A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate
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2014
Authors
Filipović, Nenad R.Marković, Ivanka
Mitić, Dragana
Polović, Natalija
Milčić, Miloš K.
Dulović, Marija
Jovanović, Maja
Savić, Milena
Nikšić, Miomir
Anđelković, Katarina K.
Todorović, Tamara
Article (Published version)
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Show full item recordAbstract
In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of ...HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.
Keywords:
N-heteroaromatic Schiff Base / Zinc / Cytotoxic Activity / Apoptosis / Oxidative StressSource:
Journal of Biochemical and Molecular Toxicology, 2014, 28, 3, 99-110Publisher:
- Wiley, Hoboken
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-MESTD-Basic Research (BR or ON)-172055)
- Modulation of intracellular energy balance-controlling signalling pathways in therapy of cancer and neuro-immuno-endocrine disorders (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41025)
- CMST COST Action [CM1106]
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3664
DOI: 10.1002/jbt.21541
ISSN: 1095-6670
PubMed: 24302597
WoS: 000332141000001
Scopus: 2-s2.0-84895437127
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Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Filipović, Nenad R. AU - Marković, Ivanka AU - Mitić, Dragana AU - Polović, Natalija AU - Milčić, Miloš K. AU - Dulović, Marija AU - Jovanović, Maja AU - Savić, Milena AU - Nikšić, Miomir AU - Anđelković, Katarina K. AU - Todorović, Tamara PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1509 AB - In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation. PB - Wiley, Hoboken T2 - Journal of Biochemical and Molecular Toxicology T1 - A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate VL - 28 IS - 3 SP - 99 EP - 110 DO - 10.1002/jbt.21541 ER -
@article{ author = "Filipović, Nenad R. and Marković, Ivanka and Mitić, Dragana and Polović, Natalija and Milčić, Miloš K. and Dulović, Marija and Jovanović, Maja and Savić, Milena and Nikšić, Miomir and Anđelković, Katarina K. and Todorović, Tamara", year = "2014", abstract = "In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.", publisher = "Wiley, Hoboken", journal = "Journal of Biochemical and Molecular Toxicology", title = "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate", volume = "28", number = "3", pages = "99-110", doi = "10.1002/jbt.21541" }
Filipović, N. R., Marković, I., Mitić, D., Polović, N., Milčić, M. K., Dulović, M., Jovanović, M., Savić, M., Nikšić, M., Anđelković, K. K.,& Todorović, T.. (2014). A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology Wiley, Hoboken., 28(3), 99-110. https://doi.org/10.1002/jbt.21541
Filipović NR, Marković I, Mitić D, Polović N, Milčić MK, Dulović M, Jovanović M, Savić M, Nikšić M, Anđelković KK, Todorović T. A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology. 2014;28(3):99-110. doi:10.1002/jbt.21541 .
Filipović, Nenad R., Marković, Ivanka, Mitić, Dragana, Polović, Natalija, Milčić, Miloš K., Dulović, Marija, Jovanović, Maja, Savić, Milena, Nikšić, Miomir, Anđelković, Katarina K., Todorović, Tamara, "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate" in Journal of Biochemical and Molecular Toxicology, 28, no. 3 (2014):99-110, https://doi.org/10.1002/jbt.21541 . .