We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2...011 Elsevier Masson SAS. All rights reserved.
TY - JOUR
AU - Miljković, Đorđe
AU - Poljarević, Jelena
AU - Petkovic, Filip
AU - Blazevski, Jana
AU - Momčilović, Miljana
AU - Nikolic, Ivana
AU - Saksida, Tamara
AU - Stošić-Grujičić, Stanislava D.
AU - Grgurić-Šipka, Sanja
AU - Sabo, Tibor
PY - 2012
UR - https://cherry.chem.bg.ac.rs/handle/123456789/1258
AB - We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved.
PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Paris
T2 - European Journal of Medicinal Chemistry
T1 - Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects
VL - 47
SP - 194
EP - 201
DO - 10.1016/j.ejmech.2011.10.042
UR - Kon_2281
ER -
@article{
author = "Miljković, Đorđe and Poljarević, Jelena and Petkovic, Filip and Blazevski, Jana and Momčilović, Miljana and Nikolic, Ivana and Saksida, Tamara and Stošić-Grujičić, Stanislava D. and Grgurić-Šipka, Sanja and Sabo, Tibor",
year = "2012",
abstract = "We have recently reported that a novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoato ligand has a potent cytotoxic effect on glioma, melanoma and fibrosarcoma cell lines. In this work, we investigated the influence of the Pt(IV) compound on immune cells. We determined its effect on the viability of spleen cells and lymph node cells and on their capability to produce interferon (IFN)-gamma and interleukin (IL)-17. Also, we researched the compound's impact on peritoneal macrophages and generation of NO in these cells. Our results show that the complex has limited influence on cell viability of immune cells, but profound inhibitory effect on the production of examined immune mediators. These results are valuable as they show that the novel Pt(IV) complex applied in concentrations which are effective against tumor cells do not affect immune cell viability. Moreover, they also imply that the complex has immunomodulatory properties. (C) 2011 Elsevier Masson SAS. All rights reserved.",
publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Paris",
journal = "European Journal of Medicinal Chemistry",
title = "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects",
volume = "47",
pages = "194-201",
doi = "10.1016/j.ejmech.2011.10.042",
url = "Kon_2281"
}
Miljković, Đ., Poljarević, J., Petkovic, F., Blazevski, J., Momčilović, M., Nikolic, I., Saksida, T., Stošić-Grujičić, S. D., Grgurić-Šipka, S.,& Sabo, T.. (2012). Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. in European Journal of Medicinal Chemistry
Elsevier France-Editions Scientifiques Medicales Elsevier, Paris., 47, 194-201.
https://doi.org/10.1016/j.ejmech.2011.10.042
Kon_2281
Miljković Đ, Poljarević J, Petkovic F, Blazevski J, Momčilović M, Nikolic I, Saksida T, Stošić-Grujičić SD, Grgurić-Šipka S, Sabo T. Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects. in European Journal of Medicinal Chemistry. 2012;47:194-201.
doi:10.1016/j.ejmech.2011.10.042
Kon_2281 .
Miljković, Đorđe, Poljarević, Jelena, Petkovic, Filip, Blazevski, Jana, Momčilović, Miljana, Nikolic, Ivana, Saksida, Tamara, Stošić-Grujičić, Stanislava D., Grgurić-Šipka, Sanja, Sabo, Tibor, "Novel octahedral Pt(IV) complex with di-n-propyl-(S,S)-ethylenediamine-N,N '-di-2-(3-cyclohexyl)propanoato ligand exerts potent immunomodulatory effects" in European Journal of Medicinal Chemistry, 47 (2012):194-201,
https://doi.org/10.1016/j.ejmech.2011.10.042 .,
Kon_2281 .
