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Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone
dc.creator | Đorđević, Milena M. | |
dc.creator | Jeremić, Dejan | |
dc.creator | Rodić, Marko | |
dc.creator | Simic, Vera S. | |
dc.creator | Brčeski, Ilija | |
dc.creator | Leovac, Vukadin M. | |
dc.date.accessioned | 2018-11-22T00:27:07Z | |
dc.date.available | 2018-11-22T00:27:07Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0277-5387 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1504 | |
dc.description.abstract | The reaction of an ethanolic solution of the newly synthesized 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone (HL) with aqueous solutions of K-2[MCl4] (M = Pd(II), Pt(II)) resulted in neutral complexes of the general formulae [M(L)Cl]. These complexes have a square-planar structure that was achieved by tridentate PNO coordination of the monoprotonated Schiff base and a chloride ligand. The ligand and its metal complexes were analyzed for their antimicrobial activity and their in vitro cytotoxicity in human larynx carcinoma cells (Hep-2) and non-cancerous human lung fibroblast cells (MRC-5). The platinum(II) complex shows cytotoxicity towards Hep-2 cells comparable to oxaliplatin and exhibited improved selectivity for cancer cells. The ligand and its complexes were characterized by elemental analysis, NMR and IR spectroscopy, and single crystal X-ray diffraction analysis. (C) 2013 Elsevier Ltd. All rights reserved. | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172017/RS// | |
dc.relation | Provincial Secretarial and Technological Development of Vojvodina, Republic of Serbia | |
dc.rights | restrictedAccess | |
dc.source | Polyhedron | |
dc.subject | 2-(Diphenylphosphino)benzaldehyde | en |
dc.subject | Adamantane | en |
dc.subject | Hydrazones | en |
dc.subject | Pd(II) and Pt(II) complexes | en |
dc.subject | Crystal structure | en |
dc.subject | Biological activity | en |
dc.title | Synthesis, structure and biological activities of Pd(II) and Pt(II) complexes with 2-(diphenylphosphino)benzaldehyde 1-adamantoylhydrazone | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Дордевиц, Милена М.; Симиц, Вера С.; Родиц, Марко В.; Јеремиц, Дејан A.; Леовац, Вукадин М.; Брчески, Илија; | |
dc.citation.volume | 68 | |
dc.citation.spage | 234 | |
dc.citation.epage | 240 | |
dc.identifier.wos | 000331421400031 | |
dc.identifier.doi | 10.1016/j.poly.2013.10.029 | |
dc.citation.other | 68: 234-240 | |
dc.citation.rank | M22 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84888360858 |