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dc.creatorSchröder, H.C.
dc.creatorWenger, R.
dc.creatorGerner, H.
dc.creatorReuter, P.
dc.creatorKuchino, Y.
dc.creatorSladić, Dušan
dc.creatorMülle, W.E.G.
dc.date.accessioned2018-11-22T00:00:11Z
dc.date.available2018-11-22T00:00:11Z
dc.date.issued1989
dc.identifier.issn0008-5472
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/15
dc.description.abstractThe amino acid L-tryptophan is known to be a modulator of many processes of cell metabolism. In this contribution we show that L-tryptophan interferes with some biological effects of the antileukemic and anti-human immunodeficiency virus agent avarol, possibly by different mechanisms. Avarol has been shown to be able to modulate posttranscriptional events of mRNA synthesis, resulting in an increase of the base-sequence complexities of the nonabundant and rare mRNA classes. Here it is demonstrated that this change in mRNA abundancy distribution is accompanied by an increase in the level of some specific, low abundant mRNAs (ras and c-myc). Addition of L-tryptophan was found to abolish avarol-caused gene relaxation in 1,1210 mouse leukemia cells. In addition, L-tryptophan suppressed the induction of γ-interferon mRNA production in human peripheral blood lymphocytes. At the level of DNA, L-tryptophan inhibited the production of strand breaks by cytotoxic avarol concentrations in Friend erythroleukemia cells in vitro. Moreover, it competed with avarol for binding to the nuclear envelope binding site; this effect was not shown by other amino acids. © 1989, American Association for Cancer Research. All rights reserved.en
dc.rightsrestrictedAccess
dc.sourceCancer Research
dc.titleSuppression of the modulatory effects of the antileukemic and anti-human immunodeficiency virus compound avarol on gene expression by tryptophanen
dc.typearticle
dc.rights.licenseARR
dc.citation.volume49
dc.citation.issue8
dc.citation.spage2069
dc.citation.epage2076
dc.citation.other49(8): 2069-2076
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-0024511570
dc.identifier.rcubKon_994


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