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Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636

Penjišević, Jelena ; Šukalović, Vladimir ; Dukić-Stefanović, Slađana; Deuther-Conrad, Winnie; Andrić, Deana ; Kostić-Rajačić, Slađana

TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 
@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}
Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845
Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .
Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry Royal Society of Chemistry., 21(6), 1187-1205. https://doi.org/10.1039/D2OB02119F

Aleksić, Jovana; Stojanović, Milovan; Bošković, Jakša; Baranac-Stojanović, Marija

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 
@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}
Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846
Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .
Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure

Milovanović, Milan R.; Nikolić, Stefan R.; Dupé, Antoine; Poljarević, Jelena M.; Schachner, Jörg A.

(2024-06)

TY  - CONF
AU  - Milovanović, Milan R.
AU  - Nikolić, Stefan R.
AU  - Dupé, Antoine
AU  - Poljarević, Jelena M.
AU  - Schachner, Jörg A.
PY  - 2024-06
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6559
AB  - A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.
C3  - 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia
T1  - The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6559
ER  - 
@conference{
author = "Milovanović, Milan R. and Nikolić, Stefan R. and Dupé, Antoine and Poljarević, Jelena M. and Schachner, Jörg A.",
year = "2024-06",
abstract = "A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.",
journal = "3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia",
title = "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6559"
}
Milovanović, M. R., Nikolić, S. R., Dupé, A., Poljarević, J. M.,& Schachner, J. A.. (2024-06). The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia.
https://hdl.handle.net/21.15107/rcub_cherry_6559
Milovanović MR, Nikolić SR, Dupé A, Poljarević JM, Schachner JA. The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6559 .
Milovanović, Milan R., Nikolić, Stefan R., Dupé, Antoine, Poljarević, Jelena M., Schachner, Jörg A., "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure" in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia (2024-06),
https://hdl.handle.net/21.15107/rcub_cherry_6559 .

Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)

Jednak Berić, Tanja; Vrvić, Miroslav; Lješević, Marija; Avdalović, Jelena; Ilić, Mila; Crnković, Dragan; Jovančićević, Branimir; Miletić, Srđan

(CSIRO Publishing, 2024)

TY  - GEN
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6580
AB  - Environmental context: Mitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents. Rationale: Bioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies. Methodology: In this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction. Results: In our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased. Discussion: The sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)
VL  - 21
IS  - 5
SP  - EN23111
ER  - 
@misc{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental context: Mitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents. Rationale: Bioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies. Methodology: In this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction. Results: In our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased. Discussion: The sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)",
volume = "21",
number = "5",
pages = "EN23111"
}
Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version). in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version). in Environmental Chemistry. 2024;21(5):EN23111..
Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage (pre-publication version)" in Environmental Chemistry, 21, no. 5 (2024):EN23111.

Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage

Jednak Berić, Tanja; Vrvić, Miroslav; Lješević, Marija; Avdalović, Jelena; Ilić, Mila; Crnković, Dragan; Jovančićević, Branimir; Miletić, Srđan

(CSIRO Publishing, 2024)

TY  - JOUR
AU  - Jednak Berić, Tanja
AU  - Vrvić, Miroslav
AU  - Lješević, Marija
AU  - Avdalović, Jelena
AU  - Ilić, Mila
AU  - Crnković, Dragan
AU  - Jovančićević, Branimir
AU  - Miletić, Srđan
PY  - 2024
UR  - https://cer.ihtm.bg.ac.rs/handle/123456789/7773
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6579
AB  - Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.
PB  - CSIRO Publishing
T2  - Environmental Chemistry
T1  - Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage
VL  - 21
IS  - 5
SP  - EN23111
DO  - 10.1071/EN23111
ER  - 
@article{
author = "Jednak Berić, Tanja and Vrvić, Miroslav and Lješević, Marija and Avdalović, Jelena and Ilić, Mila and Crnković, Dragan and Jovančićević, Branimir and Miletić, Srđan",
year = "2024",
abstract = "Environmental contextMitigating the environmental fallout of industrial accidents is crucial. In a recent study, researchers conducted tests on model substrates to explore the effectiveness of bioremediation in treating complex refinery contaminants resulting from both accidental and deliberate facility damage. The research reveals that bioremediation can be a promising, eco-friendly solution for cleaning up such pollutants, aligning with broader efforts to combat environmental harm resulting from industrial incidents.RationaleBioremediation harnesses microorganisms’ diverse metabolic abilities to detoxify and eliminate pollutants, particularly hydrocarbon-based ones such as oil. This natural biodegradation process performed by microorganisms is a cost-effective method for environmental cleanup compared to other remediation technologies.MethodologyIn this study, we examined the fate of heavy metals, cobalt and molybdenum, by the analysis of the basic chemical parameters of other sample components, such as n-hexane extractable substances and total petroleum hydrocarbons. The metal content was determined using inductively coupled plasma–optical emission spectrometry (ICP-OES). Exchangeable (loosely bound to the surface of particles and due to its high mobility and availability is crucial for understanding the potential immediate impact of metal contamination) and more stable fractions of the metal and the metal forms were determined using a sequential extraction method. The phase composition of the samples was determined by X-ray diffraction.ResultsIn our microbiological analysis, we isolated various cultures from a consortium of microorganisms. Basic chemical analysis indicators, such as n-hexane extractable substances, total petroleum hydrocarbons and humic acids, reflected robust microbiological activity. During the study, metals in exchangeable form decreased and those in more stable forms increased.DiscussionThe sequential extraction of cobalt and molybdenum revealed shifts in various metal fractions within the bioaugmented substrate post-bioremediation, differing from the initial substrate. These alterations in metal fractions are likely attributable to microbial actions, leading to the formation of more stable metal fractions throughout the bioremediation process.",
publisher = "CSIRO Publishing",
journal = "Environmental Chemistry",
title = "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage",
volume = "21",
number = "5",
pages = "EN23111",
doi = "10.1071/EN23111"
}
Jednak Berić, T., Vrvić, M., Lješević, M., Avdalović, J., Ilić, M., Crnković, D., Jovančićević, B.,& Miletić, S.. (2024). Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry
CSIRO Publishing., 21(5), EN23111.
https://doi.org/10.1071/EN23111
Jednak Berić T, Vrvić M, Lješević M, Avdalović J, Ilić M, Crnković D, Jovančićević B, Miletić S. Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage. in Environmental Chemistry. 2024;21(5):EN23111.
doi:10.1071/EN23111 .
Jednak Berić, Tanja, Vrvić, Miroslav, Lješević, Marija, Avdalović, Jelena, Ilić, Mila, Crnković, Dragan, Jovančićević, Branimir, Miletić, Srđan, "Testing of the bioremediation on model substrates for complex refinery contaminants arising from accidental or deliberate facility damage" in Environmental Chemistry, 21, no. 5 (2024):EN23111,
https://doi.org/10.1071/EN23111 . .

Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants

Kaseke, Tafadzwa; Jovanović, Vesna B.; Ćirković Veličković, Tanja

(University of Belgrade – Faculty of Chemistry, 2024)

TY  - CONF
AU  - Kaseke, Tafadzwa
AU  - Jovanović, Vesna B.
AU  - Ćirković Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6571
AB  - Infants are exposed to and ingest more micro-and nanoplastics (MNPs) than any other age group1; however, the effect of MNPs on the digestion of proteins in infants is not known. Therefore, the current study investigated the in vitro digestion of cow’s milk proteins in the presence of polypropylene MNPs (PP-MNPs) in simulated gastric fluids (SGF) using infant digestion model (pH=5.0; pepsin activity=268 U/mL). The simulated in vitro digestion of skimmed (<1% fat) cow’s milk proteins in infants in the presence of PP-MPs (20 mg/mL; 63–180 μm in size) was done at 37 °C for 5, 30, and 120 min. The in vitro digestion experiment was repeated with different concentrations of PP-NPs (125, 250, and 500 μg/mL) for 30 min. Another experiment was set up using adult gastrointestinal conditions (pH=3.0; pepsin activity=2000 U/mL) for comparison purposes2. The final concentration of the cow’s milk protein in the digestion mixture was 1 mg/mL. Then, proteins binding to the PP-MNPs were extracted from the soft corona and hard corona using the centrifugation method and protein profiles were analyzed using SDS-PAGE. The bands of proteins of interest were carefully excised from the gels and analysed by LC–MS/MS. Both PP-MPs and PP-NPs negatively affected the digestion of proteins in infants, and binding was observed in both the soft and hard corona. Meanwhile, no significant effects of both PP-MPs and PP-NPs on protein digestion were observed in adults. These results suggest possible interference of MNPs with the utilization of proteins in infants, which could have detrimental health effects.
PB  - University of Belgrade – Faculty of Chemistry
C3  - VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
T1  - Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants
SP  - 21
EP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6571
ER  - 
@conference{
author = "Kaseke, Tafadzwa and Jovanović, Vesna B. and Ćirković Veličković, Tanja",
year = "2024",
abstract = "Infants are exposed to and ingest more micro-and nanoplastics (MNPs) than any other age group1; however, the effect of MNPs on the digestion of proteins in infants is not known. Therefore, the current study investigated the in vitro digestion of cow’s milk proteins in the presence of polypropylene MNPs (PP-MNPs) in simulated gastric fluids (SGF) using infant digestion model (pH=5.0; pepsin activity=268 U/mL). The simulated in vitro digestion of skimmed (<1% fat) cow’s milk proteins in infants in the presence of PP-MPs (20 mg/mL; 63–180 μm in size) was done at 37 °C for 5, 30, and 120 min. The in vitro digestion experiment was repeated with different concentrations of PP-NPs (125, 250, and 500 μg/mL) for 30 min. Another experiment was set up using adult gastrointestinal conditions (pH=3.0; pepsin activity=2000 U/mL) for comparison purposes2. The final concentration of the cow’s milk protein in the digestion mixture was 1 mg/mL. Then, proteins binding to the PP-MNPs were extracted from the soft corona and hard corona using the centrifugation method and protein profiles were analyzed using SDS-PAGE. The bands of proteins of interest were carefully excised from the gels and analysed by LC–MS/MS. Both PP-MPs and PP-NPs negatively affected the digestion of proteins in infants, and binding was observed in both the soft and hard corona. Meanwhile, no significant effects of both PP-MPs and PP-NPs on protein digestion were observed in adults. These results suggest possible interference of MNPs with the utilization of proteins in infants, which could have detrimental health effects.",
publisher = "University of Belgrade – Faculty of Chemistry",
journal = "VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024",
title = "Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants",
pages = "21-21",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6571"
}
Kaseke, T., Jovanović, V. B.,& Ćirković Veličković, T.. (2024). Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024
University of Belgrade – Faculty of Chemistry., 21-21.
https://hdl.handle.net/21.15107/rcub_cherry_6571
Kaseke T, Jovanović VB, Ćirković Veličković T. Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants. in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024. 2024;:21-21.
https://hdl.handle.net/21.15107/rcub_cherry_6571 .
Kaseke, Tafadzwa, Jovanović, Vesna B., Ćirković Veličković, Tanja, "Polypropylene micro-and nanoplastics affects the digestion of cow's milk proteins in infants" in VII Symposium of the Serbian Proteomics Association – SePA “Application of proteomics in biomedicine”, Belgrade, Serbia June 6th, 2024 (2024):21-21,
https://hdl.handle.net/21.15107/rcub_cherry_6571 .

Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike

Komazec, Ksenija

(2024)

TY  - THES
AU  - Komazec, Ksenija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6542
AB  - Polietilen je plastični polimer čija upotreba je široko rasprostranjena, što negativno utiče na životnu sredinu usled nagomilavanja plastičnog otpada. Kako bi se ovo sprečilo, razvijaju se brojne metode za reciklažu i degradaciju ovakvog materijala. Jedna od često korišćenih metoda za degradaciju je pirolitičko razlaganje, koja je veoma efikasna ali dovodi do stvaranja različitih ugljovodonika niže molekulske mase ali i manjih plastičnih fragmenata. Zbog toga je cilj ovog rada da ispita mogućnost mikrobne degradacije materijala nastalog pirolizom polietilena. U ovom radu ispitivana je biodegradacija polietilenskog voska, dobijenog pirolizom na 600 i 650°C pomoću konzorcijuma mikroorganizama soja Rhodococcus, kao i čistim kulturama. Biodegradacija je praćena upotrebom sveobuhvatne dvodimenzionalne gasne hromatografije sa masenom spektrometrijom (GCxGC-MS), a dodatno, aktivnost mikroorgnaizama je praćena i pomoću respirometra.
T1  - Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike
SP  - 6
EP  - 30
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6542
ER  - 
@misc{
author = "Komazec, Ksenija",
year = "2024",
abstract = "Polietilen je plastični polimer čija upotreba je široko rasprostranjena, što negativno utiče na životnu sredinu usled nagomilavanja plastičnog otpada. Kako bi se ovo sprečilo, razvijaju se brojne metode za reciklažu i degradaciju ovakvog materijala. Jedna od često korišćenih metoda za degradaciju je pirolitičko razlaganje, koja je veoma efikasna ali dovodi do stvaranja različitih ugljovodonika niže molekulske mase ali i manjih plastičnih fragmenata. Zbog toga je cilj ovog rada da ispita mogućnost mikrobne degradacije materijala nastalog pirolizom polietilena. U ovom radu ispitivana je biodegradacija polietilenskog voska, dobijenog pirolizom na 600 i 650°C pomoću konzorcijuma mikroorganizama soja Rhodococcus, kao i čistim kulturama. Biodegradacija je praćena upotrebom sveobuhvatne dvodimenzionalne gasne hromatografije sa masenom spektrometrijom (GCxGC-MS), a dodatno, aktivnost mikroorgnaizama je praćena i pomoću respirometra.",
title = "Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike",
pages = "6-30",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6542"
}
Komazec, K.. (2024). Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike. , 6-30.
https://hdl.handle.net/21.15107/rcub_cherry_6542
Komazec K. Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike. 2024;:6-30.
https://hdl.handle.net/21.15107/rcub_cherry_6542 .
Komazec, Ksenija, "Ispitivanje mikrobiološke degradacije pirolizovane polietilenske plastike" (2024):6-30,
https://hdl.handle.net/21.15107/rcub_cherry_6542 .

Razvoj biokatalizatora za razgradnju poli(uretana)

Radivojević, Nikola

(2024)

TY  - THES
AU  - Radivojević, Nikola
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6543
AB  - Sveoubhvatni cilj ovog rada je bila izučavanje biodegradacija poliuretanskih polimera i razvoj efikasnog biokatalitičkog procesa.
T1  - Razvoj biokatalizatora za razgradnju poli(uretana)
SP  - 1
EP  - 58
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6543
ER  - 
@mastersthesis{
author = "Radivojević, Nikola",
year = "2024",
abstract = "Sveoubhvatni cilj ovog rada je bila izučavanje biodegradacija poliuretanskih polimera i razvoj efikasnog biokatalitičkog procesa.",
title = "Razvoj biokatalizatora za razgradnju poli(uretana)",
pages = "1-58",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6543"
}
Radivojević, N.. (2024). Razvoj biokatalizatora za razgradnju poli(uretana). , 1-58.
https://hdl.handle.net/21.15107/rcub_cherry_6543
Radivojević N. Razvoj biokatalizatora za razgradnju poli(uretana). 2024;:1-58.
https://hdl.handle.net/21.15107/rcub_cherry_6543 .
Radivojević, Nikola, "Razvoj biokatalizatora za razgradnju poli(uretana)" (2024):1-58,
https://hdl.handle.net/21.15107/rcub_cherry_6543 .

Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation

Trmčić, Milena; Vulović, Bojan; Zlatar, Matija; Saičić, Radomir

(ARKAT USA, Inc., 2024)

TY  - JOUR
AU  - Trmčić, Milena
AU  - Vulović, Bojan
AU  - Zlatar, Matija
AU  - Saičić, Radomir
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6536
AB  - Hemiacetals of cyclopropanone can be isolated and stocked, contrary to their highly reactive parent ketone.  However, they are not readily converted to cyclopropanone, which limits their use as its synthetic equivalents.  2,2,2-trifluoroethoxy hemiacetals are expected to be better cyclopropanone surrogates, however, they have  never been prepared, so far. We show that oxyallyl cations with a heteroatom in the -position can be  intercepted with 2,2,2-trifluoroethanol, with formation of cyclopropanone trifluoroethoxy hemiacetals stable  enough to be isolated, purified and characterized. These species can serve as synthetic equivalents of  cyclopropanone under mild conditions.
PB  - ARKAT USA, Inc.
T2  - ARKIVOC - Online Journal of Organic Chemistry
T1  - Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation
VL  - 2024
IS  - 2
DO  - 10.24820/ark.5550190.p012.123
ER  - 
@article{
author = "Trmčić, Milena and Vulović, Bojan and Zlatar, Matija and Saičić, Radomir",
year = "2024",
abstract = "Hemiacetals of cyclopropanone can be isolated and stocked, contrary to their highly reactive parent ketone.  However, they are not readily converted to cyclopropanone, which limits their use as its synthetic equivalents.  2,2,2-trifluoroethoxy hemiacetals are expected to be better cyclopropanone surrogates, however, they have  never been prepared, so far. We show that oxyallyl cations with a heteroatom in the -position can be  intercepted with 2,2,2-trifluoroethanol, with formation of cyclopropanone trifluoroethoxy hemiacetals stable  enough to be isolated, purified and characterized. These species can serve as synthetic equivalents of  cyclopropanone under mild conditions.",
publisher = "ARKAT USA, Inc.",
journal = "ARKIVOC - Online Journal of Organic Chemistry",
title = "Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation",
volume = "2024",
number = "2",
doi = "10.24820/ark.5550190.p012.123"
}
Trmčić, M., Vulović, B., Zlatar, M.,& Saičić, R.. (2024). Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation. in ARKIVOC - Online Journal of Organic Chemistry
ARKAT USA, Inc.., 2024(2).
https://doi.org/10.24820/ark.5550190.p012.123
Trmčić M, Vulović B, Zlatar M, Saičić R. Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation. in ARKIVOC - Online Journal of Organic Chemistry. 2024;2024(2).
doi:10.24820/ark.5550190.p012.123 .
Trmčić, Milena, Vulović, Bojan, Zlatar, Matija, Saičić, Radomir, "Preparation of cyclopropanone 2,2,2-trifluoroethoxy hemiacetals via oxyallyl cation" in ARKIVOC - Online Journal of Organic Chemistry, 2024, no. 2 (2024),
https://doi.org/10.24820/ark.5550190.p012.123 . .

The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study

Uzelac, Tamara; Takić, Marija; Stevanović, Vuk; Vidović, Nevena; Pantović, Ana; Jovanović, Petar; Jovanović, Vesna B.

(MDPI, 2024)

TY  - JOUR
AU  - Uzelac, Tamara
AU  - Takić, Marija
AU  - Stevanović, Vuk
AU  - Vidović, Nevena
AU  - Pantović, Ana
AU  - Jovanović, Petar
AU  - Jovanović, Vesna B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6575
AB  - Intensive physical activity (PA) can lead to proteinuria and, consequently, serum protein
profiles in athletes. Therefore, the aim of this study was to investigate the effects of acute aronia juice
consumption before a simulated half-marathon race on serum protein profiles in recreational runners.
The pilot study was designed as a single-blind, placebo-controlled, crossover study, with 10
male participants who consumed aronia juice (containing 1.3 g polyphenols) or placebo before the
race. The blood levels of total proteins, albumin, the non-albumin fractions gamma, beta, alpha2
and alpha1, as well as renal function parameters, were determined before and 15 min, 1 h and 24 h
after the race. The significant changes in urea, creatinine and uric acid levels were noticed at selected
time points in both groups. In the placebo group, a significant decrease in total proteins (p < 0.05)
was observed 24 h after the race, along with an increase in gamma fraction abundance (p < 0.05). In
addition, urea and uric acid levels returned to baseline only in the aronia group 24 h after the race.
Thus, according to the results obtained, acute aronia juice supplementation before intensive PA
could influence the transient change in renal function and PA-induced protein loss in recreational
runners.
PB  - MDPI
T2  - Healthcare
T1  - The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study
VL  - 12
SP  - 1276
DO  - 10.3390/healthcare12131276
ER  - 
@article{
author = "Uzelac, Tamara and Takić, Marija and Stevanović, Vuk and Vidović, Nevena and Pantović, Ana and Jovanović, Petar and Jovanović, Vesna B.",
year = "2024",
abstract = "Intensive physical activity (PA) can lead to proteinuria and, consequently, serum protein
profiles in athletes. Therefore, the aim of this study was to investigate the effects of acute aronia juice
consumption before a simulated half-marathon race on serum protein profiles in recreational runners.
The pilot study was designed as a single-blind, placebo-controlled, crossover study, with 10
male participants who consumed aronia juice (containing 1.3 g polyphenols) or placebo before the
race. The blood levels of total proteins, albumin, the non-albumin fractions gamma, beta, alpha2
and alpha1, as well as renal function parameters, were determined before and 15 min, 1 h and 24 h
after the race. The significant changes in urea, creatinine and uric acid levels were noticed at selected
time points in both groups. In the placebo group, a significant decrease in total proteins (p < 0.05)
was observed 24 h after the race, along with an increase in gamma fraction abundance (p < 0.05). In
addition, urea and uric acid levels returned to baseline only in the aronia group 24 h after the race.
Thus, according to the results obtained, acute aronia juice supplementation before intensive PA
could influence the transient change in renal function and PA-induced protein loss in recreational
runners.",
publisher = "MDPI",
journal = "Healthcare",
title = "The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study",
volume = "12",
pages = "1276",
doi = "10.3390/healthcare12131276"
}
Uzelac, T., Takić, M., Stevanović, V., Vidović, N., Pantović, A., Jovanović, P.,& Jovanović, V. B.. (2024). The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study. in Healthcare
MDPI., 12, 1276.
https://doi.org/10.3390/healthcare12131276
Uzelac T, Takić M, Stevanović V, Vidović N, Pantović A, Jovanović P, Jovanović VB. The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study. in Healthcare. 2024;12:1276.
doi:10.3390/healthcare12131276 .
Uzelac, Tamara, Takić, Marija, Stevanović, Vuk, Vidović, Nevena, Pantović, Ana, Jovanović, Petar, Jovanović, Vesna B., "The Potential Benefits of Acute Aronia Juice Supplementation on Physical Activity Induced Alterations of the Serum Protein Profiles in Recreational Runners: A Pilot Study" in Healthcare, 12 (2024):1276,
https://doi.org/10.3390/healthcare12131276 . .

Trypsin digestion of protein in beef meat extract in the presence of microplastics

Lujić, Tamara; Krstić Ristivojević, Maja; Gligorijević, Nikola; Stanić-Vučinić, Dragana; Wimmer, Lukas; Dailey, Lea Ann; Ćirković Veličković, Tanja

(FEBS Press, 2024)

TY  - CONF
AU  - Lujić, Tamara
AU  - Krstić Ristivojević, Maja
AU  - Gligorijević, Nikola
AU  - Stanić-Vučinić, Dragana
AU  - Wimmer, Lukas
AU  - Dailey, Lea Ann
AU  - Ćirković Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6576
AB  - Trypsin is the main protease in the intestine. Microplastics (MPs) have been previously shown to interact with and decrease the activity of some digestive enzymes, including pepsin and lipase. Red meat has been shown to be a source of allergy which has been linked to the galactose-alpha-1,3-galactose (alpha-Gal) posttranslational modification of proteins. Our aim was to investigate the effect of two types of MPs commonly found in the environment – polypropylene (PP) and polyethylene terephthalate (PET) – on the digestion of protein in beef meat extract and preservation of protein harboring the alpha-Gal epitope. Digestion of beef meat extract has been performed with trypsin in simulated intestinal fluid (SIF) in the presence of MPs. After digestion was stopped with a specific inhibitor, bulk beef meat extract was separated through centrifugation from the MPs. Soft coronas were obtained by washing the MPs with SIF. The hard corona was obtained by addition of a reducing buffer for electrophoresis sample preparation to the MPs with a heating step at 95°C. All samples were analyzed with SDS-PAG electrophoresis. Selected samples were further analyzed with anti-alpha-Gal antibodies using western blot. There is an observable difference between the digestion patterns of meat extract after 1 and 2 h of digestion in the presence of MPs compared to the control. Evolution of digestion is similar for both types of MPs, without regard to plastic type. It has also been confirmed that preserved proteins possess the alpha-Gal modification. As MPs presence does not change trypsin specific activity, the change in digestion pattern is presumed to be due to steric effects and/or interplay of enzyme/protein in the corona. This study suggests that MPs presence influences trypsin digestibility of meat proteins, including alpha-Gal-bearing allergens. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 965173.
PB  - FEBS Press
C3  - FEBS Open Bio, Mining biochemistry for human health and well‐being, 48th FEBS Congress, 29 June – 3 July 2024, Milano, Italy
T1  - Trypsin digestion of protein in beef meat extract in the presence of microplastics
VL  - 14
IS  - S2
SP  - 428
EP  - 428
DO  - 10.1002/2211-5463.13837
ER  - 
@conference{
author = "Lujić, Tamara and Krstić Ristivojević, Maja and Gligorijević, Nikola and Stanić-Vučinić, Dragana and Wimmer, Lukas and Dailey, Lea Ann and Ćirković Veličković, Tanja",
year = "2024",
abstract = "Trypsin is the main protease in the intestine. Microplastics (MPs) have been previously shown to interact with and decrease the activity of some digestive enzymes, including pepsin and lipase. Red meat has been shown to be a source of allergy which has been linked to the galactose-alpha-1,3-galactose (alpha-Gal) posttranslational modification of proteins. Our aim was to investigate the effect of two types of MPs commonly found in the environment – polypropylene (PP) and polyethylene terephthalate (PET) – on the digestion of protein in beef meat extract and preservation of protein harboring the alpha-Gal epitope. Digestion of beef meat extract has been performed with trypsin in simulated intestinal fluid (SIF) in the presence of MPs. After digestion was stopped with a specific inhibitor, bulk beef meat extract was separated through centrifugation from the MPs. Soft coronas were obtained by washing the MPs with SIF. The hard corona was obtained by addition of a reducing buffer for electrophoresis sample preparation to the MPs with a heating step at 95°C. All samples were analyzed with SDS-PAG electrophoresis. Selected samples were further analyzed with anti-alpha-Gal antibodies using western blot. There is an observable difference between the digestion patterns of meat extract after 1 and 2 h of digestion in the presence of MPs compared to the control. Evolution of digestion is similar for both types of MPs, without regard to plastic type. It has also been confirmed that preserved proteins possess the alpha-Gal modification. As MPs presence does not change trypsin specific activity, the change in digestion pattern is presumed to be due to steric effects and/or interplay of enzyme/protein in the corona. This study suggests that MPs presence influences trypsin digestibility of meat proteins, including alpha-Gal-bearing allergens. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 965173.",
publisher = "FEBS Press",
journal = "FEBS Open Bio, Mining biochemistry for human health and well‐being, 48th FEBS Congress, 29 June – 3 July 2024, Milano, Italy",
title = "Trypsin digestion of protein in beef meat extract in the presence of microplastics",
volume = "14",
number = "S2",
pages = "428-428",
doi = "10.1002/2211-5463.13837"
}
Lujić, T., Krstić Ristivojević, M., Gligorijević, N., Stanić-Vučinić, D., Wimmer, L., Dailey, L. A.,& Ćirković Veličković, T.. (2024). Trypsin digestion of protein in beef meat extract in the presence of microplastics. in FEBS Open Bio, Mining biochemistry for human health and well‐being, 48th FEBS Congress, 29 June – 3 July 2024, Milano, Italy
FEBS Press., 14(S2), 428-428.
https://doi.org/10.1002/2211-5463.13837
Lujić T, Krstić Ristivojević M, Gligorijević N, Stanić-Vučinić D, Wimmer L, Dailey LA, Ćirković Veličković T. Trypsin digestion of protein in beef meat extract in the presence of microplastics. in FEBS Open Bio, Mining biochemistry for human health and well‐being, 48th FEBS Congress, 29 June – 3 July 2024, Milano, Italy. 2024;14(S2):428-428.
doi:10.1002/2211-5463.13837 .
Lujić, Tamara, Krstić Ristivojević, Maja, Gligorijević, Nikola, Stanić-Vučinić, Dragana, Wimmer, Lukas, Dailey, Lea Ann, Ćirković Veličković, Tanja, "Trypsin digestion of protein in beef meat extract in the presence of microplastics" in FEBS Open Bio, Mining biochemistry for human health and well‐being, 48th FEBS Congress, 29 June – 3 July 2024, Milano, Italy, 14, no. S2 (2024):428-428,
https://doi.org/10.1002/2211-5463.13837 . .

Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood

Jakovljević, Danijel; Nikolić, Milan; Jovanović, Vesna B.; Vidonja Uzelac, Teodora; Nikolić-Kokić, Aleksandra; Novaković, Emilija; Miljević, Čedo; Milovanović, Maja; Blagojević, Duško

(MDPI, 2024)

TY  - JOUR
AU  - Jakovljević, Danijel
AU  - Nikolić, Milan
AU  - Jovanović, Vesna B.
AU  - Vidonja Uzelac, Teodora
AU  - Nikolić-Kokić, Aleksandra
AU  - Novaković, Emilija
AU  - Miljević, Čedo
AU  - Milovanović, Maja
AU  - Blagojević, Duško
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6574
AB  - Background: Epilepsy is a chronic brain disease affecting millions of people worldwide,
but little is known about the impact of anti-seizure medications on redox homeostasis. Methods:
This study aimed to compare the effects of the long-term use of oral anti-seizure medications in
monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase,
catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin
content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and
total glutathione in the plasma of epilepsy patients and drug-naïve patients. Results: The results
showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower
concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the
other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide
dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed
(p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in
erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls
were separated from all others. Conclusions: Monotherapy with anti-seizure medications discretely
alters redox homeostasis, followed by distinct relationships between antioxidant components.
PB  - MDPI
T2  - Pharmaceuticals
T1  - Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood
VL  - 17
IS  - 1
SP  - 130
DO  - 10.3390/ph17010130
ER  - 
@article{
author = "Jakovljević, Danijel and Nikolić, Milan and Jovanović, Vesna B. and Vidonja Uzelac, Teodora and Nikolić-Kokić, Aleksandra and Novaković, Emilija and Miljević, Čedo and Milovanović, Maja and Blagojević, Duško",
year = "2024",
abstract = "Background: Epilepsy is a chronic brain disease affecting millions of people worldwide,
but little is known about the impact of anti-seizure medications on redox homeostasis. Methods:
This study aimed to compare the effects of the long-term use of oral anti-seizure medications in
monotherapy (lamotrigine, carbamazepine, and valproate) on antioxidant enzymes: superoxide dismutase,
catalase, glutathione peroxidase, glutathione reductase, haemoglobin, and methaemoglobin
content in erythrocytes, and concentrations of total proteins and thiols, nitrites, lipid peroxides and
total glutathione in the plasma of epilepsy patients and drug-naïve patients. Results: The results
showed that lamotrigine therapy led to lower superoxide dismutase activity (p < 0.005) and lower
concentrations of total thiols (p < 0.01) and lipid peroxides (p < 0.01) compared to controls. On the
other hand, therapy with carbamazepine increased nitrite levels (p < 0.01) but reduced superoxide
dismutase activity (p < 0.005). In the valproate group, only a decrease in catalase activity was observed
(p < 0.005). Canonical discriminant analysis showed that the composition of antioxidant enzymes in
erythrocytes was different for both the lamotrigine and carbamazepine groups, while the controls
were separated from all others. Conclusions: Monotherapy with anti-seizure medications discretely
alters redox homeostasis, followed by distinct relationships between antioxidant components.",
publisher = "MDPI",
journal = "Pharmaceuticals",
title = "Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood",
volume = "17",
number = "1",
pages = "130",
doi = "10.3390/ph17010130"
}
Jakovljević, D., Nikolić, M., Jovanović, V. B., Vidonja Uzelac, T., Nikolić-Kokić, A., Novaković, E., Miljević, Č., Milovanović, M.,& Blagojević, D.. (2024). Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood. in Pharmaceuticals
MDPI., 17(1), 130.
https://doi.org/10.3390/ph17010130
Jakovljević D, Nikolić M, Jovanović VB, Vidonja Uzelac T, Nikolić-Kokić A, Novaković E, Miljević Č, Milovanović M, Blagojević D. Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood. in Pharmaceuticals. 2024;17(1):130.
doi:10.3390/ph17010130 .
Jakovljević, Danijel, Nikolić, Milan, Jovanović, Vesna B., Vidonja Uzelac, Teodora, Nikolić-Kokić, Aleksandra, Novaković, Emilija, Miljević, Čedo, Milovanović, Maja, Blagojević, Duško, "Influence of Long-Term Anti-Seizure Medications on Redox Parameters in Human Blood" in Pharmaceuticals, 17, no. 1 (2024):130,
https://doi.org/10.3390/ph17010130 . .

Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome

Takić, Marija; Ranković, Slavica; Girek, Zdenka; Pavlović, Suzana; Jovanović, Petar; Jovanović, Vesna B.

(MDPI, 2024)

TY  - JOUR
AU  - Takić, Marija
AU  - Ranković, Slavica
AU  - Girek, Zdenka
AU  - Pavlović, Suzana
AU  - Jovanović, Petar
AU  - Jovanović, Vesna B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6573
AB  - The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to
oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can
be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes),
and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation
to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency
(particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins.
At this moment, data in the literature about the effects of ALA supplementation on metabolic
syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all
MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation,
blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its
conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects
on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin
secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct
effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent
findings on this topic and discusses the possible mechanisms.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome
VL  - 25
IS  - 9
SP  - 4909
DO  - 10.3390/ijms25094909
ER  - 
@article{
author = "Takić, Marija and Ranković, Slavica and Girek, Zdenka and Pavlović, Suzana and Jovanović, Petar and Jovanović, Vesna B.",
year = "2024",
abstract = "The plant-derived α-linolenic acid (ALA) is an essential n-3 acid highly susceptible to
oxidation, present in oils of flaxseeds, walnuts, canola, perilla, soy, and chia. After ingestion, it can
be incorporated in to body lipid pools (particularly triglycerides and phospholipid membranes),
and then endogenously metabolized through desaturation, elongation, and peroxisome oxidation
to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with a very limited efficiency
(particularly for DHA), beta-oxidized as an energy source, or directly metabolized to C18-oxilipins.
At this moment, data in the literature about the effects of ALA supplementation on metabolic
syndrome (MetS) in humans are inconsistent, indicating no effects or some positive effects on all
MetS components (abdominal obesity, dyslipidemia, impaired insulin sensitivity and glucoregulation,
blood pressure, and liver steatosis). The major effects of ALA on MetS seem to be through its
conversion to more potent EPA and DHA, the impact on the n-3/n-6 ratio, and the consecutive effects
on the formation of oxylipins and endocannabinoids, inflammation, insulin sensitivity, and insulin
secretion, as well as adipocyte and hepatocytes function. It is important to distinguish the direct
effects of ALA from the effects of EPA and DHA metabolites. This review summarizes the most recent
findings on this topic and discusses the possible mechanisms.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome",
volume = "25",
number = "9",
pages = "4909",
doi = "10.3390/ijms25094909"
}
Takić, M., Ranković, S., Girek, Z., Pavlović, S., Jovanović, P.,& Jovanović, V. B.. (2024). Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences
MDPI., 25(9), 4909.
https://doi.org/10.3390/ijms25094909
Takić M, Ranković S, Girek Z, Pavlović S, Jovanović P, Jovanović VB. Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome. in International Journal of Molecular Sciences. 2024;25(9):4909.
doi:10.3390/ijms25094909 .
Takić, Marija, Ranković, Slavica, Girek, Zdenka, Pavlović, Suzana, Jovanović, Petar, Jovanović, Vesna B., "Current Insights into the Effects of Dietary α-Linolenic Acid Focusing on Alterations of Polyunsaturated Fatty Acid Profiles in Metabolic Syndrome" in International Journal of Molecular Sciences, 25, no. 9 (2024):4909,
https://doi.org/10.3390/ijms25094909 . .

Chemical defence of a centipede (Clinopodes flavidus)

Mitić, Bojan; Jovanović, Vesna B.; Todosijević, Marina M.; Eckhard, Margret; Vasiljević, Ljubica; Tešević, Vele; Vujisić, Ljubodrag

(Elsevier, 2024)

TY  - JOUR
AU  - Mitić, Bojan
AU  - Jovanović, Vesna B.
AU  - Todosijević, Marina M.
AU  - Eckhard, Margret
AU  - Vasiljević, Ljubica
AU  - Tešević, Vele
AU  - Vujisić, Ljubodrag
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6572
AB  - Chemical substances are of utmost importance for the biotic interactions between animals and their predators/
parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic
biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes
and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the
biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda). The cyanogenic
secretion of Clinopodes flavidus is discharged from the ventral glands, whose glandular units are located in the
space between the cuticle and the trunk muscles and do not extend deep into the segment. In addition to
hydrogen cyanide, the ventral secretion contains 2-methylpentanoic acid, benzaldehyde, benzoyl cyanide, 2-
methyl branched C-9 carboxylic acid (tentatively identified as 2-methyloctanoic acid), methyl 2-phenylacetate,
benzoic acid and mandelonitrile as well as four major proteins with a molecular weight of 150, 66.2, 59 and 55
kDa. The correlation between the presence of ventral glands and guarding with the female’s ventral side facing
away from the eggs and young indicates a functional link between these two traits. We hope that the specificity of
the chemical composition of the ventral secretion could serve as a criterion for chemotaxonomy and that the
analysis of more species will help to clarify the phylogenetic relationships within the Geophilomorpha.
PB  - Elsevier
T2  - Journal of Insect Physiology
T1  - Chemical defence of a centipede (Clinopodes flavidus)
VL  - 155
SP  - 104649
DO  - 10.1016/j.jinsphys.2024.104649
ER  - 
@article{
author = "Mitić, Bojan and Jovanović, Vesna B. and Todosijević, Marina M. and Eckhard, Margret and Vasiljević, Ljubica and Tešević, Vele and Vujisić, Ljubodrag",
year = "2024",
abstract = "Chemical substances are of utmost importance for the biotic interactions between animals and their predators/
parasites; many of these semiochemicals are emitted for defence purposes. One of the most deterrent and toxic
biogenic substances we know of is hydrogen cyanide, which can be stored by certain insects, millipedes, centipedes
and arachnids in the form of stable and less volatile molecules. The aim of this study was to analyse the
biology and chemistry of such a defence mechanism in a geophilomorph centipede (Chilopoda). The cyanogenic
secretion of Clinopodes flavidus is discharged from the ventral glands, whose glandular units are located in the
space between the cuticle and the trunk muscles and do not extend deep into the segment. In addition to
hydrogen cyanide, the ventral secretion contains 2-methylpentanoic acid, benzaldehyde, benzoyl cyanide, 2-
methyl branched C-9 carboxylic acid (tentatively identified as 2-methyloctanoic acid), methyl 2-phenylacetate,
benzoic acid and mandelonitrile as well as four major proteins with a molecular weight of 150, 66.2, 59 and 55
kDa. The correlation between the presence of ventral glands and guarding with the female’s ventral side facing
away from the eggs and young indicates a functional link between these two traits. We hope that the specificity of
the chemical composition of the ventral secretion could serve as a criterion for chemotaxonomy and that the
analysis of more species will help to clarify the phylogenetic relationships within the Geophilomorpha.",
publisher = "Elsevier",
journal = "Journal of Insect Physiology",
title = "Chemical defence of a centipede (Clinopodes flavidus)",
volume = "155",
pages = "104649",
doi = "10.1016/j.jinsphys.2024.104649"
}
Mitić, B., Jovanović, V. B., Todosijević, M. M., Eckhard, M., Vasiljević, L., Tešević, V.,& Vujisić, L.. (2024). Chemical defence of a centipede (Clinopodes flavidus). in Journal of Insect Physiology
Elsevier., 155, 104649.
https://doi.org/10.1016/j.jinsphys.2024.104649
Mitić B, Jovanović VB, Todosijević MM, Eckhard M, Vasiljević L, Tešević V, Vujisić L. Chemical defence of a centipede (Clinopodes flavidus). in Journal of Insect Physiology. 2024;155:104649.
doi:10.1016/j.jinsphys.2024.104649 .
Mitić, Bojan, Jovanović, Vesna B., Todosijević, Marina M., Eckhard, Margret, Vasiljević, Ljubica, Tešević, Vele, Vujisić, Ljubodrag, "Chemical defence of a centipede (Clinopodes flavidus)" in Journal of Insect Physiology, 155 (2024):104649,
https://doi.org/10.1016/j.jinsphys.2024.104649 . .

Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study

Jakšić, Jovana; Milinković, Evgenija; Cvetanović, Katarina; Tokić Vujošević, Zorana; Jovanov, Vladislav; Mitrović, Aleksandra D.; Maslak, Veselin

(2024)

TY  - JOUR
AU  - Jakšić, Jovana
AU  - Milinković, Evgenija
AU  - Cvetanović, Katarina
AU  - Tokić Vujošević, Zorana
AU  - Jovanov, Vladislav
AU  - Mitrović, Aleksandra D.
AU  - Maslak, Veselin
PY  - 2024
UR  - https://pubs.rsc.org/en/content/articlelanding/2024/cp/d3cp04322c
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6422
AB  - In this study,we conducted a comprehensive investigation of newly synthesized fullerene derivatives developed for potential application in perovskite solar cells (PSCs). We explored three novel dihydrofuran-fused C60 fullerene derivatives (13, 14, and 15) that we respecifically designed to enhance solubility and interaction with the substrate, fluorine-dopedtinoxide (FTO). A comparative analysis was performed, with reference to the widely used phenyl-C61-butyric acid methyl ester (PCBM) and compound 12, from which 13, 14, and 15 are derived, to assess the impact of sugar units on materials properties.The synthesized compounds demonstrated significant solubility in common organic solvents, a critical factor in their potential application in wet-processed PSCs. Our investigation included electrochemical property analysis, thin film deposition, surface characterization, and electrochemical impedance spectroscopy (EIS). EIS measurements unveiled key in sights into charge transfer properties at the electrode/electrolyte interface, making the compounds attractive candidates for electron transport layers (ETLs) in PSCs.
T2  - Physical Chemistry Chemical Physics
T1  - Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study
VL  - 26
IS  - 1
SP  - 517
EP  - 523
DO  - 10.1039/D3CP04322C
ER  - 
@article{
author = "Jakšić, Jovana and Milinković, Evgenija and Cvetanović, Katarina and Tokić Vujošević, Zorana and Jovanov, Vladislav and Mitrović, Aleksandra D. and Maslak, Veselin",
year = "2024",
abstract = "In this study,we conducted a comprehensive investigation of newly synthesized fullerene derivatives developed for potential application in perovskite solar cells (PSCs). We explored three novel dihydrofuran-fused C60 fullerene derivatives (13, 14, and 15) that we respecifically designed to enhance solubility and interaction with the substrate, fluorine-dopedtinoxide (FTO). A comparative analysis was performed, with reference to the widely used phenyl-C61-butyric acid methyl ester (PCBM) and compound 12, from which 13, 14, and 15 are derived, to assess the impact of sugar units on materials properties.The synthesized compounds demonstrated significant solubility in common organic solvents, a critical factor in their potential application in wet-processed PSCs. Our investigation included electrochemical property analysis, thin film deposition, surface characterization, and electrochemical impedance spectroscopy (EIS). EIS measurements unveiled key in sights into charge transfer properties at the electrode/electrolyte interface, making the compounds attractive candidates for electron transport layers (ETLs) in PSCs.",
journal = "Physical Chemistry Chemical Physics",
title = "Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study",
volume = "26",
number = "1",
pages = "517-523",
doi = "10.1039/D3CP04322C"
}
Jakšić, J., Milinković, E., Cvetanović, K., Tokić Vujošević, Z., Jovanov, V., Mitrović, A. D.,& Maslak, V.. (2024). Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study. in Physical Chemistry Chemical Physics, 26(1), 517-523.
https://doi.org/10.1039/D3CP04322C
Jakšić J, Milinković E, Cvetanović K, Tokić Vujošević Z, Jovanov V, Mitrović AD, Maslak V. Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study. in Physical Chemistry Chemical Physics. 2024;26(1):517-523.
doi:10.1039/D3CP04322C .
Jakšić, Jovana, Milinković, Evgenija, Cvetanović, Katarina, Tokić Vujošević, Zorana, Jovanov, Vladislav, Mitrović, Aleksandra D., Maslak, Veselin, "Exploring fullerene derivatives for optoelectronic applications: synthesis and characterization study" in Physical Chemistry Chemical Physics, 26, no. 1 (2024):517-523,
https://doi.org/10.1039/D3CP04322C . .

Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom

Pašić, Tijana

(2024)

TY  - THES
AU  - Pašić, Tijana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6474
AB  - Cilj rada je bila sinteza model jedinjenja lignina obleženog sa kumarinskom fluoroforom. Ciljni molekuli su dobri modeli za proučavanje delovanja različitih enzima na lignine, kao i zbog širokog spektra bioloških aktivnosti koje poseduju ove klase jedinjenja.
T1  - Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom
SP  - 1
EP  - 27
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6474
ER  - 
@misc{
author = "Pašić, Tijana",
year = "2024",
abstract = "Cilj rada je bila sinteza model jedinjenja lignina obleženog sa kumarinskom fluoroforom. Ciljni molekuli su dobri modeli za proučavanje delovanja različitih enzima na lignine, kao i zbog širokog spektra bioloških aktivnosti koje poseduju ove klase jedinjenja.",
title = "Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom",
pages = "1-27",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6474"
}
Pašić, T.. (2024). Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom. , 1-27.
https://hdl.handle.net/21.15107/rcub_cherry_6474
Pašić T. Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom. 2024;:1-27.
https://hdl.handle.net/21.15107/rcub_cherry_6474 .
Pašić, Tijana, "Dizajn i sinteza modela lignina obeleženog sa 4-metil-7-hidroksikumarinom" (2024):1-27,
https://hdl.handle.net/21.15107/rcub_cherry_6474 .

Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets

Mutić, Tamara; Stanić-Vučinić, Dragana; Mutić, Jelena; Ilić, Miloš; Jovanović, Vesna B.; Aćimović, Jelena; Anđelković, Boban; Krishna de Guzman, Maria; Anđelković, Mirjana; Turkalj, Mirjana; Ćirković Veličković, Tanja

(2024)

TY  - DATA
AU  - Mutić, Tamara
AU  - Stanić-Vučinić, Dragana
AU  - Mutić, Jelena
AU  - Ilić, Miloš
AU  - Jovanović, Vesna B.
AU  - Aćimović, Jelena
AU  - Anđelković, Boban
AU  - Krishna de Guzman, Maria
AU  - Anđelković, Mirjana
AU  - Turkalj, Mirjana
AU  - Ćirković Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6484
AB  - The experimental data for the results shown in the manuscript "Microplastic contamination of edible parts of commercially important mussels, clams and shrimps in different markets". Statistical investigation of the presence of microplastics in bivalve species using microFTIR. This dataset includes samples from various origins, including Sebia, South Korea, Croatia and Belgium, and includes species as diverse as shrimp, mussels and clams.
T1  - Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6484
ER  - 
@misc{
author = "Mutić, Tamara and Stanić-Vučinić, Dragana and Mutić, Jelena and Ilić, Miloš and Jovanović, Vesna B. and Aćimović, Jelena and Anđelković, Boban and Krishna de Guzman, Maria and Anđelković, Mirjana and Turkalj, Mirjana and Ćirković Veličković, Tanja",
year = "2024",
abstract = "The experimental data for the results shown in the manuscript "Microplastic contamination of edible parts of commercially important mussels, clams and shrimps in different markets". Statistical investigation of the presence of microplastics in bivalve species using microFTIR. This dataset includes samples from various origins, including Sebia, South Korea, Croatia and Belgium, and includes species as diverse as shrimp, mussels and clams.",
title = "Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6484"
}
Mutić, T., Stanić-Vučinić, D., Mutić, J., Ilić, M., Jovanović, V. B., Aćimović, J., Anđelković, B., Krishna de Guzman, M., Anđelković, M., Turkalj, M.,& Ćirković Veličković, T.. (2024). Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets. .
https://hdl.handle.net/21.15107/rcub_cherry_6484
Mutić T, Stanić-Vučinić D, Mutić J, Ilić M, Jovanović VB, Aćimović J, Anđelković B, Krishna de Guzman M, Anđelković M, Turkalj M, Ćirković Veličković T. Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6484 .
Mutić, Tamara, Stanić-Vučinić, Dragana, Mutić, Jelena, Ilić, Miloš, Jovanović, Vesna B., Aćimović, Jelena, Anđelković, Boban, Krishna de Guzman, Maria, Anđelković, Mirjana, Turkalj, Mirjana, Ćirković Veličković, Tanja, "Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets" (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6484 .

The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding

Uzelac, Tamara N.; Smiljanić, Katarina; Takić, Marija; Sarac, Ivana; Petovic-Oggiano, Gordana; Nikolić, Milan; Jovanović, Vesna B.

(MDPI, 2024)

TY  - JOUR
AU  - Uzelac, Tamara N.
AU  - Smiljanić, Katarina
AU  - Takić, Marija
AU  - Sarac, Ivana
AU  - Petovic-Oggiano, Gordana
AU  - Nikolić, Milan
AU  - Jovanović, Vesna B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6429
AB  - The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding
VL  - 5
SP  - 2335
DO  - 10.3390/ijms25042335
ER  - 
@article{
author = "Uzelac, Tamara N. and Smiljanić, Katarina and Takić, Marija and Sarac, Ivana and Petovic-Oggiano, Gordana and Nikolić, Milan and Jovanović, Vesna B.",
year = "2024",
abstract = "The binding of ubiquitous serum ligands (free fatty acids) to human serum albumin (HSA)
or its glycation can affect thiol group reactivity, thus influencing its antioxidant activity. The effects
of stearic acid (SA) and glucose binding on HSA structural changes and thiol group content and
reactivity were monitored by fluoroscopy and the Ellman method during a 14-day incubation in
molar ratios to HSA that mimic pathophysiological conditions. Upon incubation with 5 mM glucose,
HSA glycation was the same as HSA without it, in three different HSA:SA molar ratios (HSA:SA-
1:1-2-4). The protective effect of SA on the antioxidant property of HSA under different glucose
regimes (5-10-20 mM) was significantly affected by molar ratios of HSA:SA. Thiol reactivity was fully
restored with 5–20 mM glucose at a 1:1 HSA:SA ratio, while the highest thiol content recovery was in
pathological glucose regimes at a 1:1 HSA:SA ratio. The SA affinity for HSA increased significantly
(1.5- and 1.3-fold, p < 0.01) with 5 and 10 mM glucose compared to the control. These results deepen
the knowledge about the possible regulation of the antioxidant role of HSA in diabetes and other
pathophysiological conditions and enable the design of future HSA-drug studies which, in turn, is
important for clinicians when designing information-based treatments.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding",
volume = "5",
pages = "2335",
doi = "10.3390/ijms25042335"
}
Uzelac, T. N., Smiljanić, K., Takić, M., Sarac, I., Petovic-Oggiano, G., Nikolić, M.,& Jovanović, V. B.. (2024). The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences
MDPI., 5, 2335.
https://doi.org/10.3390/ijms25042335
Uzelac TN, Smiljanić K, Takić M, Sarac I, Petovic-Oggiano G, Nikolić M, Jovanović VB. The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding. in International Journal of Molecular Sciences. 2024;5:2335.
doi:10.3390/ijms25042335 .
Uzelac, Tamara N., Smiljanić, Katarina, Takić, Marija, Sarac, Ivana, Petovic-Oggiano, Gordana, Nikolić, Milan, Jovanović, Vesna B., "The Thiol Group Reactivity and the Antioxidant Property of Human Serum Albumin Are Controlled by the Joint Action of Fatty Acids and Glucose Binding" in International Journal of Molecular Sciences, 5 (2024):2335,
https://doi.org/10.3390/ijms25042335 . .

Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911

Petrović, Tamara; Dimitrijević, Marija; Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Vlahović, Filip; Grgurić-Šipka, Sanja; Mihajilov-Krstev, Tatjana; Miladinović, Dragoljub; Poljarević, Jelena

(Taylor & Francis, 2024)

TY  - DATA
AU  - Petrović, Tamara
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Vlahović, Filip
AU  - Grgurić-Šipka, Sanja
AU  - Mihajilov-Krstev, Tatjana
AU  - Miladinović, Dragoljub
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6570
AB  - Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The chemical structures and purity of synthesized compounds were confirmed using standard analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental analysis, and their electrochemical behavior was evaluated using cyclic voltammetry experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands (L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic microorganisms and two reference bacterial strains, using the micro-well dilution method. The highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial activity of synthesized compounds.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911
VL  - 77
IS  - 7-8
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6570
ER  - 
@misc{
author = "Petrović, Tamara and Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Vlahović, Filip and Grgurić-Šipka, Sanja and Mihajilov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena",
year = "2024",
abstract = "Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The chemical structures and purity of synthesized compounds were confirmed using standard analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental analysis, and their electrochemical behavior was evaluated using cyclic voltammetry experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands (L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic microorganisms and two reference bacterial strains, using the micro-well dilution method. The highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial activity of synthesized compounds.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911",
volume = "77",
number = "7-8",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6570"
}
Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911. in Journal of Coordination Chemistry
Taylor & Francis., 77(7-8).
https://hdl.handle.net/21.15107/rcub_cherry_6570
Petrović T, Dimitrijević M, Mihajlović-Lalić L, Stanković D, Vlahović F, Grgurić-Šipka S, Mihajilov-Krstev T, Miladinović D, Poljarević J. Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911. in Journal of Coordination Chemistry. 2024;77(7-8).
https://hdl.handle.net/21.15107/rcub_cherry_6570 .
Petrović, Tamara, Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Vlahović, Filip, Grgurić-Šipka, Sanja, Mihajilov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Supplementary material for the article: Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry Taylor & Francis., 77(7-8), 750-765. https://doi.org/10.1080/00958972.2024.2307911" in Journal of Coordination Chemistry, 77, no. 7-8 (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6570 .

Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes

Petrović, Tamara; Dimitrijević, Marija; Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Vlahović, Filip; Grgurić-Šipka, Sanja; Mihajilov-Krstev, Tatjana; Miladinović, Dragoljub; Poljarević, Jelena

(Taylor & Francis, 2024)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Vlahović, Filip
AU  - Grgurić-Šipka, Sanja
AU  - Mihajilov-Krstev, Tatjana
AU  - Miladinović, Dragoljub
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6569
AB  - Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The chemical structures and purity of synthesized compounds were confirmed using standard analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental analysis, and their electrochemical behavior was evaluated using cyclic voltammetry experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands (L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic microorganisms and two reference bacterial strains, using the micro-well dilution method. The highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial activity of synthesized compounds.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes
VL  - 77
IS  - 7-8
SP  - 750
EP  - 765
DO  - 10.1080/00958972.2024.2307911
ER  - 
@article{
author = "Petrović, Tamara and Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Vlahović, Filip and Grgurić-Šipka, Sanja and Mihajilov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena",
year = "2024",
abstract = "Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The chemical structures and purity of synthesized compounds were confirmed using standard analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental analysis, and their electrochemical behavior was evaluated using cyclic voltammetry experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands (L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic microorganisms and two reference bacterial strains, using the micro-well dilution method. The highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial activity of synthesized compounds.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes",
volume = "77",
number = "7-8",
pages = "750-765",
doi = "10.1080/00958972.2024.2307911"
}
Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry
Taylor & Francis., 77(7-8), 750-765.
https://doi.org/10.1080/00958972.2024.2307911
Petrović T, Dimitrijević M, Mihajlović-Lalić L, Stanković D, Vlahović F, Grgurić-Šipka S, Mihajilov-Krstev T, Miladinović D, Poljarević J. Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry. 2024;77(7-8):750-765.
doi:10.1080/00958972.2024.2307911 .
Petrović, Tamara, Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Vlahović, Filip, Grgurić-Šipka, Sanja, Mihajilov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes" in Journal of Coordination Chemistry, 77, no. 7-8 (2024):750-765,
https://doi.org/10.1080/00958972.2024.2307911 . .

Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes

Petrović, Tamara; Dimitrijević, Marija; Mihajlović-Lalić, Ljiljana; Stanković, Dalibor; Vlahović, Filip; Grgurić-Šipka, Sanja; Mihajilov-Krstev, Tatjana; Miladinović, Dragoljub; Poljarević, Jelena

(Taylor & Francis, 2024)

TY  - JOUR
AU  - Petrović, Tamara
AU  - Dimitrijević, Marija
AU  - Mihajlović-Lalić, Ljiljana
AU  - Stanković, Dalibor
AU  - Vlahović, Filip
AU  - Grgurić-Šipka, Sanja
AU  - Mihajilov-Krstev, Tatjana
AU  - Miladinović, Dragoljub
AU  - Poljarević, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6568
AB  - Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3
amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5
chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and 
C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The 
chemical structures and purity of synthesized compounds were confirmed using standard 
analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental 
analysis, and their electrochemical behavior was evaluated using cyclic voltammetry 
experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was 
confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex 
precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands 
(L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic 
microorganisms and two reference bacterial strains, using the micro-well dilution method. The 
highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and 
S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. 
albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed 
examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. 
Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial 
activity of synthesized compounds.
PB  - Taylor & Francis
T2  - Journal of Coordination Chemistry
T1  - Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes
VL  - 77
IS  - 7-8
SP  - 750
EP  - 765
DO  - 10.1080/00958972.2024.2307911
ER  - 
@article{
author = "Petrović, Tamara and Dimitrijević, Marija and Mihajlović-Lalić, Ljiljana and Stanković, Dalibor and Vlahović, Filip and Grgurić-Šipka, Sanja and Mihajilov-Krstev, Tatjana and Miladinović, Dragoljub and Poljarević, Jelena",
year = "2024",
abstract = "Eight new ruthenium complexes (C1, C2 (Ru-benzene or Ru-toluene complexes with L1, 3
amino-2-chloropyridine); C3, C4 (Ru-benzene or Ru-toluene complexes with L2, 2-amino-5
chloropyridine); C5, C6 (Ru-benzene or Ru-toluene complexes with L3, 3-acetylpyridine); and 
C7, C8 (Ru-benzene or Ru-toluene complexes with L4, 4-acetylpyridine) were synthesized. The 
chemical structures and purity of synthesized compounds were confirmed using standard 
analytical methods such as 1H, 13C NMR and IR spectroscopy, mass spectrometry, and elemental 
analysis, and their electrochemical behavior was evaluated using cyclic voltammetry 
experiments. The stability of synthesized compounds in dimethyl sulfoxide solution was 
confirmed using 1H NMR spectroscopy. Finally, the antimicrobial potential of two complex 
precursors (CP1, [Ru(η6-benzene)Cl(μ-Cl)]2  and CP2, [Ru(η6-toluene)Cl(μ-Cl)]2), four ligands 
(L1 – L4), and eight corresponding complexes (C1 – C8) was screened against nine pathogenic 
microorganisms and two reference bacterial strains, using the micro-well dilution method. The 
highest antibacterial activity (0.63 mg/mL) exerted C5 against S. aureus, B. cereus, E. coli, and 
S. enteritidis, while complex C8 displayed more pronounced antimicrobial activity against C. 
albicans (MIC/MMC = 0.31 mg/mL). Subsequently, the studied complexes underwent a detailed 
examination utilizing the DFT methodology, acquiring important quantum-chemical descriptors. 
Notably, the HOMO-LUMO gap was established as a significant correlate with the antimicrobial 
activity of synthesized compounds.",
publisher = "Taylor & Francis",
journal = "Journal of Coordination Chemistry",
title = "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes",
volume = "77",
number = "7-8",
pages = "750-765",
doi = "10.1080/00958972.2024.2307911"
}
Petrović, T., Dimitrijević, M., Mihajlović-Lalić, L., Stanković, D., Vlahović, F., Grgurić-Šipka, S., Mihajilov-Krstev, T., Miladinović, D.,& Poljarević, J.. (2024). Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry
Taylor & Francis., 77(7-8), 750-765.
https://doi.org/10.1080/00958972.2024.2307911
Petrović T, Dimitrijević M, Mihajlović-Lalić L, Stanković D, Vlahović F, Grgurić-Šipka S, Mihajilov-Krstev T, Miladinović D, Poljarević J. Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes. in Journal of Coordination Chemistry. 2024;77(7-8):750-765.
doi:10.1080/00958972.2024.2307911 .
Petrović, Tamara, Dimitrijević, Marija, Mihajlović-Lalić, Ljiljana, Stanković, Dalibor, Vlahović, Filip, Grgurić-Šipka, Sanja, Mihajilov-Krstev, Tatjana, Miladinović, Dragoljub, Poljarević, Jelena, "Synthesis and antimicrobial activity of new pyridine-based half-sandwich Ru(II) complexes" in Journal of Coordination Chemistry, 77, no. 7-8 (2024):750-765,
https://doi.org/10.1080/00958972.2024.2307911 . .

Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду

Милановић Маштраповић, Весна Д.; Савић, Слађана Д.; Софренић, Ивана В.

(Београд : Српско хемијско друштво, 2024)

TY  - JOUR
AU  - Милановић Маштраповић, Весна Д.
AU  - Савић, Слађана Д.
AU  - Софренић, Ивана В.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6567
AB  - У октобру 2023. године обележено је 170 година од када је на Лицеју одржано прво предавање из хемије, и тиме исписане прве странице историје модерне хемије у Србији. Како бисмо боље разумели садашњи тренутак и сагледали развијеност хемије као науке на Универзитету у Београду – Хемијском факултету, вратимо се у време и околности у којима су постављени темељи хемије у Србији. У другом делу чланка дат је опис данашњег стања на Универзитету у Београду – Хемијском факултету.
AB  - In October 2023, we marked 170 years since the first chemistry lecture was held at the Lyceum, when the first pages of the history of modern chemistry in Serbia was written. In order to better understand the present moment and percieve the development of chemistry as a science at
the University of Belgrade – Faculty of Chemistry, we went back to the time and circumstances in which the foundations of chemistry in Serbia were posted. In the second part of the article, description of today’s state at the University of Belgrade – Faculty of Chemistry was provided.
PB  - Београд : Српско хемијско друштво
T2  - Хемијски преглед
T1  - Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду
T1  - A short story about 170 years of chemistry in Serbia and University of Belgrade – Faculty of chemistry
IS  - 65
IS  - 2
SP  - 41
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6567
ER  - 
@article{
author = "Милановић Маштраповић, Весна Д. and Савић, Слађана Д. and Софренић, Ивана В.",
year = "2024",
abstract = "У октобру 2023. године обележено је 170 година од када је на Лицеју одржано прво предавање из хемије, и тиме исписане прве странице историје модерне хемије у Србији. Како бисмо боље разумели садашњи тренутак и сагледали развијеност хемије као науке на Универзитету у Београду – Хемијском факултету, вратимо се у време и околности у којима су постављени темељи хемије у Србији. У другом делу чланка дат је опис данашњег стања на Универзитету у Београду – Хемијском факултету., In October 2023, we marked 170 years since the first chemistry lecture was held at the Lyceum, when the first pages of the history of modern chemistry in Serbia was written. In order to better understand the present moment and percieve the development of chemistry as a science at
the University of Belgrade – Faculty of Chemistry, we went back to the time and circumstances in which the foundations of chemistry in Serbia were posted. In the second part of the article, description of today’s state at the University of Belgrade – Faculty of Chemistry was provided.",
publisher = "Београд : Српско хемијско друштво",
journal = "Хемијски преглед",
title = "Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду, A short story about 170 years of chemistry in Serbia and University of Belgrade – Faculty of chemistry",
number = "65, 2",
pages = "41-44",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6567"
}
Милановић Маштраповић, В. Д., Савић, С. Д.,& Софренић, И. В.. (2024). Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду. in Хемијски преглед
Београд : Српско хемијско друштво.(65), 41-44.
https://hdl.handle.net/21.15107/rcub_cherry_6567
Милановић Маштраповић ВД, Савић СД, Софренић ИВ. Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду. in Хемијски преглед. 2024;(65):41-44.
https://hdl.handle.net/21.15107/rcub_cherry_6567 .
Милановић Маштраповић, Весна Д., Савић, Слађана Д., Софренић, Ивана В., "Кратка прича о 170 година хемије у Србији и Хемијском факултету Универзитета у Београду" in Хемијски преглед, no. 65 (2024):41-44,
https://hdl.handle.net/21.15107/rcub_cherry_6567 .

Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija

Križan, Pavle

(2024)

TY  - THES
AU  - Križan, Pavle
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6566
AB  - Oboljenja amiloidnog tipa su sve češća kako prosečni životni vek ljudi raste a i dalje nije u potpunosti poznato šta doprinosi procesu amiloidne fibrilacije i kako se on može zaustaviti. Problem je što i dalje ne razumemo potpuno mehanizam fibrilacije usled poteškoća sa karakterizacijom svih intermedijera na putu od nativnog proteina do amiloidnog fibrila. Usled toga, ne možemo da znamo ni koja je tačna meta koju treba da ciljaju lekovi za tretman amiloidnih oboljenja. Razvoj supramolekulske hemije fulerena kao i bolje razumevanje kako se ovi molekuli ponašaju u rastvoru i biološkim sistemima je doprineo potencijalnoj upotrebi ovakvih jedinstvenih molekula u svrhe koje nisu samo na nivou fotonaponskih uređaja. U ovom master radu je sintetisan derivat fulerena C60, fuleronikotin, i ispitano je njegovo dejstvo na formiranje amiloidnih fibrila ovalbumina uz dodatno ispitivanje protein-ligand interakcija između fuelrena C60 i fuleronikotina merenjem fluorescencije tioflavina T, korišćenjem FTIR-a, DLS-a i metoda energetskog transfera. Master teza se nastavlja na rezultate iz prethodnog završnog rada uz izvođenje novih eksperimenta koji do sada nisu izvedeni za karakterizaciju interakcija i mogućeg mehanizma dejstva fulerena na amiloidnu fibrilaciju. Otkriveno je da fuleronikotin favorizuje amiloidnu fibrilaciju pri najnižoj koncentraciji od 250 ng/mL i najvišoj koncentraciji od 1500 ng/mL. U kontrastu sa literaturom, potvrđeno je da nikotin takođe favorizuje amiloidnu fibrilaciju i predložen je mehanizam interakcije fulerena sa OVA koji se zasniva na različitom dejstvu fulerena u zavisnosti od rastvorljivosti fulerena. Neophodno je primeniti još metoda za karakterizaciju interakcija da bi se potvrdio predloženi mehanizam da bi moglo da se utvrdi koja je optimalna strategija sinteze derivata fulerena sa ciljem dobijanja što efikasnijeg inhibitora amiloidne fibrilacije.
T1  - Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija
SP  - 1
EP  - 53
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6566
ER  - 
@mastersthesis{
author = "Križan, Pavle",
year = "2024",
abstract = "Oboljenja amiloidnog tipa su sve češća kako prosečni životni vek ljudi raste a i dalje nije u potpunosti poznato šta doprinosi procesu amiloidne fibrilacije i kako se on može zaustaviti. Problem je što i dalje ne razumemo potpuno mehanizam fibrilacije usled poteškoća sa karakterizacijom svih intermedijera na putu od nativnog proteina do amiloidnog fibrila. Usled toga, ne možemo da znamo ni koja je tačna meta koju treba da ciljaju lekovi za tretman amiloidnih oboljenja. Razvoj supramolekulske hemije fulerena kao i bolje razumevanje kako se ovi molekuli ponašaju u rastvoru i biološkim sistemima je doprineo potencijalnoj upotrebi ovakvih jedinstvenih molekula u svrhe koje nisu samo na nivou fotonaponskih uređaja. U ovom master radu je sintetisan derivat fulerena C60, fuleronikotin, i ispitano je njegovo dejstvo na formiranje amiloidnih fibrila ovalbumina uz dodatno ispitivanje protein-ligand interakcija između fuelrena C60 i fuleronikotina merenjem fluorescencije tioflavina T, korišćenjem FTIR-a, DLS-a i metoda energetskog transfera. Master teza se nastavlja na rezultate iz prethodnog završnog rada uz izvođenje novih eksperimenta koji do sada nisu izvedeni za karakterizaciju interakcija i mogućeg mehanizma dejstva fulerena na amiloidnu fibrilaciju. Otkriveno je da fuleronikotin favorizuje amiloidnu fibrilaciju pri najnižoj koncentraciji od 250 ng/mL i najvišoj koncentraciji od 1500 ng/mL. U kontrastu sa literaturom, potvrđeno je da nikotin takođe favorizuje amiloidnu fibrilaciju i predložen je mehanizam interakcije fulerena sa OVA koji se zasniva na različitom dejstvu fulerena u zavisnosti od rastvorljivosti fulerena. Neophodno je primeniti još metoda za karakterizaciju interakcija da bi se potvrdio predloženi mehanizam da bi moglo da se utvrdi koja je optimalna strategija sinteze derivata fulerena sa ciljem dobijanja što efikasnijeg inhibitora amiloidne fibrilacije.",
title = "Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija",
pages = "1-53",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6566"
}
Križan, P.. (2024). Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija. , 1-53.
https://hdl.handle.net/21.15107/rcub_cherry_6566
Križan P. Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija. 2024;:1-53.
https://hdl.handle.net/21.15107/rcub_cherry_6566 .
Križan, Pavle, "Ispitivanje uticaja fuleronikotina na formiranje amiloidnih fibrila ovalbumina iz kokošjeg jajeta uz ispitivanje protein-ligand interakcija" (2024):1-53,
https://hdl.handle.net/21.15107/rcub_cherry_6566 .

Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka)

Pavićević, Ksenija

(2024)

TY  - THES
AU  - Pavićević, Ksenija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6565
AB  - U master radu je ispitivano osam uzoraka nafti iz zapadnog dela naftnog polja „Pcj“ koje se nalazi u Severnobačkom okrugu i pripada južnom delu Panonskog basena. Istraživanje je zasnovano na detaljnoj analizi biomarkerskih jedinjenja (n-alkana, izoprenoidnih alifatičnih alkana, sterana i terpana) i aromatičnih jedinjenja (fenantrena, dibenzotiofena i triaromatičnih sterana) sa ciljem određivanja porekla, sredine taloženja i stepena maturisanosti nafti. Eksperimentalni deo rada sastojao se iz izolovanja frakcija nafte hromatografijom na mikrokoloni, pri čemu su dobijene tri frakcije: zasićena, aromatična i polarna, a zatim gasnohromatografsko-masenospektrometrijske analize. Utvrđeno je da nafte nisu podlegle biodegradaciji u rezervoarskim stenama. Sve nafte su istog genetskog tipa i stepena zrelosti. Prekursorska organska supstanca nafti je pretežno algalnog porekla. Taloženje prekursorske organske supstance se odvijalo u slanoj, redukcionoj sredini. Maturisanost ispitivanih nafti odgovara piku zone generisanja nafte. Matične stene nafti „Pcj“ su laporci.
T1  - Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka)
SP  - 2
EP  - 57
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6565
ER  - 
@mastersthesis{
author = "Pavićević, Ksenija",
year = "2024",
abstract = "U master radu je ispitivano osam uzoraka nafti iz zapadnog dela naftnog polja „Pcj“ koje se nalazi u Severnobačkom okrugu i pripada južnom delu Panonskog basena. Istraživanje je zasnovano na detaljnoj analizi biomarkerskih jedinjenja (n-alkana, izoprenoidnih alifatičnih alkana, sterana i terpana) i aromatičnih jedinjenja (fenantrena, dibenzotiofena i triaromatičnih sterana) sa ciljem određivanja porekla, sredine taloženja i stepena maturisanosti nafti. Eksperimentalni deo rada sastojao se iz izolovanja frakcija nafte hromatografijom na mikrokoloni, pri čemu su dobijene tri frakcije: zasićena, aromatična i polarna, a zatim gasnohromatografsko-masenospektrometrijske analize. Utvrđeno je da nafte nisu podlegle biodegradaciji u rezervoarskim stenama. Sve nafte su istog genetskog tipa i stepena zrelosti. Prekursorska organska supstanca nafti je pretežno algalnog porekla. Taloženje prekursorske organske supstance se odvijalo u slanoj, redukcionoj sredini. Maturisanost ispitivanih nafti odgovara piku zone generisanja nafte. Matične stene nafti „Pcj“ su laporci.",
title = "Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka)",
pages = "2-57",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6565"
}
Pavićević, K.. (2024). Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka). , 2-57.
https://hdl.handle.net/21.15107/rcub_cherry_6565
Pavićević K. Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka). 2024;:2-57.
https://hdl.handle.net/21.15107/rcub_cherry_6565 .
Pavićević, Ksenija, "Procena geološke istorije nafti iz zapadnog dela naftnog polja „Pcj“ (severna Bačka)" (2024):2-57,
https://hdl.handle.net/21.15107/rcub_cherry_6565 .

Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti

Jevđević, Ana

(2024)

TY  - THES
AU  - Jevđević, Ana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6564
AB  - Glavni fokus ovog rada je na PR-10 proteinu graška, s ciljem ispitivanja njegovog alergenog potencijala. Budući da su alergijske reakcije na grašak sve češće, usled njihove povećane konzumacije u novije vreme, neophodno je precizno definisati alergenost njegovih proteina. Kako su članovi superfamilije PR-10 proteina poznati po svojoj visokoj alergenosti i široko rasprostranjenoj ukrštenoj reaktivnosti među homolozima, važno je ispitati i alergeni potencijal PR-10 proteina graška. Ispitivanje alergenosti PR-10 proteina graška doprineće razvoju skale alergenog potencijala među proteinima hrane, ključnog alata za procenu rizika od alergijskih reakcija kod različitih izvora ovih i njima sličnih proteina. Konačni cilj jeste pružiti naučnu osnovu koja će podržati bezbednu upotrebu PR-10 proteina, s ciljem minimalizacije potencijalnih zdravstvenih rizika za konzumere.
T1  - Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti
SP  - 7
EP  - 39
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6564
ER  - 
@misc{
author = "Jevđević, Ana",
year = "2024",
abstract = "Glavni fokus ovog rada je na PR-10 proteinu graška, s ciljem ispitivanja njegovog alergenog potencijala. Budući da su alergijske reakcije na grašak sve češće, usled njihove povećane konzumacije u novije vreme, neophodno je precizno definisati alergenost njegovih proteina. Kako su članovi superfamilije PR-10 proteina poznati po svojoj visokoj alergenosti i široko rasprostranjenoj ukrštenoj reaktivnosti među homolozima, važno je ispitati i alergeni potencijal PR-10 proteina graška. Ispitivanje alergenosti PR-10 proteina graška doprineće razvoju skale alergenog potencijala među proteinima hrane, ključnog alata za procenu rizika od alergijskih reakcija kod različitih izvora ovih i njima sličnih proteina. Konačni cilj jeste pružiti naučnu osnovu koja će podržati bezbednu upotrebu PR-10 proteina, s ciljem minimalizacije potencijalnih zdravstvenih rizika za konzumere.",
title = "Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti",
pages = "7-39",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6564"
}
Jevđević, A.. (2024). Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti. , 7-39.
https://hdl.handle.net/21.15107/rcub_cherry_6564
Jevđević A. Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti. 2024;:7-39.
https://hdl.handle.net/21.15107/rcub_cherry_6564 .
Jevđević, Ana, "Proizvodnja PR-10 proteina graška (Pisum sativum) rekombinantnom DNK tehnologijom i provera IgE reaktivnosti" (2024):7-39,
https://hdl.handle.net/21.15107/rcub_cherry_6564 .