Novel formulations for oral allergen vaccination
Abstract
Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsi...veness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd.
Keywords:
Allergy / Oral allergen delivery / Oral immunotherapySource:
Recent Patents on Inflammation and Allergy Drug Discovery, 2008, 2, 3, 215-221Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Polović, Natalija AU - Ćirković-Veličković, Tanja PY - 2008 UR - https://cherry.chem.bg.ac.rs/handle/123456789/101 AB - Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsiveness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd. T2 - Recent Patents on Inflammation and Allergy Drug Discovery T1 - Novel formulations for oral allergen vaccination VL - 2 IS - 3 SP - 215 EP - 221 DO - 10.2174/187221308786241956 ER -
@article{ author = "Polović, Natalija and Ćirković-Veličković, Tanja", year = "2008", abstract = "Allergen specific immunotherapy, comprised of subcutanoues injections of increasing doses of allergen extracts, has been shown to be the only treatment able to influence the natural progression of allergic disease. Different forms of local immunotherapies, involving oral, sublingual and nasal routes of allergen adminstration, have also been considered in clinical practice. The inability of the protein to survive gastrointestinal physiological barriers is a generally encountered problem in oral administration of protein drugs. In order to overcome the problems of low allergen bioavailability and absorptivity, during oral immunotherapy, several stabilization strategies have been outlined in the recent years. This review focuses on interventions including: hexose monosaccharide, ethyl alcohol and water vehicles, oxygen-containing metal salt based preparations, particles with enteric coating, and poly (lactic-co-glycolic) acid microspheres. Regarding the enormous potential of oral responsiveness and/or oral tolerance, research that focuses on new and improved carriers or vehicles for safe allergen oral delivery has great potential in treating allergic diseases. This article also review some of the recent patent related to the field. © 2008 Bentham Science Publishers Ltd.", journal = "Recent Patents on Inflammation and Allergy Drug Discovery", title = "Novel formulations for oral allergen vaccination", volume = "2", number = "3", pages = "215-221", doi = "10.2174/187221308786241956" }
Polović, N.,& Ćirković-Veličković, T.. (2008). Novel formulations for oral allergen vaccination. in Recent Patents on Inflammation and Allergy Drug Discovery, 2(3), 215-221. https://doi.org/10.2174/187221308786241956
Polović N, Ćirković-Veličković T. Novel formulations for oral allergen vaccination. in Recent Patents on Inflammation and Allergy Drug Discovery. 2008;2(3):215-221. doi:10.2174/187221308786241956 .
Polović, Natalija, Ćirković-Veličković, Tanja, "Novel formulations for oral allergen vaccination" in Recent Patents on Inflammation and Allergy Drug Discovery, 2, no. 3 (2008):215-221, https://doi.org/10.2174/187221308786241956 . .