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dc.creatorZmejkovski, Bojana B.
dc.creatorSavić, Aleksandar
dc.creatorPoljarević, Jelena
dc.creatorPantelić, Nebojša Đ.
dc.creatorAranđelović, Sandra
dc.creatorRadulović, Siniša
dc.creatorGrgurić-Šipka, Sanja
dc.creatorKaluđerović, Goran N.
dc.creatorSabo, Tibor
dc.date.accessioned2018-11-22T00:29:00Z
dc.date.available2018-11-22T00:29:00Z
dc.date.issued2014
dc.identifier.issn0277-5387
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1840
dc.description.abstractSix palladium(II) complexes with (S,S)-R(2)edda-type esters ((S,S)-R2edda-type; (S,S)-eddch = (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Me, Et, n-Pr, 1-3; (S,S)-pddch = (S,S)-propylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate, R = Et, n-Pr, 4, 5; and (S,S)-eddip = (S,S)-ethylenediamne-N,N'-di-2-propanoate, R = i-Am, 6) were synthesized, characterized by IR, NMR spectroscopy, ESI-MS and elemental analysis. DFT calculations indicate that in case of 1-4, the most stable isomers are with (S,S)- and (R,S)-configuration of nitrogen atoms, but for complex 6 (R,R)- and (R,S)-N,N'-configured isomers. Furthermore, complex 5 was obtained as (S,S)-N,N' configured isomer. Cytotoxicity study was performed against human cervical adenocarcinoma (HeLa), human alveolar basal adenocarcinoma (A549) and non-cancerous human fetal lung fibroblast (MRC-5) cell lines using colorimetric MTT assay. From the investigated palladium(II) complexes 2, 3 and 5 exhibited highest cytotoxic potential against HeLa (IC50: 28.5 +/- 3.9, 29.5 +/- 1.3 and 34.3 +/- 3.2, respectively). (C) 2014 Elsevier Ltd. All rights reserved.en
dc.publisherPergamon-Elsevier Science Ltd, Oxford
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/256716/EU//
dc.rightsrestrictedAccess
dc.sourcePolyhedron
dc.subjectPalladium(II) complexesen
dc.subjectR(2)edda-type ligandsen
dc.subjectDFT calculationsen
dc.subjectDiastereoisomersen
dc.subjectCytotoxic activityen
dc.titleSynthesis, characterization and in vitro antitumor activity of new palladium(II) complexes with (S,S)-R(2)edda-type estersen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractAранделовиц, Сандра; Калудеровиц, Горан Н.; Сабо, Тибор; Змејковски, Бојана Б.; Гргурић-Шипка, Сања; Пољаревић, Јелена; Савић, Aлександар; Пантелиц, Небојса; Радуловиц, Синиса;
dc.citation.volume80
dc.citation.spage106
dc.citation.epage111
dc.identifier.wos000341348300014
dc.identifier.doi10.1016/j.poly.2014.02.026
dc.citation.other80: 106-111
dc.citation.rankM22
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84905493340
dc.identifier.rcubKon_2723


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