Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

2012
Authors
Milenković, Milica R.
Warżajtis, Beata

Rychlewska, Urszula

Radanović, Dušanka D.

Anđelković, Katarina K.

Božić, Tatjana T.

Vujčić, Miroslava

Sladić, Dušan

Article (Published version)
Metadata
Show full item recordAbstract
The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords:
hydrazine bridged diphosphonium compound / DNA cleavage / brine shrimp test / X-raySource:
Molecules, 2012, 17, 3, 2567-2578Publisher:
- Mdpi Ag, Basel
Projects:
DOI: 10.3390/molecules17032567
ISSN: 1420-3049
PubMed: 22388967