The aim of the study was an assessment of the antioxidant, antifungal and cytotoxic potentials of L. betulinus and T. hirsuta mycelia extracts and the effect of selenium on these activities. Extracts of L. betulinus were twice as efficient in DPPH center dot scavenging as those of T. hirsuta. The phenol content in Se-enriched L. betulinus extracts was higher than in non-enriched extracts, in contrast to the effect of Se-enrichment on T. hirsuta extracts, and a direct correlation between the amount and DPPH center dot scavenging effect was observed. Ethanol extracts exhibited fungistatic but not fungicidal activity against a range of micromycetes, and mycelium enrichment with selenium inhibited this effect. Although the extracts showed low cytotoxic activity against HeLa and LS174 cells, T. hirsuta extracts, especially those enriched with selenium, had better potential. L. betulinus extracts showed better antioxidant and antifungal activity than T. hirsuta extracts which were more activ...e cytotoxic agents. The presence of selenium stimulated antioxidant and cytotoxic, and inhibited antifungal activity in L. betulinus, while in T. hirsuta its effect was slight.
TY - JOUR
AU - Milovanović, Ivan
AU - Stanojković, Tatjana
AU - Stajić, Mirjana
AU - Brčeski, Ilija
AU - Knežević, Aleksandar
AU - Ćilerdžić, Jasmina
AU - Vukojević, Jelena
PY - 2015
UR - https://cherry.chem.bg.ac.rs/handle/123456789/1752
AB - The aim of the study was an assessment of the antioxidant, antifungal and cytotoxic potentials of L. betulinus and T. hirsuta mycelia extracts and the effect of selenium on these activities. Extracts of L. betulinus were twice as efficient in DPPH center dot scavenging as those of T. hirsuta. The phenol content in Se-enriched L. betulinus extracts was higher than in non-enriched extracts, in contrast to the effect of Se-enrichment on T. hirsuta extracts, and a direct correlation between the amount and DPPH center dot scavenging effect was observed. Ethanol extracts exhibited fungistatic but not fungicidal activity against a range of micromycetes, and mycelium enrichment with selenium inhibited this effect. Although the extracts showed low cytotoxic activity against HeLa and LS174 cells, T. hirsuta extracts, especially those enriched with selenium, had better potential. L. betulinus extracts showed better antioxidant and antifungal activity than T. hirsuta extracts which were more active cytotoxic agents. The presence of selenium stimulated antioxidant and cytotoxic, and inhibited antifungal activity in L. betulinus, while in T. hirsuta its effect was slight.
PB - Bentham Science Publ Ltd, Sharjah
T2 - Current Pharmaceutical Biotechnology
T1 - Effect of Selenium Enrichment of Lenzites betulinus and Trametes hirsuta Mycelia on Antioxidant, Antifungal and Cytostatics Potential
VL - 16
IS - 10
SP - 920
EP - 926
DO - 10.2174/1389201016666150618152531
UR - Kon_2898
ER -
@article{
author = "Milovanović, Ivan and Stanojković, Tatjana and Stajić, Mirjana and Brčeski, Ilija and Knežević, Aleksandar and Ćilerdžić, Jasmina and Vukojević, Jelena",
year = "2015",
abstract = "The aim of the study was an assessment of the antioxidant, antifungal and cytotoxic potentials of L. betulinus and T. hirsuta mycelia extracts and the effect of selenium on these activities. Extracts of L. betulinus were twice as efficient in DPPH center dot scavenging as those of T. hirsuta. The phenol content in Se-enriched L. betulinus extracts was higher than in non-enriched extracts, in contrast to the effect of Se-enrichment on T. hirsuta extracts, and a direct correlation between the amount and DPPH center dot scavenging effect was observed. Ethanol extracts exhibited fungistatic but not fungicidal activity against a range of micromycetes, and mycelium enrichment with selenium inhibited this effect. Although the extracts showed low cytotoxic activity against HeLa and LS174 cells, T. hirsuta extracts, especially those enriched with selenium, had better potential. L. betulinus extracts showed better antioxidant and antifungal activity than T. hirsuta extracts which were more active cytotoxic agents. The presence of selenium stimulated antioxidant and cytotoxic, and inhibited antifungal activity in L. betulinus, while in T. hirsuta its effect was slight.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Effect of Selenium Enrichment of Lenzites betulinus and Trametes hirsuta Mycelia on Antioxidant, Antifungal and Cytostatics Potential",
volume = "16",
number = "10",
pages = "920-926",
doi = "10.2174/1389201016666150618152531",
url = "Kon_2898"
}
Milovanović, I., Stanojković, T., Stajić, M., Brčeski, I., Knežević, A., Ćilerdžić, J.,& Vukojević, J.. (2015). Effect of Selenium Enrichment of Lenzites betulinus and Trametes hirsuta Mycelia on Antioxidant, Antifungal and Cytostatics Potential. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 16(10), 920-926.
https://doi.org/10.2174/1389201016666150618152531
Kon_2898
Milovanović I, Stanojković T, Stajić M, Brčeski I, Knežević A, Ćilerdžić J, Vukojević J. Effect of Selenium Enrichment of Lenzites betulinus and Trametes hirsuta Mycelia on Antioxidant, Antifungal and Cytostatics Potential. in Current Pharmaceutical Biotechnology. 2015;16(10):920-926.
doi:10.2174/1389201016666150618152531
Kon_2898 .
Milovanović, Ivan, Stanojković, Tatjana, Stajić, Mirjana, Brčeski, Ilija, Knežević, Aleksandar, Ćilerdžić, Jasmina, Vukojević, Jelena, "Effect of Selenium Enrichment of Lenzites betulinus and Trametes hirsuta Mycelia on Antioxidant, Antifungal and Cytostatics Potential" in Current Pharmaceutical Biotechnology, 16, no. 10 (2015):920-926,
https://doi.org/10.2174/1389201016666150618152531 .,
Kon_2898 .
