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New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3-and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity
dc.creator | Ivanović, Ivanka | |
dc.creator | Gligorijević, Nevenka | |
dc.creator | Aranđelović, Sandra | |
dc.creator | Radulović, Siniša | |
dc.creator | Roller, Alexander | |
dc.creator | Keppler, Bernhard K. | |
dc.creator | Tešić, Živoslav Lj. | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.date.accessioned | 2018-11-22T00:23:43Z | |
dc.date.available | 2018-11-22T00:23:43Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0277-5387 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1386 | |
dc.description.abstract | Metal semicarbazone and thiosemicarbazone complexes have attracted much attention due to their diverse biological activities. Because of the ability of ruthenium(II)-arene species to coordinate to different classes of ligands, they are suitable for fine-tuning chemical and pharmaceutical properties. Ruthenium(II) arene-complexes containing different types of ligands: namely caprylic hydrazide (a hydrazide with a long hydrocarbon chain), isonicotinic acid hydrazide (a hydrazide with an aromatic pyridine ring), thiosemicarbazones and semicarbazones (derived from the reaction of 3- and 4-acetylpyridine with either thiosemicarbazide or caprylic hydrazide), were obtained in the reaction of [(eta(6)-p-cymene)RuCl2](2) with the corresponding ligands in a 1:2 or 1:2.2 molar ratio in methanol, ethanol or isopropanol with mild heating. The complexes were characterized by elemental analysis, mass spectrometry, IR and NMR spectroscopies. The structure of complex 1 was determined by X-ray crystallography. Antiproliferative activity of the investigated complexes, determined for three human cancer cell lines (HeLa, A549 and LS-174) revealed moderate activity without significant influence on the matrix metalloproteinases (MMP-2 and MMP-9) activity. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS// | |
dc.relation | COST Action [CM1105] | |
dc.rights | restrictedAccess | |
dc.source | Polyhedron | |
dc.subject | Ruthenium(II)-arene | en |
dc.subject | Hydrazides | en |
dc.subject | Thiosemicarbazones | en |
dc.subject | Semicarbazones | en |
dc.subject | Cytotoxicity | en |
dc.title | New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3-and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Глигоријевиц, Невенка; Гргурић-Шипка, Сања; Тешић, Живослав Љ.; Кепплер, Бернхард К.; Ивановиц, Иванка; Aранделовиц, Сандра; Радуловиц, Синиса; Роллер, Aлеxандер; | |
dc.citation.volume | 61 | |
dc.citation.spage | 112 | |
dc.citation.epage | 118 | |
dc.identifier.wos | 000322938100016 | |
dc.identifier.doi | 10.1016/j.poly.2013.05.050 | |
dc.citation.other | 61: 112-118 | |
dc.citation.rank | M22 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84879210266 |