9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation
2015
Autori
Veljović, ElmaŠpirtović-Halilović, Selma
Muratovic, Samija
Zulj, Lidija Valek
Roca, Sunčica
Trifunović, Snežana S.
Osmanović, Amar
Završnik, Davorka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.
Ključne reči:
xanthen-3-one derivatives / antioxidant potency / cyclic voltammetryIzvor:
Croatica Chemica Acta, 2015, 88, 2, 121-127Izdavač:
- Croatian Chemical Soc, Zagreb
DOI: 10.5562/cca2595
ISSN: 0011-1643
WoS: 000358441800004
Scopus: 2-s2.0-84938378595
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Veljović, Elma AU - Špirtović-Halilović, Selma AU - Muratovic, Samija AU - Zulj, Lidija Valek AU - Roca, Sunčica AU - Trifunović, Snežana S. AU - Osmanović, Amar AU - Završnik, Davorka PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1743 AB - Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation. PB - Croatian Chemical Soc, Zagreb T2 - Croatica Chemica Acta T1 - 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation VL - 88 IS - 2 SP - 121 EP - 127 DO - 10.5562/cca2595 ER -
@article{ author = "Veljović, Elma and Špirtović-Halilović, Selma and Muratovic, Samija and Zulj, Lidija Valek and Roca, Sunčica and Trifunović, Snežana S. and Osmanović, Amar and Završnik, Davorka", year = "2015", abstract = "Oxidative stress is directly related to several diseases and symptoms, where antioxidant compounds, such as xanthenes, may become important in prevention and/or treatmant. Ten biologically active 9-aryl substituted 2,6,7-trihydroxyxanthen-3-one derivatives were synthesized using reliable one-pot synthesis and their structures were confirmed by IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Some of the synthesized compounds were scanned for their antioxidant potency using electrochemical method cyclic voltammetry of immobilized microparticles. Substitution of hydrogen at the phenyl ring of 2,6,7-trihydroxy-9-phenylxanthen-3-one with an electron-donating group affected the reducing power of the compounds by lowering the biological oxidation potential. These results signify the importance of xanthen-3-one derivatives as antioxidant agents and their further biological evaluation.", publisher = "Croatian Chemical Soc, Zagreb", journal = "Croatica Chemica Acta", title = "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation", volume = "88", number = "2", pages = "121-127", doi = "10.5562/cca2595" }
Veljović, E., Špirtović-Halilović, S., Muratovic, S., Zulj, L. V., Roca, S., Trifunović, S. S., Osmanović, A.,& Završnik, D.. (2015). 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. in Croatica Chemica Acta Croatian Chemical Soc, Zagreb., 88(2), 121-127. https://doi.org/10.5562/cca2595
Veljović E, Špirtović-Halilović S, Muratovic S, Zulj LV, Roca S, Trifunović SS, Osmanović A, Završnik D. 9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation. in Croatica Chemica Acta. 2015;88(2):121-127. doi:10.5562/cca2595 .
Veljović, Elma, Špirtović-Halilović, Selma, Muratovic, Samija, Zulj, Lidija Valek, Roca, Sunčica, Trifunović, Snežana S., Osmanović, Amar, Završnik, Davorka, "9-Aryl Substituted Hydroxylated Xanthen-3-ones: Synthesis, Structure and Antioxidant Potency Evaluation" in Croatica Chemica Acta, 88, no. 2 (2015):121-127, https://doi.org/10.5562/cca2595 . .