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Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety

Authorized Users Only
2010
Authors
Ratkovic, Zoran
Juranić, Zorica D.
Stanojković, Tatjana
Manojlović, Dragan D.
Vukicevic, Rastko D.
Radulović, Niko S.
Joksović, Milan D.
Article (Published version)
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Abstract
A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
Keywords:
Ferrocene / Chalcone analogues / Pyrazole / Cytotoxicity
Source:
Bioorganic Chemistry, 2010, 38, 1-3, 26-32
Publisher:
  • Academic Press Inc Elsevier Science, San Diego
Funding / projects:
  • Razvoj novih elektrohemijskih i hemijskih metoda organske sinteze (RS-142042)
  • Istraživanje dejstava modifikatora biološkog odgovora u fiziološkim i patološkim stanjima (RS-145006)

DOI: 10.1016/j.bioorg.2009.09.003

ISSN: 0045-2068

PubMed: 19846191

WoS: 000277377600004

Scopus: 2-s2.0-73349113168
[ Google Scholar ]
78
78
URI
https://cherry.chem.bg.ac.rs/handle/123456789/1078
Collections
  • Publikacije
Institution/Community
Hemijski fakultet
TY  - JOUR
AU  - Ratkovic, Zoran
AU  - Juranić, Zorica D.
AU  - Stanojković, Tatjana
AU  - Manojlović, Dragan D.
AU  - Vukicevic, Rastko D.
AU  - Radulović, Niko S.
AU  - Joksović, Milan D.
PY  - 2010
UR  - https://cherry.chem.bg.ac.rs/handle/123456789/1078
AB  - A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Bioorganic Chemistry
T1  - Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety
VL  - 38
IS  - 1-3
SP  - 26
EP  - 32
DO  - 10.1016/j.bioorg.2009.09.003
UR  - Kon_2078
ER  - 
@article{
author = "Ratkovic, Zoran and Juranić, Zorica D. and Stanojković, Tatjana and Manojlović, Dragan D. and Vukicevic, Rastko D. and Radulović, Niko S. and Joksović, Milan D.",
year = "2010",
abstract = "A series of new raft-unsaturated conjugated ketones containing ferrocenyl pyrazole unit were synthesized and fully characterized by IR and NMR spectroscopy. Electrochemical characterization of subject compounds was performed by means of cyclic voltametry. The in vitro cytotoxic activity of all the synthesized compounds was studied against cervix adenocarcinoma HeLa, melanoma Fem-x and myelogenous leukemia K562 cell lines by the MIT method. Derivative II containing 3-pyridyl moiety exhibited a better cytotoxic activity in the cell growth inhibition of 1(562 cell lines in comparison with cisplatin as a reference compound. (C) 2009 Elsevier Inc. All rights reserved.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Bioorganic Chemistry",
title = "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety",
volume = "38",
number = "1-3",
pages = "26-32",
doi = "10.1016/j.bioorg.2009.09.003",
url = "Kon_2078"
}
Ratkovic, Z., Juranić, Z. D., Stanojković, T., Manojlović, D. D., Vukicevic, R. D., Radulović, N. S.,& Joksović, M. D.. (2010). Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry
Academic Press Inc Elsevier Science, San Diego., 38(1-3), 26-32.
https://doi.org/10.1016/j.bioorg.2009.09.003
Kon_2078
Ratkovic Z, Juranić ZD, Stanojković T, Manojlović DD, Vukicevic RD, Radulović NS, Joksović MD. Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety. in Bioorganic Chemistry. 2010;38(1-3):26-32.
doi:10.1016/j.bioorg.2009.09.003
Kon_2078 .
Ratkovic, Zoran, Juranić, Zorica D., Stanojković, Tatjana, Manojlović, Dragan D., Vukicevic, Rastko D., Radulović, Niko S., Joksović, Milan D., "Synthesis, characterization, electrochemical studies and antitumor activity of some new chalcone analogues containing ferrocenyl pyrazole moiety" in Bioorganic Chemistry, 38, no. 1-3 (2010):26-32,
https://doi.org/10.1016/j.bioorg.2009.09.003 .,
Kon_2078 .

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