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2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination

Pastor, Ferenc T.; Dojčinović, Biljana P.; Kodranov, Igor D.; Gorjanović, Stanislava; Ivanović, Tijana; Popović, Daniela Ž.; Miladinović, Jelena

TY  - JOUR
AU  - Pastor, Ferenc T.
AU  - Dojčinović, Biljana P.
AU  - Kodranov, Igor D.
AU  - Gorjanović, Stanislava
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6390
AB  - Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.
PB  - Wiley
T2  - Electroanalysis
T1  - 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination
VL  - n/a
IS  - n/a
SP  - e202300259
DO  - 10.1002/elan.202300259
ER  - 
@article{
author = "Pastor, Ferenc T. and Dojčinović, Biljana P. and Kodranov, Igor D. and Gorjanović, Stanislava and Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena",
abstract = "Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.",
publisher = "Wiley",
journal = "Electroanalysis",
title = "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination",
volume = "n/a",
number = "n/a",
pages = "e202300259",
doi = "10.1002/elan.202300259"
}
Pastor, F. T., Dojčinović, B. P., Kodranov, I. D., Gorjanović, S., Ivanović, T., Popović, D. Ž.,& Miladinović, J..2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis
Wiley., n/a(n/a), e202300259.
https://doi.org/10.1002/elan.202300259
Pastor FT, Dojčinović BP, Kodranov ID, Gorjanović S, Ivanović T, Popović DŽ, Miladinović J. 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis.n/a(n/a):e202300259.
doi:10.1002/elan.202300259 .
Pastor, Ferenc T., Dojčinović, Biljana P., Kodranov, Igor D., Gorjanović, Stanislava, Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination" in Electroanalysis, n/a, no. n/a:e202300259,
https://doi.org/10.1002/elan.202300259 . .
1

Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry Royal Society of Chemistry., 21(6), 1187-1205. https://doi.org/10.1039/D2OB02119F

Aleksić, Jovana; Stojanović, Milovan; Bošković, Jakša; Baranac-Stojanović, Marija

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 
@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}
Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846
Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .
Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition

Ćurčić, Vladimir; Olszewski, Mateusz; Maciejewska, Natalia; Višnjevac, Aleksandar; Srdić-Rajić, Tatjana; Dobričić, Vladimir; García-Sosa, Alfonso T.; Kokanov, Sanja B.; Araškov, Jovana; Silvestri, Romano; Schüle, Roland; Jung, Manfred; Nikolić, Milan; Filipović, Nenad R.

TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 
@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}
Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426
Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .
Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .
1

Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636

Penjišević, Jelena ; Šukalović, Vladimir ; Dukić-Stefanović, Slađana; Deuther-Conrad, Winnie; Andrić, Deana ; Kostić-Rajačić, Slađana

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 
@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}
Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845
Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .
Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom

Stanković, Sandra G.

(2024)

TY  - THES
AU  - Stanković, Sandra G.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6430
AB  - Oktaedarski kompleks Zn(II) sa ligandom iz klase 1,3-selenazolil-hidrazona na bazi piridina je sintetisan i okarakterisan primenom IC i NMR spektroskopije kao i difrakcijom X-zraka sa monokristala. Čistoća kompleksa je potvrđena elementalnom analizom. Dva liganda su koordinovana u neutralnom NNN-tridentanom obliku formirajući kompleksni katjon, dok je pozitivno naelektrisanje neutralisano tetrahlorocinkatnim anjonom [ZnCl4]2-. Kompleks kristališe u monokliničnoj C2/c prostornoj grupi pri čemu se joni Zn(II) nalaze se u specijalnom položaju. Analizirane su molekulske interakcije u čvrstom stanju čije je razumevanje od velikog značaja za ispitivanje potencijalne primene kompleksa na bazi 1,3-selenazolil-hidrazona.
T1  - Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom
SP  - 1
EP  - 24
ER  - 
@misc{
author = "Stanković, Sandra G.",
year = "2024",
abstract = "Oktaedarski kompleks Zn(II) sa ligandom iz klase 1,3-selenazolil-hidrazona na bazi piridina je sintetisan i okarakterisan primenom IC i NMR spektroskopije kao i difrakcijom X-zraka sa monokristala. Čistoća kompleksa je potvrđena elementalnom analizom. Dva liganda su koordinovana u neutralnom NNN-tridentanom obliku formirajući kompleksni katjon, dok je pozitivno naelektrisanje neutralisano tetrahlorocinkatnim anjonom [ZnCl4]2-. Kompleks kristališe u monokliničnoj C2/c prostornoj grupi pri čemu se joni Zn(II) nalaze se u specijalnom položaju. Analizirane su molekulske interakcije u čvrstom stanju čije je razumevanje od velikog značaja za ispitivanje potencijalne primene kompleksa na bazi 1,3-selenazolil-hidrazona.",
title = "Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom",
pages = "1-24"
}
Stanković, S. G.. (2024). Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom. , 1-24.
Stanković SG. Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom. 2024;:1-24..
Stanković, Sandra G., "Sinteza i kristalna struktura kompleksa Zn(II) sa 2-(2-(piridin-2-ilmetilen)hidrazonil)-4-(4-metoksifenil)-1,3-selenazolom" (2024):1-24.

Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study

Jakšić, Jovana; Milinković, Evgenija; Cvetanović, Katarina; Tokić Vujošević, Zorana; Jovanov, Vladislav; Mitrović, Aleksandra D.; Maslak, Veselin

(2024)

TY  - JOUR
AU  - Jakšić, Jovana
AU  - Milinković, Evgenija
AU  - Cvetanović, Katarina
AU  - Tokić Vujošević, Zorana
AU  - Jovanov, Vladislav
AU  - Mitrović, Aleksandra D.
AU  - Maslak, Veselin
PY  - 2024
UR  - https://pubs.rsc.org/en/content/articlelanding/2024/cp/d3cp04322c
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6422
AB  - In this study,we conducted a comprehensive investigation of newly synthesized fullerene derivatives developed for potential application in perovskite solar cells (PSCs). We explored three novel dihydrofuran-fused C60 fullerene derivatives (13, 14, and 15) that we respecifically designed to enhance solubility and interaction with the substrate, fluorine-dopedtinoxide (FTO). A comparative analysis was performed, with reference to the widely used phenyl-C61-butyric acid methyl ester (PCBM) and compound 12, from which 13, 14, and 15 are derived, to assess the impact of sugar units on materials properties.The synthesized compounds demonstrated significant solubility in common organic solvents, a critical factor in their potential application in wet-processed PSCs. Our investigation included electrochemical property analysis, thin film deposition, surface characterization, and electrochemical impedance spectroscopy (EIS). EIS measurements unveiled key in sights into charge transfer properties at the electrode/electrolyte interface, making the compounds attractive candidates for electron transport layers (ETLs) in PSCs.
T2  - Physical Chemistry Chemical Physics
T1  - Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study
VL  - 26
IS  - 1
SP  - 517
EP  - 523
DO  - 10.1039/D3CP04322C
ER  - 
@article{
author = "Jakšić, Jovana and Milinković, Evgenija and Cvetanović, Katarina and Tokić Vujošević, Zorana and Jovanov, Vladislav and Mitrović, Aleksandra D. and Maslak, Veselin",
year = "2024",
abstract = "In this study,we conducted a comprehensive investigation of newly synthesized fullerene derivatives developed for potential application in perovskite solar cells (PSCs). We explored three novel dihydrofuran-fused C60 fullerene derivatives (13, 14, and 15) that we respecifically designed to enhance solubility and interaction with the substrate, fluorine-dopedtinoxide (FTO). A comparative analysis was performed, with reference to the widely used phenyl-C61-butyric acid methyl ester (PCBM) and compound 12, from which 13, 14, and 15 are derived, to assess the impact of sugar units on materials properties.The synthesized compounds demonstrated significant solubility in common organic solvents, a critical factor in their potential application in wet-processed PSCs. Our investigation included electrochemical property analysis, thin film deposition, surface characterization, and electrochemical impedance spectroscopy (EIS). EIS measurements unveiled key in sights into charge transfer properties at the electrode/electrolyte interface, making the compounds attractive candidates for electron transport layers (ETLs) in PSCs.",
journal = "Physical Chemistry Chemical Physics",
title = "Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study",
volume = "26",
number = "1",
pages = "517-523",
doi = "10.1039/D3CP04322C"
}
Jakšić, J., Milinković, E., Cvetanović, K., Tokić Vujošević, Z., Jovanov, V., Mitrović, A. D.,& Maslak, V.. (2024). Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study. in Physical Chemistry Chemical Physics, 26(1), 517-523.
https://doi.org/10.1039/D3CP04322C
Jakšić J, Milinković E, Cvetanović K, Tokić Vujošević Z, Jovanov V, Mitrović AD, Maslak V. Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study. in Physical Chemistry Chemical Physics. 2024;26(1):517-523.
doi:10.1039/D3CP04322C .
Jakšić, Jovana, Milinković, Evgenija, Cvetanović, Katarina, Tokić Vujošević, Zorana, Jovanov, Vladislav, Mitrović, Aleksandra D., Maslak, Veselin, "Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study" in Physical Chemistry Chemical Physics, 26, no. 1 (2024):517-523,
https://doi.org/10.1039/D3CP04322C . .

Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika

Botić, Marija D.

(2024)

TY  - THES
AU  - Botić, Marija D.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6427
AB  - U ovom radu biće opisana upotreba protočne injekcione analize sa amperometrijskom detekcijom za određivanje sadržaja kofeina u uzorcima komercijalno dostupnih kafa i čajeva. Kao elektrohemijski detektor upotrebljena je elektroda od staklastog ugljenika, modifikovana MnCo2O4 nanočesticama.
Uticaj nanočestica na oksidaciju kofeina ispitvan je snimanjem cikličnih voltamograma i poređenjem nemodifikovane i modifikovane površine radne elektrode. Određena je elektroaktivna površina obe elektrode da bi se pokazao uticaj modifikacije.
Određeni su analitički parametri metode kao što su linearni opseg i limit detekcije i kvantifikacije.
Opisana metoda je korištena za određivanje sadržaja kofeina u komercijalno dostupnim uzorcima kafa i čajeva. Validacija metode je urađena i provjerom tačnosti i preciznosti.
Cilj rada bio je primjena modifikovane elektrode u protočnom injekcionom sistemu za određivanje sadržaja kofeina u realnim uzorcima.
T1  - Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika
SP  - 6
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6427
ER  - 
@mastersthesis{
author = "Botić, Marija D.",
year = "2024",
abstract = "U ovom radu biće opisana upotreba protočne injekcione analize sa amperometrijskom detekcijom za određivanje sadržaja kofeina u uzorcima komercijalno dostupnih kafa i čajeva. Kao elektrohemijski detektor upotrebljena je elektroda od staklastog ugljenika, modifikovana MnCo2O4 nanočesticama.
Uticaj nanočestica na oksidaciju kofeina ispitvan je snimanjem cikličnih voltamograma i poređenjem nemodifikovane i modifikovane površine radne elektrode. Određena je elektroaktivna površina obe elektrode da bi se pokazao uticaj modifikacije.
Određeni su analitički parametri metode kao što su linearni opseg i limit detekcije i kvantifikacije.
Opisana metoda je korištena za određivanje sadržaja kofeina u komercijalno dostupnim uzorcima kafa i čajeva. Validacija metode je urađena i provjerom tačnosti i preciznosti.
Cilj rada bio je primjena modifikovane elektrode u protočnom injekcionom sistemu za određivanje sadržaja kofeina u realnim uzorcima.",
title = "Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika",
pages = "6-30",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6427"
}
Botić, M. D.. (2024). Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika. , 6-30.
https://hdl.handle.net/21.15107/rcub_cherry_6427
Botić MD. Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika. 2024;:6-30.
https://hdl.handle.net/21.15107/rcub_cherry_6427 .
Botić, Marija D., "Primjena protočne injekcione analize sa amperometrijskom detekcijom za određivanje kofeina upotrebom modifikovane elektrode od staklastog ugljenika" (2024):6-30,
https://hdl.handle.net/21.15107/rcub_cherry_6427 .

Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska

Tukelić, Tamara

(2024)

TY  - THES
AU  - Tukelić, Tamara
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6425
AB  - U ovom radu su ispitivani uzorci mrkog uglja iz sloja IIa basena Bobov Dol (Bugarska), starosti kasnog oligocena (pre oko 25 miliona godina). Cilj rada je bio određivanje porekla, paleosredine taloženja, maturisanosti i ugljovodoničnog potencijala organske supstance. Primenjene su organsko-petrografske metode (maceralna analiza i merenje refleksije huminita), Rock-Eval piroliza i detaljna analiza biomarkera u alifatičnoj i aromatičnoj frakciji bitumena uglja.
Glavni prekursori organske supstance uglja su bile golosemenice iz familija Cupressaceae i Pinaceae. Takođe, dokazan je doprinos akvatičnih makrofita i paprati, a u manjoj meri bakterija, algi i skrivenosemenica. Organska supstanca je taložena u blago oksidacionoj, slabo kiseloj do kiseloj sredini. Tokom stvaranja ugljonosnog sloja IIa dolazilo je do promena uslova u paleomočvari. Donji i gornji deo sloja formirani su u uslovima visokog vodenog stuba sa čestim plavljenjem, koje je rezultovalo većim sadržajem pepela, nešto višim pH i većim udelom akvatičnih makrofita i drugih akvatičnih organizama u prekursorskoj biomasi. Može se pretpostaviti da je veliko plavljenje močvare i njeno pretvaranje u jezero predstavljalo kraj stvaranja uglja u IIa sloju. Središnji deo ugljonosnog sloja formiran je uslovima vlažne šumske močvare, sa relativno niskim, ali stabilnim nivoom vodenog stuba. Organska supstanca uglja je nezrela i njena maturisanost odgovara kasnoj fazi dijageneze. Organska supstanca se pretežno sastoji od kerogena tipa III i nema potencijal za generisanje tečnih ugljovodonika, ali može biti značajan izvor gasa na višim stupnjevima zrelosti (kasna katageneza i metageneza).
T1  - Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska
SP  - 1
EP  - 42
ER  - 
@misc{
author = "Tukelić, Tamara",
year = "2024",
abstract = "U ovom radu su ispitivani uzorci mrkog uglja iz sloja IIa basena Bobov Dol (Bugarska), starosti kasnog oligocena (pre oko 25 miliona godina). Cilj rada je bio određivanje porekla, paleosredine taloženja, maturisanosti i ugljovodoničnog potencijala organske supstance. Primenjene su organsko-petrografske metode (maceralna analiza i merenje refleksije huminita), Rock-Eval piroliza i detaljna analiza biomarkera u alifatičnoj i aromatičnoj frakciji bitumena uglja.
Glavni prekursori organske supstance uglja su bile golosemenice iz familija Cupressaceae i Pinaceae. Takođe, dokazan je doprinos akvatičnih makrofita i paprati, a u manjoj meri bakterija, algi i skrivenosemenica. Organska supstanca je taložena u blago oksidacionoj, slabo kiseloj do kiseloj sredini. Tokom stvaranja ugljonosnog sloja IIa dolazilo je do promena uslova u paleomočvari. Donji i gornji deo sloja formirani su u uslovima visokog vodenog stuba sa čestim plavljenjem, koje je rezultovalo većim sadržajem pepela, nešto višim pH i većim udelom akvatičnih makrofita i drugih akvatičnih organizama u prekursorskoj biomasi. Može se pretpostaviti da je veliko plavljenje močvare i njeno pretvaranje u jezero predstavljalo kraj stvaranja uglja u IIa sloju. Središnji deo ugljonosnog sloja formiran je uslovima vlažne šumske močvare, sa relativno niskim, ali stabilnim nivoom vodenog stuba. Organska supstanca uglja je nezrela i njena maturisanost odgovara kasnoj fazi dijageneze. Organska supstanca se pretežno sastoji od kerogena tipa III i nema potencijal za generisanje tečnih ugljovodonika, ali može biti značajan izvor gasa na višim stupnjevima zrelosti (kasna katageneza i metageneza).",
title = "Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska",
pages = "1-42"
}
Tukelić, T.. (2024). Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska. , 1-42.
Tukelić T. Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska. 2024;:1-42..
Tukelić, Tamara, "Poreklo, sredina taloženja, zrelost i ugljovodonični potencijal oligocenskih mrkih ugljeva iz sloja IIa basena Bobov Dol, Bugarska" (2024):1-42.

The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding

Uzelac, Tamara N.; Smiljanić, Katarina; Takić, Marija; Sarac, Ivana; Petovic-Oggiano, Gordana; Nikolić, Milan; Jovanović, Vesna B.

(MDPI, 2024)

TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Smiljanić, Katarina
AU  - Takić, Marija
AU  - Sarac, Ivana
AU  - Petovic-Oggiano, Gordana
AU  - Nikolić, Milan
AU  - Jovanović, Vesna B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6429
AB  - The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
VL  - 5
SP  - 2335
DO  - 10.3390/ijms25042335
ER  - 
@article{
author = "Uzelac, Tamara N. and Smiljanić, Katarina and Takić, Marija and Sarac, Ivana and Petovic-Oggiano, Gordana and Nikolić, Milan and Jovanović, Vesna B.",
year = "2024",
abstract = "The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding",
volume = "5",
pages = "2335",
doi = "10.3390/ijms25042335"
}
Uzelac, T. N., Smiljanić, K., Takić, M., Sarac, I., Petovic-Oggiano, G., Nikolić, M.,& Jovanović, V. B.. (2024). The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences
MDPI., 5, 2335.
https://doi.org/10.3390/ijms25042335
Uzelac TN, Smiljanić K, Takić M, Sarac I, Petovic-Oggiano G, Nikolić M, Jovanović VB. The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences. 2024;5:2335.
doi:10.3390/ijms25042335 .
Uzelac, Tamara N., Smiljanić, Katarina, Takić, Marija, Sarac, Ivana, Petovic-Oggiano, Gordana, Nikolić, Milan, Jovanović, Vesna B., "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding" in International Journal of Molecular Sciences, 5 (2024):2335,
https://doi.org/10.3390/ijms25042335 . .

Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde

Cmiljanović, Katarina

(2024)

TY  - THES
AU  - Cmiljanović, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6426
AB  - Završni rad imao je za cilj da se ispita da li postoje promene u sadržaju esencijalnih i toksičnih elemenata u tragu u uzorcima pune krvi pacijenata sa TA, TC, MNG kao i da se uporede vrednosti sa kontrolama. Dalji cilj bio je da se porede vrednosti iz završnog rada sa rezultatima studija širom sveta. Takođe, rad je imao za cilj da ispita da li se neki od određivanih elemenata ili odnos elemenata može smatrati pogodnim biomarkerom za identifikaciju oboljenja štitaste žlezde.
T1  - Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde
SP  - 1
EP  - 31
ER  - 
@misc{
author = "Cmiljanović, Katarina",
year = "2024",
abstract = "Završni rad imao je za cilj da se ispita da li postoje promene u sadržaju esencijalnih i toksičnih elemenata u tragu u uzorcima pune krvi pacijenata sa TA, TC, MNG kao i da se uporede vrednosti sa kontrolama. Dalji cilj bio je da se porede vrednosti iz završnog rada sa rezultatima studija širom sveta. Takođe, rad je imao za cilj da ispita da li se neki od određivanih elemenata ili odnos elemenata može smatrati pogodnim biomarkerom za identifikaciju oboljenja štitaste žlezde.",
title = "Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde",
pages = "1-31"
}
Cmiljanović, K.. (2024). Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde. , 1-31.
Cmiljanović K. Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde. 2024;:1-31..
Cmiljanović, Katarina, "Izmenjen elementalni status u uzorcima pune krvi osoba sa malignim i benignim oboljenjima štitaste žlezde" (2024):1-31.

Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata

Planić, Dragana

(2024)

TY  - THES
AU  - Planić, Dragana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6428
AB  - Ekotoksikološka istraživanja imaju veliku primenu u zaštiti životne sredine. Različite vrste zmija su konstantno izložene dejstvu različitih ekoloških faktora u vodenoj sredini. Zmije se nalaze na vrhu lanca ishrane, imaju dug životni vek, kreću se po manjim površinama u odnosu na ostale organizme i to ih čini idealnim modelom za istraživanja u prirodnim uslovima.
Teški metali predstavljaju jednu od najrasprostranjenijih grupa zagađivača. Neizostavna su karika u istraživanjima, zbog svoje toksičnosti i biomagnifikacije kroz lanac ishrane.
Cilj ovog rada je ispitivanje koncentracije teških metala u tkivima belouške i ribarice sa područja Specijalnog rezervata prirode Zasavica.
T1  - Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata
SP  - 2
EP  - 36
ER  - 
@mastersthesis{
author = "Planić, Dragana",
year = "2024",
abstract = "Ekotoksikološka istraživanja imaju veliku primenu u zaštiti životne sredine. Različite vrste zmija su konstantno izložene dejstvu različitih ekoloških faktora u vodenoj sredini. Zmije se nalaze na vrhu lanca ishrane, imaju dug životni vek, kreću se po manjim površinama u odnosu na ostale organizme i to ih čini idealnim modelom za istraživanja u prirodnim uslovima.
Teški metali predstavljaju jednu od najrasprostranjenijih grupa zagađivača. Neizostavna su karika u istraživanjima, zbog svoje toksičnosti i biomagnifikacije kroz lanac ishrane.
Cilj ovog rada je ispitivanje koncentracije teških metala u tkivima belouške i ribarice sa područja Specijalnog rezervata prirode Zasavica.",
title = "Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata",
pages = "2-36"
}
Planić, D.. (2024). Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata. , 2-36.
Planić D. Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata. 2024;:2-36..
Planić, Dragana, "Određivanje koncentracije teških metala u tkivima zmija Natrix natrix i Natrix tessellata" (2024):2-36.

Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects

Milenković, Mila; Ciasca, Gabriele; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Verbić, Tatjana; Todorović Marković, Biljana; Jovanović, Svetlana

(Elsevier, 2024)

TY  - JOUR
AU  - Milenković, Mila
AU  - Ciasca, Gabriele
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6414
AB  - The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L-cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.
PB  - Elsevier
T2  - Journal of Photochemistry and Photobiology B: Biology
T1  - Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects
VL  - 250
SP  - 112818
DO  - 10.1016/j.jphotobiol.2023.112818
ER  - 
@article{
author = "Milenković, Mila and Ciasca, Gabriele and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L-cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.",
publisher = "Elsevier",
journal = "Journal of Photochemistry and Photobiology B: Biology",
title = "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects",
volume = "250",
pages = "112818",
doi = "10.1016/j.jphotobiol.2023.112818"
}
Milenković, M., Ciasca, G., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Todorović Marković, B.,& Jovanović, S.. (2024). Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects. in Journal of Photochemistry and Photobiology B: Biology
Elsevier., 250, 112818.
https://doi.org/10.1016/j.jphotobiol.2023.112818
Milenković M, Ciasca G, Bonasera A, Scopelliti M, Marković O, Verbić T, Todorović Marković B, Jovanović S. Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects. in Journal of Photochemistry and Photobiology B: Biology. 2024;250:112818.
doi:10.1016/j.jphotobiol.2023.112818 .
Milenković, Mila, Ciasca, Gabriele, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Todorović Marković, Biljana, Jovanović, Svetlana, "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects" in Journal of Photochemistry and Photobiology B: Biology, 250 (2024):112818,
https://doi.org/10.1016/j.jphotobiol.2023.112818 . .

Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects

Baranac-Stojanović, Marija; Aleksić, Jovana; Stojanović, Milovan

(2024)

TY  - JOUR
AU  - Baranac-Stojanović, Marija
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6417
AB  - Computational investigationattheBHandHLYP/6-311+G(d,p) leveloftheoryofthegas-phasetautomerismof2-and4-pyridonesconfirmedtheslightprevalenceof lactiminthecaseof theformer,but its dominance inthecaseof the latter, asshownpreviously. Examinationof aromaticitybyusingHOMA, EDDB, NBOdel, NICSandAICD led to theconclusion that tautomerizationof 4-pyridone results in greateraromaticitygain. ItisalsodrivenbythePaulirepulsionrelief,whichwasrevealedbythetautomerizationenergydecompositionanalysis.Bycontrast, inthecaseof2-pyridone, lactimisfavouredbyorbital andelectrostatic interactions anddisfavouredby thePauli repulsion. Aromaticitygain in this case is smaller.Thepositionofthetautomericequilibriumcanbemodulatedbysubstituent inductiveeffects(Cl andF), inductiveandresonanceeffects (NH2andNO2),hydrogenbonding(NO2),andmediumpolarity, theincreaseofwhichincreaseslactampopulation.
T2  - Organic & Biomolecular Chemistry
T1  - Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects
VL  - 22
IS  - 1
SP  - 144
EP  - 158
DO  - 10.1039/D3OB01588B
ER  - 
@article{
author = "Baranac-Stojanović, Marija and Aleksić, Jovana and Stojanović, Milovan",
year = "2024",
abstract = "Computational investigationattheBHandHLYP/6-311+G(d,p) leveloftheoryofthegas-phasetautomerismof2-and4-pyridonesconfirmedtheslightprevalenceof lactiminthecaseof theformer,but its dominance inthecaseof the latter, asshownpreviously. Examinationof aromaticitybyusingHOMA, EDDB, NBOdel, NICSandAICD led to theconclusion that tautomerizationof 4-pyridone results in greateraromaticitygain. ItisalsodrivenbythePaulirepulsionrelief,whichwasrevealedbythetautomerizationenergydecompositionanalysis.Bycontrast, inthecaseof2-pyridone, lactimisfavouredbyorbital andelectrostatic interactions anddisfavouredby thePauli repulsion. Aromaticitygain in this case is smaller.Thepositionofthetautomericequilibriumcanbemodulatedbysubstituent inductiveeffects(Cl andF), inductiveandresonanceeffects (NH2andNO2),hydrogenbonding(NO2),andmediumpolarity, theincreaseofwhichincreaseslactampopulation.",
journal = "Organic & Biomolecular Chemistry",
title = "Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects",
volume = "22",
number = "1",
pages = "144-158",
doi = "10.1039/D3OB01588B"
}
Baranac-Stojanović, M., Aleksić, J.,& Stojanović, M.. (2024). Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects. in Organic & Biomolecular Chemistry, 22(1), 144-158.
https://doi.org/10.1039/D3OB01588B
Baranac-Stojanović M, Aleksić J, Stojanović M. Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects. in Organic & Biomolecular Chemistry. 2024;22(1):144-158.
doi:10.1039/D3OB01588B .
Baranac-Stojanović, Marija, Aleksić, Jovana, Stojanović, Milovan, "Theoretical investigation of tautomerism of 2- and 4-pyridones: origin, substituent and solvent effects" in Organic & Biomolecular Chemistry, 22, no. 1 (2024):144-158,
https://doi.org/10.1039/D3OB01588B . .

Blue-light-driven photoactivity of L-cysteine-modified graphene quantum dots and their antibacterial effects

Milenković, Mila; Ciasca, Gabriele; Bonasera, Aurelio; Scopelliti, Michelangelo; Marković, Olivera; Verbić, Tatjana; Todorović Marković, Biljana; Jovanović, Svetlana

(Elsevier, 2024)

TY  - JOUR
AU  - Milenković, Mila
AU  - Ciasca, Gabriele
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Todorović Marković, Biljana
AU  - Jovanović, Svetlana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6303
AB  - The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give 
in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, 
smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the 
antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. 
Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic 
resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of 
modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in 
the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol 
groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 
4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed 
that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs 
combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 
sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against 
S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.
PB  - Elsevier
T2  - Journal of Photochemistry & Photobiology, B: Biology
T1  - Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects
VL  - 250
SP  - 112818
DO  - 10.1016/j.jphotobiol.2023.112818
ER  - 
@article{
author = "Milenković, Mila and Ciasca, Gabriele and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Todorović Marković, Biljana and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread abuse of traditional antibiotics has led to a global rise in antibiotic-resistant bacteria, which give 
in return unprecedented health risks. Therefore, there is a large and urgent need for the development of new, 
smart antibacterial agents able to efficiently kill or inhibit bacterial growth. In this study, we investigated the 
antibacterial activity of S, N-doped Graphene Quantum Dots (GQDs) as a light-triggered antibacterial agent. 
Gamma irradiation was employed as a tool to achieve one-step modification of GQDs in the presence of L cysteine amino acid as a source of heteroatoms. X-ray Photoelectron Spectroscopy (XPS), nuclear magnetic 
resonance (NMR), and zeta potential measurements provided the necessary data to clarify the structure of 
modified dots and verify the introduction of both S- and N-atoms in GQDs structure, but also severe changes in 
the aromatic, sp2 domains. Namely, γ-irradiation caused a bonding of S atoms in 1.14 at.% mainly as thiol 
groups, and N in 1.81 at.% as amino groups, but sp2 contribution in GQD structure was lowered from 63.00 to 
4.86 at.%, as measured in dots irradiated at a dose of 200 kGy. Fluorescence quenching measurements showed 
that L-cysteine-modified dots are able to bind to human serum albumin. The antibacterial activity of GQDs 
combined with 1 and 6 h of blue light (470 nm) irradiation was tested against 8 bacterial strains. GQD-cys-25 
sample provided the best results, with minimum inhibitory concentration (MIC) as low as 125 μg/mL against 
S. aureus, E. faecalis, and E. coli after only 1 h of blue light exposure.",
publisher = "Elsevier",
journal = "Journal of Photochemistry & Photobiology, B: Biology",
title = "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects",
volume = "250",
pages = "112818",
doi = "10.1016/j.jphotobiol.2023.112818"
}
Milenković, M., Ciasca, G., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Todorović Marković, B.,& Jovanović, S.. (2024). Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology
Elsevier., 250, 112818.
https://doi.org/10.1016/j.jphotobiol.2023.112818
Milenković M, Ciasca G, Bonasera A, Scopelliti M, Marković O, Verbić T, Todorović Marković B, Jovanović S. Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects. in Journal of Photochemistry & Photobiology, B: Biology. 2024;250:112818.
doi:10.1016/j.jphotobiol.2023.112818 .
Milenković, Mila, Ciasca, Gabriele, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Todorović Marković, Biljana, Jovanović, Svetlana, "Blue-light-driven photoactivity of L-cysteine-modified graphene quantum  dots and their antibacterial effects" in Journal of Photochemistry & Photobiology, B: Biology, 250 (2024):112818,
https://doi.org/10.1016/j.jphotobiol.2023.112818 . .

Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina

Vujasinović, Vanja D.

(2024)

TY  - THES
AU  - Vujasinović, Vanja D.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6413
AB  - Cilj ovog master rada bila je sinteza željenog proizvoda 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina, u čiju svrhu su primenjena dva sintetička puta. U okviru prvog pristupa predstavljena su tri načina za izvođenje "click" reakcije cikloadicije, pri čemu se dobija molekul sa triazolskom jedinicom. Drugi sintetički put željenog jedinjenja je 1,3-dipolarna cikloadicija. Ishod reakcije alkilovanja dobijenog triazola bilo je dobijanje tri regioizomerna jedinjenja.
T1  - Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina
SP  - 1
EP  - 36
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6413
ER  - 
@mastersthesis{
author = "Vujasinović, Vanja D.",
year = "2024",
abstract = "Cilj ovog master rada bila je sinteza željenog proizvoda 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina, u čiju svrhu su primenjena dva sintetička puta. U okviru prvog pristupa predstavljena su tri načina za izvođenje "click" reakcije cikloadicije, pri čemu se dobija molekul sa triazolskom jedinicom. Drugi sintetički put željenog jedinjenja je 1,3-dipolarna cikloadicija. Ishod reakcije alkilovanja dobijenog triazola bilo je dobijanje tri regioizomerna jedinjenja.",
title = "Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina",
pages = "1-36",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6413"
}
Vujasinović, V. D.. (2024). Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina. , 1-36.
https://hdl.handle.net/21.15107/rcub_cherry_6413
Vujasinović VD. Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina. 2024;:1-36.
https://hdl.handle.net/21.15107/rcub_cherry_6413 .
Vujasinović, Vanja D., "Primena "click" reakcije cikloadicije u sintezi 2-(1-(4-brombenzil)-1H-1,2,3-triazol-4-il)piridina" (2024):1-36,
https://hdl.handle.net/21.15107/rcub_cherry_6413 .

Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen

Đurašinović, Tatjana; Lopandić, Zorana; Protić-Rosić, Isidora; Nešić, Andrijana; Trbojević-Ivić, Jovana; Jappe, Uta; Gavrović-Jankulović, Marija

(Elsevier, 2024)

TY  - JOUR
AU  - Đurašinović, Tatjana
AU  - Lopandić, Zorana
AU  - Protić-Rosić, Isidora
AU  - Nešić, Andrijana
AU  - Trbojević-Ivić, Jovana
AU  - Jappe, Uta
AU  - Gavrović-Jankulović, Marija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6338
AB  - Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.
PB  - Elsevier
T2  - Food Chemistry
T1  - Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen
VL  - 437
SP  - 137782
DO  - 10.1016/j.foodchem.2023.137782
ER  - 
@article{
author = "Đurašinović, Tatjana and Lopandić, Zorana and Protić-Rosić, Isidora and Nešić, Andrijana and Trbojević-Ivić, Jovana and Jappe, Uta and Gavrović-Jankulović, Marija",
year = "2024",
abstract = "Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen",
volume = "437",
pages = "137782",
doi = "10.1016/j.foodchem.2023.137782"
}
Đurašinović, T., Lopandić, Z., Protić-Rosić, I., Nešić, A., Trbojević-Ivić, J., Jappe, U.,& Gavrović-Jankulović, M.. (2024). Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry
Elsevier., 437, 137782.
https://doi.org/10.1016/j.foodchem.2023.137782
Đurašinović T, Lopandić Z, Protić-Rosić I, Nešić A, Trbojević-Ivić J, Jappe U, Gavrović-Jankulović M. Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry. 2024;437:137782.
doi:10.1016/j.foodchem.2023.137782 .
Đurašinović, Tatjana, Lopandić, Zorana, Protić-Rosić, Isidora, Nešić, Andrijana, Trbojević-Ivić, Jovana, Jappe, Uta, Gavrović-Jankulović, Marija, "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen" in Food Chemistry, 437 (2024):137782,
https://doi.org/10.1016/j.foodchem.2023.137782 . .

Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes

Djapovic, Milica; Apostolović, Danijela; Postic, Vojislava; Lujić, Tamara; Jovanović, Vesna; Stanić-Vučinić, Dragana; van Hage, Marianne; Maslak, Veselin; Ćirković Veličković, Tanja

(MDPI, 2023)

TY  - JOUR
AU  - Djapovic, Milica
AU  - Apostolović, Danijela
AU  - Postic, Vojislava
AU  - Lujić, Tamara
AU  - Jovanović, Vesna
AU  - Stanić-Vučinić, Dragana
AU  - van Hage, Marianne
AU  - Maslak, Veselin
AU  - Ćirković Veličković, Tanja
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6433
AB  - Manufactured nanoplastic particles (NPs) are indispensable for in vitro and in vivo testing and a health risk assessment of this emerging environmental contaminant is needed. The high surface area and inherent hydrophobicity of plastic materials makes the production of NPs devoid of any contaminants very challenging. In this study, we produced nanoprecipitated polyethylene terephthalate (PET) NPs (300 nm hydrodynamic diameter) with an overall yield of 0.76%. The presence of the ionic surfactant sodium dodecyl sulfate (SDS) was characterized by 1H NMR, where the relative ratio of NP/surfactant was monitored on the basis of the chemical shifts characteristic of PET and SDS. For a wide range of surfactant/NP ratios (17:100 to 1.2:100), the measured zeta potential changed from −42.10 to −34.93 mV, but with an NP concentration up to 100 μg/mL, no clear differences were observed in the cellular assays performed in protein-rich media on primary human cells. The remaining impurities contributed to the outcome of the biological assays applied in protein-free buffers, such as human red blood cell hemolysis. The presence of SDS increased the NP-induced hemolysis by 1.5% in protein-rich buffer and by 7.5% in protein-free buffer. As the size, shape, zeta potential, and contaminants of NPs may all be relevant parameters for the biological effects of NPs, the relative quantification of impurities exemplified in our work by the application of 1H NMR for PET NPs and the ionic surfactant SDS could be a valuable auxiliary method in the quality control of manufactured NPs.
PB  - MDPI
T2  - Polymers
T1  - Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes
VL  - 15
IS  - 24
SP  - 4703
DO  - 10.3390/polym15244703
ER  - 
@article{
author = "Djapovic, Milica and Apostolović, Danijela and Postic, Vojislava and Lujić, Tamara and Jovanović, Vesna and Stanić-Vučinić, Dragana and van Hage, Marianne and Maslak, Veselin and Ćirković Veličković, Tanja",
year = "2023",
abstract = "Manufactured nanoplastic particles (NPs) are indispensable for in vitro and in vivo testing and a health risk assessment of this emerging environmental contaminant is needed. The high surface area and inherent hydrophobicity of plastic materials makes the production of NPs devoid of any contaminants very challenging. In this study, we produced nanoprecipitated polyethylene terephthalate (PET) NPs (300 nm hydrodynamic diameter) with an overall yield of 0.76%. The presence of the ionic surfactant sodium dodecyl sulfate (SDS) was characterized by 1H NMR, where the relative ratio of NP/surfactant was monitored on the basis of the chemical shifts characteristic of PET and SDS. For a wide range of surfactant/NP ratios (17:100 to 1.2:100), the measured zeta potential changed from −42.10 to −34.93 mV, but with an NP concentration up to 100 μg/mL, no clear differences were observed in the cellular assays performed in protein-rich media on primary human cells. The remaining impurities contributed to the outcome of the biological assays applied in protein-free buffers, such as human red blood cell hemolysis. The presence of SDS increased the NP-induced hemolysis by 1.5% in protein-rich buffer and by 7.5% in protein-free buffer. As the size, shape, zeta potential, and contaminants of NPs may all be relevant parameters for the biological effects of NPs, the relative quantification of impurities exemplified in our work by the application of 1H NMR for PET NPs and the ionic surfactant SDS could be a valuable auxiliary method in the quality control of manufactured NPs.",
publisher = "MDPI",
journal = "Polymers",
title = "Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes",
volume = "15",
number = "24",
pages = "4703",
doi = "10.3390/polym15244703"
}
Djapovic, M., Apostolović, D., Postic, V., Lujić, T., Jovanović, V., Stanić-Vučinić, D., van Hage, M., Maslak, V.,& Ćirković Veličković, T.. (2023). Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes. in Polymers
MDPI., 15(24), 4703.
https://doi.org/10.3390/polym15244703
Djapovic M, Apostolović D, Postic V, Lujić T, Jovanović V, Stanić-Vučinić D, van Hage M, Maslak V, Ćirković Veličković T. Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes. in Polymers. 2023;15(24):4703.
doi:10.3390/polym15244703 .
Djapovic, Milica, Apostolović, Danijela, Postic, Vojislava, Lujić, Tamara, Jovanović, Vesna, Stanić-Vučinić, Dragana, van Hage, Marianne, Maslak, Veselin, Ćirković Veličković, Tanja, "Characterization of Nanoprecipitated PET Nanoplastics by 1H NMR and Impact of Residual Ionic Surfactant on Viability of Human Primary Mononuclear Cells and Hemolysis of Erythrocytes" in Polymers, 15, no. 24 (2023):4703,
https://doi.org/10.3390/polym15244703 . .
1

LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity

Jadranin, Milka; Savić, Danica; Lupšić, Ema; Podolski-Renić, Ana; Pešić, Milica; Tešević, Vele; Milosavljević, Slobodan M.; Krstić, Gordana B.

(MDPI, 2023)

TY  - JOUR
AU  - Jadranin, Milka
AU  - Savić, Danica
AU  - Lupšić, Ema
AU  - Podolski-Renić, Ana
AU  - Pešić, Milica
AU  - Tešević, Vele
AU  - Milosavljević, Slobodan M.
AU  - Krstić, Gordana B.
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6432
AB  - Euphorbia seguieriana ssp. seguieriana Necker (ES) and Euphorbia cyparissias (EC) with a habitat in the Deliblato Sands were the subject of this examination. The latexes of these so far insufficiently investigated species of the Euphorbia genus are used in traditional medicine for the treatment of wounds and warts on the skin. To determine their chemical composition, non-targeted screening of the latexes’ chloroform extracts was performed using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry employing an electrospray ionization source (LC-ESI QTOF MS). The analysis of the obtained results showed that the latexes of ES and EC represent rich sources of diterpenes, tentatively identified as jatrophanes, ingenanes, tiglianes, myrsinanes, premyrsinanes, and others. Examination of the anticancer activity of the ES and EC latex extracts showed that both extracts significantly inhibited the growth of the non-small cell lung carcinoma NCI-H460 and glioblastoma U87 cell lines as well as of their corresponding multi-drug resistant (MDR) cell lines, NCI-H460/R and U87-TxR. The obtained results also revealed that the ES and EC extracts inhibited the function of P-glycoprotein (P-gp) in MDR cancer cells, whose overexpression is one of the main mechanisms underlying MDR.
PB  - MDPI
T2  - Plants
T1  - LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity
VL  - 12
IS  - 24
SP  - 4181
DO  - 10.3390/plants12244181
ER  - 
@article{
author = "Jadranin, Milka and Savić, Danica and Lupšić, Ema and Podolski-Renić, Ana and Pešić, Milica and Tešević, Vele and Milosavljević, Slobodan M. and Krstić, Gordana B.",
year = "2023",
abstract = "Euphorbia seguieriana ssp. seguieriana Necker (ES) and Euphorbia cyparissias (EC) with a habitat in the Deliblato Sands were the subject of this examination. The latexes of these so far insufficiently investigated species of the Euphorbia genus are used in traditional medicine for the treatment of wounds and warts on the skin. To determine their chemical composition, non-targeted screening of the latexes’ chloroform extracts was performed using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry employing an electrospray ionization source (LC-ESI QTOF MS). The analysis of the obtained results showed that the latexes of ES and EC represent rich sources of diterpenes, tentatively identified as jatrophanes, ingenanes, tiglianes, myrsinanes, premyrsinanes, and others. Examination of the anticancer activity of the ES and EC latex extracts showed that both extracts significantly inhibited the growth of the non-small cell lung carcinoma NCI-H460 and glioblastoma U87 cell lines as well as of their corresponding multi-drug resistant (MDR) cell lines, NCI-H460/R and U87-TxR. The obtained results also revealed that the ES and EC extracts inhibited the function of P-glycoprotein (P-gp) in MDR cancer cells, whose overexpression is one of the main mechanisms underlying MDR.",
publisher = "MDPI",
journal = "Plants",
title = "LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity",
volume = "12",
number = "24",
pages = "4181",
doi = "10.3390/plants12244181"
}
Jadranin, M., Savić, D., Lupšić, E., Podolski-Renić, A., Pešić, M., Tešević, V., Milosavljević, S. M.,& Krstić, G. B.. (2023). LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity. in Plants
MDPI., 12(24), 4181.
https://doi.org/10.3390/plants12244181
Jadranin M, Savić D, Lupšić E, Podolski-Renić A, Pešić M, Tešević V, Milosavljević SM, Krstić GB. LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity. in Plants. 2023;12(24):4181.
doi:10.3390/plants12244181 .
Jadranin, Milka, Savić, Danica, Lupšić, Ema, Podolski-Renić, Ana, Pešić, Milica, Tešević, Vele, Milosavljević, Slobodan M., Krstić, Gordana B., "LC-ESI QToF MS Non-Targeted Screening of Latex Extracts of Euphorbia seguieriana ssp. seguieriana Necker and Euphorbia cyparissias and Determination of Their Potential Anticancer Activity" in Plants, 12, no. 24 (2023):4181,
https://doi.org/10.3390/plants12244181 . .

A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode

Kulizić, Mihajlo N.; Stanković, Milan; Rašić, Marija; Mijatović, Aleksandar; Baošić, Rada; Lolić, Aleksandar

(Wiley, 2023)

TY  - JOUR
AU  - Kulizić, Mihajlo N.
AU  - Stanković, Milan
AU  - Rašić, Marija
AU  - Mijatović, Aleksandar
AU  - Baošić, Rada
AU  - Lolić, Aleksandar
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6431
AB  - In this paper, a simple, sensitive, and precise flow injection system was optimized and applied to ascorbic acid determination with a carbon paste electrode modified with the Schiff base copper complex. The modified sensor showed increased sensitivity toward ascorbic acid oxidation with a decrease of oxidation potential by 200 mV. Under optimized flow parameters, working potential, gasket thickness, sample and reaction coil volumes, and flow rate, the developed flow system gave a linear response from 5 to 75 μmol/L of ascorbic acid. The calculated limit of detection was 4.5 μmol/L, calculated as 3σ/s which corresponds to the absolute value of 40 ng for the 50 μL sample coil. The precision for six consecutive injections of 5 and 75 μmol/L ascorbic acid solutions was determined as a relative standard deviation of 5.8 % and 1.5 %, respectively. The flow injection system enabled up to 120 analyses per hour. An optimized flow system was applied to the determination of ascorbic acid in dietary supplements, after simple preparation.
PB  - Wiley
T1  - A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode
VL  - 8
IS  - 48
SP  - e202304631
DO  - 10.1002/slct.202304631
ER  - 
@article{
author = "Kulizić, Mihajlo N. and Stanković, Milan and Rašić, Marija and Mijatović, Aleksandar and Baošić, Rada and Lolić, Aleksandar",
year = "2023",
abstract = "In this paper, a simple, sensitive, and precise flow injection system was optimized and applied to ascorbic acid determination with a carbon paste electrode modified with the Schiff base copper complex. The modified sensor showed increased sensitivity toward ascorbic acid oxidation with a decrease of oxidation potential by 200 mV. Under optimized flow parameters, working potential, gasket thickness, sample and reaction coil volumes, and flow rate, the developed flow system gave a linear response from 5 to 75 μmol/L of ascorbic acid. The calculated limit of detection was 4.5 μmol/L, calculated as 3σ/s which corresponds to the absolute value of 40 ng for the 50 μL sample coil. The precision for six consecutive injections of 5 and 75 μmol/L ascorbic acid solutions was determined as a relative standard deviation of 5.8 % and 1.5 %, respectively. The flow injection system enabled up to 120 analyses per hour. An optimized flow system was applied to the determination of ascorbic acid in dietary supplements, after simple preparation.",
publisher = "Wiley",
title = "A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode",
volume = "8",
number = "48",
pages = "e202304631",
doi = "10.1002/slct.202304631"
}
Kulizić, M. N., Stanković, M., Rašić, M., Mijatović, A., Baošić, R.,& Lolić, A.. (2023). A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode. 
Wiley., 8(48), e202304631.
https://doi.org/10.1002/slct.202304631
Kulizić MN, Stanković M, Rašić M, Mijatović A, Baošić R, Lolić A. A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode. 2023;8(48):e202304631.
doi:10.1002/slct.202304631 .
Kulizić, Mihajlo N., Stanković, Milan, Rašić, Marija, Mijatović, Aleksandar, Baošić, Rada, Lolić, Aleksandar, "A Simple Flow Injection System for Amperometric Detection of Ascorbic Acid using Carbon Paste/Copper Schiff Base Composite Electrode", 8, no. 48 (2023):e202304631,
https://doi.org/10.1002/slct.202304631 . .
1

Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts

Topakas, Evangelos; Siaperas, Romanos; Taxeidis, George; Makryniotis, Konstantinos; Guzik, Maciej; Maslak, Veselin; Beškoski, Vladimir; Lončarević, Branka; Ilić-Tomić, Tatjana; Milivojević, Dušan; Škaro Bogojević, Sanja; Pantelić, Brana

(MDPI, 2023)

TY  - JOUR
AU  - Topakas, Evangelos
AU  - Siaperas, Romanos
AU  - Taxeidis, George
AU  - Makryniotis, Konstantinos
AU  - Guzik, Maciej
AU  - Maslak, Veselin
AU  - Beškoski, Vladimir
AU  - Lončarević, Branka
AU  - Ilić-Tomić, Tatjana
AU  - Milivojević, Dušan
AU  - Škaro Bogojević, Sanja
AU  - Pantelić, Brana
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5969
AB  - Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.
PB  - MDPI
T2  - Catalysts
T1  - Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts
VL  - 13
IS  - 2
SP  - 278
DO  - 10.3390/catal13020278
ER  - 
@article{
author = "Topakas, Evangelos and Siaperas, Romanos and Taxeidis, George and Makryniotis, Konstantinos and Guzik, Maciej and Maslak, Veselin and Beškoski, Vladimir and Lončarević, Branka and Ilić-Tomić, Tatjana and Milivojević, Dušan and Škaro Bogojević, Sanja and Pantelić, Brana",
year = "2023",
abstract = "Polyurethanes (PUs) are an exceedingly heterogeneous group of plastic polymers, widely used in a variety of industries from construction to medical implants. In the past decades, we have witnessed the accumulation of PU waste and its detrimental environmental impacts. PUs have been identified as one of the most toxic polymers leaching hazardous compounds derived both from the polymer itself and the additives used in production. Further environmental impact assessment, identification and characterization of substances derived from PU materials and establishing efficient degradation strategies are crucial. Thus, a selection of eight synthetic model compounds which represent partial PU hydrolysis products were synthesized and characterized both in terms of toxicity and suitability to be used as substrates for the identification of novel biocatalysts for PU biodegradation. Overall, the compounds exhibited low in vitro cytotoxicity against a healthy human fibroblast cell line and virtually no toxic effect on the nematode Caenorhabditis elegans up to 500 µg mL−1, and two of the substrates showed moderate aquatic ecotoxicity with EC50 values 53 µg mL−1 and 45 µg mL−1, respectively, on Aliivibrio fischeri. The compounds were successfully applied to study the mechanism of ester and urethane bond cleaving preference of known plastic-degrading enzymes and were used to single out a novel PU-degrading biocatalyst, Amycolatopsis mediterranei ISP5501, among 220 microbial strains. A. mediterranei ISP5501 can also degrade commercially available polyether and polyester PU materials, reducing the average molecular number of the polymer up to 13.5%. This study uncovered a biocatalyst capable of degrading different types of PUs and identified potential enzymes responsible as a key step in developing biotechnological process for PU waste treatment options.",
publisher = "MDPI",
journal = "Catalysts",
title = "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts",
volume = "13",
number = "2",
pages = "278",
doi = "10.3390/catal13020278"
}
Topakas, E., Siaperas, R., Taxeidis, G., Makryniotis, K., Guzik, M., Maslak, V., Beškoski, V., Lončarević, B., Ilić-Tomić, T., Milivojević, D., Škaro Bogojević, S.,& Pantelić, B.. (2023). Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts
MDPI., 13(2), 278.
https://doi.org/10.3390/catal13020278
Topakas E, Siaperas R, Taxeidis G, Makryniotis K, Guzik M, Maslak V, Beškoski V, Lončarević B, Ilić-Tomić T, Milivojević D, Škaro Bogojević S, Pantelić B. Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts. in Catalysts. 2023;13(2):278.
doi:10.3390/catal13020278 .
Topakas, Evangelos, Siaperas, Romanos, Taxeidis, George, Makryniotis, Konstantinos, Guzik, Maciej, Maslak, Veselin, Beškoski, Vladimir, Lončarević, Branka, Ilić-Tomić, Tatjana, Milivojević, Dušan, Škaro Bogojević, Sanja, Pantelić, Brana, "Set of Small Molecule Polyurethane (PU) Model Substrates: Ecotoxicity Evaluation and Identification of PU Degrading Biocatalysts" in Catalysts, 13, no. 2 (2023):278,
https://doi.org/10.3390/catal13020278 . .
2
2
2

Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring

Jakšić, Jovana; Solymosi, Iris; Hirsch, Andreas; Pérez-Ojeda, M. Eugenia; Mitrović, Aleksandra D.; Maslak, Veselin

(John Wiley and Sons Inc, 2023)

TY  - JOUR
AU  - Jakšić, Jovana
AU  - Solymosi, Iris
AU  - Hirsch, Andreas
AU  - Pérez-Ojeda, M. Eugenia
AU  - Mitrović, Aleksandra D.
AU  - Maslak, Veselin
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6272
AB  - The synthesis and characterization of four dumbbell-shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron-donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2 ⊃C60derivative . However, the methano-dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono- and bis-pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.
PB  - John Wiley and Sons Inc
T2  - Chemistry (Weinheim an Der Bergstrasse, Germany)
T1  - Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring
VL  - 29
IS  - 44
SP  - e202301061
DO  - 10.1002/chem.202301061
ER  - 
@article{
author = "Jakšić, Jovana and Solymosi, Iris and Hirsch, Andreas and Pérez-Ojeda, M. Eugenia and Mitrović, Aleksandra D. and Maslak, Veselin",
year = "2023",
abstract = "The synthesis and characterization of four dumbbell-shaped fullerene molecules connected by isosorbide and isomannide moieties is presented. Additionally, their electrochemical behavior and their ability to form complexes with [10]cycloparaphenylene ([10]CPP) were investigated. The cyclic voltammetry (CV) results of the fullerene dumbbells demonstrate a high electron affinity, indicating their strong interaction with electron-donating counterparts such as carbon nanorings, which possess complementary charge and shape properties. To study the thermodynamic and kinetic parameters of complexation, isothermal titration calorimetry (ITC) was employed. NMR titration experiments provided further insights into the binding stoichiometries. Two distinct approaches were utilized to create bridged structures: one based on cyclopropane and the other based on furan. Regardless of the type of linker used, all derivatives formed conventional 2 : 1 complexes denoted as [10]CPP2 ⊃C60derivative . However, the methano-dumbbell molecules exhibited distinct binding behavior, resulting in the formation of mono- and bis-pseudorotaxanes, as well as oligomers (polymers). The formation of linear polymers holds significant potential for applications in solar energy conversion processes.",
publisher = "John Wiley and Sons Inc",
journal = "Chemistry (Weinheim an Der Bergstrasse, Germany)",
title = "Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring",
volume = "29",
number = "44",
pages = "e202301061",
doi = "10.1002/chem.202301061"
}
Jakšić, J., Solymosi, I., Hirsch, A., Pérez-Ojeda, M. E., Mitrović, A. D.,& Maslak, V.. (2023). Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring. in Chemistry (Weinheim an Der Bergstrasse, Germany)
John Wiley and Sons Inc., 29(44), e202301061.
https://doi.org/10.1002/chem.202301061
Jakšić J, Solymosi I, Hirsch A, Pérez-Ojeda ME, Mitrović AD, Maslak V. Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring. in Chemistry (Weinheim an Der Bergstrasse, Germany). 2023;29(44):e202301061.
doi:10.1002/chem.202301061 .
Jakšić, Jovana, Solymosi, Iris, Hirsch, Andreas, Pérez-Ojeda, M. Eugenia, Mitrović, Aleksandra D., Maslak, Veselin, "Sugar-Bridged Fullerene Dumbbells and Their Interaction with the [10]Cycloparaphenylene Nanoring" in Chemistry (Weinheim an Der Bergstrasse, Germany), 29, no. 44 (2023):e202301061,
https://doi.org/10.1002/chem.202301061 . .
17
3
3

Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis

Jovanović, Miloš; Jovanović, Predrag; Tasić, Gordana; Simić, Milena R.; Maslak, Veselin; Rakić, Srđan; Rodić, Marko; Vlahović, Filip; Petković, Miloš; Savić, Vladimir

(John Wiley and Sons Inc, 2023)

TY  - JOUR
AU  - Jovanović, Miloš
AU  - Jovanović, Predrag
AU  - Tasić, Gordana
AU  - Simić, Milena R.
AU  - Maslak, Veselin
AU  - Rakić, Srđan
AU  - Rodić, Marko
AU  - Vlahović, Filip
AU  - Petković, Miloš
AU  - Savić, Vladimir
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6284
AB  - Enallenylamideshave been utilizedforthe synthesisof heterobicycle[4.2.0]octanederiva-tives via Ir/hν promoted[2+2] cycloadditionreaction.The reactionspecificallytargets the distaldoublebond of the allene moiety, and resultsin theexclusiveformationof thetransproduct.Theprocessis conductedat room temperatureand underan inert atmosphere.An extensivestudy on thesubstituentpropensitiesduringthe cycloadditionstep revealedvariableeffects.Electron-withdrawinggroupsconjugatedwith the doublebond participat-ing in the cycloadditioneither hinderedthe processor reducedits yield. Conversely, electron-donatingsubstituentsenhancedthe efficiency, resultinginproductyields rangingfrom 60% to 88%. Our studyalso demonstratedthe influenceof protectinggroupson the reactionpathway.
PB  - John Wiley and Sons Inc
T2  - Advanced Synthesis and Catalysis
T1  - Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis
VL  - 365
IS  - 15
SP  - 2516
EP  - 2523
DO  - 10.1002/adsc.202300301
ER  - 
@article{
author = "Jovanović, Miloš and Jovanović, Predrag and Tasić, Gordana and Simić, Milena R. and Maslak, Veselin and Rakić, Srđan and Rodić, Marko and Vlahović, Filip and Petković, Miloš and Savić, Vladimir",
year = "2023",
abstract = "Enallenylamideshave been utilizedforthe synthesisof heterobicycle[4.2.0]octanederiva-tives via Ir/hν promoted[2+2] cycloadditionreaction.The reactionspecificallytargets the distaldoublebond of the allene moiety, and resultsin theexclusiveformationof thetransproduct.Theprocessis conductedat room temperatureand underan inert atmosphere.An extensivestudy on thesubstituentpropensitiesduringthe cycloadditionstep revealedvariableeffects.Electron-withdrawinggroupsconjugatedwith the doublebond participat-ing in the cycloadditioneither hinderedthe processor reducedits yield. Conversely, electron-donatingsubstituentsenhancedthe efficiency, resultinginproductyields rangingfrom 60% to 88%. Our studyalso demonstratedthe influenceof protectinggroupson the reactionpathway.",
publisher = "John Wiley and Sons Inc",
journal = "Advanced Synthesis and Catalysis",
title = "Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis",
volume = "365",
number = "15",
pages = "2516-2523",
doi = "10.1002/adsc.202300301"
}
Jovanović, M., Jovanović, P., Tasić, G., Simić, M. R., Maslak, V., Rakić, S., Rodić, M., Vlahović, F., Petković, M.,& Savić, V.. (2023). Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis. in Advanced Synthesis and Catalysis
John Wiley and Sons Inc., 365(15), 2516-2523.
https://doi.org/10.1002/adsc.202300301
Jovanović M, Jovanović P, Tasić G, Simić MR, Maslak V, Rakić S, Rodić M, Vlahović F, Petković M, Savić V. Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis. in Advanced Synthesis and Catalysis. 2023;365(15):2516-2523.
doi:10.1002/adsc.202300301 .
Jovanović, Miloš, Jovanović, Predrag, Tasić, Gordana, Simić, Milena R., Maslak, Veselin, Rakić, Srđan, Rodić, Marko, Vlahović, Filip, Petković, Miloš, Savić, Vladimir, "Regio‐ and Stereoselective, Intramolecular [2+2] Cycloaddition of Allenes, Promoted by Visible Light Photocatalysis" in Advanced Synthesis and Catalysis, 365, no. 15 (2023):2516-2523,
https://doi.org/10.1002/adsc.202300301 . .
2
2
1

Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase

Mitrović, Aleksandra D.; Milovanović, Jelena; Gurgul, Jacek; Žekić, Andrijana; Nikodinović-Runić, Jasmina; Maslak, Veselin

(Elsevier, 2023)

TY  - JOUR
AU  - Mitrović, Aleksandra D.
AU  - Milovanović, Jelena
AU  - Gurgul, Jacek
AU  - Žekić, Andrijana
AU  - Nikodinović-Runić, Jasmina
AU  - Maslak, Veselin
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6287
AB  - We present a novel approach for the enzymatic functionalization of graphene, utilizing horseradish peroxidase (HPO) and laccase (LC) from Trametes versicolor. This study demonstrates, for the first time, the covalent modification of non-homogeneous graphene with a low surface-to-volume ratio, both in solution and on solid support. Through thermogravimetry analysis, we estimate the degree of functionalization to be 11% with HPO and 4% with LC, attributed to the varying redox potentials of the enzymes. This work highlights the potential of enzymatic reactions for tailored functionalization of graphene under mild conditions.
PB  - Elsevier
T2  - Enzyme and Microbial Technology
T1  - Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase
VL  - 170
SP  - 110293
DO  - 10.1016/j.enzmictec.2023.110293
ER  - 
@article{
author = "Mitrović, Aleksandra D. and Milovanović, Jelena and Gurgul, Jacek and Žekić, Andrijana and Nikodinović-Runić, Jasmina and Maslak, Veselin",
year = "2023",
abstract = "We present a novel approach for the enzymatic functionalization of graphene, utilizing horseradish peroxidase (HPO) and laccase (LC) from Trametes versicolor. This study demonstrates, for the first time, the covalent modification of non-homogeneous graphene with a low surface-to-volume ratio, both in solution and on solid support. Through thermogravimetry analysis, we estimate the degree of functionalization to be 11% with HPO and 4% with LC, attributed to the varying redox potentials of the enzymes. This work highlights the potential of enzymatic reactions for tailored functionalization of graphene under mild conditions.",
publisher = "Elsevier",
journal = "Enzyme and Microbial Technology",
title = "Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase",
volume = "170",
pages = "110293",
doi = "10.1016/j.enzmictec.2023.110293"
}
Mitrović, A. D., Milovanović, J., Gurgul, J., Žekić, A., Nikodinović-Runić, J.,& Maslak, V.. (2023). Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase. in Enzyme and Microbial Technology
Elsevier., 170, 110293.
https://doi.org/10.1016/j.enzmictec.2023.110293
Mitrović AD, Milovanović J, Gurgul J, Žekić A, Nikodinović-Runić J, Maslak V. Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase. in Enzyme and Microbial Technology. 2023;170:110293.
doi:10.1016/j.enzmictec.2023.110293 .
Mitrović, Aleksandra D., Milovanović, Jelena, Gurgul, Jacek, Žekić, Andrijana, Nikodinović-Runić, Jasmina, Maslak, Veselin, "Enzymatic functionalization of liquid phase exfoliated graphene using horseradish peroxidase and laccase" in Enzyme and Microbial Technology, 170 (2023):110293,
https://doi.org/10.1016/j.enzmictec.2023.110293 . .
3
2

Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity

Saidu, Muhammad Bello; Krstić, Gordana B.; Todorović, Nina; Berkecz, Róbert; Ali, Hazhmat; Zupkó, István; Hohmann, Judit; Rédei, Dóra

(Elsevier, 2023)

TY  - JOUR
AU  - Saidu, Muhammad Bello
AU  - Krstić, Gordana B.
AU  - Todorović, Nina
AU  - Berkecz, Róbert
AU  - Ali, Hazhmat
AU  - Zupkó, István
AU  - Hohmann, Judit
AU  - Rédei, Dóra
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6186
AB  - Thirteen undescribed monoterpene-fused 5-methylcoumarins, named centrapalus coumarins A–M, were isolated from the aerial parts of the Centrapalus pauciflorus together with seven known compounds. The structures were established by extensive spectroscopic analyses, including 1D NMR, 2D NMR, and HR-ESI-MS experiments. The compounds represent a wide range of chemical diversity depending on the connection of the head-to-tail coupled diisoprene unit. Centrapalus coumarins A–H and I–L are based on 6–6–6- and 6–6-7-membered tricyclic ring systems, respectively. Centrapalus coumarins D and E exhibit cyclic hemiketal structures, while centrapalus coumarins F is unique because its monoterpene part forms an additional lactone ring. Centrapalus coumarin L is the only compound containing a modified trinor-monoterpene part. Centrapalus coumarin M is unprecedented as it contains a pentacyclic heterocyclic ring system. Sixteen isolated compounds were investigated for antiproliferative activity on the human breast (MCF-7 and MDA-MB-231), cervical (HeLa and SiHa), and ovarian (A2780) cancer-cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and a few of them exhibited substantial activity. Centrapalus coumarin F demonstrated the highest potency against MCF-7, HeLa, and A2780 cells with IC50 values of 6.59, 2.28, and 15.41 μM, respectively. The cytotoxic activity of centrapalus coumarin F showed moderate cancer selectivity, as determined using intact fibroblast cells (NIH-3 T3). The antiproliferative activity of these 5-methylcoumarin derivatives provides evidence for the establishment of structure–activity relationships.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity
VL  - 16
IS  - 6
SP  - 104777
DO  - 10.1016/j.arabjc.2023.104777
ER  - 
@article{
author = "Saidu, Muhammad Bello and Krstić, Gordana B. and Todorović, Nina and Berkecz, Róbert and Ali, Hazhmat and Zupkó, István and Hohmann, Judit and Rédei, Dóra",
year = "2023",
abstract = "Thirteen undescribed monoterpene-fused 5-methylcoumarins, named centrapalus coumarins A–M, were isolated from the aerial parts of the Centrapalus pauciflorus together with seven known compounds. The structures were established by extensive spectroscopic analyses, including 1D NMR, 2D NMR, and HR-ESI-MS experiments. The compounds represent a wide range of chemical diversity depending on the connection of the head-to-tail coupled diisoprene unit. Centrapalus coumarins A–H and I–L are based on 6–6–6- and 6–6-7-membered tricyclic ring systems, respectively. Centrapalus coumarins D and E exhibit cyclic hemiketal structures, while centrapalus coumarins F is unique because its monoterpene part forms an additional lactone ring. Centrapalus coumarin L is the only compound containing a modified trinor-monoterpene part. Centrapalus coumarin M is unprecedented as it contains a pentacyclic heterocyclic ring system. Sixteen isolated compounds were investigated for antiproliferative activity on the human breast (MCF-7 and MDA-MB-231), cervical (HeLa and SiHa), and ovarian (A2780) cancer-cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and a few of them exhibited substantial activity. Centrapalus coumarin F demonstrated the highest potency against MCF-7, HeLa, and A2780 cells with IC50 values of 6.59, 2.28, and 15.41 μM, respectively. The cytotoxic activity of centrapalus coumarin F showed moderate cancer selectivity, as determined using intact fibroblast cells (NIH-3 T3). The antiproliferative activity of these 5-methylcoumarin derivatives provides evidence for the establishment of structure–activity relationships.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity",
volume = "16",
number = "6",
pages = "104777",
doi = "10.1016/j.arabjc.2023.104777"
}
Saidu, M. B., Krstić, G. B., Todorović, N., Berkecz, R., Ali, H., Zupkó, I., Hohmann, J.,& Rédei, D.. (2023). Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity. in Arabian Journal of Chemistry
Elsevier., 16(6), 104777.
https://doi.org/10.1016/j.arabjc.2023.104777
Saidu MB, Krstić GB, Todorović N, Berkecz R, Ali H, Zupkó I, Hohmann J, Rédei D. Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity. in Arabian Journal of Chemistry. 2023;16(6):104777.
doi:10.1016/j.arabjc.2023.104777 .
Saidu, Muhammad Bello, Krstić, Gordana B., Todorović, Nina, Berkecz, Róbert, Ali, Hazhmat, Zupkó, István, Hohmann, Judit, Rédei, Dóra, "Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity" in Arabian Journal of Chemistry, 16, no. 6 (2023):104777,
https://doi.org/10.1016/j.arabjc.2023.104777 . .
1
1

Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus

Krstić, Gordana B.; Saidu, Muhammad Bello; Bombicz, Petra; De, Sourav; Ali, Hazhmat; Zupkó, István; Berkecz, Róbert; Gallah, Umar Shehu; Rédei, Dóra; Hohmann, Judit

(American Chemical Society, 2023)

TY  - JOUR
AU  - Krstić, Gordana B.
AU  - Saidu, Muhammad Bello
AU  - Bombicz, Petra
AU  - De, Sourav
AU  - Ali, Hazhmat
AU  - Zupkó, István
AU  - Berkecz, Róbert
AU  - Gallah, Umar Shehu
AU  - Rédei, Dóra
AU  - Hohmann, Judit
PY  - 2023
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6197
AB  - Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A–E (1–5), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of Centrapalus pauciflorus. Compounds 1–3 are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas 4 and 5 are dihydrochromone–monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A–E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC50 < 10 μM) in each case.
PB  - American Chemical Society
T2  - Journal of Natural Products
T1  - Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus
VL  - 86
IS  - 4
SP  - 891
EP  - 896
DO  - 10.1021/acs.jnatprod.2c01132
ER  - 
@article{
author = "Krstić, Gordana B. and Saidu, Muhammad Bello and Bombicz, Petra and De, Sourav and Ali, Hazhmat and Zupkó, István and Berkecz, Róbert and Gallah, Umar Shehu and Rédei, Dóra and Hohmann, Judit",
year = "2023",
abstract = "Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A–E (1–5), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of Centrapalus pauciflorus. Compounds 1–3 are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas 4 and 5 are dihydrochromone–monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A–E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC50 < 10 μM) in each case.",
publisher = "American Chemical Society",
journal = "Journal of Natural Products",
title = "Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus",
volume = "86",
number = "4",
pages = "891-896",
doi = "10.1021/acs.jnatprod.2c01132"
}
Krstić, G. B., Saidu, M. B., Bombicz, P., De, S., Ali, H., Zupkó, I., Berkecz, R., Gallah, U. S., Rédei, D.,& Hohmann, J.. (2023). Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus. in Journal of Natural Products
American Chemical Society., 86(4), 891-896.
https://doi.org/10.1021/acs.jnatprod.2c01132
Krstić GB, Saidu MB, Bombicz P, De S, Ali H, Zupkó I, Berkecz R, Gallah US, Rédei D, Hohmann J. Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus. in Journal of Natural Products. 2023;86(4):891-896.
doi:10.1021/acs.jnatprod.2c01132 .
Krstić, Gordana B., Saidu, Muhammad Bello, Bombicz, Petra, De, Sourav, Ali, Hazhmat, Zupkó, István, Berkecz, Róbert, Gallah, Umar Shehu, Rédei, Dóra, Hohmann, Judit, "Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus" in Journal of Natural Products, 86, no. 4 (2023):891-896,
https://doi.org/10.1021/acs.jnatprod.2c01132 . .
1
1