Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography
Samo za registrovane korisnike
2015
Autori
Tosti, TomislavŠegan, Sandra B.
Milić, Dragana
Radoičić, Aleksandra
Tešić, Živoslav Lj.
Milojković-Opsenica, Dušanka
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Unmodified silica gel in combination with two mobile phases, acetone-n-hexane and acetonitrile-dichloromethane, was used in order to evaluate the capability of normal-phase (NP) chromatography on bare silica gel in estimation of lipophilicity of some polyoxygenated steroids. Soczewinski equation coefficients were employed as a measure of lipophilicity. The R-M(0) values obtained in NP-systems were correlated with those derived by extrapolation from reversed-phase (RP) systems. In addition, retention data, i.e., lipophilicity parameters determined in NP systems were compared with logP values calculated by use of several commercial computer programs. The results showed that chromatographic parameters R-M(0), and m obtained in NP system consisted of silica gel as stationary phase and acetone-n-hexane as mobile phase, are acceptable as the measures of lipophilicity of polyoxygenated steroids. The mechanism of retention was discussed.
Ključne reči:
polyoxygenated steroids / structure-retention relationship / lipophilicity / normal-phase chromatography / silica gel / calculated lipophilicityIzvor:
Journal of Liquid Chromatography and Related Technologies, 2015, 38, 11, 1097-1103Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Korelacija strukture i osobina prirodnih i sintetičkih molekula i njihovih kompleksa sa metalima (RS-172017)
DOI: 10.1080/10826076.2015.1028287
ISSN: 1082-6076
WoS: 000354045900002
Scopus: 2-s2.0-84929237845
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Tosti, Tomislav AU - Šegan, Sandra B. AU - Milić, Dragana AU - Radoičić, Aleksandra AU - Tešić, Živoslav Lj. AU - Milojković-Opsenica, Dušanka PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1706 AB - Unmodified silica gel in combination with two mobile phases, acetone-n-hexane and acetonitrile-dichloromethane, was used in order to evaluate the capability of normal-phase (NP) chromatography on bare silica gel in estimation of lipophilicity of some polyoxygenated steroids. Soczewinski equation coefficients were employed as a measure of lipophilicity. The R-M(0) values obtained in NP-systems were correlated with those derived by extrapolation from reversed-phase (RP) systems. In addition, retention data, i.e., lipophilicity parameters determined in NP systems were compared with logP values calculated by use of several commercial computer programs. The results showed that chromatographic parameters R-M(0), and m obtained in NP system consisted of silica gel as stationary phase and acetone-n-hexane as mobile phase, are acceptable as the measures of lipophilicity of polyoxygenated steroids. The mechanism of retention was discussed. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography and Related Technologies T1 - Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography VL - 38 IS - 11 SP - 1097 EP - 1103 DO - 10.1080/10826076.2015.1028287 ER -
@article{ author = "Tosti, Tomislav and Šegan, Sandra B. and Milić, Dragana and Radoičić, Aleksandra and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka", year = "2015", abstract = "Unmodified silica gel in combination with two mobile phases, acetone-n-hexane and acetonitrile-dichloromethane, was used in order to evaluate the capability of normal-phase (NP) chromatography on bare silica gel in estimation of lipophilicity of some polyoxygenated steroids. Soczewinski equation coefficients were employed as a measure of lipophilicity. The R-M(0) values obtained in NP-systems were correlated with those derived by extrapolation from reversed-phase (RP) systems. In addition, retention data, i.e., lipophilicity parameters determined in NP systems were compared with logP values calculated by use of several commercial computer programs. The results showed that chromatographic parameters R-M(0), and m obtained in NP system consisted of silica gel as stationary phase and acetone-n-hexane as mobile phase, are acceptable as the measures of lipophilicity of polyoxygenated steroids. The mechanism of retention was discussed.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography and Related Technologies", title = "Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography", volume = "38", number = "11", pages = "1097-1103", doi = "10.1080/10826076.2015.1028287" }
Tosti, T., Šegan, S. B., Milić, D., Radoičić, A., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2015). Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography. in Journal of Liquid Chromatography and Related Technologies Taylor & Francis Inc, Philadelphia., 38(11), 1097-1103. https://doi.org/10.1080/10826076.2015.1028287
Tosti T, Šegan SB, Milić D, Radoičić A, Tešić ŽL, Milojković-Opsenica D. Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography. in Journal of Liquid Chromatography and Related Technologies. 2015;38(11):1097-1103. doi:10.1080/10826076.2015.1028287 .
Tosti, Tomislav, Šegan, Sandra B., Milić, Dragana, Radoičić, Aleksandra, Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Estimation of Lipophilicity of Some Polyoxygenated Steroids by the Means of Normal-Phase Thin-Layer Chromatography" in Journal of Liquid Chromatography and Related Technologies, 38, no. 11 (2015):1097-1103, https://doi.org/10.1080/10826076.2015.1028287 . .