Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes
Само за регистроване кориснике
2014
Аутори
Mojic, MarijaSavić, Aleksandar
Arion, Vladimir B.
Bulatović, Mirna Z.
Poljarević, Jelena
Miljković, Đorđe
Sabo, Tibor
Mijatovic, Sanja
Maksimovic-Ivanic, Danijela
Grgurić-Šipka, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50 gt 50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50 gt 120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected... by these compounds. (C) 2013 Elsevier B. V. All rights reserved.
Кључне речи:
Apoptosis / Cancer / Organoruthenium / Amine ligandsИзвор:
Journal of Organometallic Chemistry, 2014, 749, 142-149Издавач:
- Elsevier Science Sa, Lausanne
Финансирање / пројекти:
- Рационални дизајн и синтеза биолошки активних и координационих једињења и функционалних материјала, релевантних у (био)нанотехнологији (RS-MESTD-Basic Research (BR or ON)-172035)
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
DOI: 10.1016/j.jorganchem.2013.08.041
ISSN: 0022-328X
WoS: 000327939000023
Scopus: 2-s2.0-84885363912
Колекције
Институција/група
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Mojic, Marija AU - Savić, Aleksandar AU - Arion, Vladimir B. AU - Bulatović, Mirna Z. AU - Poljarević, Jelena AU - Miljković, Đorđe AU - Sabo, Tibor AU - Mijatovic, Sanja AU - Maksimovic-Ivanic, Danijela AU - Grgurić-Šipka, Sanja PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1450 AB - Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50 gt 50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50 gt 120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved. PB - Elsevier Science Sa, Lausanne T2 - Journal of Organometallic Chemistry T1 - Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes VL - 749 SP - 142 EP - 149 DO - 10.1016/j.jorganchem.2013.08.041 ER -
@article{ author = "Mojic, Marija and Savić, Aleksandar and Arion, Vladimir B. and Bulatović, Mirna Z. and Poljarević, Jelena and Miljković, Đorđe and Sabo, Tibor and Mijatovic, Sanja and Maksimovic-Ivanic, Danijela and Grgurić-Šipka, Sanja", year = "2014", abstract = "Two p-cymene ruthenium chlorido complexes containing isobutyl (C1) and isoamyl (C2) esters of (S,S)ethylenediamine-N,N'-di-2-(3-cyclohexyl) propanoic acid as ligands were prepared from p-cymene ruthenium dichloride dimer and corresponding ester. All compounds have been characterized by elemental analysis, IR, ESI-MS, H-1 and C-13 NMR spectroscopy. Single crystal X-ray structure diffraction analysis of C1 shows the usual piano-stool geometry of complexes, with coordination of ester ligand via nitrogen donor atoms. Ligands exhibit moderate anticancer activity (IC50 gt 50 mu M), while the complexes were significantly more cytotoxic towards various cancer cell lines, including B16, A375, HCT116, A549 and MCF7 cells (IC50 min.-max. 2.9-8.0 mu M). We stress that cisplatin resistant HCT116 cell line was highly sensitive to the treatment with C1 and C2 (IC50 values: 4.4 and 5.5 mu M versus IC50 gt 120 mu M for cisplatin). In parallel, primary fibroblasts-MRC-5 were remarkably less affected by these compounds. (C) 2013 Elsevier B. V. All rights reserved.", publisher = "Elsevier Science Sa, Lausanne", journal = "Journal of Organometallic Chemistry", title = "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes", volume = "749", pages = "142-149", doi = "10.1016/j.jorganchem.2013.08.041" }
Mojic, M., Savić, A., Arion, V. B., Bulatović, M. Z., Poljarević, J., Miljković, Đ., Sabo, T., Mijatovic, S., Maksimovic-Ivanic, D.,& Grgurić-Šipka, S.. (2014). Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes. in Journal of Organometallic Chemistry Elsevier Science Sa, Lausanne., 749, 142-149. https://doi.org/10.1016/j.jorganchem.2013.08.041
Mojic M, Savić A, Arion VB, Bulatović MZ, Poljarević J, Miljković Đ, Sabo T, Mijatovic S, Maksimovic-Ivanic D, Grgurić-Šipka S. Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes. in Journal of Organometallic Chemistry. 2014;749:142-149. doi:10.1016/j.jorganchem.2013.08.041 .
Mojic, Marija, Savić, Aleksandar, Arion, Vladimir B., Bulatović, Mirna Z., Poljarević, Jelena, Miljković, Đorđe, Sabo, Tibor, Mijatovic, Sanja, Maksimovic-Ivanic, Danijela, Grgurić-Šipka, Sanja, "Synthesis, X-ray structure and strong in vitro cytotoxicity of novel organoruthenium complexes" in Journal of Organometallic Chemistry, 749 (2014):142-149, https://doi.org/10.1016/j.jorganchem.2013.08.041 . .