Red meat allergic patients have a selective IgE response to the alpha-Gal glycan
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2015
Authors
Apostolović, DanijelaTran, Thi Anh Thu
Sanchez-Vidaurre, Sara
Ćirković-Veličković, Tanja
Starkhammar, Maria
Hamsten, Carl
van Hage, Marianne
Article (Published version)
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Show full item recordAbstract
Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE....
Keywords:
alpha-Gal / cross-reactive carbohydrate determinant / glycan / IgE / red meat allergySource:
Allergy, 2015, 70, 11, 1497-1500Publisher:
- Wiley, Hoboken
Funding / projects:
- Molecular properties and modifications of some respiratory and nutritional allergens (RS-MESTD-Basic Research (BR or ON)-172024)
- Reinforcement of the Faculty of Chemistry, University of Belgrade, towards becoming a Center of Excellence in the region of WB for Molecular Biotechnology and Food research (EU-FP7-256716)
- Karolinska Institutet
- King Gustaf V 80th Birthday Foundation
- Stockholm County Council
- Swedish Research Council
- Swedish Asthma and Allergy Associations Research Foundation
- Swedish Heart-Lung Foundation
- Swedish Cancer and Allergy Foundation
- Center for Inflammatory Diseases, Karolinska Institutet
- EAACI Fellowship Award
- Magnus Bergvall Foundation
- Konsul Th C Berg Foundation
Note:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3407
DOI: 10.1111/all.12695
ISSN: 0105-4538
PubMed: 26190542
WoS: 000363329400016
Scopus: 2-s2.0-84945463671
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Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Apostolović, Danijela AU - Tran, Thi Anh Thu AU - Sanchez-Vidaurre, Sara AU - Ćirković-Veličković, Tanja AU - Starkhammar, Maria AU - Hamsten, Carl AU - van Hage, Marianne PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/1982 AB - Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE. PB - Wiley, Hoboken T2 - Allergy T1 - Red meat allergic patients have a selective IgE response to the alpha-Gal glycan VL - 70 IS - 11 SP - 1497 EP - 1500 DO - 10.1111/all.12695 ER -
@article{ author = "Apostolović, Danijela and Tran, Thi Anh Thu and Sanchez-Vidaurre, Sara and Ćirković-Veličković, Tanja and Starkhammar, Maria and Hamsten, Carl and van Hage, Marianne", year = "2015", abstract = "Galactose--1,3-galactose (-Gal) is a mammalian carbohydrate with significance in a novel type of food allergy. Patients with IgE against -Gal report severe allergic symptoms 3-6h after consumption of red meat. We investigated whether IgE from red meat allergic patients recognizes other mammalian glycans than -Gal or glycans from the plant kingdom and insects of importance in allergy. We found that none of the 24 red meat allergic patients investigated had an IgE antibody response against the other abundant mammalian glycan N-glycolylneuraminic acid or against cross-reactive carbohydrate determinants from plant or venom sources (nCup a 1, nArt v 1, and MUXF3). Deglycosylation of an -Gal-containing protein, bovine thyroglobulin, significantly reduced the IgE response. In conclusion, we show that red meat allergic patients have a selective IgE response to the -Gal glycan found in red meat. Other common glycans reactive in allergic disease are not targets of red meat allergic patients' IgE.", publisher = "Wiley, Hoboken", journal = "Allergy", title = "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan", volume = "70", number = "11", pages = "1497-1500", doi = "10.1111/all.12695" }
Apostolović, D., Tran, T. A. T., Sanchez-Vidaurre, S., Ćirković-Veličković, T., Starkhammar, M., Hamsten, C.,& van Hage, M.. (2015). Red meat allergic patients have a selective IgE response to the alpha-Gal glycan. in Allergy Wiley, Hoboken., 70(11), 1497-1500. https://doi.org/10.1111/all.12695
Apostolović D, Tran TAT, Sanchez-Vidaurre S, Ćirković-Veličković T, Starkhammar M, Hamsten C, van Hage M. Red meat allergic patients have a selective IgE response to the alpha-Gal glycan. in Allergy. 2015;70(11):1497-1500. doi:10.1111/all.12695 .
Apostolović, Danijela, Tran, Thi Anh Thu, Sanchez-Vidaurre, Sara, Ćirković-Veličković, Tanja, Starkhammar, Maria, Hamsten, Carl, van Hage, Marianne, "Red meat allergic patients have a selective IgE response to the alpha-Gal glycan" in Allergy, 70, no. 11 (2015):1497-1500, https://doi.org/10.1111/all.12695 . .