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dc.creatorMilenković, Milica R.
dc.creatorPevec, Andrej
dc.creatorTurel, Iztok
dc.creatorVujčić, Miroslava
dc.creatorMilenković, Marina
dc.creatorJovanović, Katarina
dc.creatorGligorijević, Nevenka
dc.creatorRadulović, Siniša
dc.creatorSwart, Marcel
dc.creatorGruden-Pavlović, Maja
dc.creatorAdaila, Kawther
dc.creatorČobeljić, Božidar
dc.creatorAnđelković, Katarina K.
dc.date.accessioned2018-11-22T00:29:52Z
dc.date.available2018-11-22T00:29:52Z
dc.date.issued2014
dc.identifier.issn0223-5234
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/1986
dc.description.abstractThree square-planar complexes of Ni(II) with condensation derivative of 2-(diphenylphosphino)benzaldehyde and 4-phenylsemicarbazide and monodentate pseudohalides have been synthesized and characterized on the basis of the results of X-ray. NMR and IR spectroscopy and elemental analysis. Investigated complexes exhibited moderate antibacterial and cytotoxic activity. The most pronounced cytotoxic activity (in the range of cisplatin) to HeLa cell line was observed for ligand and all the complexes. Azido complex and ligand induced concentration dependent cell cycle arrest in the S phase, as well as decrease of percentage of cells in G1 phase, without significant increase of apoptotic fraction of cells. The interaction of the azido complex and ligand with CT-DNA results in changes in UV-Vis spectra typical for non-covalent bonding. The observed intrinsic binding constant of azido complex CT-DNA and ligand-CT-DNA were 3.22 x 10(5) M-1 and 2.79 x 10(5) M-1. The results of DNA cleavage experiments showed that azido complex nicked supercoiled plasmid DNA. (C) 2014 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier, Paris
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.relationICREA
dc.relationSlovenian Research Agency (ARRS) [P-0175]
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Medicinal Chemistry
dc.subjectNickel(II) complexesen
dc.subjectPseudohalidesen
dc.subjectX-ray crystal structuresen
dc.subjectAntimicrobial activityen
dc.subjectCytotoxicityen
dc.titleSynthesis, characterization, DFT calculation and biological activity of square-planar Ni(II) complexes with tridentate PNO ligands and monodentate pseudohalides. Part IIen
dc.typearticle
dc.rights.licenseARR
dcterms.abstractЈовановиц, Катарина; Миленковић, Милица; Радуловиц, Синиса; Миленковиц, Марина; Певец, Aндреј; Груден-Павловић, Маја; Чобељић, Божидар; Aдаила, Каwтхер; Турел, Изток; Вујциц, Мирослава; Aнђелковић, Катарина; Сwарт, Марцел; Глигоријевиц, Невенка;
dc.citation.volume87
dc.citation.spage284
dc.citation.epage297
dc.identifier.wos000363431300027
dc.identifier.doi10.1016/j.ejmech.2014.06.079
dc.citation.other87: 284-297
dc.citation.rankM21
dc.identifier.pmid25262049
dc.type.versionpublishedVersionen
dc.identifier.scopus2-s2.0-84907517896
dc.identifier.rcubKon_2941


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