Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
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2010
Authors
Ratkovic, Zoran
Juranić, Zorica D.
Stanojković, Tatjana

Manojlović, Dragan D.

Vukicevic, Rastko D.
Radulović, Niko S.

Joksović, Milan D.

Article (Published version)

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A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
Keywords:
Ferrocene / Chalcone analogues / Pyrazole / CytotoxicitySource:
Bioorganic Chemistry, 2010, 38, 1-3, 26-32Publisher:
- Academic Press Inc Elsevier Science, San Diego
Funding / projects:
- Razvoj novih elektrohemijskih i hemijskih metoda organske sinteze (RS-142042)
- Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)
DOI: 10.1016/j.bioorg.2009.09.003
ISSN: 0045-2068
PubMed: 19846191
WoS: 000277377600004
Scopus: 2-s2.0-73349113168
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Hemijski fakultetTY - JOUR AU - Ratkovic, Zoran AU - Juranić, Zorica D. AU - Stanojković, Tatjana AU - Manojlović, Dragan D. AU - Vukicevic, Rastko D. AU - Radulović, Niko S. AU - Joksović, Milan D. PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1078 AB - A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved. PB - Academic Press Inc Elsevier Science, San Diego T2 - Bioorganic Chemistry T1 - Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety VL - 38 IS - 1-3 SP - 26 EP - 32 DO - 10.1016/j.bioorg.2009.09.003 UR - Kon_2078 ER -
@article{ author = "Ratkovic, Zoran and Juranić, Zorica D. and Stanojković, Tatjana and Manojlović, Dragan D. and Vukicevic, Rastko D. and Radulović, Niko S. and Joksović, Milan D.", year = "2010", abstract = "A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.", publisher = "Academic Press Inc Elsevier Science, San Diego", journal = "Bioorganic Chemistry", title = "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety", volume = "38", number = "1-3", pages = "26-32", doi = "10.1016/j.bioorg.2009.09.003", url = "Kon_2078" }
Ratkovic, Z., Juranić, Z. D., Stanojković, T., Manojlović, D. D., Vukicevic, R. D., Radulović, N. S.,& Joksović, M. D.. (2010). Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry Academic Press Inc Elsevier Science, San Diego., 38(1-3), 26-32. https://doi.org/10.1016/j.bioorg.2009.09.003 Kon_2078
Ratkovic Z, Juranić ZD, Stanojković T, Manojlović DD, Vukicevic RD, Radulović NS, Joksović MD. Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry. 2010;38(1-3):26-32. doi:10.1016/j.bioorg.2009.09.003 Kon_2078 .
Ratkovic, Zoran, Juranić, Zorica D., Stanojković, Tatjana, Manojlović, Dragan D., Vukicevic, Rastko D., Radulović, Niko S., Joksović, Milan D., "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety" in Bioorganic Chemistry, 38, no. 1-3 (2010):26-32, https://doi.org/10.1016/j.bioorg.2009.09.003 ., Kon_2078 .