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Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
dc.creator | Jadranin, Milka | |
dc.creator | Pešić, Milica | |
dc.creator | Aljančić, Ivana | |
dc.creator | Milosavljević, Slobodan M. | |
dc.creator | Todorović, Nina | |
dc.creator | Podolski-Renić, Ana | |
dc.creator | Banković, Jasna | |
dc.creator | Tanić, Nikola | |
dc.creator | Marković, Ivanka | |
dc.creator | Vajs, Vlatka | |
dc.creator | Tešević, Vele | |
dc.date.accessioned | 2018-11-22T00:25:16Z | |
dc.date.available | 2018-11-22T00:25:16Z | |
dc.date.issued | 2013 | |
dc.identifier.issn | 0031-9422 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/1585 | |
dc.description.abstract | Thirteen jatrophane diterpenoids (1-10, 13-15), three previously isolated (11, 12, 16) and a known tigliane (17) were isolated from the latex of Euphorbia dendroides. The structures and relative configurations of compounds were elucidated by spectroscopic techniques. The P-glycoprotein (P-gp) inhibiting activities of the representative set of jatrophanes (1-6 and 11-16) have been assessed. Jatrophanes 2 and 5 demonstrated the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR). | en |
dc.publisher | Pergamon-Elsevier Science Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41031/RS// | |
dc.rights | restrictedAccess | |
dc.source | Phytochemistry | |
dc.subject | Euphorbia dendroides | en |
dc.subject | Euphorbiaceae | en |
dc.subject | Isolation | en |
dc.subject | Jatrophanes | en |
dc.subject | Euphodendrophanes G-S | en |
dc.subject | P-glycoprotein | en |
dc.subject | Multi-drug resistance | en |
dc.title | Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines | en |
dc.type | article | |
dc.rights.license | ARR | |
dcterms.abstract | Песиц, Милица; Јадранин, Милка; Таниц, Никола; Банковиц, Јасна; Тодоровиц, Нина М.; Тешевић, Веле; Aљанциц, Ивана С.; Милосављевиц, Слободан М.; Марковиц, Иванка; Подолски-Рениц, Aна; Вајс, Влатка Е.; | |
dc.citation.volume | 86 | |
dc.citation.spage | 208 | |
dc.citation.epage | 217 | |
dc.identifier.wos | 000315017100024 | |
dc.identifier.doi | 10.1016/j.phytochem.2012.09.003 | |
dc.citation.other | 86: 208-217 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 23079764 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/2902] | |
dc.type.version | publishedVersion | en |
dc.identifier.scopus | 2-s2.0-84872042428 |