Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
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AuthorsNovaković, Miroslav M.
Vučković, Ivan M.
Trifunović, Snežana S.
Marin, Petar D.
Milosavljević, Slobodan M.
Article (Published version)
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Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
Keywords:Cytokinesis-block micronucleus (CBMN) assay / Green alder / Heptanoids, diaryl-
Source:Chemistry and Biodiversity, 2014, 11, 6, 872-885
- Wiley-V C H Verlag Gmbh, Weinheim