Show simple item record

dc.creatorPasti, Tamara Lazarevic
dc.creatorMomic, Tatjana
dc.creatorOnjia, Antonije E.
dc.creatorVujisić, Ljubodrag V.
dc.creatorVasic, Vesna
dc.date.accessioned2018-11-22T00:16:50Z
dc.date.available2018-11-22T00:16:50Z
dc.date.issued2010
dc.identifier.issn0026-3672
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1106
dc.description.abstractIn order to improve the sensitivity of assays for inhibitors of the enzyme acetylcholine esterase (AChE), an effective method was developed for the conversion of the organophosphate pesticides (OPs) diazinon, malathion, chlorpyrifos, azinphos-methyl and phorate into more toxic inhibitors. This was accomplished by converting them from the thio form into their oxo form using the enzyme myeloperoxidase. The oxo forms, which are the only products of conversion, were determined by AChE bioassays, using either the free enzyme, or a flow injection analysis manifold with immobilized AChE and spectrophotometric detection. All modified OPs exhibited inhibitory power at ppb levels and within 10 min. The method is considered to represent an excellent means for improving the sensitivity of assays for determination of OPs.en
dc.publisherSpringer Wien, Wien
dc.relationMinistry of Science and Environmental Protection of the Republic of Serbia
dc.rightsrestrictedAccess
dc.sourceMicrochimica Acta
dc.subjectOrganophosphate pesticidesen
dc.subjectMyeloperoxidaseen
dc.subjectOxidationen
dc.subjectBioanalyticsen
dc.subjectAcethylcholinesteraseen
dc.titleMyeloperoxidase-mediated oxidation of organophosphorus pesticides as a pre-step in their determination by AChE based bioanalytical methodsen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractМомиц, Татјана; Васиц, Весна; Вујисић, Љубодраг; Оњиа, Aнтоније; Пасти, Тамара Лазаревиц;
dc.citation.volume170
dc.citation.issue3-4
dc.citation.spage289
dc.citation.epage297
dc.identifier.wos000281384000011
dc.identifier.doi10.1007/s00604-010-0324-2
dc.citation.other170(3-4): 289-297
dc.citation.rankM22
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-77956180737
dc.identifier.rcubKon_2106


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record