Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents
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2013
Authors
Chen, ShiguiRuan, Yian
Brown, Jason D.
Gallucci, Judith
Maslak, Veselin

Hadad, Christopher M.

Bađić, Jovica D.
Article (Published version)

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Show full item recordAbstract
We designed basket 1 to comprise a C-3-symmetric hydrophobic cage (477 angstrom(3)) at its southern edge and three polar ammonium caps at the northern edge. This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 angstrom(3)) in its cavity (K-app = (1.97 +/- 0.02) X 10(3) M-1). The entrapment of the organophosphonate, akin to soman in size (186 angstrom(3)), triggers the transformation of the vesicular material into nanoparticles (100 nm,of type 1 in their bilayer membrane, are unique assemblies and important for obtaining novel sensing devices.
Source:
Journal of the American Chemical Society, 2013, 135, 40, 14964-14967Publisher:
- Amer Chemical Soc, Washington
Funding / projects:
- Department of Defense, Defense Threat Reduction Agency [HDTRA1-11-1-0042]
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3469
DOI: 10.1021/ja408585j
ISSN: 0002-7863
PubMed: 24063351
WoS: 000326356400018
Scopus: 2-s2.0-84885577274
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Chen, Shigui AU - Ruan, Yian AU - Brown, Jason D. AU - Gallucci, Judith AU - Maslak, Veselin AU - Hadad, Christopher M. AU - Bađić, Jovica D. PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1427 AB - We designed basket 1 to comprise a C-3-symmetric hydrophobic cage (477 angstrom(3)) at its southern edge and three polar ammonium caps at the northern edge. This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 angstrom(3)) in its cavity (K-app = (1.97 +/- 0.02) X 10(3) M-1). The entrapment of the organophosphonate, akin to soman in size (186 angstrom(3)), triggers the transformation of the vesicular material into nanoparticles (100 nm,of type 1 in their bilayer membrane, are unique assemblies and important for obtaining novel sensing devices. PB - Amer Chemical Soc, Washington T2 - Journal of the American Chemical Society T1 - Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents VL - 135 IS - 40 SP - 14964 EP - 14967 DO - 10.1021/ja408585j ER -
@article{ author = "Chen, Shigui and Ruan, Yian and Brown, Jason D. and Gallucci, Judith and Maslak, Veselin and Hadad, Christopher M. and Bađić, Jovica D.", year = "2013", abstract = "We designed basket 1 to comprise a C-3-symmetric hydrophobic cage (477 angstrom(3)) at its southern edge and three polar ammonium caps at the northern edge. This amphiphilic molecule was observed to assemble into large unilamellar vesicles (350 nm, TEM) in water and thereby entrap dimethyl phenylphosphonate (184 angstrom(3)) in its cavity (K-app = (1.97 +/- 0.02) X 10(3) M-1). The entrapment of the organophosphonate, akin to soman in size (186 angstrom(3)), triggers the transformation of the vesicular material into nanoparticles (100 nm,of type 1 in their bilayer membrane, are unique assemblies and important for obtaining novel sensing devices.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of the American Chemical Society", title = "Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents", volume = "135", number = "40", pages = "14964-14967", doi = "10.1021/ja408585j" }
Chen, S., Ruan, Y., Brown, J. D., Gallucci, J., Maslak, V., Hadad, C. M.,& Bađić, J. D.. (2013). Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents. in Journal of the American Chemical Society Amer Chemical Soc, Washington., 135(40), 14964-14967. https://doi.org/10.1021/ja408585j
Chen S, Ruan Y, Brown JD, Gallucci J, Maslak V, Hadad CM, Bađić JD. Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents. in Journal of the American Chemical Society. 2013;135(40):14964-14967. doi:10.1021/ja408585j .
Chen, Shigui, Ruan, Yian, Brown, Jason D., Gallucci, Judith, Maslak, Veselin, Hadad, Christopher M., Bađić, Jovica D., "Assembly of Amphiphilic Baskets into Stimuli-Responsive Vesicles. Developing a Strategy for the Detection of Organophosphorus Chemical Nerve Agents" in Journal of the American Chemical Society, 135, no. 40 (2013):14964-14967, https://doi.org/10.1021/ja408585j . .