Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
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2012
Authors
Maksimovic-Ivanic, DanijelaMijatovic, Sanja
Mirkov, Ivana
Stošić-Grujičić, Stanislava D.
Miljković, Đorđe
Sabo, Tibor
Trajković, Vladimir S.
Kaluđerović, Goran N.
Article (Published version)
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Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.
Source:
Metallomics, 2012, 4, 11, 1155-1159Publisher:
- Royal Soc Chemistry, Cambridge
Funding / projects:
- Molecular mechanisms of physiological and pharmacological control of inflammation and cancer (RS-MESTD-Basic Research (BR or ON)-173013)
- Rational design and synthesis of biologically active and coordination compounds and functional materials, relevant for (bio)nanotechnology (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.1039/c2mt20150j
ISSN: 1756-5901
PubMed: 23014886
WoS: 000311186400004
Scopus: 2-s2.0-84867870472
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Maksimovic-Ivanic, Danijela AU - Mijatovic, Sanja AU - Mirkov, Ivana AU - Stošić-Grujičić, Stanislava D. AU - Miljković, Đorđe AU - Sabo, Tibor AU - Trajković, Vladimir S. AU - Kaluđerović, Goran N. PY - 2012 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1551 AB - Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity. PB - Royal Soc Chemistry, Cambridge T2 - Metallomics T1 - Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations VL - 4 IS - 11 SP - 1155 EP - 1159 DO - 10.1039/c2mt20150j ER -
@article{ author = "Maksimovic-Ivanic, Danijela and Mijatovic, Sanja and Mirkov, Ivana and Stošić-Grujičić, Stanislava D. and Miljković, Đorđe and Sabo, Tibor and Trajković, Vladimir S. and Kaluđerović, Goran N.", year = "2012", abstract = "Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity.", publisher = "Royal Soc Chemistry, Cambridge", journal = "Metallomics", title = "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations", volume = "4", number = "11", pages = "1155-1159", doi = "10.1039/c2mt20150j" }
Maksimovic-Ivanic, D., Mijatovic, S., Mirkov, I., Stošić-Grujičić, S. D., Miljković, Đ., Sabo, T., Trajković, V. S.,& Kaluđerović, G. N.. (2012). Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics Royal Soc Chemistry, Cambridge., 4(11), 1155-1159. https://doi.org/10.1039/c2mt20150j
Maksimovic-Ivanic D, Mijatovic S, Mirkov I, Stošić-Grujičić SD, Miljković Đ, Sabo T, Trajković VS, Kaluđerović GN. Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations. in Metallomics. 2012;4(11):1155-1159. doi:10.1039/c2mt20150j .
Maksimovic-Ivanic, Danijela, Mijatovic, Sanja, Mirkov, Ivana, Stošić-Grujičić, Stanislava D., Miljković, Đorđe, Sabo, Tibor, Trajković, Vladimir S., Kaluđerović, Goran N., "Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations" in Metallomics, 4, no. 11 (2012):1155-1159, https://doi.org/10.1039/c2mt20150j . .