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Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations
dc.creator | Maksimovic-Ivanic, Danijela | |
dc.creator | Mijatovic, Sanja | |
dc.creator | Mirkov, Ivana | |
dc.creator | Stošić-Grujičić, Stanislava D. | |
dc.creator | Miljković, Đorđe | |
dc.creator | Sabo, Tibor | |
dc.creator | Trajković, Vladimir S. | |
dc.creator | Kaluđerović, Goran N. | |
dc.date.accessioned | 2018-11-22T00:22:17Z | |
dc.date.available | 2018-11-22T00:22:17Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1756-5901 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1551 | |
dc.description.abstract | Tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)-platinum(IV) complex, [PtCl4(n-Bu(2)eddp)], was previously found to be effective against fibrosarcoma and glioma cell lines. Here we presented that [PtCl4(n-Bu(2)eddp)] strongly reduced the growth of B16 melanoma cells in vitro. Inhibition of cell viability was accompanied with induction of both necrotic and apoptotic cell death. In addition, [PtCl4(n-Bu(2)eddp)] concealed the expansion of tumors induced in syngeneic C57BI/6 mice without visible signs of nephrotoxicity. | en |
dc.publisher | Royal Soc Chemistry, Cambridge | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173013/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.rights | restrictedAccess | |
dc.source | Metallomics | |
dc.title | Melanoma tumor inhibition by tetrachlorido(O,O '-dibutyl-ethylenediamine-N,N '-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Мирков, Ивана; Трајковиц, Владимир; Калудеровиц, Горан Н.; Сабо, Тибор; Максимовиц-Иваниц, Данијела; Мијатовиц, Сања; Стосиц-Грујициц, Станислава; Миљковиц, Дјордје; | |
dc.citation.volume | 4 | |
dc.citation.issue | 11 | |
dc.citation.spage | 1155 | |
dc.citation.epage | 1159 | |
dc.identifier.wos | 000311186400004 | |
dc.identifier.doi | 10.1039/c2mt20150j | |
dc.citation.other | 4(11): 1155-1159 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 23014886 | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84867870472 |