Maslak V. Novel cinnamic acid-based PET derivatives as quorum sensing modulators. in Journal of Molecular Structure. 2024;1300:137291.
doi:10.1016/j.molstruc.2023.137291 .
Škaro Bogojević, Sanja, Perminova, D, Jakšić, Jovana, Milčić, Miloš K., Medaković, Vesna, Milovanović, Jelena, Nikodinović-Runić, Jasmina, Maslak, V, "Novel cinnamic acid-based PET derivatives as quorum sensing modulators" in Journal of Molecular Structure, 1300 (2024):137291,
https://doi.org/10.1016/j.molstruc.2023.137291 . .
1

Позитрон - 33

Шишаковић, Исидора; Мирковић, Ања; Радовановић, Мина; Крмпота, Ивана; Шкиљевић, Романа; Цветковић, Јован; Савић, Слађана; Деновић, Вања; Симеуновић, Бојана; Арсенијевић, Марија; Лазовић, Марина; Вујновић, Милица; Ћирић, Теодора; Станков, Јелена; Јакановски, Михајло; Лазовић, Мила; Кесић, Јелена

(Универзитет у Београду – Хемијски факултет, 2024)

TY  - GEN
AU  - Шишаковић, Исидора
AU  - Мирковић, Ања
AU  - Радовановић, Мина
AU  - Крмпота, Ивана
AU  - Шкиљевић, Романа
AU  - Цветковић, Јован
AU  - Савић, Слађана
AU  - Деновић, Вања
AU  - Симеуновић, Бојана
AU  - Арсенијевић, Марија
AU  - Лазовић, Марина
AU  - Вујновић, Милица
AU  - Ћирић, Теодора
AU  - Станков, Јелена
AU  - Јакановски, Михајло
AU  - Лазовић, Мила
AU  - Кесић, Јелена
PY  - 2024
UR  - http://chem.bg.ac.rs/studorg/
UR  - https://www.facebook.com/pozitroncasopis/
UR  - https://www.instagram.com/pozitroncasopis/
UR  - pozitron@chem.bg.ac.rs
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6531
AB  - На самом почетку броја, подсећамо се овогодишњеманифестације Global Women’s Breakfast, одржане у фебруару. Даље се упознајемо са радом организације Лицеулице. Студенткиња мастер студија Романа Шкиљевић представља Иновациони инкубатор, а Јован Цветковић се осврће на Дан отворених врата Хемијског факултета одржан у марту. Разговарамо са Наталијом Грујић, студенткињом Новинарства на Факултету политичких наука, а такође чланицом редакције њиховог студентског медија, Слушаонице 6, као и са студенткињом докторских академских студија у области биохемијских наука и генералном  секретарком Биохемијског друштва Србије, Исидором Протић Росић у оквиру рубрике Укратко о подугачком. У овом броју можете да откријете и нешто више о најстаријем предмету на Хемијском факултету, јеличком метеориту. Још један од наших саговорника је др Алекс Авдиф, гостујући виши сарадник на Кингс колеџу у Лондону и аутор књиге Absorption and Drug Development. Студенти Хемије животне средине нам приказују како изгледа теренска настава у оквиру изборног предмета на завршним годинама студија, Природни ресурси. Пишемо и о другом по реду Фестивалу хемије, одржаном у организацији Клуба младих хемичара Србије и Српског хемијског друштва. Препоруку за добру књигу можете да пронађете у Позитроновој листи омиљених књига, а најновије вести из хемије и студентског живота пточитајте у Ретросинтези. За крај, насмејте се кроз Позитиву и уживајте у броју пред вама.
PB  - Универзитет у Београду – Хемијски факултет
T1  - Позитрон - 33
VL  - 33
SP  - 1
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6531
ER  - 
@misc{
author = "Шишаковић, Исидора and Мирковић, Ања and Радовановић, Мина and Крмпота, Ивана and Шкиљевић, Романа and Цветковић, Јован and Савић, Слађана and Деновић, Вања and Симеуновић, Бојана and Арсенијевић, Марија and Лазовић, Марина and Вујновић, Милица and Ћирић, Теодора and Станков, Јелена and Јакановски, Михајло and Лазовић, Мила and Кесић, Јелена",
year = "2024",
abstract = "На самом почетку броја, подсећамо се овогодишњеманифестације Global Women’s Breakfast, одржане у фебруару. Даље се упознајемо са радом организације Лицеулице. Студенткиња мастер студија Романа Шкиљевић представља Иновациони инкубатор, а Јован Цветковић се осврће на Дан отворених врата Хемијског факултета одржан у марту. Разговарамо са Наталијом Грујић, студенткињом Новинарства на Факултету политичких наука, а такође чланицом редакције њиховог студентског медија, Слушаонице 6, као и са студенткињом докторских академских студија у области биохемијских наука и генералном  секретарком Биохемијског друштва Србије, Исидором Протић Росић у оквиру рубрике Укратко о подугачком. У овом броју можете да откријете и нешто више о најстаријем предмету на Хемијском факултету, јеличком метеориту. Још један од наших саговорника је др Алекс Авдиф, гостујући виши сарадник на Кингс колеџу у Лондону и аутор књиге Absorption and Drug Development. Студенти Хемије животне средине нам приказују како изгледа теренска настава у оквиру изборног предмета на завршним годинама студија, Природни ресурси. Пишемо и о другом по реду Фестивалу хемије, одржаном у организацији Клуба младих хемичара Србије и Српског хемијског друштва. Препоруку за добру књигу можете да пронађете у Позитроновој листи омиљених књига, а најновије вести из хемије и студентског живота пточитајте у Ретросинтези. За крај, насмејте се кроз Позитиву и уживајте у броју пред вама.",
publisher = "Универзитет у Београду – Хемијски факултет",
title = "Позитрон - 33",
volume = "33",
pages = "1-26",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6531"
}
Шишаковић, И., Мирковић, А., Радовановић, М., Крмпота, И., Шкиљевић, Р., Цветковић, Ј., Савић, С., Деновић, В., Симеуновић, Б., Арсенијевић, М., Лазовић, М., Вујновић, М., Ћирић, Т., Станков, Ј., Јакановски, М., Лазовић, М.,& Кесић, Ј.. (2024). Позитрон - 33. 
Универзитет у Београду – Хемијски факултет., 33, 1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6531
Шишаковић И, Мирковић А, Радовановић М, Крмпота И, Шкиљевић Р, Цветковић Ј, Савић С, Деновић В, Симеуновић Б, Арсенијевић М, Лазовић М, Вујновић М, Ћирић Т, Станков Ј, Јакановски М, Лазовић М, Кесић Ј. Позитрон - 33. 2024;33:1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6531 .
Шишаковић, Исидора, Мирковић, Ања, Радовановић, Мина, Крмпота, Ивана, Шкиљевић, Романа, Цветковић, Јован, Савић, Слађана, Деновић, Вања, Симеуновић, Бојана, Арсенијевић, Марија, Лазовић, Марина, Вујновић, Милица, Ћирић, Теодора, Станков, Јелена, Јакановски, Михајло, Лазовић, Мила, Кесић, Јелена, "Позитрон - 33", 33 (2024):1-26,
https://hdl.handle.net/21.15107/rcub_cherry_6531 .

Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?

Savić, Slađana D.; Županec, Vera S.; Đorđević, Dragana S.; Marušić Jablanović, Milica V.

(Beograd : Srpsko hemijsko društvo, 2024)

TY  - CONF
AU  - Savić, Slađana D.
AU  - Županec, Vera S.
AU  - Đorđević, Dragana S.
AU  - Marušić Jablanović, Milica V.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6533
AB  - Koristeći međunarodni upitnik za ispitivanje ekološke pismenosti (MSELS), utvrđen je nivo kognitivnih veština učenika sedmog razreda osnovne škole u Srbiji (n=877). Maksimalni skor na skali kognitivnih veština je iznosio 60 poena, a učenici su prosečno osvojili 25,97 poena. Na različitim vrstama zadataka postignuti su podjednaki rezultati: zadaci koji mere prepoznavanje problema (8,27), analiza problema (8,96), kao i planiranje aktivnosti za rešavanje problema (8,74). Kao način da se kognitivne veštine učenika podstaknu, u radu je predstavljen primer zadatka kojim se zahteva od učenika da analiziraju opisani problem zagađenja reke i da koncipiraju strategije za njegovo rešenje.
AB  - Using the international environmental literacy survey (MSELS), the level of cognitive skills of seventh-grade elementary school students in Serbia (n=877) was determined. The maximum score on the cognitive skills scale was 60 points, and the students scored an average of 25.97 points. Students performed similarly on all task types: tasks that measure issue identification (8.27), issue analysis (8.96), as well as planning activities to solve issues (8.74). As a way to encourage students' cognitive skills, the paper presents an example of a task that requires students to analyze the specific problem of river pollution and to devise strategies for its solution.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024
T1  - Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?
T1  - How 7th-grade students in Serbia identify and analyze environmental issues?
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6533
ER  - 
@conference{
author = "Savić, Slađana D. and Županec, Vera S. and Đorđević, Dragana S. and Marušić Jablanović, Milica V.",
year = "2024",
abstract = "Koristeći međunarodni upitnik za ispitivanje ekološke pismenosti (MSELS), utvrđen je nivo kognitivnih veština učenika sedmog razreda osnovne škole u Srbiji (n=877). Maksimalni skor na skali kognitivnih veština je iznosio 60 poena, a učenici su prosečno osvojili 25,97 poena. Na različitim vrstama zadataka postignuti su podjednaki rezultati: zadaci koji mere prepoznavanje problema (8,27), analiza problema (8,96), kao i planiranje aktivnosti za rešavanje problema (8,74). Kao način da se kognitivne veštine učenika podstaknu, u radu je predstavljen primer zadatka kojim se zahteva od učenika da analiziraju opisani problem zagađenja reke i da koncipiraju strategije za njegovo rešenje., Using the international environmental literacy survey (MSELS), the level of cognitive skills of seventh-grade elementary school students in Serbia (n=877) was determined. The maximum score on the cognitive skills scale was 60 points, and the students scored an average of 25.97 points. Students performed similarly on all task types: tasks that measure issue identification (8.27), issue analysis (8.96), as well as planning activities to solve issues (8.74). As a way to encourage students' cognitive skills, the paper presents an example of a task that requires students to analyze the specific problem of river pollution and to devise strategies for its solution.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024",
title = "Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?, How 7th-grade students in Serbia identify and analyze environmental issues?",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6533"
}
Savić, S. D., Županec, V. S., Đorđević, D. S.,& Marušić Jablanović, M. V.. (2024). Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?. in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024
Beograd : Srpsko hemijsko društvo..
https://hdl.handle.net/21.15107/rcub_cherry_6533
Savić SD, Županec VS, Đorđević DS, Marušić Jablanović MV. Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?. in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6533 .
Savić, Slađana D., Županec, Vera S., Đorđević, Dragana S., Marušić Jablanović, Milica V., "Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?" in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6533 .

Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?

Savić, Slađana D.; Županec, Vera S.; Đorđević, Dragana S.; Marušić Jablanović, Milica V.

(Beograd : Srpsko hemijsko društvo, 2024)

TY  - CONF
AU  - Savić, Slađana D.
AU  - Županec, Vera S.
AU  - Đorđević, Dragana S.
AU  - Marušić Jablanović, Milica V.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6532
AB  - Koristeći međunarodni upitnik za ispitivanje ekološke pismenosti (MSELS), utvrđen je nivo kognitivnih veština učenika sedmog razreda osnovne škole u Srbiji (n=877). Maksimalni skor na skali kognitivnih veština je iznosio 60 poena, a učenici su prosečno osvojili 25,97 poena. Na različitim vrstama zadataka postignuti su podjednaki rezultati: zadaci koji mere prepoznavanje problema (8,27), analiza problema (8,96), kao i planiranje aktivnosti za rešavanje problema (8,74). Kao način da se kognitivne veštine učenika podstaknu, u radu je predstavljen primer zadatka kojim se zahteva od učenika da analiziraju opisani problem zagađenja reke i da koncipiraju strategije za njegovo rešenje.
AB  - Using the international environmental literacy survey (MSELS), the level of cognitive skills of seventh-grade elementary school students in Serbia (n=877) was determined. The maximum score on the cognitive skills scale was 60 points, and the students scored an average of 25.97 points. Students performed similarly on all task types: tasks that measure issue identification (8.27), issue analysis (8.96), as well as planning activities to solve issues (8.74). As a way to encourage students' cognitive skills, the paper presents an example of a task that requires students to analyze the specific problem of river pollution and to devise strategies for its solution.
PB  - Beograd : Srpsko hemijsko društvo
C3  - 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024
T1  - Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?
T1  - How 7th-grade students in Serbia identify and analyze environmental issues?
IS  - 60
SP  - 99
EP  - 99
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6532
ER  - 
@conference{
author = "Savić, Slađana D. and Županec, Vera S. and Đorđević, Dragana S. and Marušić Jablanović, Milica V.",
year = "2024",
abstract = "Koristeći međunarodni upitnik za ispitivanje ekološke pismenosti (MSELS), utvrđen je nivo kognitivnih veština učenika sedmog razreda osnovne škole u Srbiji (n=877). Maksimalni skor na skali kognitivnih veština je iznosio 60 poena, a učenici su prosečno osvojili 25,97 poena. Na različitim vrstama zadataka postignuti su podjednaki rezultati: zadaci koji mere prepoznavanje problema (8,27), analiza problema (8,96), kao i planiranje aktivnosti za rešavanje problema (8,74). Kao način da se kognitivne veštine učenika podstaknu, u radu je predstavljen primer zadatka kojim se zahteva od učenika da analiziraju opisani problem zagađenja reke i da koncipiraju strategije za njegovo rešenje., Using the international environmental literacy survey (MSELS), the level of cognitive skills of seventh-grade elementary school students in Serbia (n=877) was determined. The maximum score on the cognitive skills scale was 60 points, and the students scored an average of 25.97 points. Students performed similarly on all task types: tasks that measure issue identification (8.27), issue analysis (8.96), as well as planning activities to solve issues (8.74). As a way to encourage students' cognitive skills, the paper presents an example of a task that requires students to analyze the specific problem of river pollution and to devise strategies for its solution.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024",
title = "Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?, How 7th-grade students in Serbia identify and analyze environmental issues?",
number = "60",
pages = "99-99",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6532"
}
Savić, S. D., Županec, V. S., Đorđević, D. S.,& Marušić Jablanović, M. V.. (2024). Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?. in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024
Beograd : Srpsko hemijsko društvo.(60), 99-99.
https://hdl.handle.net/21.15107/rcub_cherry_6532
Savić SD, Županec VS, Đorđević DS, Marušić Jablanović MV. Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?. in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024. 2024;(60):99-99.
https://hdl.handle.net/21.15107/rcub_cherry_6532 .
Savić, Slađana D., Županec, Vera S., Đorđević, Dragana S., Marušić Jablanović, Milica V., "Kako učenici sedmog razreda u Srbiji prepoznaju i analiziraju probleme u životnoj sredini?" in 60. Savetovanje Srpskog hemijskog društva, Kratki izvodi radova, Univerzitet u Nišu - Prirodno-matematički fakultet, Niš, 8. i 9. jun 2024, no. 60 (2024):99-99,
https://hdl.handle.net/21.15107/rcub_cherry_6532 .

Позитрон - 32

Šišaković, Isidora; Mirković, Anja; Radovanović, Mina; Krmpota, Ivana; Savić, Slađana D.; Jakovljević, Danijel; Milanović Maštrapović, Vesna; Sofrenić, Ivana; Đorđević, Ana

(Универзитет у Београду – Хемијски факултет, 2024)

TY  - GEN
AU  - Šišaković, Isidora
AU  - Mirković, Anja
AU  - Radovanović, Mina
AU  - Krmpota, Ivana
AU  - Savić, Slađana D.
AU  - Jakovljević, Danijel
AU  - Milanović Maštrapović, Vesna
AU  - Sofrenić, Ivana
AU  - Đorđević, Ana
PY  - 2024
UR  - http://chem.bg.ac.rs/studorg/
UR  - https://www.facebook.com/pozitroncasopis/
UR  - https://www.instagram.com/pozitroncasopis/
UR  - pozitron@chem.bg.ac.rs
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6456
AB  - Овај број почињемо причом о историјату и развоју хемије у Србији, како је прошле године обележено 170 година од њеног доласка у нашу државу. Мина Радовановић, председница Студентског парламента Хемијског факултета, нам открива изазове које ова позиција носи са собом, као и планове за предстојећи период. У новој рубрици о актуелним пројектима на Хемијском факултету доцент др. Симеон Минић нас упознаје са пројектом Оснаживања потенцијала протеина из алги за бојење и фортификацију хране коришћењем технологије високог притиска – PRESSION. Даље се осврћемо на глобална научна достигнућа из хемије која су прошле године заслужила Нобелову награду. Нешто другачију врсту успеха, успех професора и асистената међу студентима, пратимо кроз разговор са онима који су на Позитроновој анкети имали највише гласова. Осим са њима, разговарамо и са Урошем Анђелковићем, алумнистом Хемијског факултета. Ана Ђорђевић, запослена у библиотеци Хемијског факултета, објашњава шта је то отворена наука и како је она примењена у оквиру пројекта GraspOs. Девету конференцију Клуба младих хемичара Србије смо испратили посебним текстом, а остале вести из хемије Ретросинтезом. Као и увек, на крају броја ће вам осмех на лице измамити Позитива. Уживајте!
PB  - Универзитет у Београду – Хемијски факултет
T1  - Позитрон - 32
VL  - 32
SP  - 1
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6456
ER  - 
@misc{
author = "Šišaković, Isidora and Mirković, Anja and Radovanović, Mina and Krmpota, Ivana and Savić, Slađana D. and Jakovljević, Danijel and Milanović Maštrapović, Vesna and Sofrenić, Ivana and Đorđević, Ana",
year = "2024",
abstract = "Овај број почињемо причом о историјату и развоју хемије у Србији, како је прошле године обележено 170 година од њеног доласка у нашу државу. Мина Радовановић, председница Студентског парламента Хемијског факултета, нам открива изазове које ова позиција носи са собом, као и планове за предстојећи период. У новој рубрици о актуелним пројектима на Хемијском факултету доцент др. Симеон Минић нас упознаје са пројектом Оснаживања потенцијала протеина из алги за бојење и фортификацију хране коришћењем технологије високог притиска – PRESSION. Даље се осврћемо на глобална научна достигнућа из хемије која су прошле године заслужила Нобелову награду. Нешто другачију врсту успеха, успех професора и асистената међу студентима, пратимо кроз разговор са онима који су на Позитроновој анкети имали највише гласова. Осим са њима, разговарамо и са Урошем Анђелковићем, алумнистом Хемијског факултета. Ана Ђорђевић, запослена у библиотеци Хемијског факултета, објашњава шта је то отворена наука и како је она примењена у оквиру пројекта GraspOs. Девету конференцију Клуба младих хемичара Србије смо испратили посебним текстом, а остале вести из хемије Ретросинтезом. Као и увек, на крају броја ће вам осмех на лице измамити Позитива. Уживајте!",
publisher = "Универзитет у Београду – Хемијски факултет",
title = "Позитрон - 32",
volume = "32",
pages = "1-26",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6456"
}
Šišaković, I., Mirković, A., Radovanović, M., Krmpota, I., Savić, S. D., Jakovljević, D., Milanović Maštrapović, V., Sofrenić, I.,& Đorđević, A.. (2024). Позитрон - 32. 
Универзитет у Београду – Хемијски факултет., 32, 1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6456
Šišaković I, Mirković A, Radovanović M, Krmpota I, Savić SD, Jakovljević D, Milanović Maštrapović V, Sofrenić I, Đorđević A. Позитрон - 32. 2024;32:1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6456 .
Šišaković, Isidora, Mirković, Anja, Radovanović, Mina, Krmpota, Ivana, Savić, Slađana D., Jakovljević, Danijel, Milanović Maštrapović, Vesna, Sofrenić, Ivana, Đorđević, Ana, "Позитрон - 32", 32 (2024):1-26,
https://hdl.handle.net/21.15107/rcub_cherry_6456 .

Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343

Putica, Katarina B.

(American Chemical Society, 2024)

TY  - DATA
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6529
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343
VL  - 101
IS  - 4
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6529
ER  - 
@misc{
author = "Putica, Katarina B.",
year = "2024",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343",
volume = "101",
number = "4",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6529"
}
Putica, K. B.. (2024). Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343. in Journal of Chemical Education
American Chemical Society., 101(4).
https://hdl.handle.net/21.15107/rcub_cherry_6529
Putica KB. Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343. in Journal of Chemical Education. 2024;101(4).
https://hdl.handle.net/21.15107/rcub_cherry_6529 .
Putica, Katarina B., "Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343" in Journal of Chemical Education, 101, no. 4 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6529 .

Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test

Putica, Katarina B.

(American Chemical Society, 2024)

TY  - JOUR
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6528
AB  - As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test
VL  - 101
IS  - 4
SP  - 1442
EP  - 1456
DO  - 10.1021/acs.jchemed.3c01343
ER  - 
@article{
author = "Putica, Katarina B.",
year = "2024",
abstract = "As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test",
volume = "101",
number = "4",
pages = "1442-1456",
doi = "10.1021/acs.jchemed.3c01343"
}
Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education
American Chemical Society., 101(4), 1442-1456.
https://doi.org/10.1021/acs.jchemed.3c01343
Putica KB. Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education. 2024;101(4):1442-1456.
doi:10.1021/acs.jchemed.3c01343 .
Putica, Katarina B., "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test" in Journal of Chemical Education, 101, no. 4 (2024):1442-1456,
https://doi.org/10.1021/acs.jchemed.3c01343 . .

Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences

Putica, Katarina

(2024)

TY  - CONF
AU  - Putica, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6525
AB  - In light of the fact that fast scientific growth has a profound impact on life in the 21st century, this research aimed to explore the effects of STEM teaching approach on the development of key 21st century competencies related to learning of natural sciences. Consequently, four research hypotheses which state that STEM approach promotes the development of creativity (H1), critical thinking (H2), problem-solving (H3), and science-processing skills (H4) to a greater extent than the traditional approach to teaching of natural sciences have been posed, and their correctness was assessed by means of the meta-analysis. Within the meta-analysis, the results of 21 studies that examined the effects of STEM approach on the development of the above-mentioned competencies among both elementary and high-school pupils were used to calculate the corresponding mean Cohen’s d value for each of the four hypotheses. The mean Cohen’s d values for hypotheses related to creativity and science-processing skills were in the range between 0.5 and 0.8 indicating a moderate positive effect, while the mean Cohen’s d values for hypotheses referring to critical thinking and problem-solving skills were higher than 0.8, indicating a strong positive effect of STEM approach on the development of these competencies, in comparison to traditional teaching approach. Based on such results it can be concluded that all four research hypotheses that were posed are correct, which confirms the considerable potential of STEM teaching approach to contribute to the development of key 21st century skills related to leaning of natural sciences.
C3  - International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024
T1  - Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6525
ER  - 
@conference{
author = "Putica, Katarina",
year = "2024",
abstract = "In light of the fact that fast scientific growth has a profound impact on life in the 21st century, this research aimed to explore the effects of STEM teaching approach on the development of key 21st century competencies related to learning of natural sciences. Consequently, four research hypotheses which state that STEM approach promotes the development of creativity (H1), critical thinking (H2), problem-solving (H3), and science-processing skills (H4) to a greater extent than the traditional approach to teaching of natural sciences have been posed, and their correctness was assessed by means of the meta-analysis. Within the meta-analysis, the results of 21 studies that examined the effects of STEM approach on the development of the above-mentioned competencies among both elementary and high-school pupils were used to calculate the corresponding mean Cohen’s d value for each of the four hypotheses. The mean Cohen’s d values for hypotheses related to creativity and science-processing skills were in the range between 0.5 and 0.8 indicating a moderate positive effect, while the mean Cohen’s d values for hypotheses referring to critical thinking and problem-solving skills were higher than 0.8, indicating a strong positive effect of STEM approach on the development of these competencies, in comparison to traditional teaching approach. Based on such results it can be concluded that all four research hypotheses that were posed are correct, which confirms the considerable potential of STEM teaching approach to contribute to the development of key 21st century skills related to leaning of natural sciences.",
journal = "International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024",
title = "Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6525"
}
Putica, K.. (2024). Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences. in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024.
https://hdl.handle.net/21.15107/rcub_cherry_6525
Putica K. Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences. in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6525 .
Putica, Katarina, "Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences" in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6525 .

The influence of suspension concentration on the pHmax – pHmin range during the solubility determination

Marković, Olivera S.; Mrđinac, Jelena Ž.; Pepić, Sara V.; Verbić, Tatjana Ž.

(Belgrade : Serbian Chemical Society, 2024)

TY  - CONF
AU  - Marković, Olivera S.
AU  - Mrđinac, Jelena Ž.
AU  - Pepić, Sara V.
AU  - Verbić, Tatjana Ž.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6530
AB  - The solubility profile of a drug typically consists of two independent curves that intersect 
at a specific point called pHmax. At pHmax, both salt and base coexist as solid phases. While 
two solids coexist, pH and solubility in the heterogeneous system remain constant 
(according to the Gibbs Phase Rule). Recent studies, however, have shown that pH and 
solubility might change during the salt-to-free-base transformation. This pH range, 
containing two solids, is termed the pHmax – pHmin range. pHmax refers to the pH value at 
the maximum solubility of a eutectic mixture, whereas pHmin represents the pH value at the 
minimum solubility of the eutectic mixture. The objective of this study was to investigate 
the influence of suspension concentration (the ratio of drug mass to suspension volume) on 
the pHmax – pHmin range during solubility determination using the pH-Ramp shake-flask
method. Nortriptyline hydrochloride (Nor, monoprotic base) and atorvastatin calcium (At, 
monoprotic acid) were employed as model compounds. Results indicate that the pHmax –
pHmin range increases as suspension concentration rises (for 20.10 mg NorHCl/mL: 
pHmax=3.55, ΔpH=0; for 59.82 mg NorHCl/mL: pHmax – pHmin= 3.56 – 4.52, ΔpH=0.96). 
Understanding the details of the pHmax – pHmin range could significantly impact product 
formulation optimization in drug research
AB  - Cilj ovog rada bio je ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin
opsega tokom određivanja rastvorljivosti pH-Ramp shake-flask metodom. Kao model 
jedinjenja izabrani su nortriptilin-hidrohlorid i atorvastatin-kalcijum. Rezultati su pokazali 
da sa porastom koncentracije suspenzije dolazi do širenja opsega pHmax – pHmin, a ovakva 
proučavanja mogu značajno doprineti optimizaciji formulacije u procesu dizajna i razvoja 
lekova.
PB  - Belgrade : Serbian Chemical Society
C3  - 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024
T1  - The influence of suspension concentration on the pHmax – pHmin range during the solubility determination
T1  - Ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti
SP  - 47
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6530
ER  - 
@conference{
author = "Marković, Olivera S. and Mrđinac, Jelena Ž. and Pepić, Sara V. and Verbić, Tatjana Ž.",
year = "2024",
abstract = "The solubility profile of a drug typically consists of two independent curves that intersect 
at a specific point called pHmax. At pHmax, both salt and base coexist as solid phases. While 
two solids coexist, pH and solubility in the heterogeneous system remain constant 
(according to the Gibbs Phase Rule). Recent studies, however, have shown that pH and 
solubility might change during the salt-to-free-base transformation. This pH range, 
containing two solids, is termed the pHmax – pHmin range. pHmax refers to the pH value at 
the maximum solubility of a eutectic mixture, whereas pHmin represents the pH value at the 
minimum solubility of the eutectic mixture. The objective of this study was to investigate 
the influence of suspension concentration (the ratio of drug mass to suspension volume) on 
the pHmax – pHmin range during solubility determination using the pH-Ramp shake-flask
method. Nortriptyline hydrochloride (Nor, monoprotic base) and atorvastatin calcium (At, 
monoprotic acid) were employed as model compounds. Results indicate that the pHmax –
pHmin range increases as suspension concentration rises (for 20.10 mg NorHCl/mL: 
pHmax=3.55, ΔpH=0; for 59.82 mg NorHCl/mL: pHmax – pHmin= 3.56 – 4.52, ΔpH=0.96). 
Understanding the details of the pHmax – pHmin range could significantly impact product 
formulation optimization in drug research, Cilj ovog rada bio je ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin
opsega tokom određivanja rastvorljivosti pH-Ramp shake-flask metodom. Kao model 
jedinjenja izabrani su nortriptilin-hidrohlorid i atorvastatin-kalcijum. Rezultati su pokazali 
da sa porastom koncentracije suspenzije dolazi do širenja opsega pHmax – pHmin, a ovakva 
proučavanja mogu značajno doprineti optimizaciji formulacije u procesu dizajna i razvoja 
lekova.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024",
title = "The influence of suspension concentration on the pHmax – pHmin range during the solubility determination, Ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti",
pages = "47-47",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6530"
}
Marković, O. S., Mrđinac, J. Ž., Pepić, S. V.,& Verbić, T. Ž.. (2024). The influence of suspension concentration on the pHmax – pHmin range during the solubility determination. in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024
Belgrade : Serbian Chemical Society., 47-47.
https://hdl.handle.net/21.15107/rcub_cherry_6530
Marković OS, Mrđinac JŽ, Pepić SV, Verbić TŽ. The influence of suspension concentration on the pHmax – pHmin range during the solubility determination. in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024. 2024;:47-47.
https://hdl.handle.net/21.15107/rcub_cherry_6530 .
Marković, Olivera S., Mrđinac, Jelena Ž., Pepić, Sara V., Verbić, Tatjana Ž., "The influence of suspension concentration on the pHmax – pHmin range during the solubility determination" in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024 (2024):47-47,
https://hdl.handle.net/21.15107/rcub_cherry_6530 .

Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane

Putica, Katarina

(Univeristy of Belgrade, Faculty of Education, 2024)

TY  - CONF
AU  - Putica, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6526
AB  - Alkanes represent the first class of organic compounds elaborated in elementary school and the principles of their isomerism apply to all the other classes of organic compounds covered by the eighth-grade chemistry curriculum. However, in ChatGPT responses to Serbian language prompts related to isomers of alkanes with more than four carbon atoms numerous errors can be observed, and if a prompt about isomers of one such alkane is repeated several times, these errors often vary from response to response. Thus, one ChatGPT response regarding isomers of heptane, along with seven correct isomers, included incorrect isomers 4-methylhexane and 3-ethyl-2-methylpentane but excluded correct isomers 2,4-dimethylpentane and 2,2,3-trimethylbutane. To assess their understanding of alkane isomerism, 107 eighth-grade pupils were asked to detect errors in this response. 4-methylhexane and 3-ethyl-2-methyl-pentane were identified as incorrect isomers by 71.96% and 64.48% of the pupils, respectively. Furthermore, 55.14% of the pupils enlisted 2,4-dimethylpentane as an additional isomer, while only 36.45% of them identified 2,2,3-trimethylbutane as the other missing isomer. Ultimately, through class discussion, the complete list of isomers of heptane was produced, with the conclusion that the correctness of all ChatGPT responses to organic chemistry questions needs to be critically assessed.
AB  - Алкани представљају прву класу органских једињења која се обрађује у основној школи а принципи њихове изомерије применљиви су и код свих осталих класа органских једињења обухваћених наставним програмом хемије за осми разред. Међутим, у одговорима ChatGPT-а на упите на српском језику везане за изомере алкана са више од четири угљеникова атома могу се уочити бројне грешке, а ако се питање у вези изомера једног таквог алкана постави више пута, поменуте грешке се често разликују од одговора до одговора. Тако, један од одговора ChatGPT-а везан за изомере хептана, поред седам тачних изомера, садржао је и нетачне изомере 4-метилхексан и 3-етил-2-метилпентан, док су тачни изомери 2,4-диметилпентан и 2,2,3-триметилбутан били изостављени. Ради провере њиховог разумевања изомерије алкана, 107 ученика осмог разреда упитано је да детектује грешке у датом одговору. 4-метилхексан и 3-етил-2-метил-пентан идентификовани су као нетачни изомери од стане 71,96% и 64,48% ученика, респективно. Такође, 55,14% ученика навело је 2,4-диметилбутан као додатни изомер, док је само 36,45% њих идентификовало 2,2,3-триметилбутан као други недостајући изомер. Коначно, кроз дискусију на нивоу разреда, дошло се до потпуне листе изомера хептана, уз закључак да је тачност свих одговора ChatGPT-а на питања из органске хемије неопходно критички проценити
PB  - Univeristy of Belgrade, Faculty of Education
C3  - Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024
T1  - Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane
T1  - Проверава разумевања изомерије алкана код ученика осмог разреда основне школе кроз детекцију грешака у одговору ChatGPT-а везаном за изомере хептана
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6526
ER  - 
@conference{
author = "Putica, Katarina",
year = "2024",
abstract = "Alkanes represent the first class of organic compounds elaborated in elementary school and the principles of their isomerism apply to all the other classes of organic compounds covered by the eighth-grade chemistry curriculum. However, in ChatGPT responses to Serbian language prompts related to isomers of alkanes with more than four carbon atoms numerous errors can be observed, and if a prompt about isomers of one such alkane is repeated several times, these errors often vary from response to response. Thus, one ChatGPT response regarding isomers of heptane, along with seven correct isomers, included incorrect isomers 4-methylhexane and 3-ethyl-2-methylpentane but excluded correct isomers 2,4-dimethylpentane and 2,2,3-trimethylbutane. To assess their understanding of alkane isomerism, 107 eighth-grade pupils were asked to detect errors in this response. 4-methylhexane and 3-ethyl-2-methyl-pentane were identified as incorrect isomers by 71.96% and 64.48% of the pupils, respectively. Furthermore, 55.14% of the pupils enlisted 2,4-dimethylpentane as an additional isomer, while only 36.45% of them identified 2,2,3-trimethylbutane as the other missing isomer. Ultimately, through class discussion, the complete list of isomers of heptane was produced, with the conclusion that the correctness of all ChatGPT responses to organic chemistry questions needs to be critically assessed., Алкани представљају прву класу органских једињења која се обрађује у основној школи а принципи њихове изомерије применљиви су и код свих осталих класа органских једињења обухваћених наставним програмом хемије за осми разред. Међутим, у одговорима ChatGPT-а на упите на српском језику везане за изомере алкана са више од четири угљеникова атома могу се уочити бројне грешке, а ако се питање у вези изомера једног таквог алкана постави више пута, поменуте грешке се често разликују од одговора до одговора. Тако, један од одговора ChatGPT-а везан за изомере хептана, поред седам тачних изомера, садржао је и нетачне изомере 4-метилхексан и 3-етил-2-метилпентан, док су тачни изомери 2,4-диметилпентан и 2,2,3-триметилбутан били изостављени. Ради провере њиховог разумевања изомерије алкана, 107 ученика осмог разреда упитано је да детектује грешке у датом одговору. 4-метилхексан и 3-етил-2-метил-пентан идентификовани су као нетачни изомери од стане 71,96% и 64,48% ученика, респективно. Такође, 55,14% ученика навело је 2,4-диметилбутан као додатни изомер, док је само 36,45% њих идентификовало 2,2,3-триметилбутан као други недостајући изомер. Коначно, кроз дискусију на нивоу разреда, дошло се до потпуне листе изомера хептана, уз закључак да је тачност свих одговора ChatGPT-а на питања из органске хемије неопходно критички проценити",
publisher = "Univeristy of Belgrade, Faculty of Education",
journal = "Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024",
title = "Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane, Проверава разумевања изомерије алкана код ученика осмог разреда основне школе кроз детекцију грешака у одговору ChatGPT-а везаном за изомере хептана",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6526"
}
Putica, K.. (2024). Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane. in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024
Univeristy of Belgrade, Faculty of Education..
https://hdl.handle.net/21.15107/rcub_cherry_6526
Putica K. Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane. in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6526 .
Putica, Katarina, "Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane" in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6526 .

Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test

Putica, Katarina B.

(American Chemical Society, 2024)

TY  - JOUR
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6527
AB  - As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test
VL  - 101
IS  - 4
SP  - 1442
EP  - 1456
DO  - 10.1021/acs.jchemed.3c01343
ER  - 
@article{
author = "Putica, Katarina B.",
year = "2024",
abstract = "As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test",
volume = "101",
number = "4",
pages = "1442-1456",
doi = "10.1021/acs.jchemed.3c01343"
}
Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education
American Chemical Society., 101(4), 1442-1456.
https://doi.org/10.1021/acs.jchemed.3c01343
Putica KB. Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education. 2024;101(4):1442-1456.
doi:10.1021/acs.jchemed.3c01343 .
Putica, Katarina B., "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test" in Journal of Chemical Education, 101, no. 4 (2024):1442-1456,
https://doi.org/10.1021/acs.jchemed.3c01343 . .

Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina

Gligorijević, Nikola; Jovanović, Zorana; Cvijetić, Ilija; Šunderić, Miloš; Veličković, Luka; Katrlík, Jaroslav; Holazová, Alena; Nikolić, Milan; Minić, Simeon

(MDPI, 2024)

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Jovanović, Zorana
AU  - Cvijetić, Ilija
AU  - Šunderić, Miloš
AU  - Veličković, Luka
AU  - Katrlík, Jaroslav
AU  - Holazová, Alena
AU  - Nikolić, Milan
AU  - Minić, Simeon
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6524
AB  - Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina
DO  - 10.3390/ijms25010229
ER  - 
@article{
author = "Gligorijević, Nikola and Jovanović, Zorana and Cvijetić, Ilija and Šunderić, Miloš and Veličković, Luka and Katrlík, Jaroslav and Holazová, Alena and Nikolić, Milan and Minić, Simeon",
year = "2024",
abstract = "Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina",
doi = "10.3390/ijms25010229"
}
Gligorijević, N., Jovanović, Z., Cvijetić, I., Šunderić, M., Veličković, L., Katrlík, J., Holazová, A., Nikolić, M.,& Minić, S.. (2024). Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences
MDPI..
https://doi.org/10.3390/ijms25010229
Gligorijević N, Jovanović Z, Cvijetić I, Šunderić M, Veličković L, Katrlík J, Holazová A, Nikolić M, Minić S. Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences. 2024;.
doi:10.3390/ijms25010229 .
Gligorijević, Nikola, Jovanović, Zorana, Cvijetić, Ilija, Šunderić, Miloš, Veličković, Luka, Katrlík, Jaroslav, Holazová, Alena, Nikolić, Milan, Minić, Simeon, "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina" in International Journal of Molecular Sciences (2024),
https://doi.org/10.3390/ijms25010229 . .

High-performing structural optimization of graphene quantum dots as glyphosate herbicide photoluminescent probes: real case studies and mechanism insights

Dorontić, Slađana; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Verbić, Tatjana; Sredojević, Dušan; Ciasca, Gabriele; Di Santo, Riccardo; Mead, James L.; Budimir, Milica; Bajuk-Bogdanović, Danica; Mojsin, Marija; Pejić, Jelena; Stevanović, Milena; Jovanović, Svetlana

(Elsevier, 2024)

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Sredojević, Dušan
AU  - Ciasca, Gabriele
AU  - Di Santo, Riccardo
AU  - Mead, James L.
AU  - Budimir, Milica
AU  - Bajuk-Bogdanović, Danica
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena
AU  - Jovanović, Svetlana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6523
AB  - The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, 
simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum 
dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative 
structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocom patibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs 
structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, 
and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to 
the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich 
GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. 
The high coefficient of determination (R-squared (R2
) = 0.99) and very low limit of detection (3.02 μmol L-1) 
reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully 
detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the 
proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the 
death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an 
air medium can be potentially applied for glyphosate detection.
PB  - Elsevier
T2  - Journal of Environmental Chemical Engineering
T1  - High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights
VL  - 12
SP  - 113193
DO  - 10.1016/j.jece.2024.113193
ER  - 
@article{
author = "Dorontić, Slađana and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Sredojević, Dušan and Ciasca, Gabriele and Di Santo, Riccardo and Mead, James L. and Budimir, Milica and Bajuk-Bogdanović, Danica and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, 
simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum 
dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative 
structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocom patibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs 
structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, 
and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to 
the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich 
GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. 
The high coefficient of determination (R-squared (R2
) = 0.99) and very low limit of detection (3.02 μmol L-1) 
reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully 
detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the 
proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the 
death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an 
air medium can be potentially applied for glyphosate detection.",
publisher = "Elsevier",
journal = "Journal of Environmental Chemical Engineering",
title = "High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights",
volume = "12",
pages = "113193",
doi = "10.1016/j.jece.2024.113193"
}
Dorontić, S., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Sredojević, D., Ciasca, G., Di Santo, R., Mead, J. L., Budimir, M., Bajuk-Bogdanović, D., Mojsin, M., Pejić, J., Stevanović, M.,& Jovanović, S.. (2024). High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights. in Journal of Environmental Chemical Engineering
Elsevier., 12, 113193.
https://doi.org/10.1016/j.jece.2024.113193
Dorontić S, Bonasera A, Scopelliti M, Marković O, Verbić T, Sredojević D, Ciasca G, Di Santo R, Mead JL, Budimir M, Bajuk-Bogdanović D, Mojsin M, Pejić J, Stevanović M, Jovanović S. High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights. in Journal of Environmental Chemical Engineering. 2024;12:113193.
doi:10.1016/j.jece.2024.113193 .
Dorontić, Slađana, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Sredojević, Dušan, Ciasca, Gabriele, Di Santo, Riccardo, Mead, James L., Budimir, Milica, Bajuk-Bogdanović, Danica, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena, Jovanović, Svetlana, "High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights" in Journal of Environmental Chemical Engineering, 12 (2024):113193,
https://doi.org/10.1016/j.jece.2024.113193 . .

Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen

Đurašinović, Tatjana; Lopandić, Zorana; Protić-Rosić, Isidora; Nešić, Andrijana; Trbojević-Ivić, Jovana; Jappe, Uta; Gavrović-Jankulović, Marija

(Elsevier, 2024)

TY  - JOUR
AU  - Đurašinović, Tatjana
AU  - Lopandić, Zorana
AU  - Protić-Rosić, Isidora
AU  - Nešić, Andrijana
AU  - Trbojević-Ivić, Jovana
AU  - Jappe, Uta
AU  - Gavrović-Jankulović, Marija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6338
AB  - Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.
PB  - Elsevier
T2  - Food Chemistry
T1  - Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen
VL  - 437
SP  - 137782
DO  - 10.1016/j.foodchem.2023.137782
ER  - 
@article{
author = "Đurašinović, Tatjana and Lopandić, Zorana and Protić-Rosić, Isidora and Nešić, Andrijana and Trbojević-Ivić, Jovana and Jappe, Uta and Gavrović-Jankulović, Marija",
year = "2024",
abstract = "Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen",
volume = "437",
pages = "137782",
doi = "10.1016/j.foodchem.2023.137782"
}
Đurašinović, T., Lopandić, Z., Protić-Rosić, I., Nešić, A., Trbojević-Ivić, J., Jappe, U.,& Gavrović-Jankulović, M.. (2024). Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry
Elsevier., 437, 137782.
https://doi.org/10.1016/j.foodchem.2023.137782
Đurašinović T, Lopandić Z, Protić-Rosić I, Nešić A, Trbojević-Ivić J, Jappe U, Gavrović-Jankulović M. Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry. 2024;437:137782.
doi:10.1016/j.foodchem.2023.137782 .
Đurašinović, Tatjana, Lopandić, Zorana, Protić-Rosić, Isidora, Nešić, Andrijana, Trbojević-Ivić, Jovana, Jappe, Uta, Gavrović-Jankulović, Marija, "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen" in Food Chemistry, 437 (2024):137782,
https://doi.org/10.1016/j.foodchem.2023.137782 . .

Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides

Andrić, Deana; Dukić-Stefanović, Slađana; Krunić, Mihajlo J.; Jevtić, Ivana I.; Penjišević, Jelena Z.; Šukalović, Vladimir B.; Kostić-Rajačić, Slađana

(Belgrade : Serbian Chemical Society, 2024)

TY  - JOUR
AU  - Andrić, Deana
AU  - Dukić-Stefanović, Slađana
AU  - Krunić, Mihajlo J.
AU  - Jevtić, Ivana I.
AU  - Penjišević, Jelena Z.
AU  - Šukalović, Vladimir B.
AU  - Kostić-Rajačić, Slađana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6472
AB  - Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most
noted as a neurotransmitter, an activator of the utmost subtype family of G-protein-
coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors
treat central nervous system diseases such as schizophrenia and depression.
Recent advances in serotonin receptor structure research gave us several
crystal 5-HT1A receptor structures, most notably 5-HT1A bound to the antipsychotic
drug aripiprazole (Abilify®). This discovery prompted us to evaluate
a series of newly synthesized ligands for serotonergic activity since those arylpiperazine
derivatives share minimal general structure with aripiprazole. The
results of molecular docking analysis of unsubstituted starting substances
encouraged us to propound further modifications of the tail and head parts of
the parent molecules to maximize receptor binding affinity. Intrigued by the
results of molecular analysis, all foreseen derivatives were synthesized. The
pharmacological activity of all nine (5a and 6a are synthesized previously)
compounds was assessed by the in vitro tests and in silico pharmacokinetics
predictions for the most promising candidates. All tested ligands have improved
affinity compering to parent compounds (10a and 11a), 8b and 9b expressed
the best pharmacological profile with an improved binding affinity
toward serotonin 5-HT1A receptors (Ki 12.1 and 4.8 nM, respectively).
PB  - Belgrade : Serbian Chemical Society
T2  - J. Serb. Chem. Soc.
T1  - Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides
VL  - 89
IS  - 3
SP  - 291
EP  - 303
DO  - 10.2298/JSC230906076A
ER  - 
@article{
author = "Andrić, Deana and Dukić-Stefanović, Slađana and Krunić, Mihajlo J. and Jevtić, Ivana I. and Penjišević, Jelena Z. and Šukalović, Vladimir B. and Kostić-Rajačić, Slađana",
year = "2024",
abstract = "Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most
noted as a neurotransmitter, an activator of the utmost subtype family of G-protein-
coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors
treat central nervous system diseases such as schizophrenia and depression.
Recent advances in serotonin receptor structure research gave us several
crystal 5-HT1A receptor structures, most notably 5-HT1A bound to the antipsychotic
drug aripiprazole (Abilify®). This discovery prompted us to evaluate
a series of newly synthesized ligands for serotonergic activity since those arylpiperazine
derivatives share minimal general structure with aripiprazole. The
results of molecular docking analysis of unsubstituted starting substances
encouraged us to propound further modifications of the tail and head parts of
the parent molecules to maximize receptor binding affinity. Intrigued by the
results of molecular analysis, all foreseen derivatives were synthesized. The
pharmacological activity of all nine (5a and 6a are synthesized previously)
compounds was assessed by the in vitro tests and in silico pharmacokinetics
predictions for the most promising candidates. All tested ligands have improved
affinity compering to parent compounds (10a and 11a), 8b and 9b expressed
the best pharmacological profile with an improved binding affinity
toward serotonin 5-HT1A receptors (Ki 12.1 and 4.8 nM, respectively).",
publisher = "Belgrade : Serbian Chemical Society",
journal = "J. Serb. Chem. Soc.",
title = "Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides",
volume = "89",
number = "3",
pages = "291-303",
doi = "10.2298/JSC230906076A"
}
Andrić, D., Dukić-Stefanović, S., Krunić, M. J., Jevtić, I. I., Penjišević, J. Z., Šukalović, V. B.,& Kostić-Rajačić, S.. (2024). Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides. in J. Serb. Chem. Soc.
Belgrade : Serbian Chemical Society., 89(3), 291-303.
https://doi.org/10.2298/JSC230906076A
Andrić D, Dukić-Stefanović S, Krunić MJ, Jevtić II, Penjišević JZ, Šukalović VB, Kostić-Rajačić S. Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides. in J. Serb. Chem. Soc.. 2024;89(3):291-303.
doi:10.2298/JSC230906076A .
Andrić, Deana, Dukić-Stefanović, Slađana, Krunić, Mihajlo J., Jevtić, Ivana I., Penjišević, Jelena Z., Šukalović, Vladimir B., Kostić-Rajačić, Slađana, "Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides" in J. Serb. Chem. Soc., 89, no. 3 (2024):291-303,
https://doi.org/10.2298/JSC230906076A . .

Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography

Šegan, Sandra B.; Krunić, Mihajlo J.; Andrić, Deana; Šukalović, Vladimir B.; Penjišević, Jelena Z.; Jevtić, Ivana I.

(Wiley, 2024)

TY  - JOUR
AU  - Šegan, Sandra B.
AU  - Krunić, Mihajlo J.
AU  - Andrić, Deana
AU  - Šukalović, Vladimir B.
AU  - Penjišević, Jelena Z.
AU  - Jevtić, Ivana I.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6473
AB  - Fourteen donepezil-like acetylcholinesterase (AChE) inhibitors from our library were
analyzed using reversed-phase thin-layer chromatography to assess their lipophilicity
and blood–brain barrier permeability. Compounds possessed N-benzylpiperidine and
N,N-diarylpiperazine moieties connected via a short carboxamide or amine linker.
Retention parameters RM
0, b, and C0 were considered as the measures of lipophilicity.
Besides, logD of the investigated compounds was determined chromatographically
using standard compounds with known logPow and logD values at pH 11. Experimentally
obtained lipophilicity parameters correlated well with in silico generated results,
and the effect of the nature of the linker between two pharmacophores and
substituents on the arylpiperazine part of the molecule was observed. As a result of
drug-likeness analysis, both Lipinski's rule of five and Veber's rule parameters were
determined, suggesting that examined compounds could be potential candidates for
further drug development. Principal component analysis was performed to obtain an
insight into a grouping of compounds based on calculated structural descriptors,
experimentally obtained values of lipophilicity, and AChE inhibitory activity.
PB  - Wiley
T2  - Biomedical Chromatography
T1  - Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography
VL  - n/a
SP  - e5864
DO  - 10.1002/bmc.5867
ER  - 
@article{
author = "Šegan, Sandra B. and Krunić, Mihajlo J. and Andrić, Deana and Šukalović, Vladimir B. and Penjišević, Jelena Z. and Jevtić, Ivana I.",
year = "2024",
abstract = "Fourteen donepezil-like acetylcholinesterase (AChE) inhibitors from our library were
analyzed using reversed-phase thin-layer chromatography to assess their lipophilicity
and blood–brain barrier permeability. Compounds possessed N-benzylpiperidine and
N,N-diarylpiperazine moieties connected via a short carboxamide or amine linker.
Retention parameters RM
0, b, and C0 were considered as the measures of lipophilicity.
Besides, logD of the investigated compounds was determined chromatographically
using standard compounds with known logPow and logD values at pH 11. Experimentally
obtained lipophilicity parameters correlated well with in silico generated results,
and the effect of the nature of the linker between two pharmacophores and
substituents on the arylpiperazine part of the molecule was observed. As a result of
drug-likeness analysis, both Lipinski's rule of five and Veber's rule parameters were
determined, suggesting that examined compounds could be potential candidates for
further drug development. Principal component analysis was performed to obtain an
insight into a grouping of compounds based on calculated structural descriptors,
experimentally obtained values of lipophilicity, and AChE inhibitory activity.",
publisher = "Wiley",
journal = "Biomedical Chromatography",
title = "Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography",
volume = "n/a",
pages = "e5864",
doi = "10.1002/bmc.5867"
}
Šegan, S. B., Krunić, M. J., Andrić, D., Šukalović, V. B., Penjišević, J. Z.,& Jevtić, I. I.. (2024). Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography. in Biomedical Chromatography
Wiley., n/a, e5864.
https://doi.org/10.1002/bmc.5867
Šegan SB, Krunić MJ, Andrić D, Šukalović VB, Penjišević JZ, Jevtić II. Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography. in Biomedical Chromatography. 2024;n/a:e5864.
doi:10.1002/bmc.5867 .
Šegan, Sandra B., Krunić, Mihajlo J., Andrić, Deana, Šukalović, Vladimir B., Penjišević, Jelena Z., Jevtić, Ivana I., "Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography" in Biomedical Chromatography, n/a (2024):e5864,
https://doi.org/10.1002/bmc.5867 . .

Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location

Natić, Maja; Dabić Zagorac, Dragana; Jakanovski, Mihajlo V.; Smailagić, Anita; Čolić, Slavica; Meland, Mekjell; Fotirić Akšić, Milica

(MDPI, 2024)

TY  - JOUR
AU  - Natić, Maja
AU  - Dabić Zagorac, Dragana
AU  - Jakanovski, Mihajlo V.
AU  - Smailagić, Anita
AU  - Čolić, Slavica
AU  - Meland, Mekjell
AU  - Fotirić Akšić, Milica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6507
AB  - In this work, 12 apple cultivars grown organically in three regions of Norway (Telemark, Ullensvang, Viken) were analyzed in terms of fruit quality, with the aim of equating different growing regions under specific climatic conditions. Apples were analyzed for concentration levels of minerals, sugars, sugar alcohols, organic acids, total phenolic content (TPC), radical scavenging activity (RSA), and phenolic profiles. Discovery “Rose” from Telemark stored the highest level of minerals (24,094.5 mg/kg dry weight). Glucose, fructose, sucrose, and sorbitol were the major carbohydrates, whereas the predominant organic acids were quinic acid and malic acid. Cultivar Discovery from Ullensvang had the highest TPC (9.22 g/kg) and RSA (229.32 mmol TE/kg). Of the polyphenols quantified, chlorogenic acid and kaempferol-3-O-glucoside were the most abounded, accounting for 85.50%. Principal component analysis (PCA) shows that the Ullensvang region is the richest source of most carbohydrates, organic acids (quinic, shikimic, and galacturonic), and most polyphenols, whereas the highest content of minerals and maleic acid characterized Viken. Regardless of location, the Discovery cultivar had, on average, the highest sugar and polyphenol contents. The results obtained suggest that organic apples from Norway are a rich source of beneficial compounds that can have a positive impact on human health. In addition, these results may be useful for consumers in identifying apple cultivars with desirable characteristics and for the fruit industry in tracing back the origin of apples. The findings could also be of great interest for locations with similar climate and soil conditions worldwide.
PB  - MDPI
T2  - Plants
T1  - Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location
VL  - 13
IS  - 147
DO  - 10.3390/plants13010147
ER  - 
@article{
author = "Natić, Maja and Dabić Zagorac, Dragana and Jakanovski, Mihajlo V. and Smailagić, Anita and Čolić, Slavica and Meland, Mekjell and Fotirić Akšić, Milica",
year = "2024",
abstract = "In this work, 12 apple cultivars grown organically in three regions of Norway (Telemark, Ullensvang, Viken) were analyzed in terms of fruit quality, with the aim of equating different growing regions under specific climatic conditions. Apples were analyzed for concentration levels of minerals, sugars, sugar alcohols, organic acids, total phenolic content (TPC), radical scavenging activity (RSA), and phenolic profiles. Discovery “Rose” from Telemark stored the highest level of minerals (24,094.5 mg/kg dry weight). Glucose, fructose, sucrose, and sorbitol were the major carbohydrates, whereas the predominant organic acids were quinic acid and malic acid. Cultivar Discovery from Ullensvang had the highest TPC (9.22 g/kg) and RSA (229.32 mmol TE/kg). Of the polyphenols quantified, chlorogenic acid and kaempferol-3-O-glucoside were the most abounded, accounting for 85.50%. Principal component analysis (PCA) shows that the Ullensvang region is the richest source of most carbohydrates, organic acids (quinic, shikimic, and galacturonic), and most polyphenols, whereas the highest content of minerals and maleic acid characterized Viken. Regardless of location, the Discovery cultivar had, on average, the highest sugar and polyphenol contents. The results obtained suggest that organic apples from Norway are a rich source of beneficial compounds that can have a positive impact on human health. In addition, these results may be useful for consumers in identifying apple cultivars with desirable characteristics and for the fruit industry in tracing back the origin of apples. The findings could also be of great interest for locations with similar climate and soil conditions worldwide.",
publisher = "MDPI",
journal = "Plants",
title = "Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location",
volume = "13",
number = "147",
doi = "10.3390/plants13010147"
}
Natić, M., Dabić Zagorac, D., Jakanovski, M. V., Smailagić, A., Čolić, S., Meland, M.,& Fotirić Akšić, M.. (2024). Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location. in Plants
MDPI., 13(147).
https://doi.org/10.3390/plants13010147
Natić M, Dabić Zagorac D, Jakanovski MV, Smailagić A, Čolić S, Meland M, Fotirić Akšić M. Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location. in Plants. 2024;13(147).
doi:10.3390/plants13010147 .
Natić, Maja, Dabić Zagorac, Dragana, Jakanovski, Mihajlo V., Smailagić, Anita, Čolić, Slavica, Meland, Mekjell, Fotirić Akšić, Milica, "Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location" in Plants, 13, no. 147 (2024),
https://doi.org/10.3390/plants13010147 . .
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