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Novel formulations for oral allergen vaccination

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Authors
Polović, Natalija
Ćirković-Veličković, Tanja
Article (Published version)
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Abstract
Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsi...veness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd.

Keywords:
Allergy / Oral allergen delivery / Oral immunotherapy
Source:
Recent Patents on Inflammation and Allergy Drug Discovery, 2008, 2, 3, 215-221

DOI: 10.2174/187221308786241956

ISSN: 1872-213X

Scopus: 2-s2.0-61449517858
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4
URI
https://cherry.chem.bg.ac.rs/handle/123456789/101
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Polović, Natalija
AU  - Ćirković-Veličković, Tanja
PY  - 2008
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/101
AB  - Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsiveness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd.
T2  - Recent Patents on Inflammation and Allergy Drug Discovery
T1  - Novel formulations for oral allergen vaccination
VL  - 2
IS  - 3
SP  - 215
EP  - 221
DO  - 10.2174/187221308786241956
UR  - Kon_1179
ER  - 
@article{
author = "Polović, Natalija and Ćirković-Veličković, Tanja",
year = "2008",
abstract = "Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsiveness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd.",
journal = "Recent Patents on Inflammation and Allergy Drug Discovery",
title = "Novel formulations for oral allergen vaccination",
volume = "2",
number = "3",
pages = "215-221",
doi = "10.2174/187221308786241956",
url = "Kon_1179"
}
Polović, N.,& Ćirković-Veličković, T.. (2008). Novel formulations for oral allergen vaccination. in Recent Patents on Inflammation and Allergy Drug Discovery, 2(3), 215-221.
https://doi.org/10.2174/187221308786241956
Kon_1179
Polović N, Ćirković-Veličković T. Novel formulations for oral allergen vaccination. in Recent Patents on Inflammation and Allergy Drug Discovery. 2008;2(3):215-221.
doi:10.2174/187221308786241956
Kon_1179 .
Polović, Natalija, Ćirković-Veličković, Tanja, "Novel formulations for oral allergen vaccination" in Recent Patents on Inflammation and Allergy Drug Discovery, 2, no. 3 (2008):215-221,
https://doi.org/10.2174/187221308786241956 .,
Kon_1179 .

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