Design and modifications of allergens for improving specific immunotherapy
Апстракт
Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts, prepared from natural sources, and as such may cause potential life-threatening anaphylactic side effects. Our increasing knowledge of mechanisms that lead to allergy and of the mechanisms of successful immunotherapy have introduced new ideas for the treatment of allergic diseases. Techniques of biochemistry and molecular biology have made it feasible to design novel therapeutic approaches for improved and safer forms of allergen-specific immunotherapy. The purpose of this review is to examine different approaches in designing novel allergen formulations for specific immunotherapy. These include chemically modified forms of allergens, genetically modified allergens (hypoallergens), hybrid allergens and allergens bearing immunostimulatory molecules, or adjuvants, which foster Th 1 immune responses. There is great interest in newly... designed allergens and their derivatives to improve the efficacy and safety of allergen immunotherapy. A better understanding of immunological mechanisms and further clinical trials utilizing new allergen formulations are needed. © 2008 Bentham Science Publishers Ltd.
Кључне речи:
Allergen / Allergoid / Hypoallergen / Immunotherapy / ModificationИзвор:
Inflammation and Allergy - Drug Targets, 2008, 7, 4, 270-278Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Ćirković-Veličković, Tanja AU - Jankov, Ratko M. PY - 2008 UR - https://cherry.chem.bg.ac.rs/handle/123456789/100 AB - Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts, prepared from natural sources, and as such may cause potential life-threatening anaphylactic side effects. Our increasing knowledge of mechanisms that lead to allergy and of the mechanisms of successful immunotherapy have introduced new ideas for the treatment of allergic diseases. Techniques of biochemistry and molecular biology have made it feasible to design novel therapeutic approaches for improved and safer forms of allergen-specific immunotherapy. The purpose of this review is to examine different approaches in designing novel allergen formulations for specific immunotherapy. These include chemically modified forms of allergens, genetically modified allergens (hypoallergens), hybrid allergens and allergens bearing immunostimulatory molecules, or adjuvants, which foster Th 1 immune responses. There is great interest in newly designed allergens and their derivatives to improve the efficacy and safety of allergen immunotherapy. A better understanding of immunological mechanisms and further clinical trials utilizing new allergen formulations are needed. © 2008 Bentham Science Publishers Ltd. T2 - Inflammation and Allergy - Drug Targets T1 - Design and modifications of allergens for improving specific immunotherapy VL - 7 IS - 4 SP - 270 EP - 278 DO - 10.2174/187152808786848432 ER -
@article{ author = "Ćirković-Veličković, Tanja and Jankov, Ratko M.", year = "2008", abstract = "Specific immunotherapy is a clinically effective causative treatment for allergic conditions. However, the reagents used for immunotherapy are crude extracts, prepared from natural sources, and as such may cause potential life-threatening anaphylactic side effects. Our increasing knowledge of mechanisms that lead to allergy and of the mechanisms of successful immunotherapy have introduced new ideas for the treatment of allergic diseases. Techniques of biochemistry and molecular biology have made it feasible to design novel therapeutic approaches for improved and safer forms of allergen-specific immunotherapy. The purpose of this review is to examine different approaches in designing novel allergen formulations for specific immunotherapy. These include chemically modified forms of allergens, genetically modified allergens (hypoallergens), hybrid allergens and allergens bearing immunostimulatory molecules, or adjuvants, which foster Th 1 immune responses. There is great interest in newly designed allergens and their derivatives to improve the efficacy and safety of allergen immunotherapy. A better understanding of immunological mechanisms and further clinical trials utilizing new allergen formulations are needed. © 2008 Bentham Science Publishers Ltd.", journal = "Inflammation and Allergy - Drug Targets", title = "Design and modifications of allergens for improving specific immunotherapy", volume = "7", number = "4", pages = "270-278", doi = "10.2174/187152808786848432" }
Ćirković-Veličković, T.,& Jankov, R. M.. (2008). Design and modifications of allergens for improving specific immunotherapy. in Inflammation and Allergy - Drug Targets, 7(4), 270-278. https://doi.org/10.2174/187152808786848432
Ćirković-Veličković T, Jankov RM. Design and modifications of allergens for improving specific immunotherapy. in Inflammation and Allergy - Drug Targets. 2008;7(4):270-278. doi:10.2174/187152808786848432 .
Ćirković-Veličković, Tanja, Jankov, Ratko M., "Design and modifications of allergens for improving specific immunotherapy" in Inflammation and Allergy - Drug Targets, 7, no. 4 (2008):270-278, https://doi.org/10.2174/187152808786848432 . .