Synthesis and antimicrobial activity of azepine and thiepine derivatives
AuthorsBožinović, Nina S.
Novaković, Irena T.
Šolaja, Bogdan A.
Article (Published version)
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A series of new pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The pyridobenzazepine derivatives showed better antibacterial and antifungal activity than the corresponding dipyridoazepine analogue. Among the synthesized azepines, derivative 8 displayed potent activity against the tested bacteria (MIC ranged 39-78 mu g mL(-1)), while azepine 12 showed promising antifungal activity (MIC ranged 156-313 mu g mL(-1)). The synthesized thiepine derivatives exhibited weak antibacterial activity, but showed pronounced antifungal activity.
Keywords:azepines / thiepines / heterocycles / palladium / antibacterials / antifungal
Source:Journal of the Serbian Chemical Society, 2015, 80, 7, 839-852
- Serbian Chemical Soc, Belgrade
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