Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation
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2014
Authors
Lippert, RainerVojnović, Sandra

Mitrović, Aleksandra D.

Jux, Norbert
Ivanović-Burmazović, Ivana

Vasiljević, Branka

Stanković, Nada
Article (Published version)

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Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 mu g/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 mu g/mL, however it does not cause hemolysis in concentrations of up to 50 mu g/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. (C) 2014 Elsevier Ltd. All rights reserved.
Keywords:
Antifungal / Porphyrins / Candida albicans / Biofilm / FerroceneSource:
Bioorganic and Medicinal Chemistry Letters, 2014, 24, 15, 3506-3511Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Microbial diversity study and characterization of beneficial environmental microorganisms (RS-173048)
- University Erlangen-Nurnberg (Emerging Field Initiative: Medicinal Redox Inorganic Chemistry)
DOI: 10.1016/j.bmcl.2014.05.061
ISSN: 0960-894X
PubMed: 24929472
WoS: 000339228700058
Scopus: 2-s2.0-84904066359
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Lippert, Rainer AU - Vojnović, Sandra AU - Mitrović, Aleksandra D. AU - Jux, Norbert AU - Ivanović-Burmazović, Ivana AU - Vasiljević, Branka AU - Stanković, Nada PY - 2014 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1815 AB - Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 mu g/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 mu g/mL, however it does not cause hemolysis in concentrations of up to 50 mu g/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. (C) 2014 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Bioorganic and Medicinal Chemistry Letters T1 - Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation VL - 24 IS - 15 SP - 3506 EP - 3511 DO - 10.1016/j.bmcl.2014.05.061 ER -
@article{ author = "Lippert, Rainer and Vojnović, Sandra and Mitrović, Aleksandra D. and Jux, Norbert and Ivanović-Burmazović, Ivana and Vasiljević, Branka and Stanković, Nada", year = "2014", abstract = "Ferrocene-substituted porphyrin RL-91 exhibits antifungal activity against opportune human pathogen Candida albicans. RL-91 efficiently inhibits growth of both planktonic C albicans cells and cells within biofilms without photoactivation. The minimal inhibitory concentration for plankton form (PMIC) was established to be 100 mu g/mL and the same concentration killed 80% of sessile cells in the mature biofilm (SMIC80). Furthermore PMIC of RL-91 efficiently prevents C albicans biofilm formation. RL-91 is cytotoxic for human fibroblasts in vitro in concentration of 10 mu g/mL, however it does not cause hemolysis in concentrations of up to 50 mu g/mL. These findings open possibility for application of RL-91 as an antifungal agent for external antibiofilm treatment of medical devices as well as a scaffold for further development of porphyrin based systemic antifungals. (C) 2014 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Bioorganic and Medicinal Chemistry Letters", title = "Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation", volume = "24", number = "15", pages = "3506-3511", doi = "10.1016/j.bmcl.2014.05.061" }
Lippert, R., Vojnović, S., Mitrović, A. D., Jux, N., Ivanović-Burmazović, I., Vasiljević, B.,& Stanković, N.. (2014). Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation. in Bioorganic and Medicinal Chemistry Letters Pergamon-Elsevier Science Ltd, Oxford., 24(15), 3506-3511. https://doi.org/10.1016/j.bmcl.2014.05.061
Lippert R, Vojnović S, Mitrović AD, Jux N, Ivanović-Burmazović I, Vasiljević B, Stanković N. Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation. in Bioorganic and Medicinal Chemistry Letters. 2014;24(15):3506-3511. doi:10.1016/j.bmcl.2014.05.061 .
Lippert, Rainer, Vojnović, Sandra, Mitrović, Aleksandra D., Jux, Norbert, Ivanović-Burmazović, Ivana, Vasiljević, Branka, Stanković, Nada, "Effect of ferrocene-substituted porphyrin RL-91 on Candida albicans biofilm formation" in Bioorganic and Medicinal Chemistry Letters, 24, no. 15 (2014):3506-3511, https://doi.org/10.1016/j.bmcl.2014.05.061 . .