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Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

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Authors
Milenković, Milica R.
Warżajtis, Beata
Rychlewska, Urszula
Radanović, Dušanka D.
Anđelković, Katarina K.
Božić, Tatjana T.
Vujčić, Miroslava
Sladić, Dušan
Article (Published version)
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Abstract
The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords:
hydrazine bridged diphosphonium compound / DNA cleavage / brine shrimp test / X-ray
Source:
Molecules, 2012, 17, 3, 2567-2578
Publisher:
  • Mdpi Ag, Basel
Projects:
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)

DOI: 10.3390/molecules17032567

ISSN: 1420-3049

PubMed: 22388967

WoS: 000302120600021

Scopus: 2-s2.0-84858966075
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URI
http://cherry.chem.bg.ac.rs/handle/123456789/1267
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