Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone
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AuthorsĐorđević, Milena M.
Simic, Vera S.
Leovac, Vukadin M.
Article (Published version)
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The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved.
Keywords:2-(Diphenylphosphino)benzaldehyde / Adamantane / Hydrazones / Pd(II) and Pt(II) complexes / Crystal structure / Biological activity
Source:Polyhedron, 2014, 68, 234-240
- Pergamon-Elsevier Science Ltd, Oxford
- Structure-properties relationships of natural and synthetic molecules and their metal complexes (RS-172017)
- Provincial Secretarial and Technological Development of Vojvodina, Republic of Serbia