Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies
Само за регистроване кориснике
2016
Аутори
Simić, Milena R.Paunović, Nikola
Borić, Ivan
Ranđelović, Jelena
Vojnović, Sandra
Nikodinović-Runić, Jasmina
Pekmezović, Marina
Savić, Vladimir
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved.
Кључне речи:
Antifungal compounds / Isocoumarin derivatives / Candida speciesИзвор:
Bioorganic and Medicinal Chemistry Letters, 2016, 26, 1, 235-239Издавач:
- Pergamon-Elsevier Science Ltd, Oxford
Финансирање / пројекти:
- Компјутерско дизајнирање, синтеза и биолошка евалуација нових хетероцикличних једињења као селективних инхибитора туморогенезе (RS-MESTD-Basic Research (BR or ON)-172009)
- Изучавање микробиолошког диверзитета и карактеризација корисних срединских микроорганизама (RS-MESTD-Basic Research (BR or ON)-173048)
DOI: 10.1016/j.bmcl.2015.08.086
ISSN: 0960-894X
PubMed: 26586600
WoS: 000366161600044
Scopus: 2-s2.0-84949570559
Колекције
Институција/група
Inovacioni centar / Innovation CentreTY - JOUR AU - Simić, Milena R. AU - Paunović, Nikola AU - Borić, Ivan AU - Ranđelović, Jelena AU - Vojnović, Sandra AU - Nikodinović-Runić, Jasmina AU - Pekmezović, Marina AU - Savić, Vladimir PY - 2016 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2008 AB - A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Bioorganic and Medicinal Chemistry Letters T1 - Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies VL - 26 IS - 1 SP - 235 EP - 239 DO - 10.1016/j.bmcl.2015.08.086 ER -
@article{ author = "Simić, Milena R. and Paunović, Nikola and Borić, Ivan and Ranđelović, Jelena and Vojnović, Sandra and Nikodinović-Runić, Jasmina and Pekmezović, Marina and Savić, Vladimir", year = "2016", abstract = "A series of novel 3-substituted isocoumarins was prepared via Pd-catalysed coupling processes and screened in vitro for antifungal activity against Candida species. The study revealed antifungal potential of isocoumarins possessing the azole substituents, which, in some cases, showed biological properties equal to those of clinically used voriconazole. Selected compounds were also screened against voriconazole resistant Candida krusei 6258 and a clinical isolate Candida parapsilosis CA-27. Although the activity against these targets needs to be improved further, the results emphasise additional potential of this new class of antifungal compounds. (C) 2015 Elsevier Ltd. All rights reserved.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Bioorganic and Medicinal Chemistry Letters", title = "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies", volume = "26", number = "1", pages = "235-239", doi = "10.1016/j.bmcl.2015.08.086" }
Simić, M. R., Paunović, N., Borić, I., Ranđelović, J., Vojnović, S., Nikodinović-Runić, J., Pekmezović, M.,& Savić, V.. (2016). Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic and Medicinal Chemistry Letters Pergamon-Elsevier Science Ltd, Oxford., 26(1), 235-239. https://doi.org/10.1016/j.bmcl.2015.08.086
Simić MR, Paunović N, Borić I, Ranđelović J, Vojnović S, Nikodinović-Runić J, Pekmezović M, Savić V. Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies. in Bioorganic and Medicinal Chemistry Letters. 2016;26(1):235-239. doi:10.1016/j.bmcl.2015.08.086 .
Simić, Milena R., Paunović, Nikola, Borić, Ivan, Ranđelović, Jelena, Vojnović, Sandra, Nikodinović-Runić, Jasmina, Pekmezović, Marina, Savić, Vladimir, "Functionalised isocoumarins as antifungal compounds: Synthesis and biological studies" in Bioorganic and Medicinal Chemistry Letters, 26, no. 1 (2016):235-239, https://doi.org/10.1016/j.bmcl.2015.08.086 . .