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dc.creatorAburas, Najat M.
dc.creatorStevanović, Nikola R.
dc.creatorMilčić, Miloš K.
dc.creatorLolić, Aleksandar
dc.creatorNatić, Maja
dc.creatorTešić, Živoslav Lj.
dc.creatorBaošić, Rada
dc.date.accessioned2018-11-22T00:23:53Z
dc.date.available2018-11-22T00:23:53Z
dc.date.issued2013
dc.identifier.issn0103-5053
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1396
dc.description.abstractThe influence of the structure on the antioxidant activity of a series of Schiff bases and their copper(II) complexes as well as possible mechanisms of antioxidant activity were investigated. Schiff bases are derived from the condensation of ethane-1,2-diamine or propane-1,2-diamine and pentane-2,4-dione and/or 1-phenylbutane-1,3-dione. The corresponding complexes were synthesized. The antioxidant activity in vitro, determined using reversed-phase thin layer chromatography assay (RP TLC) based on the reaction with 2,2'-diphenyl-1-picrylhydrazyl, was expressed as Trolox equivalent antioxidant capacity (TEAC). The influence of the structure was observed on the basis of interpretable and informative descriptors calculated by hybrid density functional theory (DFT) methods. Structural features responsible for the antioxidant activity of the investigated compounds were discussed. Copper(II) complexes showed a significantly higher antioxidant activity than their corresponding ligands. Calculated quantum-chemical descriptors gave an insight to the reaction mechanism of the scavenging/antioxidant activity of tetradentate Schiff bases and their copper(II) complexes and two different reaction mechanisms were proposed.en
dc.publisherSoc Brasileira Quimica, Sao Paulo
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS//
dc.rightsopenAccess
dc.sourceJournal of the Brazilian Chemical Society
dc.subjectantioxidant activityen
dc.subjectantioxidant mechanismen
dc.subjectSchiff baseen
dc.subjectcopper(II) complexesen
dc.subjectDFTen
dc.titleInfluence of the Structure on the Antioxidant Activity of Tetradentate Schiff Bases and their Copper(II) Complexes: Possible Mechanismsen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractТешић, Живослав Љ.; Aбурас, Најат М.; Стевановић, Никола; Милчић, Милош; Лолић, Aлександар; Натић, Маја; Баошић, Рада;
dc.citation.volume24
dc.citation.issue8
dc.citation.spage1322
dc.identifier.wos000323725700013
dc.identifier.doi10.5935/0103-5053.20130167
dc.citation.other24(8): 1322-1328
dc.citation.rankM23
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-84883675719
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/8537/1394.pdf
dc.identifier.rcubKon_2516


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