TY  - DATA
AU  - Penjišević, Jelena 
AU  - Šukalović, Vladimir 
AU  - Dukić-Stefanović, Slađana
AU  - Deuther-Conrad, Winnie
AU  - Andrić, Deana 
AU  - Kostić-Rajačić, Slađana
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5845
AB  - Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.
PB  - Elsevier
T2  - Arabian Journal of Chemistry
T1  - Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636
VL  - 16
IS  - 4
SP  - 104636
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5845
ER  - 

@misc{
author = "Penjišević, Jelena  and Šukalović, Vladimir  and Dukić-Stefanović, Slađana and Deuther-Conrad, Winnie and Andrić, Deana  and Kostić-Rajačić, Slađana",
abstract = "Serotonin receptors modulate numerous behavioral and neuropsychological processes. Therefore, they are the target for the action of many drugs, such as antipsychotics, antidepressants, antiemetics, migraine remedies, and many others. The 5-HT1A receptors have been involved in the pathogenesis and treatment of anxiety and depression and represent a promising target for new drugs with reduced extrapyramidal side effects. In most antidepressants, a piperazine-based structural motif can be identified as a common moiety. Here we describe the synthesis, pharmacological, and in silico characterization of a novel arylpiperazines series with excellent 5-HT1A affinity. The final compounds, 4a, 8a, and 8b, were selected according to predictions of in silico pharmacokinetics, docking analysis, and molecular dynamics in conjunction with physical properties, and metabolic stability. The accentuated molecules could serve as a lead compound for developing 5-HT1A drug-like molecules for depression treatment.",
publisher = "Elsevier",
journal = "Arabian Journal of Chemistry",
title = "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636",
volume = "16",
number = "4",
pages = "104636",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5845"
}

Penjišević, J., Šukalović, V., Dukić-Stefanović, S., Deuther-Conrad, W., Andrić, D.,& Kostić-Rajačić, S..Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry
Elsevier., 16(4), 104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845

Penjišević J, Šukalović V, Dukić-Stefanović S, Deuther-Conrad W, Andrić D, Kostić-Rajačić S. Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636. in Arabian Journal of Chemistry.16(4):104636.
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

Penjišević, Jelena , Šukalović, Vladimir , Dukić-Stefanović, Slađana, Deuther-Conrad, Winnie, Andrić, Deana , Kostić-Rajačić, Slađana, "Supplementary material for: Penjišević, J. Z., Šukalović, V. B., Dukic-Stefanovic, S., Deuther-Conrad, W., Andrić, D. B.,& Kostić-Rajačić, S. V.. (2023). Synthesis of novel 5-HT1A arylpiperazine ligands: Binding data and computer-aided analysis of pharmacological potency. in Arabian Journal of Chemistry Elsevier., 16(4), 104636. https://doi.org/10.1016/j.arabjc.2023.104636" in Arabian Journal of Chemistry, 16, no. 4:104636,
https://hdl.handle.net/21.15107/rcub_cherry_5845 .

TY  - JOUR
AU  - Pastor, Ferenc T.
AU  - Dojčinović, Biljana P.
AU  - Kodranov, Igor D.
AU  - Gorjanović, Stanislava
AU  - Ivanović, Tijana
AU  - Popović, Daniela Ž.
AU  - Miladinović, Jelena
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6390
AB  - Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.
PB  - Wiley
T2  - Electroanalysis
T1  - 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination
VL  - n/a
IS  - n/a
SP  - e202300259
DO  - 10.1002/elan.202300259
ER  - 

@article{
author = "Pastor, Ferenc T. and Dojčinović, Biljana P. and Kodranov, Igor D. and Gorjanović, Stanislava and Ivanović, Tijana and Popović, Daniela Ž. and Miladinović, Jelena",
abstract = "Due to the similar chemical properties of Ni2+ and Co2+, several dozens of adsorptive stripping voltammetric (AdSV) methods have been developed for their simultaneous determination. The question was would there be some benefits if a stripping method made for simultaneous determination of Ni2+ and Co2+ will be optimized for the determination of only one of them (Ni2+). It was found that the optimized method has for an order of magnitude lower LOQ (1.89×10−10 M), an order of magnitude lower influence of Co2+, and the applicability of one calibration line for four orders of magnitude of Ni2+ concentration. The influence of some common anions and cations has been examined. The developed method was successfully applied for nickel content determination in real samples. The suitability of the developed method for the determination of Co2+ from the same solution in the second run, upon optimizations of deposition potential and time, was also explored. The LOQ obtained for Co2+ (3.61×10−11 M) is almost two orders of magnitude lower than LOQ of the method for simultaneous determination of both cations and, its LOD and LOQ are among few lowest obtained by AdSV methods for Co2+ determination. The developed method for Ni2+ and Co2+ determination from the same solution in two successive runs has significantly better analytical performances than the starting method for their simultaneous determination in one run.",
publisher = "Wiley",
journal = "Electroanalysis",
title = "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination",
volume = "n/a",
number = "n/a",
pages = "e202300259",
doi = "10.1002/elan.202300259"
}

Pastor, F. T., Dojčinović, B. P., Kodranov, I. D., Gorjanović, S., Ivanović, T., Popović, D. Ž.,& Miladinović, J..2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis
Wiley., n/a(n/a), e202300259.
https://doi.org/10.1002/elan.202300259

Pastor FT, Dojčinović BP, Kodranov ID, Gorjanović S, Ivanović T, Popović DŽ, Miladinović J. 2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination. in Electroanalysis.n/a(n/a):e202300259.
doi:10.1002/elan.202300259 .

Pastor, Ferenc T., Dojčinović, Biljana P., Kodranov, Igor D., Gorjanović, Stanislava, Ivanović, Tijana, Popović, Daniela Ž., Miladinović, Jelena, "2 in 1 versus 1 plus 1 – Outcomes of the transformation of adsorptive stripping method for the Ni2+ and Co2+ determination" in Electroanalysis, n/a, no. n/a:e202300259,
https://doi.org/10.1002/elan.202300259 . .

TY  - DATA
AU  - Aleksić, Jovana
AU  - Stojanović, Milovan
AU  - Bošković, Jakša
AU  - Baranac-Stojanović, Marija
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/5846
AB  - We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.
PB  - Royal Society of Chemistry
T2  - Organic & Biomolecular Chemistry
T1  - Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F
VL  - 21
IS  - 6
UR  - https://hdl.handle.net/21.15107/rcub_cherry_5846
ER  - 

@misc{
author = "Aleksić, Jovana and Stojanović, Milovan and Bošković, Jakša and Baranac-Stojanović, Marija",
abstract = "We present the green, highly atom-economical, solid-state silica gel-catalyzed synthesis of polysubstituted 1,4- and 1,2-dihydropyridines (DHPs) from commercially available materials, amines and ethyl propiolate. The DHP skeleton was assembled by heating the reactants and silica gel in a closed vessel. Aliphatic amines provided 1,4-isomers as the main or only DHP products, but the reactions of aromatic amines yielded a mixture of 1,4- and 1,2-isomers. To the best of our knowledge, this is the first example of the formation of a 1,2-DHP structure by the reaction of an amine with propiolic ester. Addition of 1 mass percent of H2SO4 to silica gel shifted the product distribution to 1,4-DHP as the main or the only isomer obtained. Experimental and theoretical analyses led to the identification of two key intermediates en route to DHPs and the explanation of the observed regioisomeric ratios. 1,2-DHPs show blue-cyan fluorescence in MeOH with the quantum yield Φ = 0.10–0.22 relative to quinine sulfate Φ = 0.58 and 1,4-DHPs show blue-violet fluorescence with Φ = 0.09–0.81.",
publisher = "Royal Society of Chemistry",
journal = "Organic & Biomolecular Chemistry",
title = "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F",
volume = "21",
number = "6",
url = "https://hdl.handle.net/21.15107/rcub_cherry_5846"
}

Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M..Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846

Aleksić J, Stojanović M, Bošković J, Baranac-Stojanović M. Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F. in Organic & Biomolecular Chemistry.21(6).
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

Aleksić, Jovana, Stojanović, Milovan, Bošković, Jakša, Baranac-Stojanović, Marija, "Supplementary material for: Aleksić, J., Stojanović, M., Bošković, J.,& Baranac-Stojanović, M.. (2023). Solid-state silica gel-catalyzed synthesis of fluorescent polysubstituted 1,4- and 1,2-dihydropyridines. in Organic & Biomolecular Chemistry
Royal Society of Chemistry., 21(6), 1187-1205.
https://doi.org/10.1039/D2OB02119F" in Organic & Biomolecular Chemistry, 21, no. 6,
https://hdl.handle.net/21.15107/rcub_cherry_5846 .

TY  - JOUR
AU  - Ćurčić, Vladimir
AU  - Olszewski, Mateusz
AU  - Maciejewska, Natalia
AU  - Višnjevac, Aleksandar
AU  - Srdić-Rajić, Tatjana
AU  - Dobričić, Vladimir
AU  - García-Sosa, Alfonso T.
AU  - Kokanov, Sanja B.
AU  - Araškov, Jovana
AU  - Silvestri, Romano
AU  - Schüle, Roland
AU  - Jung, Manfred
AU  - Nikolić, Milan
AU  - Filipović, Nenad R.
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6392
AB  - Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.
PB  - John Wiley and Sons Inc
T2  - Archiv der Pharmazie
T2  - Archiv der Pharmazie
T1  - Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
VL  - n/a
IS  - n/a
SP  - e2300426
DO  - 10.1002/ardp.202300426
ER  - 

@article{
author = "Ćurčić, Vladimir and Olszewski, Mateusz and Maciejewska, Natalia and Višnjevac, Aleksandar and Srdić-Rajić, Tatjana and Dobričić, Vladimir and García-Sosa, Alfonso T. and Kokanov, Sanja B. and Araškov, Jovana and Silvestri, Romano and Schüle, Roland and Jung, Manfred and Nikolić, Milan and Filipović, Nenad R.",
abstract = "Heterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based on the 8-quinoline (1a–c), 2-quinoline (2a–c), and 8-hydroxy-2-quinolyl moiety (3a–c). The panel of several human cancer cell lines and the nontumorigenic human embryonic kidney cell line HEK-293 were used to evaluate the compound-mediated in vitro anticancer activities, leading to [2-(2-(quinolyl-8-ol-2-ylmethylene)hydrazinyl)]-4-(4-methoxyphenyl)-1,3-thiazole (3c) as the most promising compound. The study revealed that 3c blocks the cell-cycle progression of a human colon cancer cell line (HCT-116) in the S phase and induces DNA double-strand breaks. Also, our findings demonstrate that 3c accumulates in lysosomes, ultimately leading to the cell death of the hepatocellular carcinoma cell line (Hep-G2) and HCT-116 cells, by the mechanism of autophagy inhibition.",
publisher = "John Wiley and Sons Inc",
journal = "Archiv der Pharmazie, Archiv der Pharmazie",
title = "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition",
volume = "n/a",
number = "n/a",
pages = "e2300426",
doi = "10.1002/ardp.202300426"
}

Ćurčić, V., Olszewski, M., Maciejewska, N., Višnjevac, A., Srdić-Rajić, T., Dobričić, V., García-Sosa, A. T., Kokanov, S. B., Araškov, J., Silvestri, R., Schüle, R., Jung, M., Nikolić, M.,& Filipović, N. R..Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie
John Wiley and Sons Inc., n/a(n/a), e2300426.
https://doi.org/10.1002/ardp.202300426

Ćurčić V, Olszewski M, Maciejewska N, Višnjevac A, Srdić-Rajić T, Dobričić V, García-Sosa AT, Kokanov SB, Araškov J, Silvestri R, Schüle R, Jung M, Nikolić M, Filipović NR. Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition. in Archiv der Pharmazie.n/a(n/a):e2300426.
doi:10.1002/ardp.202300426 .

Ćurčić, Vladimir, Olszewski, Mateusz, Maciejewska, Natalia, Višnjevac, Aleksandar, Srdić-Rajić, Tatjana, Dobričić, Vladimir, García-Sosa, Alfonso T., Kokanov, Sanja B., Araškov, Jovana, Silvestri, Romano, Schüle, Roland, Jung, Manfred, Nikolić, Milan, Filipović, Nenad R., "Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition" in Archiv der Pharmazie, n/a, no. n/a:e2300426,
https://doi.org/10.1002/ardp.202300426 . .

TY  - DATA
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6529
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343
VL  - 101
IS  - 4
ER  - 

@misc{
author = "Putica, Katarina B.",
year = "2024",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343",
volume = "101",
number = "4"
}

Putica, K. B.. (2024). Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343. in Journal of Chemical Education
American Chemical Society., 101(4).

Putica KB. Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343. in Journal of Chemical Education. 2024;101(4)..

Putica, Katarina B., "Supplementary material for: Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education American Chemical Society., 101(4), 1442-1456. https://doi.org/10.1021/acs.jchemed.3c01343" in Journal of Chemical Education, 101, no. 4 (2024).

TY  - JOUR
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6528
AB  - As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test
VL  - 101
IS  - 4
SP  - 1442
EP  - 1456
DO  - 10.1021/acs.jchemed.3c01343
ER  - 

@article{
author = "Putica, Katarina B.",
year = "2024",
abstract = "As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test",
volume = "101",
number = "4",
pages = "1442-1456",
doi = "10.1021/acs.jchemed.3c01343"
}

Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education
American Chemical Society., 101(4), 1442-1456.
https://doi.org/10.1021/acs.jchemed.3c01343

Putica KB. Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education. 2024;101(4):1442-1456.
doi:10.1021/acs.jchemed.3c01343 .

Putica, Katarina B., "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test" in Journal of Chemical Education, 101, no. 4 (2024):1442-1456,
https://doi.org/10.1021/acs.jchemed.3c01343 . .

TY  - CONF
AU  - Putica, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6525
AB  - In light of the fact that fast scientific growth has a profound impact on life in the 21st century, this research aimed to explore the effects of STEM teaching approach on the development of key 21st century competencies related to learning of natural sciences. Consequently, four research hypotheses which state that STEM approach promotes the development of creativity (H1), critical thinking (H2), problem-solving (H3), and science-processing skills (H4) to a greater extent than the traditional approach to teaching of natural sciences have been posed, and their correctness was assessed by means of the meta-analysis. Within the meta-analysis, the results of 21 studies that examined the effects of STEM approach on the development of the above-mentioned competencies among both elementary and high-school pupils were used to calculate the corresponding mean Cohen’s d value for each of the four hypotheses. The mean Cohen’s d values for hypotheses related to creativity and science-processing skills were in the range between 0.5 and 0.8 indicating a moderate positive effect, while the mean Cohen’s d values for hypotheses referring to critical thinking and problem-solving skills were higher than 0.8, indicating a strong positive effect of STEM approach on the development of these competencies, in comparison to traditional teaching approach. Based on such results it can be concluded that all four research hypotheses that were posed are correct, which confirms the considerable potential of STEM teaching approach to contribute to the development of key 21st century skills related to leaning of natural sciences.
C3  - International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024
T1  - Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences
ER  - 

@conference{
author = "Putica, Katarina",
year = "2024",
abstract = "In light of the fact that fast scientific growth has a profound impact on life in the 21st century, this research aimed to explore the effects of STEM teaching approach on the development of key 21st century competencies related to learning of natural sciences. Consequently, four research hypotheses which state that STEM approach promotes the development of creativity (H1), critical thinking (H2), problem-solving (H3), and science-processing skills (H4) to a greater extent than the traditional approach to teaching of natural sciences have been posed, and their correctness was assessed by means of the meta-analysis. Within the meta-analysis, the results of 21 studies that examined the effects of STEM approach on the development of the above-mentioned competencies among both elementary and high-school pupils were used to calculate the corresponding mean Cohen’s d value for each of the four hypotheses. The mean Cohen’s d values for hypotheses related to creativity and science-processing skills were in the range between 0.5 and 0.8 indicating a moderate positive effect, while the mean Cohen’s d values for hypotheses referring to critical thinking and problem-solving skills were higher than 0.8, indicating a strong positive effect of STEM approach on the development of these competencies, in comparison to traditional teaching approach. Based on such results it can be concluded that all four research hypotheses that were posed are correct, which confirms the considerable potential of STEM teaching approach to contribute to the development of key 21st century skills related to leaning of natural sciences.",
journal = "International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024",
title = "Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences"
}

Putica, K.. (2024). Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences. in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024.

Putica K. Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences. in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024. 2024;..

Putica, Katarina, "Meta-analysis of the effects of stem teaching approach on the development of 21st century competencies related to learning of natural sciences" in International Scientific Conference STEM/STEAM/STREAM Approach in Theory and Practice of Contemporary Education, University of Kragujevac, Faculty of Education in Jagodina, May 31 2024 (2024).

TY  - CONF
AU  - Marković, Olivera S.
AU  - Mrđinac, Jelena Ž.
AU  - Pepić, Sara V.
AU  - Verbić, Tatjana Ž.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6530
AB  - The solubility profile of a drug typically consists of two independent curves that intersect 
at a specific point called pHmax. At pHmax, both salt and base coexist as solid phases. While 
two solids coexist, pH and solubility in the heterogeneous system remain constant 
(according to the Gibbs Phase Rule). Recent studies, however, have shown that pH and 
solubility might change during the salt-to-free-base transformation. This pH range, 
containing two solids, is termed the pHmax – pHmin range. pHmax refers to the pH value at 
the maximum solubility of a eutectic mixture, whereas pHmin represents the pH value at the 
minimum solubility of the eutectic mixture. The objective of this study was to investigate 
the influence of suspension concentration (the ratio of drug mass to suspension volume) on 
the pHmax – pHmin range during solubility determination using the pH-Ramp shake-flask
method. Nortriptyline hydrochloride (Nor, monoprotic base) and atorvastatin calcium (At, 
monoprotic acid) were employed as model compounds. Results indicate that the pHmax –
pHmin range increases as suspension concentration rises (for 20.10 mg NorHCl/mL: 
pHmax=3.55, ΔpH=0; for 59.82 mg NorHCl/mL: pHmax – pHmin= 3.56 – 4.52, ΔpH=0.96). 
Understanding the details of the pHmax – pHmin range could significantly impact product 
formulation optimization in drug research
AB  - Cilj ovog rada bio je ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin
opsega tokom određivanja rastvorljivosti pH-Ramp shake-flask metodom. Kao model 
jedinjenja izabrani su nortriptilin-hidrohlorid i atorvastatin-kalcijum. Rezultati su pokazali 
da sa porastom koncentracije suspenzije dolazi do širenja opsega pHmax – pHmin, a ovakva 
proučavanja mogu značajno doprineti optimizaciji formulacije u procesu dizajna i razvoja 
lekova.
PB  - Belgrade : Serbian Chemical Society
C3  - 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024
T1  - The influence of suspension concentration on the pHmax – pHmin range during the solubility determination
T1  - Ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti
SP  - 47
EP  - 47
ER  - 

@conference{
author = "Marković, Olivera S. and Mrđinac, Jelena Ž. and Pepić, Sara V. and Verbić, Tatjana Ž.",
year = "2024",
abstract = "The solubility profile of a drug typically consists of two independent curves that intersect 
at a specific point called pHmax. At pHmax, both salt and base coexist as solid phases. While 
two solids coexist, pH and solubility in the heterogeneous system remain constant 
(according to the Gibbs Phase Rule). Recent studies, however, have shown that pH and 
solubility might change during the salt-to-free-base transformation. This pH range, 
containing two solids, is termed the pHmax – pHmin range. pHmax refers to the pH value at 
the maximum solubility of a eutectic mixture, whereas pHmin represents the pH value at the 
minimum solubility of the eutectic mixture. The objective of this study was to investigate 
the influence of suspension concentration (the ratio of drug mass to suspension volume) on 
the pHmax – pHmin range during solubility determination using the pH-Ramp shake-flask
method. Nortriptyline hydrochloride (Nor, monoprotic base) and atorvastatin calcium (At, 
monoprotic acid) were employed as model compounds. Results indicate that the pHmax –
pHmin range increases as suspension concentration rises (for 20.10 mg NorHCl/mL: 
pHmax=3.55, ΔpH=0; for 59.82 mg NorHCl/mL: pHmax – pHmin= 3.56 – 4.52, ΔpH=0.96). 
Understanding the details of the pHmax – pHmin range could significantly impact product 
formulation optimization in drug research, Cilj ovog rada bio je ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin
opsega tokom određivanja rastvorljivosti pH-Ramp shake-flask metodom. Kao model 
jedinjenja izabrani su nortriptilin-hidrohlorid i atorvastatin-kalcijum. Rezultati su pokazali 
da sa porastom koncentracije suspenzije dolazi do širenja opsega pHmax – pHmin, a ovakva 
proučavanja mogu značajno doprineti optimizaciji formulacije u procesu dizajna i razvoja 
lekova.",
publisher = "Belgrade : Serbian Chemical Society",
journal = "60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024",
title = "The influence of suspension concentration on the pHmax – pHmin range during the solubility determination, Ispitivanje uticaja koncentracije suspenzije na širinu pHmax – pHmin opsega tokom određivanja rastvorljivosti",
pages = "47-47"
}

Marković, O. S., Mrđinac, J. Ž., Pepić, S. V.,& Verbić, T. Ž.. (2024). The influence of suspension concentration on the pHmax – pHmin range during the solubility determination. in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024
Belgrade : Serbian Chemical Society., 47-47.

Marković OS, Mrđinac JŽ, Pepić SV, Verbić TŽ. The influence of suspension concentration on the pHmax – pHmin range during the solubility determination. in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024. 2024;:47-47..

Marković, Olivera S., Mrđinac, Jelena Ž., Pepić, Sara V., Verbić, Tatjana Ž., "The influence of suspension concentration on the pHmax – pHmin range during the solubility determination" in 60th Meeting of the Serbian Chemical Society, Niš, Serbia, 8-9 June 2024 (2024):47-47.

TY  - CONF
AU  - Putica, Katarina
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6526
AB  - Alkanes represent the first class of organic compounds elaborated in elementary school and the principles of their isomerism apply to all the other classes of organic compounds covered by the eighth-grade chemistry curriculum. However, in ChatGPT responses to Serbian language prompts related to isomers of alkanes with more than four carbon atoms numerous errors can be observed, and if a prompt about isomers of one such alkane is repeated several times, these errors often vary from response to response. Thus, one ChatGPT response regarding isomers of heptane, along with seven correct isomers, included incorrect isomers 4-methylhexane and 3-ethyl-2-methylpentane but excluded correct isomers 2,4-dimethylpentane and 2,2,3-trimethylbutane. To assess their understanding of alkane isomerism, 107 eighth-grade pupils were asked to detect errors in this response. 4-methylhexane and 3-ethyl-2-methyl-pentane were identified as incorrect isomers by 71.96% and 64.48% of the pupils, respectively. Furthermore, 55.14% of the pupils enlisted 2,4-dimethylpentane as an additional isomer, while only 36.45% of them identified 2,2,3-trimethylbutane as the other missing isomer. Ultimately, through class discussion, the complete list of isomers of heptane was produced, with the conclusion that the correctness of all ChatGPT responses to organic chemistry questions needs to be critically assessed.
AB  - Алкани представљају прву класу органских једињења која се обрађује у основној школи а принципи њихове изомерије применљиви су и код свих осталих класа органских једињења обухваћених наставним програмом хемије за осми разред. Међутим, у одговорима ChatGPT-а на упите на српском језику везане за изомере алкана са више од четири угљеникова атома могу се уочити бројне грешке, а ако се питање у вези изомера једног таквог алкана постави више пута, поменуте грешке се често разликују од одговора до одговора. Тако, један од одговора ChatGPT-а везан за изомере хептана, поред седам тачних изомера, садржао је и нетачне изомере 4-метилхексан и 3-етил-2-метилпентан, док су тачни изомери 2,4-диметилпентан и 2,2,3-триметилбутан били изостављени. Ради провере њиховог разумевања изомерије алкана, 107 ученика осмог разреда упитано је да детектује грешке у датом одговору. 4-метилхексан и 3-етил-2-метил-пентан идентификовани су као нетачни изомери од стане 71,96% и 64,48% ученика, респективно. Такође, 55,14% ученика навело је 2,4-диметилбутан као додатни изомер, док је само 36,45% њих идентификовало 2,2,3-триметилбутан као други недостајући изомер. Коначно, кроз дискусију на нивоу разреда, дошло се до потпуне листе изомера хептана, уз закључак да је тачност свих одговора ChatGPT-а на питања из органске хемије неопходно критички проценити
PB  - Univeristy of Belgrade, Faculty of Education
C3  - Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024
T1  - Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane
T1  - Проверава разумевања изомерије алкана код ученика осмог разреда основне школе кроз детекцију грешака у одговору ChatGPT-а везаном за изомере хептана
ER  - 

@conference{
author = "Putica, Katarina",
year = "2024",
abstract = "Alkanes represent the first class of organic compounds elaborated in elementary school and the principles of their isomerism apply to all the other classes of organic compounds covered by the eighth-grade chemistry curriculum. However, in ChatGPT responses to Serbian language prompts related to isomers of alkanes with more than four carbon atoms numerous errors can be observed, and if a prompt about isomers of one such alkane is repeated several times, these errors often vary from response to response. Thus, one ChatGPT response regarding isomers of heptane, along with seven correct isomers, included incorrect isomers 4-methylhexane and 3-ethyl-2-methylpentane but excluded correct isomers 2,4-dimethylpentane and 2,2,3-trimethylbutane. To assess their understanding of alkane isomerism, 107 eighth-grade pupils were asked to detect errors in this response. 4-methylhexane and 3-ethyl-2-methyl-pentane were identified as incorrect isomers by 71.96% and 64.48% of the pupils, respectively. Furthermore, 55.14% of the pupils enlisted 2,4-dimethylpentane as an additional isomer, while only 36.45% of them identified 2,2,3-trimethylbutane as the other missing isomer. Ultimately, through class discussion, the complete list of isomers of heptane was produced, with the conclusion that the correctness of all ChatGPT responses to organic chemistry questions needs to be critically assessed., Алкани представљају прву класу органских једињења која се обрађује у основној школи а принципи њихове изомерије применљиви су и код свих осталих класа органских једињења обухваћених наставним програмом хемије за осми разред. Међутим, у одговорима ChatGPT-а на упите на српском језику везане за изомере алкана са више од четири угљеникова атома могу се уочити бројне грешке, а ако се питање у вези изомера једног таквог алкана постави више пута, поменуте грешке се често разликују од одговора до одговора. Тако, један од одговора ChatGPT-а везан за изомере хептана, поред седам тачних изомера, садржао је и нетачне изомере 4-метилхексан и 3-етил-2-метилпентан, док су тачни изомери 2,4-диметилпентан и 2,2,3-триметилбутан били изостављени. Ради провере њиховог разумевања изомерије алкана, 107 ученика осмог разреда упитано је да детектује грешке у датом одговору. 4-метилхексан и 3-етил-2-метил-пентан идентификовани су као нетачни изомери од стане 71,96% и 64,48% ученика, респективно. Такође, 55,14% ученика навело је 2,4-диметилбутан као додатни изомер, док је само 36,45% њих идентификовало 2,2,3-триметилбутан као други недостајући изомер. Коначно, кроз дискусију на нивоу разреда, дошло се до потпуне листе изомера хептана, уз закључак да је тачност свих одговора ChatGPT-а на питања из органске хемије неопходно критички проценити",
publisher = "Univeristy of Belgrade, Faculty of Education",
journal = "Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024",
title = "Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane, Проверава разумевања изомерије алкана код ученика осмог разреда основне школе кроз детекцију грешака у одговору ChatGPT-а везаном за изомере хептана"
}

Putica, K.. (2024). Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane. in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024
Univeristy of Belgrade, Faculty of Education..

Putica K. Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane. in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024. 2024;..

Putica, Katarina, "Assessment of eight-grade elementary school pupils’ understanding of isomerism of alkanes through detection of errors in ChatGPT response related to isomers of heptane" in Book of Abstracts of International Scientific Conference ART (OF) EDUCATION IN A CHANGING WORLD, University of Belgrade, Faculty of Education, June 1, 2024 (2024).

TY  - JOUR
AU  - Putica, Katarina B.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6527
AB  - As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.
PB  - American Chemical Society
PB  - Division of Chemical Education, Inc.
T2  - Journal of Chemical Education
T1  - Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test
VL  - 101
IS  - 4
SP  - 1442
EP  - 1456
DO  - 10.1021/acs.jchemed.3c01343
ER  - 

@article{
author = "Putica, Katarina B.",
year = "2024",
abstract = "As detection and subsequent remediation of misconceptions developed within high-school organic chemistry courses in regard to various classes of organic compounds are a prerequisite for meaningful learning of more advanced organic chemistry content, this study sought to identify high-school students’ misconceptions about alcohols and carbonyl compounds by means of a four-tier test. The test items comprise the answer and reason tier in a multiple-choice question format, and the response to each tier is accompanied by a confidence rating provided on a six-point confidence scale. The test was administered to 154 students, and evidence of satisfactory validity and internal consistency of both the cognitive scores and confidence ratings was obtained. Since a correct response to a four-tier item presupposes that both the answer and the reason tier within which all the distracters originate from the previously detected challenges with the above-mentioned content are answered correctly, the mean score on the test was predictably low. At the same time, the confidence ratings associated with the students’ incorrect responses enabled a more accurate differentiation between wrong answers caused by the lack of knowledge and the existence of misconceptions, compared to all of the other types of diagnostic tests that were previously implemented for this purpose. The identification of eight misconceptions about alcohols and carbonyl compounds within this study paves the way for the development of remediation approaches that would neutralize the negative impact of these conceptual difficulties on the meaningful learning of all related organic chemistry content.",
publisher = "American Chemical Society, Division of Chemical Education, Inc.",
journal = "Journal of Chemical Education",
title = "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test",
volume = "101",
number = "4",
pages = "1442-1456",
doi = "10.1021/acs.jchemed.3c01343"
}

Putica, K. B.. (2024). Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education
American Chemical Society., 101(4), 1442-1456.
https://doi.org/10.1021/acs.jchemed.3c01343

Putica KB. Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test. in Journal of Chemical Education. 2024;101(4):1442-1456.
doi:10.1021/acs.jchemed.3c01343 .

Putica, Katarina B., "Identification of High-School Students’ Conceptual Challenges Related to Alcohols and Carbonyl Compounds by Means of a Four-Tier Diagnostic Test" in Journal of Chemical Education, 101, no. 4 (2024):1442-1456,
https://doi.org/10.1021/acs.jchemed.3c01343 . .

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Jovanović, Zorana
AU  - Cvijetić, Ilija
AU  - Šunderić, Miloš
AU  - Veličković, Luka
AU  - Katrlík, Jaroslav
AU  - Holazová, Alena
AU  - Nikolić, Milan
AU  - Minić, Simeon
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6524
AB  - Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina
DO  - 10.3390/ijms25010229
ER  - 

@article{
author = "Gligorijević, Nikola and Jovanović, Zorana and Cvijetić, Ilija and Šunderić, Miloš and Veličković, Luka and Katrlík, Jaroslav and Holazová, Alena and Nikolić, Milan and Minić, Simeon",
year = "2024",
abstract = "Blue C-phycocyanin (C-PC), the major Spirulina protein with innumerable health-promoting
benefits, is an attractive colourant and food supplement. A crucial obstacle to its more extensive
use is its relatively low stability. This study aimed to screen various food-derived ligands for their
ability to bind and stabilise C-PC, utilising spectroscopic techniques and molecular docking. Among twelve examined ligands, the protein fluorescence quenching revealed that only quercetin, coenzyme Q10 and resveratrol had a moderate affinity to C-PC (Ka of 2.2 to 3.7 × 105 M–1). Docking revealed these three ligands bind more strongly to the C-PC hexamer than the trimer, with the binding sites located at the interface of two (αβ)3 trimers. UV/VIS absorption spectroscopy demonstrated the changes in the C-PC absorption spectra in a complex with quercetin and resveratrol compared to the spectra of free protein and ligands. Selected ligands did not affect the secondary structure content, but they induced changes in the tertiary protein structure in the CD study. A fluorescence-based thermal stability assay demonstrated quercetin and coenzyme Q10 increased the C-PC melting point by nearly 5 ◦C. Our study identified food-derived ligands that interact with C-PC and improve its thermal stability, indicating their potential as stabilising agents for C-PC in the food industry.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina",
doi = "10.3390/ijms25010229"
}

Gligorijević, N., Jovanović, Z., Cvijetić, I., Šunderić, M., Veličković, L., Katrlík, J., Holazová, A., Nikolić, M.,& Minić, S.. (2024). Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences
MDPI..
https://doi.org/10.3390/ijms25010229

Gligorijević N, Jovanović Z, Cvijetić I, Šunderić M, Veličković L, Katrlík J, Holazová A, Nikolić M, Minić S. Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina. in International Journal of Molecular Sciences. 2024;.
doi:10.3390/ijms25010229 .

Gligorijević, Nikola, Jovanović, Zorana, Cvijetić, Ilija, Šunderić, Miloš, Veličković, Luka, Katrlík, Jaroslav, Holazová, Alena, Nikolić, Milan, Minić, Simeon, "Investigation of the Potential of Selected Food-Derived Antioxidants to Bind and Stabilise the Bioactive Blue Protein C-Phycocyanin from Cyanobacteria Spirulina" in International Journal of Molecular Sciences (2024),
https://doi.org/10.3390/ijms25010229 . .

TY  - JOUR
AU  - Dorontić, Slađana
AU  - Bonasera, Aurelio
AU  - Scopelliti, Michelangelo
AU  - Marković, Olivera
AU  - Verbić, Tatjana
AU  - Sredojević, Dušan
AU  - Ciasca, Gabriele
AU  - Di Santo, Riccardo
AU  - Mead, James L.
AU  - Budimir, Milica
AU  - Bajuk-Bogdanović, Danica
AU  - Mojsin, Marija
AU  - Pejić, Jelena
AU  - Stevanović, Milena
AU  - Jovanović, Svetlana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6523
AB  - The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, 
simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum 
dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative 
structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocom patibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs 
structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, 
and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to 
the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich 
GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. 
The high coefficient of determination (R-squared (R2
) = 0.99) and very low limit of detection (3.02 μmol L-1) 
reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully 
detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the 
proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the 
death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an 
air medium can be potentially applied for glyphosate detection.
PB  - Elsevier
T2  - Journal of Environmental Chemical Engineering
T1  - High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights
VL  - 12
SP  - 113193
DO  - 10.1016/j.jece.2024.113193
ER  - 

@article{
author = "Dorontić, Slađana and Bonasera, Aurelio and Scopelliti, Michelangelo and Marković, Olivera and Verbić, Tatjana and Sredojević, Dušan and Ciasca, Gabriele and Di Santo, Riccardo and Mead, James L. and Budimir, Milica and Bajuk-Bogdanović, Danica and Mojsin, Marija and Pejić, Jelena and Stevanović, Milena and Jovanović, Svetlana",
year = "2024",
abstract = "The widespread usage of the herbicide glyphosate calls for urgent action, aiming at the development of new, 
simple, low-cost, and eco-friendly detection approaches. In the last decade, investigation of graphene quantum 
dots (GQDs) as potential optical probes for various pollutants rapidly grew, thanks to their easy-manipulative 
structure, remarkable photoluminescence (PL) in the visible part of the spectrum, good dispersibility, biocom patibility, and non-toxicity, as well. Herein, a fast, simple, and environmentally friendly method for GQDs 
structural modification is presented. GQDs raw powder was exposed to γ- rays at three different doses (100, 200, 
and 300 kGy) in air, without any solvent or reagents. Irradiation of dots under such affordable conditions led to 
the additional incorporation of oxygen-containing moieties in the GQD structure. For the first time, oxygen-rich 
GQDs irradiated at a 300 kGy dose were successfully applied as direct turn-off PL probe for glyphosate detection. 
The high coefficient of determination (R-squared (R2
) = 0.99) and very low limit of detection (3.02 μmol L-1) 
reveal good linearity between the potential sensor and analyte, as well as sensitivity. Glyphosate was successfully 
detected in celery samples, with a recovery value of 107 ± 0.85%. To evaluate the biological safety of the 
proposed sensing probe, [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) and the hemolysis assays were performed. Obtained results show that irradiated and non-irradiated GQDs did not cause the 
death of MRC-5 cells, and hemolysis of erythrocytes. The obtained results demonstrate that GQDs irradiated in an 
air medium can be potentially applied for glyphosate detection.",
publisher = "Elsevier",
journal = "Journal of Environmental Chemical Engineering",
title = "High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights",
volume = "12",
pages = "113193",
doi = "10.1016/j.jece.2024.113193"
}

Dorontić, S., Bonasera, A., Scopelliti, M., Marković, O., Verbić, T., Sredojević, D., Ciasca, G., Di Santo, R., Mead, J. L., Budimir, M., Bajuk-Bogdanović, D., Mojsin, M., Pejić, J., Stevanović, M.,& Jovanović, S.. (2024). High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights. in Journal of Environmental Chemical Engineering
Elsevier., 12, 113193.
https://doi.org/10.1016/j.jece.2024.113193

Dorontić S, Bonasera A, Scopelliti M, Marković O, Verbić T, Sredojević D, Ciasca G, Di Santo R, Mead JL, Budimir M, Bajuk-Bogdanović D, Mojsin M, Pejić J, Stevanović M, Jovanović S. High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights. in Journal of Environmental Chemical Engineering. 2024;12:113193.
doi:10.1016/j.jece.2024.113193 .

Dorontić, Slađana, Bonasera, Aurelio, Scopelliti, Michelangelo, Marković, Olivera, Verbić, Tatjana, Sredojević, Dušan, Ciasca, Gabriele, Di Santo, Riccardo, Mead, James L., Budimir, Milica, Bajuk-Bogdanović, Danica, Mojsin, Marija, Pejić, Jelena, Stevanović, Milena, Jovanović, Svetlana, "High-performing structural optimization of graphene quantum dots as  glyphosate herbicide photoluminescent probes: real case studies and  mechanism insights" in Journal of Environmental Chemical Engineering, 12 (2024):113193,
https://doi.org/10.1016/j.jece.2024.113193 . .

TY  - JOUR
AU  - Đurašinović, Tatjana
AU  - Lopandić, Zorana
AU  - Protić-Rosić, Isidora
AU  - Nešić, Andrijana
AU  - Trbojević-Ivić, Jovana
AU  - Jappe, Uta
AU  - Gavrović-Jankulović, Marija
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6338
AB  - Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.
PB  - Elsevier
T2  - Food Chemistry
T1  - Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen
VL  - 437
SP  - 137782
DO  - 10.1016/j.foodchem.2023.137782
ER  - 

@article{
author = "Đurašinović, Tatjana and Lopandić, Zorana and Protić-Rosić, Isidora and Nešić, Andrijana and Trbojević-Ivić, Jovana and Jappe, Uta and Gavrović-Jankulović, Marija",
year = "2024",
abstract = "Banana allergy is often associated with the pollen and latex allergies, which led us to the  hypothesis that some yet unidentified banana allergen could provide a basis of the latex-pollen-fruit syndrome. S-adenosyl-L-homocysteine hydrolase (SAHH) was recently identified in the literature as a novel plant allergen. This study aimed to assess the allergenic potential of the naturally occurring banana SAHH (nSAHH) and its recombinant homolog produced in E. coli (rSAHH). nSAHH showed IgE reactivity with a serum pool of twelve banana-allergic persons,
while rSAHH displayed IgE reactivity in ten out of the twelve tested patients. Five linear B-cell epitopes were identified on the rSAHH surface, exhibiting ≥ 90 % sequence homology with relevant plant SAHH allergens. Our findings have elucidated SAHH as a novel plant panallergen, underlying the cross-reactivity between plant derived food and respiratory allergens, confirming our initial hypothesis.",
publisher = "Elsevier",
journal = "Food Chemistry",
title = "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen",
volume = "437",
pages = "137782",
doi = "10.1016/j.foodchem.2023.137782"
}

Đurašinović, T., Lopandić, Z., Protić-Rosić, I., Nešić, A., Trbojević-Ivić, J., Jappe, U.,& Gavrović-Jankulović, M.. (2024). Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry
Elsevier., 437, 137782.
https://doi.org/10.1016/j.foodchem.2023.137782

Đurašinović T, Lopandić Z, Protić-Rosić I, Nešić A, Trbojević-Ivić J, Jappe U, Gavrović-Jankulović M. Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen. in Food Chemistry. 2024;437:137782.
doi:10.1016/j.foodchem.2023.137782 .

Đurašinović, Tatjana, Lopandić, Zorana, Protić-Rosić, Isidora, Nešić, Andrijana, Trbojević-Ivić, Jovana, Jappe, Uta, Gavrović-Jankulović, Marija, "Identification of S-adenosyl-L-homocysteine hydrolase from banana fruit as a novel plant panallergen" in Food Chemistry, 437 (2024):137782,
https://doi.org/10.1016/j.foodchem.2023.137782 . .

TY  - JOUR
AU  - Škaro Bogojević, Sanja
AU  - Perminova, D
AU  - Jakšić, Jovana
AU  - Milčić, Miloš K.
AU  - Medaković, Vesna
AU  - Milovanović, Jelena
AU  - Nikodinović-Runić, Jasmina
AU  - Maslak, V
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6476
AB  - Poly(ethylene terephthalate) (PET) is widely used material in the healthcare due to its mechanical properties including resistance to chemicals and abrasion. However, it is susceptible to bacterial attachment and contamination. This study addresses some newly designed model compounds of PET with antimicrobial properties that could potentially be incorporated into PET materials. All compounds were synthesized for the first time by labeling an integral part of PET with chromophores in the form of esters of cinnamic and ferulic acids. After complete structural characterization, the effect of new compounds on microbial growth and communication (quorum sensing, QS) was analyzed and further investigated using molecular docking. The obtained results indicate that the introduction of chromophores that have one part of cinnamic acid enriched with a methoxy functional group in them acts as QS modulators. Moreover, compounds exhibited dose-dependent selectivity toward QS signaling pathways and the highest tested concentration of compounds showed Pseudomonas Quinolone Signal (PQS) inhibitory activity suggesting that these compounds have a potential effect on pyocyanin production. Docking studies demonstrated that compounds hold binding power to all four QS protein targets (LuxP, periplasmatic protein that binds AI-2 inducer and forms a complex able to transduce the autoinducer signal, RhIR protein that is a key QS transcriptional regulator that activates the genes involved in the synthesis of rhamnolipids and pyocyanin, AbaI protein that has a role in QS signal transduction, and LasR protein which is a key QS transcriptional regulator that activates transcription of genes coding for some virulence-associated traits) while the highest binding strength is observed with compounds 2 and 6 containing single cinnamic acid fragment, suggesting their further biomedical application.
PB  - Elsevier
T2  - Journal of Molecular Structure
T1  - Novel cinnamic acid-based PET derivatives as quorum sensing modulators
VL  - 1300
SP  - 137291
DO  - 10.1016/j.molstruc.2023.137291
ER  - 

@article{
author = "Škaro Bogojević, Sanja and Perminova, D and Jakšić, Jovana and Milčić, Miloš K. and Medaković, Vesna and Milovanović, Jelena and Nikodinović-Runić, Jasmina and Maslak, V",
year = "2024",
abstract = "Poly(ethylene terephthalate) (PET) is widely used material in the healthcare due to its mechanical properties including resistance to chemicals and abrasion. However, it is susceptible to bacterial attachment and contamination. This study addresses some newly designed model compounds of PET with antimicrobial properties that could potentially be incorporated into PET materials. All compounds were synthesized for the first time by labeling an integral part of PET with chromophores in the form of esters of cinnamic and ferulic acids. After complete structural characterization, the effect of new compounds on microbial growth and communication (quorum sensing, QS) was analyzed and further investigated using molecular docking. The obtained results indicate that the introduction of chromophores that have one part of cinnamic acid enriched with a methoxy functional group in them acts as QS modulators. Moreover, compounds exhibited dose-dependent selectivity toward QS signaling pathways and the highest tested concentration of compounds showed Pseudomonas Quinolone Signal (PQS) inhibitory activity suggesting that these compounds have a potential effect on pyocyanin production. Docking studies demonstrated that compounds hold binding power to all four QS protein targets (LuxP, periplasmatic protein that binds AI-2 inducer and forms a complex able to transduce the autoinducer signal, RhIR protein that is a key QS transcriptional regulator that activates the genes involved in the synthesis of rhamnolipids and pyocyanin, AbaI protein that has a role in QS signal transduction, and LasR protein which is a key QS transcriptional regulator that activates transcription of genes coding for some virulence-associated traits) while the highest binding strength is observed with compounds 2 and 6 containing single cinnamic acid fragment, suggesting their further biomedical application.",
publisher = "Elsevier",
journal = "Journal of Molecular Structure",
title = "Novel cinnamic acid-based PET derivatives as quorum sensing modulators",
volume = "1300",
pages = "137291",
doi = "10.1016/j.molstruc.2023.137291"
}

Škaro Bogojević, S., Perminova, D., Jakšić, J., Milčić, M. K., Medaković, V., Milovanović, J., Nikodinović-Runić, J.,& Maslak, V.. (2024). Novel cinnamic acid-based PET derivatives as quorum sensing modulators. in Journal of Molecular Structure
Elsevier., 1300, 137291.
https://doi.org/10.1016/j.molstruc.2023.137291

Škaro Bogojević S, Perminova D, Jakšić J, Milčić MK, Medaković V, Milovanović J, Nikodinović-Runić J, Maslak V. Novel cinnamic acid-based PET derivatives as quorum sensing modulators. in Journal of Molecular Structure. 2024;1300:137291.
doi:10.1016/j.molstruc.2023.137291 .

Škaro Bogojević, Sanja, Perminova, D, Jakšić, Jovana, Milčić, Miloš K., Medaković, Vesna, Milovanović, Jelena, Nikodinović-Runić, Jasmina, Maslak, V, "Novel cinnamic acid-based PET derivatives as quorum sensing modulators" in Journal of Molecular Structure, 1300 (2024):137291,
https://doi.org/10.1016/j.molstruc.2023.137291 . .

TY  - JOUR
AU  - Andrić, Deana
AU  - Dukić-Stefanović, Slađana
AU  - Krunić, Mihajlo J.
AU  - Jevtić, Ivana I.
AU  - Penjišević, Jelena Z.
AU  - Šukalović, Vladimir B.
AU  - Kostić-Rajačić, Slađana
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6472
AB  - Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most
noted as a neurotransmitter, an activator of the utmost subtype family of G-protein-
coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors
treat central nervous system diseases such as schizophrenia and depression.
Recent advances in serotonin receptor structure research gave us several
crystal 5-HT1A receptor structures, most notably 5-HT1A bound to the antipsychotic
drug aripiprazole (Abilify®). This discovery prompted us to evaluate
a series of newly synthesized ligands for serotonergic activity since those arylpiperazine
derivatives share minimal general structure with aripiprazole. The
results of molecular docking analysis of unsubstituted starting substances
encouraged us to propound further modifications of the tail and head parts of
the parent molecules to maximize receptor binding affinity. Intrigued by the
results of molecular analysis, all foreseen derivatives were synthesized. The
pharmacological activity of all nine (5a and 6a are synthesized previously)
compounds was assessed by the in vitro tests and in silico pharmacokinetics
predictions for the most promising candidates. All tested ligands have improved
affinity compering to parent compounds (10a and 11a), 8b and 9b expressed
the best pharmacological profile with an improved binding affinity
toward serotonin 5-HT1A receptors (Ki 12.1 and 4.8 nM, respectively).
PB  - Belgrade : Serbian Chemical Society
T2  - J. Serb. Chem. Soc.
T1  - Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides
VL  - 89
IS  - 3
SP  - 291
EP  - 303
DO  - 10.2298/JSC230906076A
ER  - 

@article{
author = "Andrić, Deana and Dukić-Stefanović, Slađana and Krunić, Mihajlo J. and Jevtić, Ivana I. and Penjišević, Jelena Z. and Šukalović, Vladimir B. and Kostić-Rajačić, Slađana",
year = "2024",
abstract = "Serotonin, or 5-hydroxytryptamine (5-HT), is a biogenic amine most
noted as a neurotransmitter, an activator of the utmost subtype family of G-protein-
coupled receptors (GPCR). Drugs targeting 5-HT1A and other 5-HT receptors
treat central nervous system diseases such as schizophrenia and depression.
Recent advances in serotonin receptor structure research gave us several
crystal 5-HT1A receptor structures, most notably 5-HT1A bound to the antipsychotic
drug aripiprazole (Abilify®). This discovery prompted us to evaluate
a series of newly synthesized ligands for serotonergic activity since those arylpiperazine
derivatives share minimal general structure with aripiprazole. The
results of molecular docking analysis of unsubstituted starting substances
encouraged us to propound further modifications of the tail and head parts of
the parent molecules to maximize receptor binding affinity. Intrigued by the
results of molecular analysis, all foreseen derivatives were synthesized. The
pharmacological activity of all nine (5a and 6a are synthesized previously)
compounds was assessed by the in vitro tests and in silico pharmacokinetics
predictions for the most promising candidates. All tested ligands have improved
affinity compering to parent compounds (10a and 11a), 8b and 9b expressed
the best pharmacological profile with an improved binding affinity
toward serotonin 5-HT1A receptors (Ki 12.1 and 4.8 nM, respectively).",
publisher = "Belgrade : Serbian Chemical Society",
journal = "J. Serb. Chem. Soc.",
title = "Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides",
volume = "89",
number = "3",
pages = "291-303",
doi = "10.2298/JSC230906076A"
}

Andrić, D., Dukić-Stefanović, S., Krunić, M. J., Jevtić, I. I., Penjišević, J. Z., Šukalović, V. B.,& Kostić-Rajačić, S.. (2024). Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides. in J. Serb. Chem. Soc.
Belgrade : Serbian Chemical Society., 89(3), 291-303.
https://doi.org/10.2298/JSC230906076A

Andrić D, Dukić-Stefanović S, Krunić MJ, Jevtić II, Penjišević JZ, Šukalović VB, Kostić-Rajačić S. Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides. in J. Serb. Chem. Soc.. 2024;89(3):291-303.
doi:10.2298/JSC230906076A .

Andrić, Deana, Dukić-Stefanović, Slađana, Krunić, Mihajlo J., Jevtić, Ivana I., Penjišević, Jelena Z., Šukalović, Vladimir B., Kostić-Rajačić, Slađana, "Synthesis, computational and pharmacological evaluation of novel N-{4-[2-(4-aryl-piperazin-1-yl)ethyl]phenyl}-arylamides" in J. Serb. Chem. Soc., 89, no. 3 (2024):291-303,
https://doi.org/10.2298/JSC230906076A . .

TY  - JOUR
AU  - Šegan, Sandra B.
AU  - Krunić, Mihajlo J.
AU  - Andrić, Deana
AU  - Šukalović, Vladimir B.
AU  - Penjišević, Jelena Z.
AU  - Jevtić, Ivana I.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6473
AB  - Fourteen donepezil-like acetylcholinesterase (AChE) inhibitors from our library were
analyzed using reversed-phase thin-layer chromatography to assess their lipophilicity
and blood–brain barrier permeability. Compounds possessed N-benzylpiperidine and
N,N-diarylpiperazine moieties connected via a short carboxamide or amine linker.
Retention parameters RM
0, b, and C0 were considered as the measures of lipophilicity.
Besides, logD of the investigated compounds was determined chromatographically
using standard compounds with known logPow and logD values at pH 11. Experimentally
obtained lipophilicity parameters correlated well with in silico generated results,
and the effect of the nature of the linker between two pharmacophores and
substituents on the arylpiperazine part of the molecule was observed. As a result of
drug-likeness analysis, both Lipinski's rule of five and Veber's rule parameters were
determined, suggesting that examined compounds could be potential candidates for
further drug development. Principal component analysis was performed to obtain an
insight into a grouping of compounds based on calculated structural descriptors,
experimentally obtained values of lipophilicity, and AChE inhibitory activity.
PB  - Wiley
T2  - Biomedical Chromatography
T1  - Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography
VL  - n/a
SP  - e5864
DO  - 10.1002/bmc.5867
ER  - 

@article{
author = "Šegan, Sandra B. and Krunić, Mihajlo J. and Andrić, Deana and Šukalović, Vladimir B. and Penjišević, Jelena Z. and Jevtić, Ivana I.",
year = "2024",
abstract = "Fourteen donepezil-like acetylcholinesterase (AChE) inhibitors from our library were
analyzed using reversed-phase thin-layer chromatography to assess their lipophilicity
and blood–brain barrier permeability. Compounds possessed N-benzylpiperidine and
N,N-diarylpiperazine moieties connected via a short carboxamide or amine linker.
Retention parameters RM
0, b, and C0 were considered as the measures of lipophilicity.
Besides, logD of the investigated compounds was determined chromatographically
using standard compounds with known logPow and logD values at pH 11. Experimentally
obtained lipophilicity parameters correlated well with in silico generated results,
and the effect of the nature of the linker between two pharmacophores and
substituents on the arylpiperazine part of the molecule was observed. As a result of
drug-likeness analysis, both Lipinski's rule of five and Veber's rule parameters were
determined, suggesting that examined compounds could be potential candidates for
further drug development. Principal component analysis was performed to obtain an
insight into a grouping of compounds based on calculated structural descriptors,
experimentally obtained values of lipophilicity, and AChE inhibitory activity.",
publisher = "Wiley",
journal = "Biomedical Chromatography",
title = "Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography",
volume = "n/a",
pages = "e5864",
doi = "10.1002/bmc.5867"
}

Šegan, S. B., Krunić, M. J., Andrić, D., Šukalović, V. B., Penjišević, J. Z.,& Jevtić, I. I.. (2024). Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography. in Biomedical Chromatography
Wiley., n/a, e5864.
https://doi.org/10.1002/bmc.5867

Šegan SB, Krunić MJ, Andrić D, Šukalović VB, Penjišević JZ, Jevtić II. Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography. in Biomedical Chromatography. 2024;n/a:e5864.
doi:10.1002/bmc.5867 .

Šegan, Sandra B., Krunić, Mihajlo J., Andrić, Deana, Šukalović, Vladimir B., Penjišević, Jelena Z., Jevtić, Ivana I., "Evaluation of lipophilicity and drug-likeness of donepezil-like compounds using reversed-phase thin-layer chromatography" in Biomedical Chromatography, n/a (2024):e5864,
https://doi.org/10.1002/bmc.5867 . .

TY  - JOUR
AU  - Natić, Maja
AU  - Dabić Zagorac, Dragana
AU  - Jakanovski, Mihajlo V.
AU  - Smailagić, Anita
AU  - Čolić, Slavica
AU  - Meland, Mekjell
AU  - Fotirić Akšić, Milica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6507
AB  - In this work, 12 apple cultivars grown organically in three regions of Norway (Telemark, Ullensvang, Viken) were analyzed in terms of fruit quality, with the aim of equating different growing regions under specific climatic conditions. Apples were analyzed for concentration levels of minerals, sugars, sugar alcohols, organic acids, total phenolic content (TPC), radical scavenging activity (RSA), and phenolic profiles. Discovery “Rose” from Telemark stored the highest level of minerals (24,094.5 mg/kg dry weight). Glucose, fructose, sucrose, and sorbitol were the major carbohydrates, whereas the predominant organic acids were quinic acid and malic acid. Cultivar Discovery from Ullensvang had the highest TPC (9.22 g/kg) and RSA (229.32 mmol TE/kg). Of the polyphenols quantified, chlorogenic acid and kaempferol-3-O-glucoside were the most abounded, accounting for 85.50%. Principal component analysis (PCA) shows that the Ullensvang region is the richest source of most carbohydrates, organic acids (quinic, shikimic, and galacturonic), and most polyphenols, whereas the highest content of minerals and maleic acid characterized Viken. Regardless of location, the Discovery cultivar had, on average, the highest sugar and polyphenol contents. The results obtained suggest that organic apples from Norway are a rich source of beneficial compounds that can have a positive impact on human health. In addition, these results may be useful for consumers in identifying apple cultivars with desirable characteristics and for the fruit industry in tracing back the origin of apples. The findings could also be of great interest for locations with similar climate and soil conditions worldwide.
PB  - MDPI
T2  - Plants
T1  - Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location
VL  - 13
IS  - 147
DO  - 10.3390/plants13010147
ER  - 

@article{
author = "Natić, Maja and Dabić Zagorac, Dragana and Jakanovski, Mihajlo V. and Smailagić, Anita and Čolić, Slavica and Meland, Mekjell and Fotirić Akšić, Milica",
year = "2024",
abstract = "In this work, 12 apple cultivars grown organically in three regions of Norway (Telemark, Ullensvang, Viken) were analyzed in terms of fruit quality, with the aim of equating different growing regions under specific climatic conditions. Apples were analyzed for concentration levels of minerals, sugars, sugar alcohols, organic acids, total phenolic content (TPC), radical scavenging activity (RSA), and phenolic profiles. Discovery “Rose” from Telemark stored the highest level of minerals (24,094.5 mg/kg dry weight). Glucose, fructose, sucrose, and sorbitol were the major carbohydrates, whereas the predominant organic acids were quinic acid and malic acid. Cultivar Discovery from Ullensvang had the highest TPC (9.22 g/kg) and RSA (229.32 mmol TE/kg). Of the polyphenols quantified, chlorogenic acid and kaempferol-3-O-glucoside were the most abounded, accounting for 85.50%. Principal component analysis (PCA) shows that the Ullensvang region is the richest source of most carbohydrates, organic acids (quinic, shikimic, and galacturonic), and most polyphenols, whereas the highest content of minerals and maleic acid characterized Viken. Regardless of location, the Discovery cultivar had, on average, the highest sugar and polyphenol contents. The results obtained suggest that organic apples from Norway are a rich source of beneficial compounds that can have a positive impact on human health. In addition, these results may be useful for consumers in identifying apple cultivars with desirable characteristics and for the fruit industry in tracing back the origin of apples. The findings could also be of great interest for locations with similar climate and soil conditions worldwide.",
publisher = "MDPI",
journal = "Plants",
title = "Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location",
volume = "13",
number = "147",
doi = "10.3390/plants13010147"
}

Natić, M., Dabić Zagorac, D., Jakanovski, M. V., Smailagić, A., Čolić, S., Meland, M.,& Fotirić Akšić, M.. (2024). Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location. in Plants
MDPI., 13(147).
https://doi.org/10.3390/plants13010147

Natić M, Dabić Zagorac D, Jakanovski MV, Smailagić A, Čolić S, Meland M, Fotirić Akšić M. Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location. in Plants. 2024;13(147).
doi:10.3390/plants13010147 .

Natić, Maja, Dabić Zagorac, Dragana, Jakanovski, Mihajlo V., Smailagić, Anita, Čolić, Slavica, Meland, Mekjell, Fotirić Akšić, Milica, "Fruit Quality Attributes of Organically Grown Norwegian Apples Are Affected by Cultivar and Location" in Plants, 13, no. 147 (2024),
https://doi.org/10.3390/plants13010147 . .

TY  - JOUR
AU  - Dinić, Ivana
AU  - Vuković, Marina
AU  - Rabanal, Maria Eugenia
AU  - Milošević, Milica
AU  - Bukumira, Marta
AU  - Tomić, Nina
AU  - Tomić, Miloš
AU  - Mančić, Lidija
AU  - Ignjatović, Nenad
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6477
AB  - Y0.8−xGdxF3:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy and energy dispersive X-ray analysis, were further correlated with the up-conversion emission (λexc = 976 nm) recorded in function of temperature. Based on the change in the visible green emissions originating from the thermally coupled 2H11/2 and 4S3/2 levels of Er3+, the corresponding LIR was acquired in the physiologically relevant range of temperatures (25–50 °C). The detected absolute sensitivity of about 0.0042 °C−1, along with the low cytotoxicity toward both normal human lung fibroblasts (MRC-5) and cancerous lung epithelial (A549) cells, indicate a potential for use in temperature sensing in biomedicine. Additionally, their enhanced internalization in cells, without suppression of cell viability, enabled in vitro labeling of cancer and healthy cells upon 976 nm laser irradiation.
PB  - MDPI
T2  - Journal of Functional Biomaterials
T1  - Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals
VL  - 15
IS  - 1
SP  - 6
DO  - 10.3390/jfb15010006
ER  - 

@article{
author = "Dinić, Ivana and Vuković, Marina and Rabanal, Maria Eugenia and Milošević, Milica and Bukumira, Marta and Tomić, Nina and Tomić, Miloš and Mančić, Lidija and Ignjatović, Nenad",
year = "2024",
abstract = "Y0.8−xGdxF3:Yb/Er mesocrystals with a biocompatible surface and diverse morphological characteristics were successfully synthesized using chitosan-assisted solvothermal processing. Their structural properties, studied using X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning and transmission electron microscopy and energy dispersive X-ray analysis, were further correlated with the up-conversion emission (λexc = 976 nm) recorded in function of temperature. Based on the change in the visible green emissions originating from the thermally coupled 2H11/2 and 4S3/2 levels of Er3+, the corresponding LIR was acquired in the physiologically relevant range of temperatures (25–50 °C). The detected absolute sensitivity of about 0.0042 °C−1, along with the low cytotoxicity toward both normal human lung fibroblasts (MRC-5) and cancerous lung epithelial (A549) cells, indicate a potential for use in temperature sensing in biomedicine. Additionally, their enhanced internalization in cells, without suppression of cell viability, enabled in vitro labeling of cancer and healthy cells upon 976 nm laser irradiation.",
publisher = "MDPI",
journal = "Journal of Functional Biomaterials",
title = "Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals",
volume = "15",
number = "1",
pages = "6",
doi = "10.3390/jfb15010006"
}

Dinić, I., Vuković, M., Rabanal, M. E., Milošević, M., Bukumira, M., Tomić, N., Tomić, M., Mančić, L.,& Ignjatović, N.. (2024). Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals. in Journal of Functional Biomaterials
MDPI., 15(1), 6.
https://doi.org/10.3390/jfb15010006

Dinić I, Vuković M, Rabanal ME, Milošević M, Bukumira M, Tomić N, Tomić M, Mančić L, Ignjatović N. Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals. in Journal of Functional Biomaterials. 2024;15(1):6.
doi:10.3390/jfb15010006 .

Dinić, Ivana, Vuković, Marina, Rabanal, Maria Eugenia, Milošević, Milica, Bukumira, Marta, Tomić, Nina, Tomić, Miloš, Mančić, Lidija, Ignjatović, Nenad, "Temperature Sensing Properties of Biocompatible Yb/Er-Doped GdF3 and YF3 Mesocrystals" in Journal of Functional Biomaterials, 15, no. 1 (2024):6,
https://doi.org/10.3390/jfb15010006 . .

TY  - JOUR
AU  - Ferjančić, Zorana
AU  - Bihelović, Filip
AU  - Vulović, Bojan
AU  - Matović, Radomir
AU  - Trmčić, Milena
AU  - Jankovic, Aleksandar
AU  - Pavlovic, Milos
AU  - Đurković, Filip T.
AU  - Prodanović, Radivoje
AU  - Djurdjevic Djelmas, Aleksandra
AU  - Kalicanin, Nevena
AU  - Zlatović, Mario
AU  - Sladić, Dušan
AU  - Vallet, Thomas
AU  - Vignuzzi, Marco
AU  - Saicic, Radomir N.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6475
AB  - We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase, and mannosidase). Molecular modelling of the lead compounds, synthesis of the compounds with the highest docking scores, enzyme inhibition tests, and in vitro antiviral assays afforded rationally designed inhibitors. Two highly active α-glucosidase inhibitors were discovered, where one of them is the most potent iminosugar-based anti-SARS-CoV-2 agent to date (EC90 = 1.94 µM in A549-ACE2 cells against Omicron BA.1 strain). However, galactosidase inhibitors did not exhibit antiviral activity, whereas mannosidase inhibitors were both active and cytotoxic. As our iminosugar-based drug candidates act by a host-directed mechanism, they should be more resilient to drug resistance. Moreover, this strategy could be extended to identify potential drug candidates for other viral infections.
PB  - Taylor and Francis Group
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies
VL  - 39
IS  - 1
SP  - 2289007
DO  - 10.1080/14756366.2023.2289007
ER  - 

@article{
author = "Ferjančić, Zorana and Bihelović, Filip and Vulović, Bojan and Matović, Radomir and Trmčić, Milena and Jankovic, Aleksandar and Pavlovic, Milos and Đurković, Filip T. and Prodanović, Radivoje and Djurdjevic Djelmas, Aleksandra and Kalicanin, Nevena and Zlatović, Mario and Sladić, Dušan and Vallet, Thomas and Vignuzzi, Marco and Saicic, Radomir N.",
year = "2024",
abstract = "We developed new iminosugar-based glycosidase inhibitors against SARS-CoV-2. Known drugs (miglustat, migalastat, miglitol, and swainsonine) were chosen as lead compounds to develop three classes of glycosidase inhibitors (α-glucosidase, α-galactosidase, and mannosidase). Molecular modelling of the lead compounds, synthesis of the compounds with the highest docking scores, enzyme inhibition tests, and in vitro antiviral assays afforded rationally designed inhibitors. Two highly active α-glucosidase inhibitors were discovered, where one of them is the most potent iminosugar-based anti-SARS-CoV-2 agent to date (EC90 = 1.94 µM in A549-ACE2 cells against Omicron BA.1 strain). However, galactosidase inhibitors did not exhibit antiviral activity, whereas mannosidase inhibitors were both active and cytotoxic. As our iminosugar-based drug candidates act by a host-directed mechanism, they should be more resilient to drug resistance. Moreover, this strategy could be extended to identify potential drug candidates for other viral infections.",
publisher = "Taylor and Francis Group",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies",
volume = "39",
number = "1",
pages = "2289007",
doi = "10.1080/14756366.2023.2289007"
}

Ferjančić, Z., Bihelović, F., Vulović, B., Matović, R., Trmčić, M., Jankovic, A., Pavlovic, M., Đurković, F. T., Prodanović, R., Djurdjevic Djelmas, A., Kalicanin, N., Zlatović, M., Sladić, D., Vallet, T., Vignuzzi, M.,& Saicic, R. N.. (2024). Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor and Francis Group., 39(1), 2289007.
https://doi.org/10.1080/14756366.2023.2289007

Ferjančić Z, Bihelović F, Vulović B, Matović R, Trmčić M, Jankovic A, Pavlovic M, Đurković FT, Prodanović R, Djurdjevic Djelmas A, Kalicanin N, Zlatović M, Sladić D, Vallet T, Vignuzzi M, Saicic RN. Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2024;39(1):2289007.
doi:10.1080/14756366.2023.2289007 .

Ferjančić, Zorana, Bihelović, Filip, Vulović, Bojan, Matović, Radomir, Trmčić, Milena, Jankovic, Aleksandar, Pavlovic, Milos, Đurković, Filip T., Prodanović, Radivoje, Djurdjevic Djelmas, Aleksandra, Kalicanin, Nevena, Zlatović, Mario, Sladić, Dušan, Vallet, Thomas, Vignuzzi, Marco, Saicic, Radomir N., "Development of iminosugar-based glycosidase inhibitors as drug candidates for SARS-CoV-2 virus via molecular modelling and in vitro studies" in Journal of Enzyme Inhibition and Medicinal Chemistry, 39, no. 1 (2024):2289007,
https://doi.org/10.1080/14756366.2023.2289007 . .

TY  - JOUR
AU  - Meland, Mekjell
AU  - Dabić Zagorac, Dragana
AU  - Jakanovski, Mihajlo V.
AU  - Sredojević, Milica
AU  - Natić, Maja
AU  - Kitanović, Marko
AU  - Fotirić Akšić, Milica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6506
AB  - The aim of this work was to investigate the influence of two locations and seven cultivars on the profiling of metabolites in organically grown plums (Prunus domestica L.) fruit in Norway. P, K, and Ca were most abundant in the studied fruits, while Ba and Sr formed a clear line between the locations. The most abundant sugars were glucose, fructose, sucrose, and sorbitol, which together accounted for up to 97.00%. Quinic acid and malic acid were the predominant organic acids, while chlorogenic acid, rutin, and kaempferol-3-O-glucoside were the most abundant polyphenols. Plums from Ullensvang were characterized by a higher content of minerals, sugars, organic acids, total polyphenol content (TPC), and radical scavenging activity (RSA), while plums from Telemark had a higher content of quantified polyphenols. The cultivar ‘Mallard’ had the highest mineral and radical scavenging activity, ‘Opal’ had the sweetest fruit, ‘Jubileum’ had the highest acidity, ‘Excalibur’ had the highest TPC content, and ‘Valor’ stored the highest content of quantified polyphenols, especially chlorogenic acid. These results provide comprehensive information on the chemical profiles of selected plum cultivars, suggesting that organic plums are a rich source of beneficial compounds that can have a positive impact on human health.
PB  - MDPI
T1  - Profiling of Metabolites in Organically Grown Plums from Norway: Does Location or Cultivar Matter?
VL  - 13
DO  - 10.3390/antiox13050526
ER  - 

@article{
author = "Meland, Mekjell and Dabić Zagorac, Dragana and Jakanovski, Mihajlo V. and Sredojević, Milica and Natić, Maja and Kitanović, Marko and Fotirić Akšić, Milica",
year = "2024",
abstract = "The aim of this work was to investigate the influence of two locations and seven cultivars on the profiling of metabolites in organically grown plums (Prunus domestica L.) fruit in Norway. P, K, and Ca were most abundant in the studied fruits, while Ba and Sr formed a clear line between the locations. The most abundant sugars were glucose, fructose, sucrose, and sorbitol, which together accounted for up to 97.00%. Quinic acid and malic acid were the predominant organic acids, while chlorogenic acid, rutin, and kaempferol-3-O-glucoside were the most abundant polyphenols. Plums from Ullensvang were characterized by a higher content of minerals, sugars, organic acids, total polyphenol content (TPC), and radical scavenging activity (RSA), while plums from Telemark had a higher content of quantified polyphenols. The cultivar ‘Mallard’ had the highest mineral and radical scavenging activity, ‘Opal’ had the sweetest fruit, ‘Jubileum’ had the highest acidity, ‘Excalibur’ had the highest TPC content, and ‘Valor’ stored the highest content of quantified polyphenols, especially chlorogenic acid. These results provide comprehensive information on the chemical profiles of selected plum cultivars, suggesting that organic plums are a rich source of beneficial compounds that can have a positive impact on human health.",
publisher = "MDPI",
title = "Profiling of Metabolites in Organically Grown Plums from Norway: Does Location or Cultivar Matter?",
volume = "13",
doi = "10.3390/antiox13050526"
}

Meland, M., Dabić Zagorac, D., Jakanovski, M. V., Sredojević, M., Natić, M., Kitanović, M.,& Fotirić Akšić, M.. (2024). Profiling of Metabolites in Organically Grown Plums from Norway: Does Location or Cultivar Matter?. 
MDPI., 13.
https://doi.org/10.3390/antiox13050526

Meland M, Dabić Zagorac D, Jakanovski MV, Sredojević M, Natić M, Kitanović M, Fotirić Akšić M. Profiling of Metabolites in Organically Grown Plums from Norway: Does Location or Cultivar Matter?. 2024;13.
doi:10.3390/antiox13050526 .

Meland, Mekjell, Dabić Zagorac, Dragana, Jakanovski, Mihajlo V., Sredojević, Milica, Natić, Maja, Kitanović, Marko, Fotirić Akšić, Milica, "Profiling of Metabolites in Organically Grown Plums from Norway: Does Location or Cultivar Matter?", 13 (2024),
https://doi.org/10.3390/antiox13050526 . .

TY  - JOUR
AU  - Gligorijević, Nikola
AU  - Lujić, Tamara
AU  - Mutić, Tamara
AU  - Vasović, Tamara
AU  - Aćimović, Jelena
AU  - de Guzman, Maria Krishna
AU  - Stanić-Vučinić, Dragana
AU  - Ćirković-Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6510
PB  - Elsevier
T2  - International Journal of Biological Macromolecules
T1  - Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties
VL  - 267
SP  - 131564
DO  - 10.1016/j.ijbiomac.2024.131564
ER  - 

@article{
author = "Gligorijević, Nikola and Lujić, Tamara and Mutić, Tamara and Vasović, Tamara and Aćimović, Jelena and de Guzman, Maria Krishna and Stanić-Vučinić, Dragana and Ćirković-Veličković, Tanja",
year = "2024",
publisher = "Elsevier",
journal = "International Journal of Biological Macromolecules",
title = "Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties",
volume = "267",
pages = "131564",
doi = "10.1016/j.ijbiomac.2024.131564"
}

Gligorijević, N., Lujić, T., Mutić, T., Vasović, T., Aćimović, J., de Guzman, M. K., Stanić-Vučinić, D.,& Ćirković-Veličković, T.. (2024). Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties. in International Journal of Biological Macromolecules
Elsevier., 267, 131564.
https://doi.org/10.1016/j.ijbiomac.2024.131564

Gligorijević N, Lujić T, Mutić T, Vasović T, Aćimović J, de Guzman MK, Stanić-Vučinić D, Ćirković-Veličković T. Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties. in International Journal of Biological Macromolecules. 2024;267:131564.
doi:10.1016/j.ijbiomac.2024.131564 .

Gligorijević, Nikola, Lujić, Tamara, Mutić, Tamara, Vasović, Tamara, Aćimović, Jelena, de Guzman, Maria Krishna, Stanić-Vučinić, Dragana, Ćirković-Veličković, Tanja, "Ovalbumin interaction with polystyrene and polyethylene terephthalate microplastics alters its structural properties" in International Journal of Biological Macromolecules, 267 (2024):131564,
https://doi.org/10.1016/j.ijbiomac.2024.131564 . .

TY  - THES
AU  - Samac, Milena
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6515
AB  - Tokom ovog istraživačkog rada a u okviru diplomskog rada, bavili smo se ispitivanjem bioraposloživosti potencijalno štetnih elemenata iz atmosfere koji su u istu oslobođeni bilo prirodnim ili antropogenim procesima. Korišćenjem robusne in vitro simulirane epitelne plućne tečnosti koja predstavlja ekstracelularnu sredinu pluća, vršili smo ekstrakciju bioraspoloživih koncentracija elemenata. U datom radu, bilo je reči o načinima kontakta istih sa čovekom, puteva izloženosti, količine elemenata koja putem pluća i alveola uđu u čovekov cirkularni, krvni sistem kao i da li postoji razlika u bioraspoloživosti u odnosu na veličine čestica (PM10, PM2,5). Upoređivali smo ekstrahovane bioraspoložive koncentracije elemenata sa ukupnom koncentracijom istih elemenata u suspendovanim česticama (PM10, PM2,5) sakupljenim u okviru istraživanja sprovedenog na Institutu za fiziku u Beogradu u periodu od aprila do oktobra 2019. godine (u toku ovog perioda su detektovane i tri epizode saharskog peska što dodatno može biti izvor nekog od elemenata koji su tipični za ove epizode - Al, Si, Ti, Fe, K, Mn, Rb, V, Cr, Sc i Be.
Uzorkovanje je sprovođeno od aprila do jula s tim što je bio sakupljen i jedan uzorak u oktobru kada je počela grejna sezona. Uzorci su prikupljani, označeni datumima prikupljanja, izmerene su njihove mase i odrađena je hemijska analiza nakon čega je koncentracije različitih elemenata, kao potencijalnih neorganskih zagađujućih supstanci, određivana metodom ICP-OES (indukovano spregnuta plazma – optička emisiona sprektrometrija).
Određivane su koncentracije sledećih potencijalno štetnih elemenata (PŠE): B, Be, Ba, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, As, Cd, Pb, kao i koncentracija makroelementa Na, Mg, Ca i S. U diplomskom radu cilj je bila procena zavisnosti bioraspoloživosti čestica od njihove veličine (da li su PM2,5 čestice bioraspoloživije od PM10).
T1  - Pregled značajnih korelacija koncentracija elemenata iz PM10 i PM2,5 čestica
SP  - 1
EP  - 62
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6515
ER  - 

@mastersthesis{
author = "Samac, Milena",
year = "2024",
abstract = "Tokom ovog istraživačkog rada a u okviru diplomskog rada, bavili smo se ispitivanjem bioraposloživosti potencijalno štetnih elemenata iz atmosfere koji su u istu oslobođeni bilo prirodnim ili antropogenim procesima. Korišćenjem robusne in vitro simulirane epitelne plućne tečnosti koja predstavlja ekstracelularnu sredinu pluća, vršili smo ekstrakciju bioraspoloživih koncentracija elemenata. U datom radu, bilo je reči o načinima kontakta istih sa čovekom, puteva izloženosti, količine elemenata koja putem pluća i alveola uđu u čovekov cirkularni, krvni sistem kao i da li postoji razlika u bioraspoloživosti u odnosu na veličine čestica (PM10, PM2,5). Upoređivali smo ekstrahovane bioraspoložive koncentracije elemenata sa ukupnom koncentracijom istih elemenata u suspendovanim česticama (PM10, PM2,5) sakupljenim u okviru istraživanja sprovedenog na Institutu za fiziku u Beogradu u periodu od aprila do oktobra 2019. godine (u toku ovog perioda su detektovane i tri epizode saharskog peska što dodatno može biti izvor nekog od elemenata koji su tipični za ove epizode - Al, Si, Ti, Fe, K, Mn, Rb, V, Cr, Sc i Be.
Uzorkovanje je sprovođeno od aprila do jula s tim što je bio sakupljen i jedan uzorak u oktobru kada je počela grejna sezona. Uzorci su prikupljani, označeni datumima prikupljanja, izmerene su njihove mase i odrađena je hemijska analiza nakon čega je koncentracije različitih elemenata, kao potencijalnih neorganskih zagađujućih supstanci, određivana metodom ICP-OES (indukovano spregnuta plazma – optička emisiona sprektrometrija).
Određivane su koncentracije sledećih potencijalno štetnih elemenata (PŠE): B, Be, Ba, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, As, Cd, Pb, kao i koncentracija makroelementa Na, Mg, Ca i S. U diplomskom radu cilj je bila procena zavisnosti bioraspoloživosti čestica od njihove veličine (da li su PM2,5 čestice bioraspoloživije od PM10).",
title = "Pregled značajnih korelacija koncentracija elemenata iz PM10 i PM2,5 čestica",
pages = "1-62",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6515"
}

Samac, M.. (2024). Pregled značajnih korelacija koncentracija elemenata iz PM10 i PM2,5 čestica. , 1-62.
https://hdl.handle.net/21.15107/rcub_cherry_6515

Samac M. Pregled značajnih korelacija koncentracija elemenata iz PM10 i PM2,5 čestica. 2024;:1-62.
https://hdl.handle.net/21.15107/rcub_cherry_6515 .

Samac, Milena, "Pregled značajnih korelacija koncentracija elemenata iz PM10 i PM2,5 čestica" (2024):1-62,
https://hdl.handle.net/21.15107/rcub_cherry_6515 .

TY  - THES
AU  - Spasić, Vuk M.
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6516
AB  - U ovom radu su ispitivani uzorci mrkog uglja iz III sloja basena Bobov Dol (Bugarska), starosti kasnog oligocena (pre oko 25 miliona godina). Cilj rada je bio određivanje porekla, paleosredine taloženja, maturisanosti i ugljovodoničnog potencijala organske supstance. Primenjene su organsko-petrografske metode (maceralna analiza i merenje refleksije huminita), Rock-Eval piroliza i detaljna analiza biomarkera u alifatičnoj i aromatičnoj frakciji bitumena uglja.
U svim uzorcima u znatnoj meri dominira huminit nad liptinitom, dok je sadržaj inertinita veoma mali. Glavni prekursori organske supstance ispitivanih ugljeva bile su familije golosemenica, Cupressaceae i Pinaceae, uz dokazano učešće roda Chamaecyparis, submerzne makrofite i paprati iz familija Equisetum i Salvinia. Doprinos skrivenosemenica i algi je bio manji. Ugalj je taložen u blago oksidacionoj, slabo kiseloj, slatkovodnoj sredini. Taloženje uglja u III sloju započelo je pod umereno visokim stabilnim nivoom vodenog stuba u izdignutoj u odnosu na okolni teren močvari, koja stoga nije plavljena što je rezultovalo niskim sadržajem pepela, ali i nešto slabijim prilivom nutrijenata za razvoj algi. Sledeća faza stvaranja uglja odigravala se pod vrlo sličnim uslovima, ali je dolazilo do povremenog plavljenja koje se manifistuje kroz viši sadržaj pepela, što ukazuje na blago spuštanje močvare, usled tektonske aktivnosti. Češći priliv minaralnim materijama bogate vode doprineo je razvoju algi. Poslednja faza taloženja uglja u ovom sloju bila je praćena daljim spuštanjem terena i češćim plavljenjem paleomočvare, što je dovelo do daljeg porasta sadržaja mineralnih materija/pepela i donekle, algalne biomase. Masivno plavljenje i pretvaranje močvare u jezero rezultovalo je završetkom taloženja uglja u III sloju, što potvrđuje prisustvo sloja glinaca u povlati. Organska supstanca uglja je nezrela i njena maturisanost odgovara kasnoj fazi dijageneze. Organska supstanca se pretežno sastoji od kerogena tipa III, i prema vrednostima vodoničnog indeksa, može biti značajan izvor gasa na višim stupnjevima zrelosti (kasna katageneza i metageneza).
T1  - Procena geološke istorije trećeg ugljenog sloja basena Bobov Dol (Ćustendilska oblast, Republika Bugarska)
SP  - 1
EP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6516
ER  - 

@mastersthesis{
author = "Spasić, Vuk M.",
year = "2024",
abstract = "U ovom radu su ispitivani uzorci mrkog uglja iz III sloja basena Bobov Dol (Bugarska), starosti kasnog oligocena (pre oko 25 miliona godina). Cilj rada je bio određivanje porekla, paleosredine taloženja, maturisanosti i ugljovodoničnog potencijala organske supstance. Primenjene su organsko-petrografske metode (maceralna analiza i merenje refleksije huminita), Rock-Eval piroliza i detaljna analiza biomarkera u alifatičnoj i aromatičnoj frakciji bitumena uglja.
U svim uzorcima u znatnoj meri dominira huminit nad liptinitom, dok je sadržaj inertinita veoma mali. Glavni prekursori organske supstance ispitivanih ugljeva bile su familije golosemenica, Cupressaceae i Pinaceae, uz dokazano učešće roda Chamaecyparis, submerzne makrofite i paprati iz familija Equisetum i Salvinia. Doprinos skrivenosemenica i algi je bio manji. Ugalj je taložen u blago oksidacionoj, slabo kiseloj, slatkovodnoj sredini. Taloženje uglja u III sloju započelo je pod umereno visokim stabilnim nivoom vodenog stuba u izdignutoj u odnosu na okolni teren močvari, koja stoga nije plavljena što je rezultovalo niskim sadržajem pepela, ali i nešto slabijim prilivom nutrijenata za razvoj algi. Sledeća faza stvaranja uglja odigravala se pod vrlo sličnim uslovima, ali je dolazilo do povremenog plavljenja koje se manifistuje kroz viši sadržaj pepela, što ukazuje na blago spuštanje močvare, usled tektonske aktivnosti. Češći priliv minaralnim materijama bogate vode doprineo je razvoju algi. Poslednja faza taloženja uglja u ovom sloju bila je praćena daljim spuštanjem terena i češćim plavljenjem paleomočvare, što je dovelo do daljeg porasta sadržaja mineralnih materija/pepela i donekle, algalne biomase. Masivno plavljenje i pretvaranje močvare u jezero rezultovalo je završetkom taloženja uglja u III sloju, što potvrđuje prisustvo sloja glinaca u povlati. Organska supstanca uglja je nezrela i njena maturisanost odgovara kasnoj fazi dijageneze. Organska supstanca se pretežno sastoji od kerogena tipa III, i prema vrednostima vodoničnog indeksa, može biti značajan izvor gasa na višim stupnjevima zrelosti (kasna katageneza i metageneza).",
title = "Procena geološke istorije trećeg ugljenog sloja basena Bobov Dol (Ćustendilska oblast, Republika Bugarska)",
pages = "1-47",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6516"
}

Spasić, V. M.. (2024). Procena geološke istorije trećeg ugljenog sloja basena Bobov Dol (Ćustendilska oblast, Republika Bugarska). , 1-47.
https://hdl.handle.net/21.15107/rcub_cherry_6516

Spasić VM. Procena geološke istorije trećeg ugljenog sloja basena Bobov Dol (Ćustendilska oblast, Republika Bugarska). 2024;:1-47.
https://hdl.handle.net/21.15107/rcub_cherry_6516 .

Spasić, Vuk M., "Procena geološke istorije trećeg ugljenog sloja basena Bobov Dol (Ćustendilska oblast, Republika Bugarska)" (2024):1-47,
https://hdl.handle.net/21.15107/rcub_cherry_6516 .

TY  - THES
AU  - Topić, Milica
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6514
AB  - Starenje kože je složen biohemijski proces koji dovodi do oštećenja na ćelijskom nivou što se odražava gubitkom elastina i kolagena što progresivno dovodi do propadanja strukture kože i nastanka bora. Pored toga, prekomerna aktivnost tirozinaze u kasnijem životnom dobu dovodi do hiperpigmentacije i formiranja staračkih pega. Slobodni radikali su nestabilni molekuli koji nastaju tokom normalnih metaboličkih procesa. Međutim, nagomilavanjem slobodnih radikala dovodi do okisadtivnog stresa koji uzrokuje oštećenja ćelijskih struktura, kolagena i elastina a to se na koži primeti kao gubitak elstičnosti i nastanak bora.
Ublažavanje ili usporavanje starenja kože mogao bi se prevazići upotrebom inhibitora navedenoh enzima kao aktivnih komponenti u kozmetičkim preparatima. Prema tome, u ovom radu ispitivano je 17 vrsta biljnih latica gajenih u Srbiji. Latice su ekstrahovane metodom ekstrakcije potpomognute ultrazvukom primenom metanola kao rastvarača.
Visoko-efikasna tankoslojna hromatografija (eng. High performance thin layer chromatography, HPTLC) primenjena je u cilju razdvajanja i identifikacije sekundarnih metabolita latica kao što su fenolna jedinjenja. Ekstrakti su analizirani spektrofotometrijskim antioksidativnim esejima u cilju iznalaženja najaktivnijeg biljnog ekstrakta. Primenom bioautografske tehnike (HPTLC-DPPH) omogućila je detekciju pojedinačnih antioksidanasa u okviru ekstrakata. Ispitivanjem potencijala inhibicije tirozinaze ponađeni su ekstrakti latica sa najvišim procentom inhibicije ezima odgovornog za stvaranje sraračkih pega.
Cilj ovog diplomskog rada bio je pronalazak najaktivnijih ekstrakata latica biljaka kao novih sirovina sa potencijalom za inkorporiranje u kozmetičke preparate namenjene usporavanju procesa starenja kože i hiperpigmentacije.
T1  - Određivanje fenolnog sastava ekstrakta odabranih cvetnih latica i ispitivanje njihove efikasnosti u usporavanju starenja kože
SP  - 1
EP  - 46
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6514
ER  - 

@misc{
author = "Topić, Milica",
year = "2024",
abstract = "Starenje kože je složen biohemijski proces koji dovodi do oštećenja na ćelijskom nivou što se odražava gubitkom elastina i kolagena što progresivno dovodi do propadanja strukture kože i nastanka bora. Pored toga, prekomerna aktivnost tirozinaze u kasnijem životnom dobu dovodi do hiperpigmentacije i formiranja staračkih pega. Slobodni radikali su nestabilni molekuli koji nastaju tokom normalnih metaboličkih procesa. Međutim, nagomilavanjem slobodnih radikala dovodi do okisadtivnog stresa koji uzrokuje oštećenja ćelijskih struktura, kolagena i elastina a to se na koži primeti kao gubitak elstičnosti i nastanak bora.
Ublažavanje ili usporavanje starenja kože mogao bi se prevazići upotrebom inhibitora navedenoh enzima kao aktivnih komponenti u kozmetičkim preparatima. Prema tome, u ovom radu ispitivano je 17 vrsta biljnih latica gajenih u Srbiji. Latice su ekstrahovane metodom ekstrakcije potpomognute ultrazvukom primenom metanola kao rastvarača.
Visoko-efikasna tankoslojna hromatografija (eng. High performance thin layer chromatography, HPTLC) primenjena je u cilju razdvajanja i identifikacije sekundarnih metabolita latica kao što su fenolna jedinjenja. Ekstrakti su analizirani spektrofotometrijskim antioksidativnim esejima u cilju iznalaženja najaktivnijeg biljnog ekstrakta. Primenom bioautografske tehnike (HPTLC-DPPH) omogućila je detekciju pojedinačnih antioksidanasa u okviru ekstrakata. Ispitivanjem potencijala inhibicije tirozinaze ponađeni su ekstrakti latica sa najvišim procentom inhibicije ezima odgovornog za stvaranje sraračkih pega.
Cilj ovog diplomskog rada bio je pronalazak najaktivnijih ekstrakata latica biljaka kao novih sirovina sa potencijalom za inkorporiranje u kozmetičke preparate namenjene usporavanju procesa starenja kože i hiperpigmentacije.",
title = "Određivanje fenolnog sastava ekstrakta odabranih cvetnih latica i ispitivanje njihove efikasnosti u usporavanju starenja kože",
pages = "1-46",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6514"
}

Topić, M.. (2024). Određivanje fenolnog sastava ekstrakta odabranih cvetnih latica i ispitivanje njihove efikasnosti u usporavanju starenja kože. , 1-46.
https://hdl.handle.net/21.15107/rcub_cherry_6514

Topić M. Određivanje fenolnog sastava ekstrakta odabranih cvetnih latica i ispitivanje njihove efikasnosti u usporavanju starenja kože. 2024;:1-46.
https://hdl.handle.net/21.15107/rcub_cherry_6514 .

Topić, Milica, "Određivanje fenolnog sastava ekstrakta odabranih cvetnih latica i ispitivanje njihove efikasnosti u usporavanju starenja kože" (2024):1-46,
https://hdl.handle.net/21.15107/rcub_cherry_6514 .

TY  - DATA
AU  - Mutić, Tamara
AU  - Stanić-Vučinić, Dragana
AU  - Mutić, Jelena
AU  - Ilić, Miloš
AU  - Jovanović, Vesna
AU  - Aćimović, Jelena
AU  - Anđelković, Boban
AU  - Krishna de Guzman, Maria
AU  - Anđelković, Mirjana
AU  - Turkalj, Mirjana
AU  - Ćirković-Veličković, Tanja
PY  - 2024
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/6484
AB  - The experimental data for the results shown in the manuscript "Microplastic contamination of edible parts of commercially important mussels, clams and shrimps in different markets". Statistical investigation of the presence of microplastics in bivalve species using microFTIR. This dataset includes samples from various origins, including Sebia, South Korea, Croatia and Belgium, and includes species as diverse as shrimp, mussels and clams.
T1  - Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets
UR  - https://hdl.handle.net/21.15107/rcub_cherry_6484
ER  - 

@misc{
author = "Mutić, Tamara and Stanić-Vučinić, Dragana and Mutić, Jelena and Ilić, Miloš and Jovanović, Vesna and Aćimović, Jelena and Anđelković, Boban and Krishna de Guzman, Maria and Anđelković, Mirjana and Turkalj, Mirjana and Ćirković-Veličković, Tanja",
year = "2024",
abstract = "The experimental data for the results shown in the manuscript "Microplastic contamination of edible parts of commercially important mussels, clams and shrimps in different markets". Statistical investigation of the presence of microplastics in bivalve species using microFTIR. This dataset includes samples from various origins, including Sebia, South Korea, Croatia and Belgium, and includes species as diverse as shrimp, mussels and clams.",
title = "Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets",
url = "https://hdl.handle.net/21.15107/rcub_cherry_6484"
}

Mutić, T., Stanić-Vučinić, D., Mutić, J., Ilić, M., Jovanović, V., Aćimović, J., Anđelković, B., Krishna de Guzman, M., Anđelković, M., Turkalj, M.,& Ćirković-Veličković, T.. (2024). Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets. .
https://hdl.handle.net/21.15107/rcub_cherry_6484

Mutić T, Stanić-Vučinić D, Mutić J, Ilić M, Jovanović V, Aćimović J, Anđelković B, Krishna de Guzman M, Anđelković M, Turkalj M, Ćirković-Veličković T. Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets. 2024;.
https://hdl.handle.net/21.15107/rcub_cherry_6484 .

Mutić, Tamara, Stanić-Vučinić, Dragana, Mutić, Jelena, Ilić, Miloš, Jovanović, Vesna, Aćimović, Jelena, Anđelković, Boban, Krishna de Guzman, Maria, Anđelković, Mirjana, Turkalj, Mirjana, Ćirković-Veličković, Tanja, "Research data no. 1 for the manuscript: Microplastics contamination of edible parts of commercially relevant species of mussels, clams and shrimps across various markets" (2024),
https://hdl.handle.net/21.15107/rcub_cherry_6484 .