TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - JOUR
AU  - Nikolić, Stefan
AU  - Stanković, Dalibor
AU  - Grgurić-Šipka, Sanja
PY  - 2025
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6647
AB  - In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes
are gaining increasing recent interest. Their cytotoxic effect is widely known, however mechanism of
action, solution behavior, redox reactions within biological system are still focus of the new studies. Various
experiments and approach techniques are used to better understand ruthenium chemistry. In this order their
biological activity and the availability of reduction potential in the biological medium, it is necessary to know
their electrochemical redox behavior and properties. In this work, we report the electrochemical activity on
synthesized and characterized (1H- and 13C NMR, FT-IR, MS) half-sandwich organometallic Ru(II) complexes of
the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene, toluene or p-cymene and XY = bidentates:
dipyrido[3,2-a:2′,3′-c]phenazine (dppz derivatives) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline
(aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool”
configuration of Ru(II)-arene complexes – as confirmed by vibrational and NMR spectra. It is shown that selected
complexes can be divided in four groups, based on their electrochemical behavior. These behaviors are correlated
with their structure and nature of ligands.
PB  - Elsevier
T2  - Inorganica Chimica Acta
T1  - Electrochemistry of different ruthenium polypyridine complexes
VL  - 574
SP  - 122352
DO  - 10.1016/j.ica.2024.122352
ER  - 

@article{
author = "Nikolić, Stefan and Stanković, Dalibor and Grgurić-Šipka, Sanja",
year = "2025",
abstract = "In search for antitumor metal-based drugs that would mitigate the severe side-effects of cisplatin, Ru(II) complexes
are gaining increasing recent interest. Their cytotoxic effect is widely known, however mechanism of
action, solution behavior, redox reactions within biological system are still focus of the new studies. Various
experiments and approach techniques are used to better understand ruthenium chemistry. In this order their
biological activity and the availability of reduction potential in the biological medium, it is necessary to know
their electrochemical redox behavior and properties. In this work, we report the electrochemical activity on
synthesized and characterized (1H- and 13C NMR, FT-IR, MS) half-sandwich organometallic Ru(II) complexes of
the general formula [Ru(η6-arene)(XY)Cl](PF6) where arene = benzene, toluene or p-cymene and XY = bidentates:
dipyrido[3,2-a:2′,3′-c]phenazine (dppz derivatives) or 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline
(aip), which are bound to Ru(II) via two phenanthroline-N atoms in a characteristic “piano-stool”
configuration of Ru(II)-arene complexes – as confirmed by vibrational and NMR spectra. It is shown that selected
complexes can be divided in four groups, based on their electrochemical behavior. These behaviors are correlated
with their structure and nature of ligands.",
publisher = "Elsevier",
journal = "Inorganica Chimica Acta",
title = "Electrochemistry of different ruthenium polypyridine complexes",
volume = "574",
pages = "122352",
doi = "10.1016/j.ica.2024.122352"
}

Nikolić, S., Stanković, D.,& Grgurić-Šipka, S.. (2025). Electrochemistry of different ruthenium polypyridine complexes. in Inorganica Chimica Acta
Elsevier., 574, 122352.
https://doi.org/10.1016/j.ica.2024.122352

Nikolić S, Stanković D, Grgurić-Šipka S. Electrochemistry of different ruthenium polypyridine complexes. in Inorganica Chimica Acta. 2025;574:122352.
doi:10.1016/j.ica.2024.122352 .

Nikolić, Stefan, Stanković, Dalibor, Grgurić-Šipka, Sanja, "Electrochemistry of different ruthenium polypyridine complexes" in Inorganica Chimica Acta, 574 (2025):122352,
https://doi.org/10.1016/j.ica.2024.122352 . .

TY  - JOUR
AU  - Mirković, Marija
AU  - Belaj, Ferdinand
AU  - Perić, Marko
AU  - Stanković, Dalibor
AU  - Radović, Magdalena
AU  - Milanović, Zorana
AU  - Vranješ-Đurić, Sanja
AU  - Janković, Drina
AU  - Cvijetić, Ilija
AU  - Mihajlović-Lalić, Ljiljana E.
PY  - 2025
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6636
T2  - Journal of Molecular Structure
T2  - Journal of Molecular Structure
T1  - Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical
VL  - 1321
SP  - 139791
DO  - 10.1016/j.molstruc.2024.139791
ER  - 

@article{
author = "Mirković, Marija and Belaj, Ferdinand and Perić, Marko and Stanković, Dalibor and Radović, Magdalena and Milanović, Zorana and Vranješ-Đurić, Sanja and Janković, Drina and Cvijetić, Ilija and Mihajlović-Lalić, Ljiljana E.",
year = "2025",
journal = "Journal of Molecular Structure, Journal of Molecular Structure",
title = "Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical",
volume = "1321",
pages = "139791",
doi = "10.1016/j.molstruc.2024.139791"
}

Mirković, M., Belaj, F., Perić, M., Stanković, D., Radović, M., Milanović, Z., Vranješ-Đurić, S., Janković, D., Cvijetić, I.,& Mihajlović-Lalić, L. E.. (2025). Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical. in Journal of Molecular Structure, 1321, 139791.
https://doi.org/10.1016/j.molstruc.2024.139791

Mirković M, Belaj F, Perić M, Stanković D, Radović M, Milanović Z, Vranješ-Đurić S, Janković D, Cvijetić I, Mihajlović-Lalić LE. Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical. in Journal of Molecular Structure. 2025;1321:139791.
doi:10.1016/j.molstruc.2024.139791 .

Mirković, Marija, Belaj, Ferdinand, Perić, Marko, Stanković, Dalibor, Radović, Magdalena, Milanović, Zorana, Vranješ-Đurić, Sanja, Janković, Drina, Cvijetić, Ilija, Mihajlović-Lalić, Ljiljana E., "Synthesis and characterization of Cu(II)‑meso-HMPAO complex as a model for the development of potential 64Cu radiopharmaceutical" in Journal of Molecular Structure, 1321 (2025):139791,
https://doi.org/10.1016/j.molstruc.2024.139791 . .

TY  - CONF
AU  - Milovanović, Milan R.
AU  - Nikolić, Stefan R.
AU  - Dupé, Antoine
AU  - Poljarević, Jelena M.
AU  - Schachner, Jörg A.
PY  - 2024-06
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6559
AB  - A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.
C3  - 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia
T1  - The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6559
ER  - 

@conference{
author = "Milovanović, Milan R. and Nikolić, Stefan R. and Dupé, Antoine and Poljarević, Jelena M. and Schachner, Jörg A.",
year = "2024-06",
abstract = "A lot of scientific effort was dedicated to research into a cure for cancer over past 
decades. Many of them failed due to a low solubility of synthetized compounds or low 
selectivity between healthy and pathogenic cells. It was shown that apigenin, a natural 
pigment of chamomile, showed some cytotoxic activity itself,[1] however, its extremely 
low solubility in water is a limiting factor in its use as a potential anticancer drug.
Here, we present a crystal structure of the first Re(V) complex containing apigenin 
– a natural occurring ligand. Various types of non-covalent interactions were found in 
the crystal structure (Figure 1). Namely, there are a couple of different hydrogen bonds 
(i.e. mono and bifurcated O-H∙∙∙O; O-H∙∙∙Cl; C-H∙∙∙Cl), T-shaped C-H∙∙∙π and π∙∙∙π 
stacking interactions. At least some of these interactions could be responsible for 
compounds’ final mechanism of anticancer action.",
journal = "3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia",
title = "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6559"
}

Milovanović, M. R., Nikolić, S. R., Dupé, A., Poljarević, J. M.,& Schachner, J. A.. (2024-06). The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia.
https://hdl.handle.net/21.15107/rcub_cherry_6559

Milovanović MR, Nikolić SR, Dupé A, Poljarević JM, Schachner JA. The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure. in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6559 .

Milovanović, Milan R., Nikolić, Stefan R., Dupé, Antoine, Poljarević, Jelena M., Schachner, Jörg A., "The first Re(V) Complex with a Ligand from the Nature: Non-Covalent Interactions from Crystal Structure" in 3rd International Conferences on Noncovalent Interactions (ICNI2024), June 17th-21st 2024, Belgrade, Serbia (2024-06),
https://hdl.handle.net/21.15107/rcub_cherry_6559 .

TY  - JOUR
AU  - Dorontic, Sladjana
AU  - Jovanovic, Svetlana
AU  - Stefanovic, Andjela
AU  - Kepic, Dejan
AU  - Scopelliti, Michelangelo
AU  - Ciasca, Gabriele
AU  - Di Santo, Riccardo
AU  - Bajuk Bogdanovic, Danica
AU  - Marković, Olivera
AU  - Todorovic Markovic, Biljana
AU  - Markovic, Zoran
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6649
AB  - Over the last decades, bacterial resistance has become one of the emerging health threats. Particularly dangerous
are bacterial strains resistant to various antibacterial drugs. Herein, we modified graphene quantum dots (GQDs)
to produce efficient photo-induced antibacterial agents. GQDs were modified with (a) ethylene-diamine (EDA),
(b) with EDA and gold nanoparticles (AuNPs), and (c) 3-amino-1,2,4-triazole (TA) using carbodiimide coupling.
Photo-induced antibacterial activity of modified GQDs was tested against 8 bacterial strains. Treatment with
modified GQDs and blue light (wavelength of 470 nm) resulted in remarkable antibacterial activity with minimal
inhibitory concentrations (MIC) of 7.81 μg mL-1 for K. pneumoniae and S. aureus and 3.9 μg mL -1 against MRSA
and E. faecalis. Planar organization of GQDs functionalized with AuNPs allowed direct access of molecular oxygen
to AuNPs leading to more efficient 1O2 production as well as the 1O2 production from excited GQDs. Thus,
GQDs functionalized with AuNPs showed outstanding efficiency in the battle against several bacterial strains,
particularly those that lead to nosocomial infections.
PB  - Elsevier
T2  - Synthetic Metals
T1  - Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light
VL  - 309
SP  - 117753
DO  - 10.1016/j.synthmet.2024.117753
ER  - 

@article{
author = "Dorontic, Sladjana and Jovanovic, Svetlana and Stefanovic, Andjela and Kepic, Dejan and Scopelliti, Michelangelo and Ciasca, Gabriele and Di Santo, Riccardo and Bajuk Bogdanovic, Danica and Marković, Olivera and Todorovic Markovic, Biljana and Markovic, Zoran",
year = "2024",
abstract = "Over the last decades, bacterial resistance has become one of the emerging health threats. Particularly dangerous
are bacterial strains resistant to various antibacterial drugs. Herein, we modified graphene quantum dots (GQDs)
to produce efficient photo-induced antibacterial agents. GQDs were modified with (a) ethylene-diamine (EDA),
(b) with EDA and gold nanoparticles (AuNPs), and (c) 3-amino-1,2,4-triazole (TA) using carbodiimide coupling.
Photo-induced antibacterial activity of modified GQDs was tested against 8 bacterial strains. Treatment with
modified GQDs and blue light (wavelength of 470 nm) resulted in remarkable antibacterial activity with minimal
inhibitory concentrations (MIC) of 7.81 μg mL-1 for K. pneumoniae and S. aureus and 3.9 μg mL -1 against MRSA
and E. faecalis. Planar organization of GQDs functionalized with AuNPs allowed direct access of molecular oxygen
to AuNPs leading to more efficient 1O2 production as well as the 1O2 production from excited GQDs. Thus,
GQDs functionalized with AuNPs showed outstanding efficiency in the battle against several bacterial strains,
particularly those that lead to nosocomial infections.",
publisher = "Elsevier",
journal = "Synthetic Metals",
title = "Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light",
volume = "309",
pages = "117753",
doi = "10.1016/j.synthmet.2024.117753"
}

Dorontic, S., Jovanovic, S., Stefanovic, A., Kepic, D., Scopelliti, M., Ciasca, G., Di Santo, R., Bajuk Bogdanovic, D., Marković, O., Todorovic Markovic, B.,& Markovic, Z.. (2024). Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light. in Synthetic Metals
Elsevier., 309, 117753.
https://doi.org/10.1016/j.synthmet.2024.117753

Dorontic S, Jovanovic S, Stefanovic A, Kepic D, Scopelliti M, Ciasca G, Di Santo R, Bajuk Bogdanovic D, Marković O, Todorovic Markovic B, Markovic Z. Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light. in Synthetic Metals. 2024;309:117753.
doi:10.1016/j.synthmet.2024.117753 .

Dorontic, Sladjana, Jovanovic, Svetlana, Stefanovic, Andjela, Kepic, Dejan, Scopelliti, Michelangelo, Ciasca, Gabriele, Di Santo, Riccardo, Bajuk Bogdanovic, Danica, Marković, Olivera, Todorovic Markovic, Biljana, Markovic, Zoran, "Graphene quantum dots with covalently bonded gold nanoparticles winning the battle against methicillin-resistant Staphylococcus aureus under blue light" in Synthetic Metals, 309 (2024):117753,
https://doi.org/10.1016/j.synthmet.2024.117753 . .

TY  - CONF
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Pešić, Miloš
AU  - Topalović, Igor
AU  - Đurđević, Mladen
AU  - Kuentz, Martin
AU  - Avdeef, Alex
AU  - Serajuddin, Abu
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6648
AB  - A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules [1]. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption [2]. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs [3] emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs [4-5].
A variety of methods to increase solubility and/or dissolution rate, and thereby increase their bioavailability, have been developed. Still, most of them, like particle size reduction, salt formation, conversion to amorphous form, solid dispersion, and solubilization in lipids or lipid-surfactant mixtures have their own limitations. To mitigate some of the above limitations, a novel method of drug solubilization in aqueous media by acid–base interactions has been developed [6]. This novel approach of greatly increasing the solubility is based on interactions of a model low-soluble basic drug in an aqueous medium with acidic species that would not normally form salts with it. Although quite successful, the proposed model still needs additional work and some fine-tuning with additional low-soluble drugs to establish it as a widely accepted method for increasing solubility, dissolution rate and bioavailability of poorly water-soluble drugs. Our research team is working on it.
PB  - University of Novi Sad, Faculty of Sciences
C3  - 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024
T1  - Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization
SP  - 13
EP  - 13
ER  - 

@conference{
author = "Verbić, Tatjana and Marković, Olivera and Pešić, Miloš and Topalović, Igor and Đurđević, Mladen and Kuentz, Martin and Avdeef, Alex and Serajuddin, Abu",
year = "2024",
abstract = "A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules [1]. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption [2]. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs [3] emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs [4-5].
A variety of methods to increase solubility and/or dissolution rate, and thereby increase their bioavailability, have been developed. Still, most of them, like particle size reduction, salt formation, conversion to amorphous form, solid dispersion, and solubilization in lipids or lipid-surfactant mixtures have their own limitations. To mitigate some of the above limitations, a novel method of drug solubilization in aqueous media by acid–base interactions has been developed [6]. This novel approach of greatly increasing the solubility is based on interactions of a model low-soluble basic drug in an aqueous medium with acidic species that would not normally form salts with it. Although quite successful, the proposed model still needs additional work and some fine-tuning with additional low-soluble drugs to establish it as a widely accepted method for increasing solubility, dissolution rate and bioavailability of poorly water-soluble drugs. Our research team is working on it.",
publisher = "University of Novi Sad, Faculty of Sciences",
journal = "21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024",
title = "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization",
pages = "13-13"
}

Verbić, T., Marković, O., Pešić, M., Topalović, I., Đurđević, M., Kuentz, M., Avdeef, A.,& Serajuddin, A.. (2024). Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024
University of Novi Sad, Faculty of Sciences., 13-13.

Verbić T, Marković O, Pešić M, Topalović I, Đurđević M, Kuentz M, Avdeef A, Serajuddin A. Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024. 2024;:13-13..

Verbić, Tatjana, Marković, Olivera, Pešić, Miloš, Topalović, Igor, Đurđević, Mladen, Kuentz, Martin, Avdeef, Alex, Serajuddin, Abu, "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization" in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes, Novi Sad, Serbia, September 9 – 13, 2024 (2024):13-13.

TY  - JOUR
AU  - Petrović, Tamara
AU  - Poljarević, Jelena
AU  - Nikolić, Stefan
AU  - Stojković-Filipović, Jelena
AU  - Mihajlović-Lalić, Ljiljana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6646
AB  - The skin of newborns is classified as sensitive, with a higher risk of skin barrier disruption
and irritation of a diapered area. Despite dermatologist recommendations to use only water
and a cloth for cleaning, most of the population still relies on the comforts of modern
parenting, which includes intensive daily usage of baby wet wipes. Novel baby formulations
are designed following the concept of infant skin health, containing a gentle cleanser,
suitable emollient, and buffer system enabling a slightly acidic pH value and they are free
of ethyl alcohol. Thus, it is important to understand the chemical background of such a
complex liquid formulation, with emphasis on its safety. In line with this, the present paper
discusses the scientific background of various chemical compounds found in baby wipe
formulations to improve the understanding of wet wipe designs and direct them toward
more skin-friendly solutions.
PB  - Wiley
T2  - International Journal of Dermatology
T1  - A review of the key ingredients in industrial formulations of baby wet wipes
VL  - n/a
DO  - 10.1111/ijd.17351
ER  - 

@article{
author = "Petrović, Tamara and Poljarević, Jelena and Nikolić, Stefan and Stojković-Filipović, Jelena and Mihajlović-Lalić, Ljiljana",
year = "2024",
abstract = "The skin of newborns is classified as sensitive, with a higher risk of skin barrier disruption
and irritation of a diapered area. Despite dermatologist recommendations to use only water
and a cloth for cleaning, most of the population still relies on the comforts of modern
parenting, which includes intensive daily usage of baby wet wipes. Novel baby formulations
are designed following the concept of infant skin health, containing a gentle cleanser,
suitable emollient, and buffer system enabling a slightly acidic pH value and they are free
of ethyl alcohol. Thus, it is important to understand the chemical background of such a
complex liquid formulation, with emphasis on its safety. In line with this, the present paper
discusses the scientific background of various chemical compounds found in baby wipe
formulations to improve the understanding of wet wipe designs and direct them toward
more skin-friendly solutions.",
publisher = "Wiley",
journal = "International Journal of Dermatology",
title = "A review of the key ingredients in industrial formulations of baby wet wipes",
volume = "n/a",
doi = "10.1111/ijd.17351"
}

Petrović, T., Poljarević, J., Nikolić, S., Stojković-Filipović, J.,& Mihajlović-Lalić, L.. (2024). A review of the key ingredients in industrial formulations of baby wet wipes. in International Journal of Dermatology
Wiley., n/a.
https://doi.org/10.1111/ijd.17351

Petrović T, Poljarević J, Nikolić S, Stojković-Filipović J, Mihajlović-Lalić L. A review of the key ingredients in industrial formulations of baby wet wipes. in International Journal of Dermatology. 2024;n/a.
doi:10.1111/ijd.17351 .

Petrović, Tamara, Poljarević, Jelena, Nikolić, Stefan, Stojković-Filipović, Jelena, Mihajlović-Lalić, Ljiljana, "A review of the key ingredients in industrial formulations of baby wet wipes" in International Journal of Dermatology, n/a (2024),
https://doi.org/10.1111/ijd.17351 . .

TY  - THES
AU  - Pepić, Sara V.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6645
AB  - Cilj ovog rada je ispitivanje uticaja „koncentracije suspenzije“ (odnos mase ispitivane
supstance i zapremine suspenzije) na transformacije koje se odvijaju u čvrstoj fazi i širinu
pHmax – pHmin opsega prilikom određivanja termodinamičke rastvorljivosti nortriptilinhidrohlorida,
atorvastatin-kalcijuma i prokain-hidrohlorida. Rastvorljivost ispitivanih
jedinjenja određena je primenom pH-Ramp shake-flask metode. Koncentracija nortriptilinhidrohlorida
određena je HPLC-UV/VIS metodom, koncentracija prokain-hidrohlorida je
određena spektrofotometrijski, dok je koncentracija atorvastatin-kalcijuma određena pomoću
obe pomenute metode. Eksperimentralni podaci obrađeni su u programu pDISOL–XTM (in-
ADME Research). Određene su sopstvene rastvorljivosti nortriptilina i atorvastatina, kao i
proizvodi rastvorljivosti nortriptilin-hidrohlorida, nortriptilin-hidrogenfosfata i atorvastatinkalcijuma.
Pokazalo se da sa porastom „koncentracije suspenzije“ dolazi do porasta širine
opsega u kom se odvijaju transformacije u čvrstoj fazi: – pHmax – pHmin. Ovi rezultati su
izuzetno važni za razvoj formulacije leka, posebno u slučaju jonizujućih slabo rastvorljivih
lekova. Detaljno ispitivanje pHmax – pHmin oblasti može da poboljša optimizaciju formulacije
proizvoda i da posluži kao osnova za uspešno predviđanje efikasnosti leka u uslovima in vivo,
što je od posebnog značaja za ranu fazu dizajna i razvoja lekova.
T1  - Proučavanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti nortriptilin-hidrohlorida, atorvastatin-kalcijuma i prokain-hidrohlorida
SP  - 1
EP  - 65
ER  - 

@mastersthesis{
author = "Pepić, Sara V.",
year = "2024",
abstract = "Cilj ovog rada je ispitivanje uticaja „koncentracije suspenzije“ (odnos mase ispitivane
supstance i zapremine suspenzije) na transformacije koje se odvijaju u čvrstoj fazi i širinu
pHmax – pHmin opsega prilikom određivanja termodinamičke rastvorljivosti nortriptilinhidrohlorida,
atorvastatin-kalcijuma i prokain-hidrohlorida. Rastvorljivost ispitivanih
jedinjenja određena je primenom pH-Ramp shake-flask metode. Koncentracija nortriptilinhidrohlorida
određena je HPLC-UV/VIS metodom, koncentracija prokain-hidrohlorida je
određena spektrofotometrijski, dok je koncentracija atorvastatin-kalcijuma određena pomoću
obe pomenute metode. Eksperimentralni podaci obrađeni su u programu pDISOL–XTM (in-
ADME Research). Određene su sopstvene rastvorljivosti nortriptilina i atorvastatina, kao i
proizvodi rastvorljivosti nortriptilin-hidrohlorida, nortriptilin-hidrogenfosfata i atorvastatinkalcijuma.
Pokazalo se da sa porastom „koncentracije suspenzije“ dolazi do porasta širine
opsega u kom se odvijaju transformacije u čvrstoj fazi: – pHmax – pHmin. Ovi rezultati su
izuzetno važni za razvoj formulacije leka, posebno u slučaju jonizujućih slabo rastvorljivih
lekova. Detaljno ispitivanje pHmax – pHmin oblasti može da poboljša optimizaciju formulacije
proizvoda i da posluži kao osnova za uspešno predviđanje efikasnosti leka u uslovima in vivo,
što je od posebnog značaja za ranu fazu dizajna i razvoja lekova.",
title = "Proučavanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti nortriptilin-hidrohlorida, atorvastatin-kalcijuma i prokain-hidrohlorida",
pages = "1-65"
}

Pepić, S. V.. (2024). Proučavanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti nortriptilin-hidrohlorida, atorvastatin-kalcijuma i prokain-hidrohlorida. , 1-65.

Pepić SV. Proučavanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti nortriptilin-hidrohlorida, atorvastatin-kalcijuma i prokain-hidrohlorida. 2024;:1-65..

Pepić, Sara V., "Proučavanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti nortriptilin-hidrohlorida, atorvastatin-kalcijuma i prokain-hidrohlorida" (2024):1-65.

TY  - THES
AU  - Bunović, Milenko
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6644
AB  - Za komplekse prelaznih metala je nedvosmisleno utvrđen njihov značaj u različitim granama hemije: od bioorganske hemije, preko neorganske, i na kraju, do organometalne hemije. Utvrđeno je da kompleksi prelaznih metala mogu da uspostavljaju vodonične veze na isti način kao i tipični primeri koje koristimo za njihovo opisivanje (voda, amonijak, itd.).
U ovom radu ispitivana je priroda O-H/M interakcija između molekula vode i helatnih kompleksa prelaznih metala različitog sastava. Data analiza izvedena je dekompozicijom energije interakcije metodom XEDA (Xiamen Energy Decomposition Analysis), koja ukupnu energiju deli na fizički smislene komponente: elektrostatiku, izmenu i odbijanje, polarizaciju, te disperziju i korelaciju. Proračuni su urađeni funkcionalom gustine ωB97xD i baznim skupom def2-TZVP, uz odgovarajuće pseudopotencijale za komplekse paladijuma i platine.
Energije ispitivanih O-H/M interakcija mogu dostići vrednost od -5,43 kcal/mol, i pokazuju veliku zavisnost od liganada i prelaznih metala koji čine interagujući kompleks. Pokazano je da se trendovi u energijama interakcija mogu protumačiti pomoću mapa elektrostatičkih potencijala odgovarajućih kompleksnih jedinjenja, kao i uzimajući u obzir prirodu odgovarajućih jona metala i liganada. Dekompozicija energije je pokazala da na konačnu vrednost energije interakcije najviše utiče disperziono-korelaciona komponenta, dok elektrostatička komponenta daje najbolji uvid u trendove energija interakcija, s obzirom da je sa njima u odnosu linearne zavisnosti.
T1  - Priroda O-H/M interakcija helatnih kompleksa prelaznih metala – o uticaju različitih tipova liganada i centralnih jona metala
SP  - 1
EP  - 29
ER  - 

@misc{
author = "Bunović, Milenko",
year = "2024",
abstract = "Za komplekse prelaznih metala je nedvosmisleno utvrđen njihov značaj u različitim granama hemije: od bioorganske hemije, preko neorganske, i na kraju, do organometalne hemije. Utvrđeno je da kompleksi prelaznih metala mogu da uspostavljaju vodonične veze na isti način kao i tipični primeri koje koristimo za njihovo opisivanje (voda, amonijak, itd.).
U ovom radu ispitivana je priroda O-H/M interakcija između molekula vode i helatnih kompleksa prelaznih metala različitog sastava. Data analiza izvedena je dekompozicijom energije interakcije metodom XEDA (Xiamen Energy Decomposition Analysis), koja ukupnu energiju deli na fizički smislene komponente: elektrostatiku, izmenu i odbijanje, polarizaciju, te disperziju i korelaciju. Proračuni su urađeni funkcionalom gustine ωB97xD i baznim skupom def2-TZVP, uz odgovarajuće pseudopotencijale za komplekse paladijuma i platine.
Energije ispitivanih O-H/M interakcija mogu dostići vrednost od -5,43 kcal/mol, i pokazuju veliku zavisnost od liganada i prelaznih metala koji čine interagujući kompleks. Pokazano je da se trendovi u energijama interakcija mogu protumačiti pomoću mapa elektrostatičkih potencijala odgovarajućih kompleksnih jedinjenja, kao i uzimajući u obzir prirodu odgovarajućih jona metala i liganada. Dekompozicija energije je pokazala da na konačnu vrednost energije interakcije najviše utiče disperziono-korelaciona komponenta, dok elektrostatička komponenta daje najbolji uvid u trendove energija interakcija, s obzirom da je sa njima u odnosu linearne zavisnosti.",
title = "Priroda O-H/M interakcija helatnih kompleksa prelaznih metala – o uticaju različitih tipova liganada i centralnih jona metala",
pages = "1-29"
}

Bunović, M.. (2024). Priroda O-H/M interakcija helatnih kompleksa prelaznih metala – o uticaju različitih tipova liganada i centralnih jona metala. , 1-29.

Bunović M. Priroda O-H/M interakcija helatnih kompleksa prelaznih metala – o uticaju različitih tipova liganada i centralnih jona metala. 2024;:1-29..

Bunović, Milenko, "Priroda O-H/M interakcija helatnih kompleksa prelaznih metala – o uticaju različitih tipova liganada i centralnih jona metala" (2024):1-29.

TY  - THES
AU  - Pavlović, Marija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6643
AB  - Ciljevi ovog rada su sinteza, karakterizacija i ispitivanje biološke aktivnosti kompleksa Cd(II) i Zn(II) sa metil 3-formil-4-hidroksibezoatom. U literaturi su okarakterisana kompleksna jedinjenja derivata salicilaldehida koja su pokazala antimikrobno dejstvo. Rezistencija bakterija na postojeće antibiotike podstakla je dizajniranje kompleksnih jedinjenja kao potencijalnih antibiotika. Za ispitivanje antimikrobne aktivnosti sintetisanih jedinjenja, korišćena su četiri soja Gram-pozitivnih, četiri soja Gram-negativnih bakterija, dva soja gljivica i jedan soj kvasca.
T1  - Sinteza, karakterizacija i ispitivanje antimikrobne aktivnosti kompleksa kadmijuma(II) i cinka(II) sa metil 3-formil-4-hidroksibenzoatom
SP  - 1
EP  - 24
ER  - 

@misc{
author = "Pavlović, Marija",
year = "2024",
abstract = "Ciljevi ovog rada su sinteza, karakterizacija i ispitivanje biološke aktivnosti kompleksa Cd(II) i Zn(II) sa metil 3-formil-4-hidroksibezoatom. U literaturi su okarakterisana kompleksna jedinjenja derivata salicilaldehida koja su pokazala antimikrobno dejstvo. Rezistencija bakterija na postojeće antibiotike podstakla je dizajniranje kompleksnih jedinjenja kao potencijalnih antibiotika. Za ispitivanje antimikrobne aktivnosti sintetisanih jedinjenja, korišćena su četiri soja Gram-pozitivnih, četiri soja Gram-negativnih bakterija, dva soja gljivica i jedan soj kvasca.",
title = "Sinteza, karakterizacija i ispitivanje antimikrobne aktivnosti kompleksa kadmijuma(II) i cinka(II) sa metil 3-formil-4-hidroksibenzoatom",
pages = "1-24"
}

Pavlović, M.. (2024). Sinteza, karakterizacija i ispitivanje antimikrobne aktivnosti kompleksa kadmijuma(II) i cinka(II) sa metil 3-formil-4-hidroksibenzoatom. , 1-24.

Pavlović M. Sinteza, karakterizacija i ispitivanje antimikrobne aktivnosti kompleksa kadmijuma(II) i cinka(II) sa metil 3-formil-4-hidroksibenzoatom. 2024;:1-24..

Pavlović, Marija, "Sinteza, karakterizacija i ispitivanje antimikrobne aktivnosti kompleksa kadmijuma(II) i cinka(II) sa metil 3-formil-4-hidroksibenzoatom" (2024):1-24.

TY  - JOUR
AU  - Selaković, Snežana
AU  - Rodić, Marko V.
AU  - Novaković, Irena T.
AU  - Matić, Ivana Z.
AU  - Stanojković, Tatjana
AU  - Pirković, Andrea
AU  - Živković, Lada
AU  - Spremo-Potparević, Biljana
AU  - Milčić, Miloš
AU  - Medaković, Vesna
AU  - Dimiza, Filitsa
AU  - Psomas, George
AU  - Anđelković, Katarina K.
AU  - Šumar-Ristović, Maja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6537
AB  - Copper(II) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(II) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf–thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.
PB  - Royal Society of Chemistry
T2  - Dalton Transactions
T2  - Dalton TransactionsDalton Trans.
T1  - Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach
VL  - 53
IS  - 6
SP  - 2770
EP  - 2788
DO  - 10.1039/D3DT03862A
ER  - 

@article{
author = "Selaković, Snežana and Rodić, Marko V. and Novaković, Irena T. and Matić, Ivana Z. and Stanojković, Tatjana and Pirković, Andrea and Živković, Lada and Spremo-Potparević, Biljana and Milčić, Miloš and Medaković, Vesna and Dimiza, Filitsa and Psomas, George and Anđelković, Katarina K. and Šumar-Ristović, Maja",
year = "2024",
abstract = "Copper(II) complexes with an α-diimine show a wide variety of biological activities, such as antibacterial, antifungal, antioxidant and anticancer. In this work, we synthesized and structurally characterized two novel Cu(II) complexes with methyl 3-formyl-4-hydroxybenzoate (HL) and α-diimines: 2,2′-bipyridine (bipy) and 1,10-phenanthroline (phen). Crystal structure analysis shows that the formulas of the compounds are [Cu(bipy)(L)(BF4)] (1) and [Cu(phen)(L)(H2O)](BF4)·H2O (2), with BF4− as a ligand in complex 1, which is rarely coordinated to metals. Both complexes have a square pyramidal geometry, while DFT calculations showed that the most stable structures of complexes 1 and 2 in a water/DMSO mixture are square-planar derivatives [Cu(bipy)(L)]+ and [Cu(phen)(L)]+. The antibacterial activity of compounds was evaluated in vitro on four Gram-negative and four Gram-positive bacterial strains. Complex 2 showed greater antibacterial activity towards all bacterial strains comparable to the control compound Amikacin. Complex 2 exerted a strong cytotoxic effect against the tested cancer cell lines (IC50 values ranging from 0.32 to 0.44 μM). Both complexes caused apoptotic cell death in HeLa cells and a noticeable in vitro antiangiogenic effect. In the concentration range of 5 to 100 μM, the complexes showed the absence of a genotoxic effect and displayed a protective effect against oxidative DNA damage induced by H2O2 in human peripheral blood cells. The interaction between the compounds and calf–thymus DNA was evaluated by diverse techniques suggesting a tight binding, which was also confirmed by molecular docking. In addition, it was found that the complexes bind tightly and reversibly to bovine and human serum albumin.",
publisher = "Royal Society of Chemistry",
journal = "Dalton Transactions, Dalton TransactionsDalton Trans.",
title = "Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach",
volume = "53",
number = "6",
pages = "2770-2788",
doi = "10.1039/D3DT03862A"
}

Selaković, S., Rodić, M. V., Novaković, I. T., Matić, I. Z., Stanojković, T., Pirković, A., Živković, L., Spremo-Potparević, B., Milčić, M., Medaković, V., Dimiza, F., Psomas, G., Anđelković, K. K.,& Šumar-Ristović, M.. (2024). Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions
Royal Society of Chemistry., 53(6), 2770-2788.
https://doi.org/10.1039/D3DT03862A

Selaković S, Rodić MV, Novaković IT, Matić IZ, Stanojković T, Pirković A, Živković L, Spremo-Potparević B, Milčić M, Medaković V, Dimiza F, Psomas G, Anđelković KK, Šumar-Ristović M. Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach. in Dalton Transactions. 2024;53(6):2770-2788.
doi:10.1039/D3DT03862A .

Selaković, Snežana, Rodić, Marko V., Novaković, Irena T., Matić, Ivana Z., Stanojković, Tatjana, Pirković, Andrea, Živković, Lada, Spremo-Potparević, Biljana, Milčić, Miloš, Medaković, Vesna, Dimiza, Filitsa, Psomas, George, Anđelković, Katarina K., Šumar-Ristović, Maja, "Cu(ii) complexes with a salicylaldehyde derivative and a-diimines as co-ligands: synthesis, characterization, biological activity. Experimental and theoretical approach" in Dalton Transactions, 53, no. 6 (2024):2770-2788,
https://doi.org/10.1039/D3DT03862A . .

TY  - CONF
AU  - Margetić, Aleksandra
AU  - Ristović, Marina
AU  - Stojanović, Sanja
AU  - Pavlović, Marija
AU  - Šokarda Slavić, Marinela
AU  - Vujčić, Zoran
AU  - Dojnov, Biljana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6612
AB  - Recent technological development has focused on addressing two major global issues: environmental protection and conservation of natural resources. High levels of dye production and use have led to significant environmental concerns due to large quantities of unmanaged colored wastewater. Textile dyes, in particular, are highly reactive and problematic when released into the environment.This study investigates the use of Aspergillus fungi biomass, a byproduct of enzyme production (xylanase, cellulase, amylase, and other hydrolytic enzymes), for removing textile dyes from wastewater. The strains Aspergillus niger, Aspergillus oryzae, Aspergillus welwitschiae, and Aspergillus tubingensis were cultivated on corn meal under optimized conditions for enzyme production. The adsorption capacity of the biomass was tested on eight textile dyes: Bezaktiv Gelb, Procion reactive yellow, Reactive yellow, Golden yellow, Procion amber, Congo red, Reactive black 5, and Remazol brilliant blue.The best results were achieved with Aspergillus oryzae biomass, particularly for Reactive black 5. Optimal adsorption conditions identified by DoE were pH 4-5 and a temperature of 25°C. Within the first hour, approximately 90% of the dye (2.16 mg/g biomass) was adsorbed, and after 24 hours, over 99% was adsorbed (2.4 mg/g biomass).The findings demonstrate that post-enzyme production biomass, typically considered waste, can effectively remove reactive dyes and other xenobiotics from wastewater. This dual benefit reduces waste and mitigates water pollution, contributing significantly to environmental protection.
PB  - Izmir Institute of Technology
C3  - V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
T1  - From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass
SP  - PP40
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6612
ER  - 

@conference{
author = "Margetić, Aleksandra and Ristović, Marina and Stojanović, Sanja and Pavlović, Marija and Šokarda Slavić, Marinela and Vujčić, Zoran and Dojnov, Biljana",
year = "2024",
abstract = "Recent technological development has focused on addressing two major global issues: environmental protection and conservation of natural resources. High levels of dye production and use have led to significant environmental concerns due to large quantities of unmanaged colored wastewater. Textile dyes, in particular, are highly reactive and problematic when released into the environment.This study investigates the use of Aspergillus fungi biomass, a byproduct of enzyme production (xylanase, cellulase, amylase, and other hydrolytic enzymes), for removing textile dyes from wastewater. The strains Aspergillus niger, Aspergillus oryzae, Aspergillus welwitschiae, and Aspergillus tubingensis were cultivated on corn meal under optimized conditions for enzyme production. The adsorption capacity of the biomass was tested on eight textile dyes: Bezaktiv Gelb, Procion reactive yellow, Reactive yellow, Golden yellow, Procion amber, Congo red, Reactive black 5, and Remazol brilliant blue.The best results were achieved with Aspergillus oryzae biomass, particularly for Reactive black 5. Optimal adsorption conditions identified by DoE were pH 4-5 and a temperature of 25°C. Within the first hour, approximately 90% of the dye (2.16 mg/g biomass) was adsorbed, and after 24 hours, over 99% was adsorbed (2.4 mg/g biomass).The findings demonstrate that post-enzyme production biomass, typically considered waste, can effectively remove reactive dyes and other xenobiotics from wastewater. This dual benefit reduces waste and mitigates water pollution, contributing significantly to environmental protection.",
publisher = "Izmir Institute of Technology",
journal = "V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye",
title = "From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass",
pages = "PP40",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6612"
}

Margetić, A., Ristović, M., Stojanović, S., Pavlović, M., Šokarda Slavić, M., Vujčić, Z.,& Dojnov, B.. (2024). From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye
Izmir Institute of Technology., PP40.
https://hdl.handle.net/21.15107/rcub_cherry_6612

Margetić A, Ristović M, Stojanović S, Pavlović M, Šokarda Slavić M, Vujčić Z, Dojnov B. From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass. in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye. 2024;:PP40.
https://hdl.handle.net/21.15107/rcub_cherry_6612 .

Margetić, Aleksandra, Ristović, Marina, Stojanović, Sanja, Pavlović, Marija, Šokarda Slavić, Marinela, Vujčić, Zoran, Dojnov, Biljana, "From Enzyme Production to Environmental Cleanup: The Dual Role of Aspergillus Biomass" in V International Enzyme & Bioprocess Days, Abstract Book, August 27-29, 2024; İzmir, Türkiye (2024):PP40,
https://hdl.handle.net/21.15107/rcub_cherry_6612 .

TY  - CONF
AU  - Verbić, Tatjana
AU  - Marković, Olivera
AU  - Pešić, Miloš
AU  - Topalović, Igor
AU  - Đurđević, Mladen
AU  - Kuentz, Martin
AU  - Avdeef, Alex
AU  - Serajuddin, Abu
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6642
AB  - A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs.
PB  - University of Novi Sad, Faculty of Sciences
C3  - 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes (ISSP21), Book of Abstracts; September 9–13, 2024, Novi Sad, Serbia
T1  - Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization
SP  - 13
EP  - 13
ER  - 

@conference{
author = "Verbić, Tatjana and Marković, Olivera and Pešić, Miloš and Topalović, Igor and Đurđević, Mladen and Kuentz, Martin and Avdeef, Alex and Serajuddin, Abu",
year = "2024",
abstract = "A majority of the new chemical entities (NCE) that emerged as potential drug candidates in pharmaceutical development during the past 2-3 decades are practically insoluble solids consisting of ionizable molecules. Class II BCS drugs (Biopharmaceutics Classification System) exhibit poor bioavailability due to insufficient absorption in the gastrointestinal tract with slow drug release from the dosage forms and low solubility as the limiting steps for their absorption. Thus, detailed and precise study of compound solubility and the possibilities to increase solubility and dissolution rate, are at the core of the development of bioavailable drug dosage forms and clinically effective pharmaceutical products that would dissolve in gastric and intestinal fluids after oral administration or not precipitate in the blood after intravenous administration. A white paper on consensus recommendations for improving data quality in equilibrium solubility measurement of ionizable drugs emphasizes the importance of precise solubility measurements. As a part of solubility studies of a group of tricyclic antidepressants (TCAs) we have shown the influence of competing counterions, such as buffering agents, complexing agents, salt coformers, tonicity adjusters, and solid-phase transformations on the aqueous solubility of studied drugs.",
publisher = "University of Novi Sad, Faculty of Sciences",
journal = "21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes (ISSP21), Book of Abstracts; September 9–13, 2024, Novi Sad, Serbia",
title = "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization",
pages = "13-13"
}

Verbić, T., Marković, O., Pešić, M., Topalović, I., Đurđević, M., Kuentz, M., Avdeef, A.,& Serajuddin, A.. (2024). Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes (ISSP21), Book of Abstracts; September 9–13, 2024, Novi Sad, Serbia
University of Novi Sad, Faculty of Sciences., 13-13.

Verbić T, Marković O, Pešić M, Topalović I, Đurđević M, Kuentz M, Avdeef A, Serajuddin A. Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization. in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes (ISSP21), Book of Abstracts; September 9–13, 2024, Novi Sad, Serbia. 2024;:13-13..

Verbić, Tatjana, Marković, Olivera, Pešić, Miloš, Topalović, Igor, Đurđević, Mladen, Kuentz, Martin, Avdeef, Alex, Serajuddin, Abu, "Drug solubility enhancement: from buffer complexes formation to acid-base supersolubilization" in 21st IUPAC International Symposium on Solubility Phenomena and Related Equilibrium Processes (ISSP21), Book of Abstracts; September 9–13, 2024, Novi Sad, Serbia (2024):13-13.

TY  - THES
AU  - Blagojević, Luka
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6641
AB  - Sintetisano je šest molekulski obeleženih polimera za riboflavin vezujući protein iz belanceta kokošijeg jajeta gde su kao funkcionalni monomeri korišćeni derivati riboflavina koji se razlikuju po broju kovalentno vezanih jedinica metakrilne kiseline. Za sintezu prvog seta polimera kao pomoćni monomer korišćen je akrilamid (AA); za sintezu drugog seta polimera kao pomoćni monomer iskorišćen je 2-(hidroksietil)-metakrilat (HEMA), dok je za poslednji set polimera modifikovan pristup sinteze i osim derivata riboflavina kao funkcionalni monomer dodat je i N,N-(dietilaminoetil)-metakrilat (DMAEM). Polimeri su okarakterisani FTIR spektroskopijom i ispitivanjem efikasnosti vezivanja templata. Za polimere koji su pokazali neki stepen vezivanja kobstruisane su apsorpcione izoterme. Rezultati vezivanja pokazuju da je nastanak stabilnog prepolimerizacionog kompleksa ključan za dobijanje uspešno obeleženih polimera. Polimeri koji su sadržali derivat riboflavina efikasnije su obeleženi proteinom (faktor obeležavanja 2,35) u odnosu na polimere bez derivata (faktor obeležavanja 1,49). Pozitivan uticaj prisustva afinitetnog liganda u strukturi polimera mnogo je više ispoljen u obeleženim polimerima čime je pokazan bitan efekat molekulskog obeležavanja. Takođe, rezultati vezivanja pokazuju da pozitivan efekat obeležavanja raste sa povećanjem koncentracije početnih rastvora.
T1  - Metakrilatni estri riboflavina kao novi funkcionalni monomeri za molekulsko obeležavanje polimera riboflavin vezujućim proteinom
SP  - 1
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6641
ER  - 

@misc{
author = "Blagojević, Luka",
year = "2024",
abstract = "Sintetisano je šest molekulski obeleženih polimera za riboflavin vezujući protein iz belanceta kokošijeg jajeta gde su kao funkcionalni monomeri korišćeni derivati riboflavina koji se razlikuju po broju kovalentno vezanih jedinica metakrilne kiseline. Za sintezu prvog seta polimera kao pomoćni monomer korišćen je akrilamid (AA); za sintezu drugog seta polimera kao pomoćni monomer iskorišćen je 2-(hidroksietil)-metakrilat (HEMA), dok je za poslednji set polimera modifikovan pristup sinteze i osim derivata riboflavina kao funkcionalni monomer dodat je i N,N-(dietilaminoetil)-metakrilat (DMAEM). Polimeri su okarakterisani FTIR spektroskopijom i ispitivanjem efikasnosti vezivanja templata. Za polimere koji su pokazali neki stepen vezivanja kobstruisane su apsorpcione izoterme. Rezultati vezivanja pokazuju da je nastanak stabilnog prepolimerizacionog kompleksa ključan za dobijanje uspešno obeleženih polimera. Polimeri koji su sadržali derivat riboflavina efikasnije su obeleženi proteinom (faktor obeležavanja 2,35) u odnosu na polimere bez derivata (faktor obeležavanja 1,49). Pozitivan uticaj prisustva afinitetnog liganda u strukturi polimera mnogo je više ispoljen u obeleženim polimerima čime je pokazan bitan efekat molekulskog obeležavanja. Takođe, rezultati vezivanja pokazuju da pozitivan efekat obeležavanja raste sa povećanjem koncentracije početnih rastvora.",
title = "Metakrilatni estri riboflavina kao novi funkcionalni monomeri za molekulsko obeležavanje polimera riboflavin vezujućim proteinom",
pages = "1-48",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6641"
}

Blagojević, L.. (2024). Metakrilatni estri riboflavina kao novi funkcionalni monomeri za molekulsko obeležavanje polimera riboflavin vezujućim proteinom. , 1-48.
https://hdl.handle.net/21.15107/rcub_cherry_6641

Blagojević L. Metakrilatni estri riboflavina kao novi funkcionalni monomeri za molekulsko obeležavanje polimera riboflavin vezujućim proteinom. 2024;:1-48.
https://hdl.handle.net/21.15107/rcub_cherry_6641 .

Blagojević, Luka, "Metakrilatni estri riboflavina kao novi funkcionalni monomeri za molekulsko obeležavanje polimera riboflavin vezujućim proteinom" (2024):1-48,
https://hdl.handle.net/21.15107/rcub_cherry_6641 .

TY  - THES
AU  - Radovanović, Aleksandar
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6622
AB  - U okviru ovog završnog rada ispitane su interakcije sintetičkih liganada sa α-1-kiselim glikoproteinom imobilizovanim na hiralnoj HPLC koloni. Najjače vezivanje pokazao je etilendiaminski derivat Rodamina B (EDA-RB) koji je korišćen za sintezu afinitetnih sorbenata na bazi silike sa različitim veličinama pora. Infracrvenom spektroskopijom sa Furijeovom transformacijom (FT-IR) su karakterisane dobijene modifikacije. Fluorescentnom spektroskopijom je određen broj vezivnih mesta i konstante vezivanja EDA-RB za α-1-kiseli glikoprotein (AGP) i albumin humanog seruma (HSA) pri različitim pH vrednostima. Batch binding metodom pri različitim pH vrednostima ispitano je vezivanje standarda AGP, standarda HSA, smeše standarda AGP i HSA, kao i analita, goveđeg seruma, za sintetisane sorbente. Ispitana je desorpcija vezanih molekula sa sintetisanih sorbenata. Detekcija pri sorpciji i desorpciji je izvedena korišćenjem reverzno-fazne visoko-efikasne tečne hromatografije uz detektor sa diodnim nizom (RP-HPLC-DAD).
T1  - Sinteza matriksa na bazi silike i rodamina B za sorpciju α-1-kiselog glikoproteina
SP  - 1
EP  - 44
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6622
ER  - 

@misc{
author = "Radovanović, Aleksandar",
year = "2024",
abstract = "U okviru ovog završnog rada ispitane su interakcije sintetičkih liganada sa α-1-kiselim glikoproteinom imobilizovanim na hiralnoj HPLC koloni. Najjače vezivanje pokazao je etilendiaminski derivat Rodamina B (EDA-RB) koji je korišćen za sintezu afinitetnih sorbenata na bazi silike sa različitim veličinama pora. Infracrvenom spektroskopijom sa Furijeovom transformacijom (FT-IR) su karakterisane dobijene modifikacije. Fluorescentnom spektroskopijom je određen broj vezivnih mesta i konstante vezivanja EDA-RB za α-1-kiseli glikoprotein (AGP) i albumin humanog seruma (HSA) pri različitim pH vrednostima. Batch binding metodom pri različitim pH vrednostima ispitano je vezivanje standarda AGP, standarda HSA, smeše standarda AGP i HSA, kao i analita, goveđeg seruma, za sintetisane sorbente. Ispitana je desorpcija vezanih molekula sa sintetisanih sorbenata. Detekcija pri sorpciji i desorpciji je izvedena korišćenjem reverzno-fazne visoko-efikasne tečne hromatografije uz detektor sa diodnim nizom (RP-HPLC-DAD).",
title = "Sinteza matriksa na bazi silike i rodamina B za sorpciju α-1-kiselog glikoproteina",
pages = "1-44",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6622"
}

Radovanović, A.. (2024). Sinteza matriksa na bazi silike i rodamina B za sorpciju α-1-kiselog glikoproteina. , 1-44.
https://hdl.handle.net/21.15107/rcub_cherry_6622

Radovanović A. Sinteza matriksa na bazi silike i rodamina B za sorpciju α-1-kiselog glikoproteina. 2024;:1-44.
https://hdl.handle.net/21.15107/rcub_cherry_6622 .

Radovanović, Aleksandar, "Sinteza matriksa na bazi silike i rodamina B za sorpciju α-1-kiselog glikoproteina" (2024):1-44,
https://hdl.handle.net/21.15107/rcub_cherry_6622 .

TY  - THES
AU  - Stanojević, Ana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6639
AB  - Početni korak u iniciranju alergijskog odgovora na proteine hrane je preuzimanje i obrada
alergena od strane makrofaga i dendritskih ćelija. Cilj ovog rada je in vitro ispitivanje efikasnosti
humanih naivnih THP-1 makrofaga u preuzimanju ovog alergena.
Humani THP-1 monociti diferencirani su in vitro u makrofage korišćenjem PMA, i
tretirani alergenom kikirikija Ara h 1. Ovaj alergen prethodno je izolovan i prečišćen iz sirovog
kikirikija kombinacijom frakcionisanja amonijum sulfatom i afinitetne hromatografije.
Imunološka reaktivnost Ara h 1 proverena je Western blot-om inkubiranjem sa serumima
pacijenata alergičnih na kikiriki. Prečišćeni Ara h 1 je obeležen FITC-om za potrebe ćelijskog
tretmana. Efikasnost preuzimanja Ara h 1 praćena je pomoću FACS analize, praćenjem
fluorescencije FITC-a.
T1  - Izolovanje i karakterizacija alergena Ara h 1 iz sirovog kikirikija i provera vezivanja FITC-obeleženog alergena za THP-1 makrofage
SP  - 2
EP  - 56
ER  - 

@misc{
author = "Stanojević, Ana",
year = "2024",
abstract = "Početni korak u iniciranju alergijskog odgovora na proteine hrane je preuzimanje i obrada
alergena od strane makrofaga i dendritskih ćelija. Cilj ovog rada je in vitro ispitivanje efikasnosti
humanih naivnih THP-1 makrofaga u preuzimanju ovog alergena.
Humani THP-1 monociti diferencirani su in vitro u makrofage korišćenjem PMA, i
tretirani alergenom kikirikija Ara h 1. Ovaj alergen prethodno je izolovan i prečišćen iz sirovog
kikirikija kombinacijom frakcionisanja amonijum sulfatom i afinitetne hromatografije.
Imunološka reaktivnost Ara h 1 proverena je Western blot-om inkubiranjem sa serumima
pacijenata alergičnih na kikiriki. Prečišćeni Ara h 1 je obeležen FITC-om za potrebe ćelijskog
tretmana. Efikasnost preuzimanja Ara h 1 praćena je pomoću FACS analize, praćenjem
fluorescencije FITC-a.",
title = "Izolovanje i karakterizacija alergena Ara h 1 iz sirovog kikirikija i provera vezivanja FITC-obeleženog alergena za THP-1 makrofage",
pages = "2-56"
}

Stanojević, A.. (2024). Izolovanje i karakterizacija alergena Ara h 1 iz sirovog kikirikija i provera vezivanja FITC-obeleženog alergena za THP-1 makrofage. , 2-56.

Stanojević A. Izolovanje i karakterizacija alergena Ara h 1 iz sirovog kikirikija i provera vezivanja FITC-obeleženog alergena za THP-1 makrofage. 2024;:2-56..

Stanojević, Ana, "Izolovanje i karakterizacija alergena Ara h 1 iz sirovog kikirikija i provera vezivanja FITC-obeleženog alergena za THP-1 makrofage" (2024):2-56.

TY  - THES
AU  - Milanović, Lola
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6640
AB  - Osnovni cilj ovog završnog rada je proizvodnja rekombinantnog Ara h 8 u E. coli ekspresionom sistemu i prečišćavanje hromatografskim metodama. Dalji fokus ovog rada je imunološka karakterizacija prečišćenog rekombinantnog Ara h 8 imunoblotom, u cilju ispitivanja ukrštene reaktivnosti sa glavnim alergenom polena breze, Bet v 1.
T1  - Ekspresija, prečišćavanje i imunološka karakterizacija rekombinantog alergena Ara h 8.02 iz kikirikija
SP  - 1
EP  - 33
ER  - 

@misc{
author = "Milanović, Lola",
year = "2024",
abstract = "Osnovni cilj ovog završnog rada je proizvodnja rekombinantnog Ara h 8 u E. coli ekspresionom sistemu i prečišćavanje hromatografskim metodama. Dalji fokus ovog rada je imunološka karakterizacija prečišćenog rekombinantnog Ara h 8 imunoblotom, u cilju ispitivanja ukrštene reaktivnosti sa glavnim alergenom polena breze, Bet v 1.",
title = "Ekspresija, prečišćavanje i imunološka karakterizacija rekombinantog alergena Ara h 8.02 iz kikirikija",
pages = "1-33"
}

Milanović, L.. (2024). Ekspresija, prečišćavanje i imunološka karakterizacija rekombinantog alergena Ara h 8.02 iz kikirikija. , 1-33.

Milanović L. Ekspresija, prečišćavanje i imunološka karakterizacija rekombinantog alergena Ara h 8.02 iz kikirikija. 2024;:1-33..

Milanović, Lola, "Ekspresija, prečišćavanje i imunološka karakterizacija rekombinantog alergena Ara h 8.02 iz kikirikija" (2024):1-33.

TY  - JOUR
AU  - Kocić, Jovana
AU  - Zečević, Nebojša
AU  - Jagodić, Jovana
AU  - Ardalić, Daniela
AU  - Miković, Željko
AU  - Kotur-Stevuljević, Jelena
AU  - Manojlović, Dragan
AU  - Stojsavljević, Aleksandar
PY  - 2024
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0946672X24001512
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6638
AB  - Background: Cervical intraepithelial neoplasia (CIN) represents a premalignant state presumably related to perturbations in circulating levels of trace elements. Materials and methods: Employing inductively coupled plasma mass spectrometry (ICP-MS), we quantified essential and toxic trace elements in the sera of 60 women diagnosed with CIN and 60 age-matched healthy counterparts. Results: Our investigation revealed a noteworthy higher levels in serum of Mn, Zn, and Pb, as well as lower levels in Ni, Se, Rb, and Mo levels within the CIN cohort. Levels of Mn, Zn, and Pb were higher by approximately 5.5-fold, 3.0-fold, and 7.5-fold, respectively, while Mo levels exhibited an approximate 4.5-fold reduction in CIN sera compared to the control group. While the study provided valuable insights into trace element variations, it’s important to note that the adult Serbian population is considered Zn-deficient, so the Zn data should be interpreted with caution. Age stratification (30–40 vs. 40–50 vs. 50–60 years), smoking status (smokers vs. nonsmokers), and CIN severity (CIN 2 vs. CIN 3) yielded no significant disparities in elemental profiles. Among the 10 proposed ratios, 5 demonstrated a significant surge in CIN sera relative to controls: Mn/Se, Mn/Mo, Zn/Se, Zn/Mo, and Se/Mo. Correlation analysis of trace element levels revealed a predominantly consistent pattern between CIN cases and healthy subjects, except for Zn and its negative correlations (antagonistic interactions) with other analyzed trace elements. Conclusion: Our findings underscore differences in serum levels of specific trace elements in CIN cases versus controls, implicating their potential involvement in the underlying pathophysiological cascades culminating in cervical neoplasms.
PB  - Elsevier
T2  - Journal of Trace Elements in Medicine and Biology
T2  - Journal of Trace Elements in Medicine and Biology
T1  - Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia
VL  - 86
SP  - 127531
DO  - 10.1016/j.jtemb.2024.127531
ER  - 

@article{
author = "Kocić, Jovana and Zečević, Nebojša and Jagodić, Jovana and Ardalić, Daniela and Miković, Željko and Kotur-Stevuljević, Jelena and Manojlović, Dragan and Stojsavljević, Aleksandar",
year = "2024",
abstract = "Background: Cervical intraepithelial neoplasia (CIN) represents a premalignant state presumably related to perturbations in circulating levels of trace elements. Materials and methods: Employing inductively coupled plasma mass spectrometry (ICP-MS), we quantified essential and toxic trace elements in the sera of 60 women diagnosed with CIN and 60 age-matched healthy counterparts. Results: Our investigation revealed a noteworthy higher levels in serum of Mn, Zn, and Pb, as well as lower levels in Ni, Se, Rb, and Mo levels within the CIN cohort. Levels of Mn, Zn, and Pb were higher by approximately 5.5-fold, 3.0-fold, and 7.5-fold, respectively, while Mo levels exhibited an approximate 4.5-fold reduction in CIN sera compared to the control group. While the study provided valuable insights into trace element variations, it’s important to note that the adult Serbian population is considered Zn-deficient, so the Zn data should be interpreted with caution. Age stratification (30–40 vs. 40–50 vs. 50–60 years), smoking status (smokers vs. nonsmokers), and CIN severity (CIN 2 vs. CIN 3) yielded no significant disparities in elemental profiles. Among the 10 proposed ratios, 5 demonstrated a significant surge in CIN sera relative to controls: Mn/Se, Mn/Mo, Zn/Se, Zn/Mo, and Se/Mo. Correlation analysis of trace element levels revealed a predominantly consistent pattern between CIN cases and healthy subjects, except for Zn and its negative correlations (antagonistic interactions) with other analyzed trace elements. Conclusion: Our findings underscore differences in serum levels of specific trace elements in CIN cases versus controls, implicating their potential involvement in the underlying pathophysiological cascades culminating in cervical neoplasms.",
publisher = "Elsevier",
journal = "Journal of Trace Elements in Medicine and Biology, Journal of Trace Elements in Medicine and Biology",
title = "Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia",
volume = "86",
pages = "127531",
doi = "10.1016/j.jtemb.2024.127531"
}

Kocić, J., Zečević, N., Jagodić, J., Ardalić, D., Miković, Ž., Kotur-Stevuljević, J., Manojlović, D.,& Stojsavljević, A.. (2024). Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia. in Journal of Trace Elements in Medicine and Biology
Elsevier., 86, 127531.
https://doi.org/10.1016/j.jtemb.2024.127531

Kocić J, Zečević N, Jagodić J, Ardalić D, Miković Ž, Kotur-Stevuljević J, Manojlović D, Stojsavljević A. Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia. in Journal of Trace Elements in Medicine and Biology. 2024;86:127531.
doi:10.1016/j.jtemb.2024.127531 .

Kocić, Jovana, Zečević, Nebojša, Jagodić, Jovana, Ardalić, Daniela, Miković, Željko, Kotur-Stevuljević, Jelena, Manojlović, Dragan, Stojsavljević, Aleksandar, "Exploring serum trace element shifts: Implications for cervical intraepithelial neoplasia" in Journal of Trace Elements in Medicine and Biology, 86 (2024):127531,
https://doi.org/10.1016/j.jtemb.2024.127531 . .

TY  - THES
AU  - Popović, Ljubica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6637
AB  - Piroksikam (PRX) je nesteroidni antiinfamatorni lek koji pripada klasi oksikama i pokazuje analgetsko, antipiretičko i antiinflamatorno dejstvo. PRX sadrži dve jonizabilne grupe (pKa 1,86 i pKa 5,46) i heteroatome koji se mogu koordinovati za jone različitih metala. U ovom radu ispitivane su interakcije PRX sa Fe3+ jonima u vodi na različitim pH vrednostima pomoću UV-Vis i fluorescentne spektroskopije i ciklične votametrije (CV). Formiranje PRX-Fe3+ kompleksa se dešava na kiselim pH vrednostima (pH 2, pH 4 i pH 5). U neutralnom vodenom rastvoru (pH 7). PRX je prisutan u anjonskom obliku koji favorizuje koordinovanje jona metala, ali zbog slabe rastvorljivosti Fe3+ vrsta na ovom pH ne dolazi do formiranja PRX-Fe3+ kompleksa. CV merenja su urađena na pH 4 i pH 5 u cilju ispitivanja redoks osobina PRX u prisustvu Fe3+ jona. Na pH 4, prisustvo Fe3+ jona stabilizuje PRX čineći ga manje podložnim oksidaciji, dok na pH 5 interakcije sa Fe3+ jonima favorizuju oksidaciju PRX. Uočene promene u redukcionom potencijalu Fe3+ dodatno ukazuju na formiranje PRX-Fe3+ kompleksa.
T1  - Ispitivanje interakcija piroksikama i Fe3+ jona u vodi na različitim pH
SP  - 1
EP  - 23
ER  - 

@misc{
author = "Popović, Ljubica",
year = "2024",
abstract = "Piroksikam (PRX) je nesteroidni antiinfamatorni lek koji pripada klasi oksikama i pokazuje analgetsko, antipiretičko i antiinflamatorno dejstvo. PRX sadrži dve jonizabilne grupe (pKa 1,86 i pKa 5,46) i heteroatome koji se mogu koordinovati za jone različitih metala. U ovom radu ispitivane su interakcije PRX sa Fe3+ jonima u vodi na različitim pH vrednostima pomoću UV-Vis i fluorescentne spektroskopije i ciklične votametrije (CV). Formiranje PRX-Fe3+ kompleksa se dešava na kiselim pH vrednostima (pH 2, pH 4 i pH 5). U neutralnom vodenom rastvoru (pH 7). PRX je prisutan u anjonskom obliku koji favorizuje koordinovanje jona metala, ali zbog slabe rastvorljivosti Fe3+ vrsta na ovom pH ne dolazi do formiranja PRX-Fe3+ kompleksa. CV merenja su urađena na pH 4 i pH 5 u cilju ispitivanja redoks osobina PRX u prisustvu Fe3+ jona. Na pH 4, prisustvo Fe3+ jona stabilizuje PRX čineći ga manje podložnim oksidaciji, dok na pH 5 interakcije sa Fe3+ jonima favorizuju oksidaciju PRX. Uočene promene u redukcionom potencijalu Fe3+ dodatno ukazuju na formiranje PRX-Fe3+ kompleksa.",
title = "Ispitivanje interakcija piroksikama i Fe3+ jona u vodi na različitim pH",
pages = "1-23"
}

Popović, L.. (2024). Ispitivanje interakcija piroksikama i Fe3+ jona u vodi na različitim pH. , 1-23.

Popović L. Ispitivanje interakcija piroksikama i Fe3+ jona u vodi na različitim pH. 2024;:1-23..

Popović, Ljubica, "Ispitivanje interakcija piroksikama i Fe3+ jona u vodi na različitim pH" (2024):1-23.

TY  - THES
AU  - Getl, Milica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6635
AB  - Perfluorooktanoat sulfonat (PFOS) pripada grupi perfluoroalkil-supstanci (PFAS), koje predstavljaju sintetička, stabilna jedinjenja, veoma postojana u životnoj sredini. S obzirom na njihov nepoznat uticaj na biodiverzitet, neophodno je naći najefikasniji način za njihovo uklanjanje. Cilj ovog rada bio je ispitati da li je proces fotokatalize pogodan za degradaciju PFOS-a. Korišćena su tri tipa fotokatalizatora – na bazi titanijum-dioksida, cink-oksida i titanijum-dioksida sa tečnim grafen-oksidom. Nakon završetka fotokatalize određene su koncentracije fluoridnih jona uz pomoć jon selektivne elektrode i koncentracije preostalog PFOS-a pomoću tečne hromatografije sa masenom spektrometrijom. Na kraju, ekotoksičnost degradacionih proizvoda ispitana je na model sistemu Aliivibrio fischeri. Pokazano je da fotokatalizatori na bazi cink-oksida dovode do najvećeg stepena degradacije, ali da usled toga dolazi i do porasta ekotoksičnosti u odnosu na polazno jedinjenje.
T1  - Fotokatalitička degradacija perfluorooktanoat sulfonata
SP  - 1
EP  - 26
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6635
ER  - 

@misc{
author = "Getl, Milica",
year = "2024",
abstract = "Perfluorooktanoat sulfonat (PFOS) pripada grupi perfluoroalkil-supstanci (PFAS), koje predstavljaju sintetička, stabilna jedinjenja, veoma postojana u životnoj sredini. S obzirom na njihov nepoznat uticaj na biodiverzitet, neophodno je naći najefikasniji način za njihovo uklanjanje. Cilj ovog rada bio je ispitati da li je proces fotokatalize pogodan za degradaciju PFOS-a. Korišćena su tri tipa fotokatalizatora – na bazi titanijum-dioksida, cink-oksida i titanijum-dioksida sa tečnim grafen-oksidom. Nakon završetka fotokatalize određene su koncentracije fluoridnih jona uz pomoć jon selektivne elektrode i koncentracije preostalog PFOS-a pomoću tečne hromatografije sa masenom spektrometrijom. Na kraju, ekotoksičnost degradacionih proizvoda ispitana je na model sistemu Aliivibrio fischeri. Pokazano je da fotokatalizatori na bazi cink-oksida dovode do najvećeg stepena degradacije, ali da usled toga dolazi i do porasta ekotoksičnosti u odnosu na polazno jedinjenje.",
title = "Fotokatalitička degradacija perfluorooktanoat sulfonata",
pages = "1-26",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6635"
}

Getl, M.. (2024). Fotokatalitička degradacija perfluorooktanoat sulfonata. , 1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6635

Getl M. Fotokatalitička degradacija perfluorooktanoat sulfonata. 2024;:1-26.
https://hdl.handle.net/21.15107/rcub_cherry_6635 .

Getl, Milica, "Fotokatalitička degradacija perfluorooktanoat sulfonata" (2024):1-26,
https://hdl.handle.net/21.15107/rcub_cherry_6635 .

TY  - THES
AU  - Nikolić, Atina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6634
AB  - Azobenzeni i njihovi derivati su značajna grupa molekula, jer su pored primene u industriji boja, našli ulogu i u fotofarmakologiji. Njihova primena bazira se na mogućnosti za E→Z i Z→E izomerizaciju pod uticajem svetlosti. U prvom segmentu ovog završnog rada sintetisan je (E)-1-(3-nitrofenil)-2-fenildiazen i njegovi derivati primenom reakcije Baeyer-Mills-ove kondenzacije. U drugom segmentu ispitivana je fotoizomerizacija dobijenih derivata, kao i uticaj supstituenata na istu.
T1  - Sinteza derivata (E)-1-(3-nitrofenil)-2-fenildiazena primenom Baeyer-Mills-ove reakcije i njihova fotoizomerizacija
SP  - 2
EP  - 33
ER  - 

@misc{
author = "Nikolić, Atina B.",
year = "2024",
abstract = "Azobenzeni i njihovi derivati su značajna grupa molekula, jer su pored primene u industriji boja, našli ulogu i u fotofarmakologiji. Njihova primena bazira se na mogućnosti za E→Z i Z→E izomerizaciju pod uticajem svetlosti. U prvom segmentu ovog završnog rada sintetisan je (E)-1-(3-nitrofenil)-2-fenildiazen i njegovi derivati primenom reakcije Baeyer-Mills-ove kondenzacije. U drugom segmentu ispitivana je fotoizomerizacija dobijenih derivata, kao i uticaj supstituenata na istu.",
title = "Sinteza derivata (E)-1-(3-nitrofenil)-2-fenildiazena primenom Baeyer-Mills-ove reakcije i njihova fotoizomerizacija",
pages = "2-33"
}

Nikolić, A. B.. (2024). Sinteza derivata (E)-1-(3-nitrofenil)-2-fenildiazena primenom Baeyer-Mills-ove reakcije i njihova fotoizomerizacija. , 2-33.

Nikolić AB. Sinteza derivata (E)-1-(3-nitrofenil)-2-fenildiazena primenom Baeyer-Mills-ove reakcije i njihova fotoizomerizacija. 2024;:2-33..

Nikolić, Atina B., "Sinteza derivata (E)-1-(3-nitrofenil)-2-fenildiazena primenom Baeyer-Mills-ove reakcije i njihova fotoizomerizacija" (2024):2-33.

TY  - THES
AU  - Radović, Jelena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6629
AB  - Koronavirusi neprestano mutiraju i rekombinuju, što može da poveća njihovu virulenciju. Glavna proteaza SARS-CoV-2 (Mpro/3CLpro) ima značajnu ulogu u životnom ciklusu virusa, a odsustvo homolognih proteaza kod ljudi i strukturna očuvanost Mpro među koronavirusima čine je pogodnom terapijskom metom. Fikobiliproteini (PBP) su fotosenzitivni pigmenti cijanobakterija i crvenih algi. Hromopeptidi PBP se oslobađaju delovanjem proteaza i mogu da inhibiraju enzime značajne za razvoj različitih oboljenja, kao i da se koriste u terapiji COVID-19, u kombinaciji sa postojećim tretmanima.
Osnovni cilj ovog rada bio je da se ispita da li, i u kojoj meri, enzimski digesti PBP cijanobakterije Spiruline (Arthrospira platensis) i crvene mikroalge Porfiridijuma (Porphyridium purpureum) inhibiraju aktivnost Mpro. Proteini ekstrakata algi su digestovani pepsinom i pankreatinom, a uspešnost digestije praćena je snimanjem UV-VIS apsorpcionih spektara i rasoljavanjem digesta na gel filtracionoj koloni. PBP digest koji je inhibirao aktivnost Mpro dalje je razdvojen tečnom hromatografijom visokih performansi (HPLC) kako bi se dobile frakcije hromopeptida. Urađena je enzimska kinetika da se ispita da li i koje pojedinačne frakcije hromopeptida inhibiraju Mpro, a tandemskom masenom spektrometrijom su određene sekvence peptida zaslužne za inhibiciju enzima.
Digestija PBP Spiruline bila je uspešna pri korišćenju oba enzima, dok su PBP iz Porfirdiijuma bili podložni samo digestiji pankreatinom. Praćenjem enzimske aktivnosti fluorescencijom je pokazano da samo pankreatinski digest B-fikoeritrina (B-PE), dominantnog PBP iz Porfiridijuma, inhibira aktivnost Mpro. HPLC razdvajanjem su dobijene dve glavne frakcije hromopeptida B-PE. Obe frakcije su inhibirale aktivnost Mpro, ali u manjoj meri nego pun digest B-PE. Analizom MS spektara identifikovane su sekvence hromopeptida poreklom iz α- i β-subjedinica B-PE, kao i prisustvo fikoeritrobilinskih (PEB) hromofora. Ovi rezultati ukazuju da su PEB hromofore u hromopeptidima primarno zaslužne za narušavanje aktivnosti Mpro. Buduća istraživanja biće usmerena na ispitivanje uticaja hromopeptida drugih algi na aktivnost Mpro, kao i na ispitivanja primene hromopeptida u kombinaciji sa drugim postojećim inhibitorima Mpro u tretmanu koronavirusa, uz korišćenje i životinjskih eksperimentalnih modela.
T1  - Uticaj hromopeptida iz Spiruline i Porfiridijuma na aktivnost glavne proteaze koronavirusa Mpro
SP  - 2
EP  - 58
ER  - 

@mastersthesis{
author = "Radović, Jelena",
year = "2024",
abstract = "Koronavirusi neprestano mutiraju i rekombinuju, što može da poveća njihovu virulenciju. Glavna proteaza SARS-CoV-2 (Mpro/3CLpro) ima značajnu ulogu u životnom ciklusu virusa, a odsustvo homolognih proteaza kod ljudi i strukturna očuvanost Mpro među koronavirusima čine je pogodnom terapijskom metom. Fikobiliproteini (PBP) su fotosenzitivni pigmenti cijanobakterija i crvenih algi. Hromopeptidi PBP se oslobađaju delovanjem proteaza i mogu da inhibiraju enzime značajne za razvoj različitih oboljenja, kao i da se koriste u terapiji COVID-19, u kombinaciji sa postojećim tretmanima.
Osnovni cilj ovog rada bio je da se ispita da li, i u kojoj meri, enzimski digesti PBP cijanobakterije Spiruline (Arthrospira platensis) i crvene mikroalge Porfiridijuma (Porphyridium purpureum) inhibiraju aktivnost Mpro. Proteini ekstrakata algi su digestovani pepsinom i pankreatinom, a uspešnost digestije praćena je snimanjem UV-VIS apsorpcionih spektara i rasoljavanjem digesta na gel filtracionoj koloni. PBP digest koji je inhibirao aktivnost Mpro dalje je razdvojen tečnom hromatografijom visokih performansi (HPLC) kako bi se dobile frakcije hromopeptida. Urađena je enzimska kinetika da se ispita da li i koje pojedinačne frakcije hromopeptida inhibiraju Mpro, a tandemskom masenom spektrometrijom su određene sekvence peptida zaslužne za inhibiciju enzima.
Digestija PBP Spiruline bila je uspešna pri korišćenju oba enzima, dok su PBP iz Porfirdiijuma bili podložni samo digestiji pankreatinom. Praćenjem enzimske aktivnosti fluorescencijom je pokazano da samo pankreatinski digest B-fikoeritrina (B-PE), dominantnog PBP iz Porfiridijuma, inhibira aktivnost Mpro. HPLC razdvajanjem su dobijene dve glavne frakcije hromopeptida B-PE. Obe frakcije su inhibirale aktivnost Mpro, ali u manjoj meri nego pun digest B-PE. Analizom MS spektara identifikovane su sekvence hromopeptida poreklom iz α- i β-subjedinica B-PE, kao i prisustvo fikoeritrobilinskih (PEB) hromofora. Ovi rezultati ukazuju da su PEB hromofore u hromopeptidima primarno zaslužne za narušavanje aktivnosti Mpro. Buduća istraživanja biće usmerena na ispitivanje uticaja hromopeptida drugih algi na aktivnost Mpro, kao i na ispitivanja primene hromopeptida u kombinaciji sa drugim postojećim inhibitorima Mpro u tretmanu koronavirusa, uz korišćenje i životinjskih eksperimentalnih modela.",
title = "Uticaj hromopeptida iz Spiruline i Porfiridijuma na aktivnost glavne proteaze koronavirusa Mpro",
pages = "2-58"
}

Radović, J.. (2024). Uticaj hromopeptida iz Spiruline i Porfiridijuma na aktivnost glavne proteaze koronavirusa Mpro. , 2-58.

Radović J. Uticaj hromopeptida iz Spiruline i Porfiridijuma na aktivnost glavne proteaze koronavirusa Mpro. 2024;:2-58..

Radović, Jelena, "Uticaj hromopeptida iz Spiruline i Porfiridijuma na aktivnost glavne proteaze koronavirusa Mpro" (2024):2-58.

TY  - THES
AU  - Pantović, Danijela
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6631
AB  - Cilj rada je uklanjanje azo boja (Reactive black5, Red F3B, Yellow 2G, Violet 68, Blue 354) iz vodenih rastvora pomoću huminskih kiselina po principu apsorpcije. Upoređivanjem rezultata za dve različite huminske kiseline, zaključeno je da je količina huminske kiseline za efikasno uklanjanje boja najbolja kada je veća koncentracija i pH sredine kisela. Uzorci su snimljeni na uv/vis spektrofotometru.
T1  - Apsorpcija azo boja pomoću huminskih kiselina
SP  - 1
EP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6631
ER  - 

@mastersthesis{
author = "Pantović, Danijela",
year = "2024",
abstract = "Cilj rada je uklanjanje azo boja (Reactive black5, Red F3B, Yellow 2G, Violet 68, Blue 354) iz vodenih rastvora pomoću huminskih kiselina po principu apsorpcije. Upoređivanjem rezultata za dve različite huminske kiseline, zaključeno je da je količina huminske kiseline za efikasno uklanjanje boja najbolja kada je veća koncentracija i pH sredine kisela. Uzorci su snimljeni na uv/vis spektrofotometru.",
title = "Apsorpcija azo boja pomoću huminskih kiselina",
pages = "1-28",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6631"
}

Pantović, D.. (2024). Apsorpcija azo boja pomoću huminskih kiselina. , 1-28.
https://hdl.handle.net/21.15107/rcub_cherry_6631

Pantović D. Apsorpcija azo boja pomoću huminskih kiselina. 2024;:1-28.
https://hdl.handle.net/21.15107/rcub_cherry_6631 .

Pantović, Danijela, "Apsorpcija azo boja pomoću huminskih kiselina" (2024):1-28,
https://hdl.handle.net/21.15107/rcub_cherry_6631 .

TY  - THES
AU  - Aleksić, Ljubodrag
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6632
AB  - Duktalni adenokarcinom pankreasa (PDAC) je solidni malignitet sa izuzetno visokom petogodišnjom stopom mortaliteta (~90%). Kasna dijagnoza, niska specifičnost tumorskih markera, otežana resektabilnost (mogućnost hirurškog uklanjanja tumora) i rezistencija na terapiju neki su od osnovnih razloga za visoku smrtonosnost ovog oboljenja. Feroptoza je vid ne-apoptozne regulisane ćelijske smrti koju izaziva gvožđe-zavisna peroksidacija određenih lipida ćelijske membrane i mnogi induceri feroptoze predloženi su za upotrebu u tretmanu tumora otpornih na terapiju. Kao in vitro model PDAC odabrane su ćelijske linije MIA PaCa-2 i PANC-1 zbog međusobnih metaboličkih razlika i ispitano je pro-feroptozno dejstvo tri derivata 4-aminohinolina - jedinjenja 1, 2 i 3 u ovim ćelijskim linijama praćenjem njihovog uticaja na procente vijabilnih ćelija, aktivnost kaspaza 3 i 7, distribuciju ćelija po fazama ćelijskog ciklusa, promenu mitohondrijskog membranskog potencijala, proizvodnju reaktivnih kiseoničnih vrsta i ekspresiju odabranih proteina - KEAP1, Nrf2, p62, p53 i SLC7A11 - u 2D kulturama MIA PaCa-2 i PANC-1. Na osnovu rezultata dobijenih tokom izrade ovog rada može se tvrditi da ova jedinjenja senzitiziraju MIA PaCa-2 i naročito PANC-1 ćelije na feroptozu indukovanu erastinom, klasičnog inducera feroptoze. Međutim sama jedinjenja 1-3 indukuju ranu apoptozu, regulisani vid ćelijske smrti u ovim tumorskim ćelijskim linijama u odsustvu erastina.
T1  - Ispitivanje pro-feroptozne aktivnosti odabranih derivata 4-aminohinolina u in vitro modelu duktalnog adenokarcinoma pankreasa
SP  - 1
EP  - 74
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6632
ER  - 

@mastersthesis{
author = "Aleksić, Ljubodrag",
year = "2024",
abstract = "Duktalni adenokarcinom pankreasa (PDAC) je solidni malignitet sa izuzetno visokom petogodišnjom stopom mortaliteta (~90%). Kasna dijagnoza, niska specifičnost tumorskih markera, otežana resektabilnost (mogućnost hirurškog uklanjanja tumora) i rezistencija na terapiju neki su od osnovnih razloga za visoku smrtonosnost ovog oboljenja. Feroptoza je vid ne-apoptozne regulisane ćelijske smrti koju izaziva gvožđe-zavisna peroksidacija određenih lipida ćelijske membrane i mnogi induceri feroptoze predloženi su za upotrebu u tretmanu tumora otpornih na terapiju. Kao in vitro model PDAC odabrane su ćelijske linije MIA PaCa-2 i PANC-1 zbog međusobnih metaboličkih razlika i ispitano je pro-feroptozno dejstvo tri derivata 4-aminohinolina - jedinjenja 1, 2 i 3 u ovim ćelijskim linijama praćenjem njihovog uticaja na procente vijabilnih ćelija, aktivnost kaspaza 3 i 7, distribuciju ćelija po fazama ćelijskog ciklusa, promenu mitohondrijskog membranskog potencijala, proizvodnju reaktivnih kiseoničnih vrsta i ekspresiju odabranih proteina - KEAP1, Nrf2, p62, p53 i SLC7A11 - u 2D kulturama MIA PaCa-2 i PANC-1. Na osnovu rezultata dobijenih tokom izrade ovog rada može se tvrditi da ova jedinjenja senzitiziraju MIA PaCa-2 i naročito PANC-1 ćelije na feroptozu indukovanu erastinom, klasičnog inducera feroptoze. Međutim sama jedinjenja 1-3 indukuju ranu apoptozu, regulisani vid ćelijske smrti u ovim tumorskim ćelijskim linijama u odsustvu erastina.",
title = "Ispitivanje pro-feroptozne aktivnosti odabranih derivata 4-aminohinolina u in vitro modelu duktalnog adenokarcinoma pankreasa",
pages = "1-74",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6632"
}

Aleksić, L.. (2024). Ispitivanje pro-feroptozne aktivnosti odabranih derivata 4-aminohinolina u in vitro modelu duktalnog adenokarcinoma pankreasa. , 1-74.
https://hdl.handle.net/21.15107/rcub_cherry_6632

Aleksić L. Ispitivanje pro-feroptozne aktivnosti odabranih derivata 4-aminohinolina u in vitro modelu duktalnog adenokarcinoma pankreasa. 2024;:1-74.
https://hdl.handle.net/21.15107/rcub_cherry_6632 .

Aleksić, Ljubodrag, "Ispitivanje pro-feroptozne aktivnosti odabranih derivata 4-aminohinolina u in vitro modelu duktalnog adenokarcinoma pankreasa" (2024):1-74,
https://hdl.handle.net/21.15107/rcub_cherry_6632 .