Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection
Authorized Users Only
2014
Authors
Novaković, Miroslav M.
Stanković, Miroslava

Vučković, Ivan M.
Todorović, Nina
Trifunović, Snežana S.

Apostolović, Danijela

Mandić, Boris

Veljić, Milan
Marin, Petar D.

Tešević, Vele

Vajs, Vlatka
Milosavljević, Slobodan M.
Article (Published version)

Metadata
Show full item recordAbstract
Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.
Keywords:
Cytokinesis-block micronucleus (CBMN) assay / Green alder / Heptanoids, diaryl-Source:
Chemistry and Biodiversity, 2014, 11, 6, 872-885Publisher:
- Wiley-V C H Verlag Gmbh, Weinheim
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-256716)
DOI: 10.1002/cbdv.201300277
ISSN: 1612-1872
PubMed: 24934673
WoS: 000337726800003
Scopus: 2-s2.0-84902822329
Collections
Institution/Community
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Novaković, Miroslav M. AU - Stanković, Miroslava AU - Vučković, Ivan M. AU - Todorović, Nina AU - Trifunović, Snežana S. AU - Apostolović, Danijela AU - Mandić, Boris AU - Veljić, Milan AU - Marin, Petar D. AU - Tešević, Vele AU - Vajs, Vlatka AU - Milosavljević, Slobodan M. PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1793 AB - Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine. PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Chemistry and Biodiversity T1 - Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection VL - 11 IS - 6 SP - 872 EP - 885 DO - 10.1002/cbdv.201300277 ER -
@article{ author = "Novaković, Miroslav M. and Stanković, Miroslava and Vučković, Ivan M. and Todorović, Nina and Trifunović, Snežana S. and Apostolović, Danijela and Mandić, Boris and Veljić, Milan and Marin, Petar D. and Tešević, Vele and Vajs, Vlatka and Milosavljević, Slobodan M.", year = "2014", abstract = "Nine diarylheptanoids, 1-9, catechin (11), and a phenolic glucoside, 10, were isolated from the bark of green alder (Alnus viridis). Four of the isolated compounds, i.e., 2, 5, 8, 10, are new. The structures of 1-11 were determined on the basis of spectroscopic data. All isolated compounds were evaluated for their in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using cytokinesis-block micronucleus (CBMN) assay. Almost all of them exerted a pronounced effect of decreasing DNA damage of human lymphocytes, acting stronger than the known synthetic protector amifostine.", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Chemistry and Biodiversity", title = "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection", volume = "11", number = "6", pages = "872-885", doi = "10.1002/cbdv.201300277" }
Novaković, M. M., Stanković, M., Vučković, I. M., Todorović, N., Trifunović, S. S., Apostolović, D., Mandić, B., Veljić, M., Marin, P. D., Tešević, V., Vajs, V.,& Milosavljević, S. M.. (2014). Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity Wiley-V C H Verlag Gmbh, Weinheim., 11(6), 872-885. https://doi.org/10.1002/cbdv.201300277
Novaković MM, Stanković M, Vučković IM, Todorović N, Trifunović SS, Apostolović D, Mandić B, Veljić M, Marin PD, Tešević V, Vajs V, Milosavljević SM. Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection. in Chemistry and Biodiversity. 2014;11(6):872-885. doi:10.1002/cbdv.201300277 .
Novaković, Miroslav M., Stanković, Miroslava, Vučković, Ivan M., Todorović, Nina, Trifunović, Snežana S., Apostolović, Danijela, Mandić, Boris, Veljić, Milan, Marin, Petar D., Tešević, Vele, Vajs, Vlatka, Milosavljević, Slobodan M., "Diarylheptanoids from Green Alder Bark and Their Potential for DNA Protection" in Chemistry and Biodiversity, 11, no. 6 (2014):872-885, https://doi.org/10.1002/cbdv.201300277 . .