Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes
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2010
Authors
Bjelogrlić, Snežana K.
Todorović, Tamara

Bacchi, Alessia

Zec, Manja
Sladić, Dušan

Srdić-Rajić, Tatjana

Radanović, Dušanka D.

Radulović, Siniša

Pelizzi, Giancarlo
Anđelković, Katarina K.

Article (Published version)

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Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have s...ome similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.
Keywords:
Zn(II) and Cd(II) complexes / Selenosemicarbazones / X-ray analysis / NMR spectroscopy / Antiproliferative activity / ApoptosisSource:
Journal of Inorganic Biochemistry, 2010, 104, 6, 673-682Publisher:
- Elsevier Science Inc, New York
Funding / projects:
- Interakcije prirodnih proizvoda i njihovih analoga sa proteinima i nukleinskim kiselinama (RS-142026)
- Farmakodinamska i farmakogenetska istraživanja novih lekova i prediktivna/prognostička vrednost farmakoterapije u onkologiji (RS-145035)
DOI: 10.1016/j.jinorgbio.2010.02.009
ISSN: 0162-0134
PubMed: 20356629
WoS: 000277946300008
Scopus: 2-s2.0-77952553954
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Bjelogrlić, Snežana K. AU - Todorović, Tamara AU - Bacchi, Alessia AU - Zec, Manja AU - Sladić, Dušan AU - Srdić-Rajić, Tatjana AU - Radanović, Dušanka D. AU - Radulović, Siniša AU - Pelizzi, Giancarlo AU - Anđelković, Katarina K. PY - 2010 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1081 AB - Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved. PB - Elsevier Science Inc, New York T2 - Journal of Inorganic Biochemistry T1 - Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes VL - 104 IS - 6 SP - 673 EP - 682 DO - 10.1016/j.jinorgbio.2010.02.009 ER -
@article{ author = "Bjelogrlić, Snežana K. and Todorović, Tamara and Bacchi, Alessia and Zec, Manja and Sladić, Dušan and Srdić-Rajić, Tatjana and Radanović, Dušanka D. and Radulović, Siniša and Pelizzi, Giancarlo and Anđelković, Katarina K.", year = "2010", abstract = "Two novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide were synthesized. The structure of Cd(II) complex was determined by X-ray crystallography. The ligand is coordinated in a neutral form via pyridine and azomethine nitrogen atoms and the selenium donor. The cadmium ion completes its five-coordination by two chloride ligands, forming a square-pyramidal geometry. The structure of Zn(II) complex was established by analysis of spectroscopic data, which indicated coordination of the ligand as a bidentate via the selenium and the azomethine nitrogen atoms. The cytotoxic activity of the newly synthesized complexes, as well as if five structurally related complexes and the ligand evaluated against eight tumor cell lines. The new Cd(II) complex showed the highest activity similar to cisplatin with IC50 less than 10 mu M for all cell lines. Cell cycle distribution and apoptosis study showed that Cd(II) complex and cisplatin might have some similarity in anticancer activity, which was not the case for cisplatin and other studied complexes. Effects of the complexes on matrix metalloproteinases (MMPs) MMP-9 and MMP-2 was also studied. Cd(II) and Zn(II) complexes and cisplatin increased MMP-2 activity in supernatants of tested cells. while Ni(II) complex with the same ligand decreased the activity, implying a possible activity in preventing tumor invasion and metastasis processes. (C) 2010 Elsevier Inc. All rights reserved.", publisher = "Elsevier Science Inc, New York", journal = "Journal of Inorganic Biochemistry", title = "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes", volume = "104", number = "6", pages = "673-682", doi = "10.1016/j.jinorgbio.2010.02.009" }
Bjelogrlić, S. K., Todorović, T., Bacchi, A., Zec, M., Sladić, D., Srdić-Rajić, T., Radanović, D. D., Radulović, S., Pelizzi, G.,& Anđelković, K. K.. (2010). Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry Elsevier Science Inc, New York., 104(6), 673-682. https://doi.org/10.1016/j.jinorgbio.2010.02.009
Bjelogrlić SK, Todorović T, Bacchi A, Zec M, Sladić D, Srdić-Rajić T, Radanović DD, Radulović S, Pelizzi G, Anđelković KK. Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes. in Journal of Inorganic Biochemistry. 2010;104(6):673-682. doi:10.1016/j.jinorgbio.2010.02.009 .
Bjelogrlić, Snežana K., Todorović, Tamara, Bacchi, Alessia, Zec, Manja, Sladić, Dušan, Srdić-Rajić, Tatjana, Radanović, Dušanka D., Radulović, Siniša, Pelizzi, Giancarlo, Anđelković, Katarina K., "Synthesis, structure and characterization of novel Cd(II) and Zn(II) complexes with the condensation product of 2-formylpyridine and selenosemicarbazide Antiproliferative activity of the synthesized complexes and related selenosemicarbazone complexes" in Journal of Inorganic Biochemistry, 104, no. 6 (2010):673-682, https://doi.org/10.1016/j.jinorgbio.2010.02.009 . .