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dc.creatorSrdić-Rajić, Tatjana
dc.creatorZec, Manja
dc.creatorTodorović, Tamara
dc.creatorAnđelković, Katarina K.
dc.creatorRadulović, Siniša
dc.date.accessioned2018-11-22T00:18:49Z
dc.date.available2018-11-22T00:18:49Z
dc.date.issued2011
dc.identifier.issn0223-5234
dc.identifier.urihttps://cherry.chem.bg.ac.rs/handle/123456789/1200
dc.description.abstractWe previously published the synthesis, characterization and cytotoxic effect of the novel Zn(II), Ni(II), and Cd(II) complexes with 2-formylpyridine selenosemicarbazone. Here we further investigate the mechanism of their antiproliferative activity against several cancer and vascular endothelial cell lines and compared it to the activity of the ligand itself, corresponding salts and, as a referent compound, cisplatin. Investigated complexes induced apoptosis in a time- and dose-dependent manner as well as changes in a cell cycle distribution. Caspase-3 activation in HeLa cells, MDA-MB-361 and vascular endothelial cells EA.hy 926 cells by ligand alone, as well as Zn(II), Ni(II), and Cd(II) complexes was preceded by the activation of the p53 tumor-suppressor gene family protein p73. In addition to activation of p73, these compounds also trigger cytochrome C release by upregulation of Bax expression. The release of cytochrome C has been linked to loss of mitochondrial membrane potential. However, our data indicated that the increased phosphorylation of ERK could be also one of the mechanism involved in the Zn(II), and Cd(II) complexes- induction of apoptosis. Selenosemicarbazone complexes with Cd(II) and Ni(II), possess dual ability to induce apoptosis as well as necrosis, and might present an added advantage for inducing cell death in a diverse array of malignant cells. Taken together, our findings could indicate potential role of these complexes as activator of cross-talk between different signaling pathways that leads to cell death, and thus making the complex intriguing field for further scientific, and maybe clinical investigations. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectZn(II), Ni(II), and Cd(II) complexesen
dc.subjectSelenosemicarbazoneen
dc.subjectAntiproliferative activityen
dc.subjectApoptosisen
dc.titleNon-substituted N-heteroaromatic selenosemicarbazone metal complexes induce apoptosis in cancer cells via activation of mitochondrial pathwayen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractРадуловиц, Синиса; Тодоровић, Тамара; Зец, Мања; Срдиц-Рајиц, Татјана; Aнђелковић, Катарина;
dc.citation.volume46
dc.citation.issue9
dc.citation.spage3734
dc.citation.epage3747
dc.identifier.wos000295237400021
dc.identifier.doi10.1016/j.ejmech.2011.05.039
dc.citation.other46(9): 3734-3747
dc.citation.rankM21
dc.identifier.pmid21641698
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-80052960393
dc.identifier.rcubKon_2222


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