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dc.creatorZec, Manja
dc.creatorSrdić-Rajić, Tatjana
dc.creatorKrivokuca, Ana
dc.creatorJankovic, Radmila
dc.creatorTodorović, Tamara
dc.creatorAnđelković, Katarina K.
dc.creatorRadulović, Siniša
dc.date.accessioned2018-11-22T00:29:34Z
dc.date.available2018-11-22T00:29:34Z
dc.date.issued2014
dc.identifier.issn1573-4064
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1877
dc.description.abstractThe synthesis and chemical characterization of the novel 2,6-diacetylpyridine-bis(selenosemicarbazone) metal complexes of Zn(II), Cd(II) and Ni(II) were published previously. Here we report first evidence on anti-proliferative activity of the complexes and molecular patterns that underlie it. The complexes and the corresponding ligand are shown to be cytotoxic on the panel of nine, malignant and non-malignant cell lines, with the exception of Ni(II) complex that did not achieve IC50 value on any of the cell lines tested. Further experiments on the selected cell lines including A 549, MRC-5, EA.hy 926 and HeLa, have shown that the complexes posses unambiguous property of inducing necrosis in the cells treated for 6 hours, with the ligand and Zn(II) complex being the most active on all cell lines. On the contrary, only small portion of early apoptotic events was detected, under the same experimental condition. This was in complete concordance with the results obtained from Western blot analysis of the treated cells that showed no or slight increase of the protein amounts of two crucial apoptotic mediators: Cytochrome C and Caspase III. We propose the model, under which tested complexes induce necroptosis in treated cells, a recently described type of cell death with necrotic morphological features and acting via caspase independent pathway, and without elevated amounts of intracellular ROS. Endothelial EA.hy 926 cells have proven to be extremely sensitive on the necrosis-inducing effect of the complexes, which could indicate potential anti-angiogenic effect of the novel complexes that is to be investigated.en
dc.publisherBentham Science Publ Ltd, Sharjah
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.rightsrestrictedAccess
dc.sourceMedicinal Chemistry
dc.subjectA 549en
dc.subjectEA.hy 926en
dc.subjectmetal complexesen
dc.subjectnecroptosisen
dc.subjectROSen
dc.subjectselenosemicarbazoneen
dc.subjectzinc (II) complexen
dc.titleNovel Selenosemicarbazone Metal Complexes Exert Anti-tumor Effect via Alternative, Caspase-independent Necroptotic Cell Deathen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractТодоровић, Тамара; Радуловиц, Синиса; Јанковиц, Радмила; Зец, Мања; Срдиц-Рајиц, Татјана; Aнђелковић, Катарина; Кривокуца, Aна;
dc.citation.volume10
dc.citation.issue8
dc.citation.spage759
dc.citation.epage771
dc.identifier.wos000344525700002
dc.identifier.doi10.2174/1573406410666140327122009
dc.citation.other10(8): 759-771
dc.citation.rankM23
dc.identifier.pmid24678785
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84908680415
dc.identifier.rcubKon_2760


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