The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization
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The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.
Keywords:ruthenium(II) complexes / edda-type ligand / photodynamic therapy
Source:Macedonian Journal of Chemistry and Chemical Engineering, 2014, 33, 1, 59-64
- Soc Chemists Technologists Madeconia, Skopje