The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization
Apstrakt
The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.
Ključne reči:
ruthenium(II) complexes / edda-type ligand / photodynamic therapyIzvor:
Macedonian Journal of Chemistry and Chemical Engineering, 2014, 33, 1, 59-64Izdavač:
- Soc Chemists Technologists Madeconia, Skopje
Finansiranje / projekti:
- Racionalni dizajn i sinteza biološki aktivnih i koordinacionih jedinjenja i funkcionalnih materijala, relevantnih u (bio)nanotehnologiji (RS-MESTD-Basic Research (BR or ON)-172035)
DOI: 10.20450/mjcce.2014.424
ISSN: 1857-5552
WoS: 000336241300006
Scopus: 2-s2.0-84902580817
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Savić, Aleksandar AU - Baroud, Afya A. AU - Grgurić-Šipka, Sanja PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1778 AB - The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages. PB - Soc Chemists Technologists Madeconia, Skopje T2 - Macedonian Journal of Chemistry and Chemical Engineering T1 - The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization VL - 33 IS - 1 SP - 59 EP - 64 DO - 10.20450/mjcce.2014.424 ER -
@article{ author = "Savić, Aleksandar and Baroud, Afya A. and Grgurić-Šipka, Sanja", year = "2014", abstract = "The new bipyridyl complex of ruthenium(II) with O, O'-diethyl-(S, S)-ethylenediamine- N, N'-di- 2(3-cyclohexyl) propanoate was synthesized. The reaction of cis-[RuCl2(bpy)(2)] and its ligand was performed in water/ethanol solution, in the presence of lithium hydroxide, under reflux. After the addition of ammonium hexafluorophosphate, the complex was precipitated. The complex, cis-[Ru(bpy)(2)L](PF6)(2), was characterized by H-1 and C-13 NMR, UV-Vis, IR spectroscopy, ESI-MS spectrometry and elemental analysis. Results indicate an octahedral geometry of the complex, with N, N'-coordinated O, O'- diethyl-(S, S)ethylenediamine-N, N'-di- 2-(3-cyclohexyl) propanoate. Complexes of this type are particularly important in terms of potential cytotoxicity and application in photodynamic therapy. Using this therapy, many side effects can be reduced, which may allow the administration of higher drug dosages.", publisher = "Soc Chemists Technologists Madeconia, Skopje", journal = "Macedonian Journal of Chemistry and Chemical Engineering", title = "The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization", volume = "33", number = "1", pages = "59-64", doi = "10.20450/mjcce.2014.424" }
Savić, A., Baroud, A. A.,& Grgurić-Šipka, S.. (2014). The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization. in Macedonian Journal of Chemistry and Chemical Engineering Soc Chemists Technologists Madeconia, Skopje., 33(1), 59-64. https://doi.org/10.20450/mjcce.2014.424
Savić A, Baroud AA, Grgurić-Šipka S. The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization. in Macedonian Journal of Chemistry and Chemical Engineering. 2014;33(1):59-64. doi:10.20450/mjcce.2014.424 .
Savić, Aleksandar, Baroud, Afya A., Grgurić-Šipka, Sanja, "The New Ruthenium(Ii)-Bipyridyl Complex with O,O '-Diethyl-(S,S)Ethylenediamine-N,N '-Di-2-(3-Cyclohexyl)Propanoate: Synthesis and Characterization" in Macedonian Journal of Chemistry and Chemical Engineering, 33, no. 1 (2014):59-64, https://doi.org/10.20450/mjcce.2014.424 . .