Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
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2013
Authors
Jadranin, MilkaPešić, Milica
Aljančić, Ivana
Milosavljević, Slobodan M.
Todorović, Nina
Podolski-Renić, Ana
Banković, Jasna
Tanić, Nikola
Marković, Ivanka
Vajs, Vlatka
Tešević, Vele
Article (Published version)
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Show full item recordAbstract
Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
Keywords:
Euphorbia dendroides / Euphorbiaceae / Isolation / Jatrophanes / Euphodendrophanes G-S / P-glycoprotein / Multi-drug resistanceSource:
Phytochemistry, 2013, 86, 208-217Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Identification of predictive molecular markers for cancer progression, response to therapy and disease outcome (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/2902
DOI: 10.1016/j.phytochem.2012.09.003
ISSN: 0031-9422
PubMed: 23079764
WoS: 000315017100024
Scopus: 2-s2.0-84872042428
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jadranin, Milka AU - Pešić, Milica AU - Aljančić, Ivana AU - Milosavljević, Slobodan M. AU - Todorović, Nina AU - Podolski-Renić, Ana AU - Banković, Jasna AU - Tanić, Nikola AU - Marković, Ivanka AU - Vajs, Vlatka AU - Tešević, Vele PY - 2013 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1585 AB - Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Phytochemistry T1 - Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines VL - 86 SP - 208 EP - 217 DO - 10.1016/j.phytochem.2012.09.003 ER -
@article{ author = "Jadranin, Milka and Pešić, Milica and Aljančić, Ivana and Milosavljević, Slobodan M. and Todorović, Nina and Podolski-Renić, Ana and Banković, Jasna and Tanić, Nikola and Marković, Ivanka and Vajs, Vlatka and Tešević, Vele", year = "2013", abstract = "Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Phytochemistry", title = "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines", volume = "86", pages = "208-217", doi = "10.1016/j.phytochem.2012.09.003" }
Jadranin, M., Pešić, M., Aljančić, I., Milosavljević, S. M., Todorović, N., Podolski-Renić, A., Banković, J., Tanić, N., Marković, I., Vajs, V.,& Tešević, V.. (2013). Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry Pergamon-Elsevier Science Ltd, Oxford., 86, 208-217. https://doi.org/10.1016/j.phytochem.2012.09.003
Jadranin M, Pešić M, Aljančić I, Milosavljević SM, Todorović N, Podolski-Renić A, Banković J, Tanić N, Marković I, Vajs V, Tešević V. Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines. in Phytochemistry. 2013;86:208-217. doi:10.1016/j.phytochem.2012.09.003 .
Jadranin, Milka, Pešić, Milica, Aljančić, Ivana, Milosavljević, Slobodan M., Todorović, Nina, Podolski-Renić, Ana, Banković, Jasna, Tanić, Nikola, Marković, Ivanka, Vajs, Vlatka, Tešević, Vele, "Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines" in Phytochemistry, 86 (2013):208-217, https://doi.org/10.1016/j.phytochem.2012.09.003 . .