Organocatalyzed Tsuji-Trost reaction: a new method for the closure of five- and six-membered rings
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A combination of organotransition metal catalysis and organocatalysis allows for Tsuji-Trost 5-exo- and 6-exo-cyclizations of aldehydes. This transformation can also be accomplished as a catalytic asymmetric reaction, which affords vinylcyclopentane derivatives with up to 98%ee. (C) 2009 Elsevier Ltd. All rights reserved.
Keywords:Cyclization / Organocatalysis / Enantioselective catalysis / Cyclopentanes / Cyclohexanes / pi-Allylpalladium complexes
Source:Tetrahedron, 2009, 65, 50, 10485-10494
- Pergamon-Elsevier Science Ltd, Oxford