Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound
2012
Аутори
Milenković, Milica R.Warżajtis, Beata
Rychlewska, Urszula
Radanović, Dušanka D.
Anđelković, Katarina K.
Božić, Tatjana T.
Vujčić, Miroslava
Sladić, Dušan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Кључне речи:
hydrazine bridged diphosphonium compound / DNA cleavage / brine shrimp test / X-rayИзвор:
Molecules, 2012, 17, 3, 2567-2578Издавач:
- Mdpi Ag, Basel
Финансирање / пројекти:
- Интеракције природних производа, њихових деривата и комплексних једињења са протеинима и нуклеинским киселинама (RS-MESTD-Basic Research (BR or ON)-172055)
DOI: 10.3390/molecules17032567
ISSN: 1420-3049
PubMed: 22388967
WoS: 000302120600021
Scopus: 2-s2.0-84858966075
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Milenković, Milica R. AU - Warżajtis, Beata AU - Rychlewska, Urszula AU - Radanović, Dušanka D. AU - Anđelković, Katarina K. AU - Božić, Tatjana T. AU - Vujčić, Miroslava AU - Sladić, Dušan PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1267 AB - The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA. PB - Mdpi Ag, Basel T2 - Molecules T1 - Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound VL - 17 IS - 3 SP - 2567 EP - 2578 DO - 10.3390/molecules17032567 ER -
@article{ author = "Milenković, Milica R. and Warżajtis, Beata and Rychlewska, Urszula and Radanović, Dušanka D. and Anđelković, Katarina K. and Božić, Tatjana T. and Vujčić, Miroslava and Sladić, Dušan", year = "2012", abstract = "The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.", publisher = "Mdpi Ag, Basel", journal = "Molecules", title = "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound", volume = "17", number = "3", pages = "2567-2578", doi = "10.3390/molecules17032567" }
Milenković, M. R., Warżajtis, B., Rychlewska, U., Radanović, D. D., Anđelković, K. K., Božić, T. T., Vujčić, M.,& Sladić, D.. (2012). Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. in Molecules Mdpi Ag, Basel., 17(3), 2567-2578. https://doi.org/10.3390/molecules17032567
Milenković MR, Warżajtis B, Rychlewska U, Radanović DD, Anđelković KK, Božić TT, Vujčić M, Sladić D. Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. in Molecules. 2012;17(3):2567-2578. doi:10.3390/molecules17032567 .
Milenković, Milica R., Warżajtis, Beata, Rychlewska, Urszula, Radanović, Dušanka D., Anđelković, Katarina K., Božić, Tatjana T., Vujčić, Miroslava, Sladić, Dušan, "Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound" in Molecules, 17, no. 3 (2012):2567-2578, https://doi.org/10.3390/molecules17032567 . .