Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines
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2014
Authors
Aljančić, IvanaVučković, Ivan M.
Jadranin, Milka
Pešić, Milica
Đorđević, Iris
Podolski-Renić, Ana
Stojković, Sonja
Menkovic, Nebojsa
Vajs, Vlatka
Milosavljević, Slobodan M.
Article (Published version)
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Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
Keywords:
Helichrysum zivojinii / Asteraceae / Chalcone glucoside dimers / Flavonoid glucoside / Topoisomerase II alpha / HIF-1 alpha / MAP kinase pathway / Drug combinationSource:
Phytochemistry, 2014, 98, 190-196Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
DOI: 10.1016/j.phytochem.2013.11.025
ISSN: 0031-9422
PubMed: 24361288
WoS: 000331020000022
Scopus: 2-s2.0-84892946345
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Aljančić, Ivana AU - Vučković, Ivan M. AU - Jadranin, Milka AU - Pešić, Milica AU - Đorđević, Iris AU - Podolski-Renić, Ana AU - Stojković, Sonja AU - Menkovic, Nebojsa AU - Vajs, Vlatka AU - Milosavljević, Slobodan M. PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1500 AB - Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Phytochemistry T1 - Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines VL - 98 SP - 190 EP - 196 DO - 10.1016/j.phytochem.2013.11.025 ER -
@article{ author = "Aljančić, Ivana and Vučković, Ivan M. and Jadranin, Milka and Pešić, Milica and Đorđević, Iris and Podolski-Renić, Ana and Stojković, Sonja and Menkovic, Nebojsa and Vajs, Vlatka and Milosavljević, Slobodan M.", year = "2014", abstract = "Dimers tomoroside A (1) and tomoroside B (2) of the co-occuring known chalcone monomer (3), along with the seven known flavonoid glucosides (4-10), were isolated from the aerial parts of Helichrysum zivojinii Cernjavski & Soska. The structures of the isolated compounds were elucidated by spectroscopic techniques. Compound 1 inhibited topo Ha and hif-1 alpha expression and stimulated doxorubicin anticancer effect, while 2 increased the expression of hif-1 alpha a, probably acting as antioxidant and redox status modulator. Notably, 2 synergized with Tipifarnib showing potential to improve the action of this new chemotherapeutic involved in the modulation of mitogene activated protein (MAP) kinase signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Phytochemistry", title = "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines", volume = "98", pages = "190-196", doi = "10.1016/j.phytochem.2013.11.025" }
Aljančić, I., Vučković, I. M., Jadranin, M., Pešić, M., Đorđević, I., Podolski-Renić, A., Stojković, S., Menkovic, N., Vajs, V.,& Milosavljević, S. M.. (2014). Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry Pergamon-Elsevier Science Ltd, Oxford., 98, 190-196. https://doi.org/10.1016/j.phytochem.2013.11.025
Aljančić I, Vučković IM, Jadranin M, Pešić M, Đorđević I, Podolski-Renić A, Stojković S, Menkovic N, Vajs V, Milosavljević SM. Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines. in Phytochemistry. 2014;98:190-196. doi:10.1016/j.phytochem.2013.11.025 .
Aljančić, Ivana, Vučković, Ivan M., Jadranin, Milka, Pešić, Milica, Đorđević, Iris, Podolski-Renić, Ana, Stojković, Sonja, Menkovic, Nebojsa, Vajs, Vlatka, Milosavljević, Slobodan M., "Two structurally distinct chalcone dimers from Helichrysum zivojinii and their activities in cancer cell lines" in Phytochemistry, 98 (2014):190-196, https://doi.org/10.1016/j.phytochem.2013.11.025 . .