Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis
Samo za registrovane korisnike
2014
Autori
Stanojević, MarijaTrifković, Jelena
Kostić-Rajačić, Slađana
Šoškić, Vukić
Tešić, Živoslav Lj.
Milojković-Opsenica, Dušanka
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance... of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems.
Ključne reči:
arilpiperazines / high-performance thin-layer chromatography / lipophilicity / partial least squares / principal component analysis / quantitative structure-retention relationshipsIzvor:
Journal of Liquid Chromatography and Related Technologies, 2014, 37, 20, 2814-2828Izdavač:
- Taylor & Francis Inc, Philadelphia
Finansiranje / projekti:
- Korelacija strukture i osobina prirodnih i sintetičkih molekula i njihovih kompleksa sa metalima (RS-MESTD-Basic Research (BR or ON)-172017)
DOI: 10.1080/10826076.2014.907112
ISSN: 1082-6076
WoS: 000337971200002
Scopus: 2-s2.0-84903212960
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Stanojević, Marija AU - Trifković, Jelena AU - Kostić-Rajačić, Slađana AU - Šoškić, Vukić AU - Tešić, Živoslav Lj. AU - Milojković-Opsenica, Dušanka PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1796 AB - The chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems. PB - Taylor & Francis Inc, Philadelphia T2 - Journal of Liquid Chromatography and Related Technologies T1 - Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis VL - 37 IS - 20 SP - 2814 EP - 2828 DO - 10.1080/10826076.2014.907112 ER -
@article{ author = "Stanojević, Marija and Trifković, Jelena and Kostić-Rajačić, Slađana and Šoškić, Vukić and Tešić, Živoslav Lj. and Milojković-Opsenica, Dušanka", year = "2014", abstract = "The chromatographic behavior of arylureas and arylacetamides derivatives with observed biological activity toward dopamine D-2 and 5-hydroxytryptamine 5HT(1A) receptors were examined by high-performance thin-layer chromatography in order to determine their lipophilicity and to correlate their structure and retention. The binary water-dimethyl sulfoxid mobile phases and RP-18 silica as stationary phase were used in order to determine chromatographic descriptors R-M(0), b, and C-0, as a measure of the lipophilicity of tested compounds. Based on the respective retention, the lipophilicity of the investigated compounds was discussed. Principal component analysis followed by partial least squares was used to select variables that best describe the behavior of the investigated compounds in the chromatographic system and to quantify their influences. The models reveal the importance of nonpolar properties of the solutes and their ability for hydrophobic interactions, as well as the importance of proton donating abilities and the size and the shape of the molecule, pointing out on that way the possible separation mechanism in the studied chromatographic systems.", publisher = "Taylor & Francis Inc, Philadelphia", journal = "Journal of Liquid Chromatography and Related Technologies", title = "Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis", volume = "37", number = "20", pages = "2814-2828", doi = "10.1080/10826076.2014.907112" }
Stanojević, M., Trifković, J., Kostić-Rajačić, S., Šoškić, V., Tešić, Ž. Lj.,& Milojković-Opsenica, D.. (2014). Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis. in Journal of Liquid Chromatography and Related Technologies Taylor & Francis Inc, Philadelphia., 37(20), 2814-2828. https://doi.org/10.1080/10826076.2014.907112
Stanojević M, Trifković J, Kostić-Rajačić S, Šoškić V, Tešić ŽL, Milojković-Opsenica D. Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis. in Journal of Liquid Chromatography and Related Technologies. 2014;37(20):2814-2828. doi:10.1080/10826076.2014.907112 .
Stanojević, Marija, Trifković, Jelena, Kostić-Rajačić, Slađana, Šoškić, Vukić, Tešić, Živoslav Lj., Milojković-Opsenica, Dušanka, "Assessment of Lipophilicity of Some Biologically Active Arylpiperazines by Rptlc and Multivariate Analysis" in Journal of Liquid Chromatography and Related Technologies, 37, no. 20 (2014):2814-2828, https://doi.org/10.1080/10826076.2014.907112 . .