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Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action
(European Journal of Medicinal Chemistry, 2019)
Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral ...
Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action
(Elsevier, 2019)
Ebola virus (EBOV) causes a deadly hemorrhagic fever in humans and non-human primates. There is currently no FDA-approved vaccine or medication to counter this disease. Here, we report on the design, synthesis and anti-viral ...
4-Aminoquinoline-based compounds as antileishmanial agents that inhibit the energy metabolism of Leishmania
(Elsevier, 2019)
Among neglected tropical diseases, leishmaniasis is one of the most relevant with an estimated 30,000 deaths annually. Existing therapies have serious drawbacks in safety, drug resistance, field-adapted application and ...