Anti-Ebola Activity of Diazachrysene Small Molecules
Samo za registrovane korisnike
2015
Autori
Selaković, ŽivotaSoloveva, Veronica
Gharaibeh, Dima N.
Wells, Jay
Šegan, Sandra B.
Panchal, Rekha G.
Šolaja, Bogdan A.
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.
Ključne reči:
Ebola virus / antiviral diazachrysenes / inhibitory efficacy small molecule / toxicityIzvor:
ACS INFECTIOUS DISEASES, 2015, 1, 6, 264-271Izdavač:
- Amer Chemical Soc, Washington
Finansiranje / projekti:
- Sinteza aminohinolina i njihovih derivata kao antimalarika i inhibitora botulinum neurotoksina A (RS-MESTD-Basic Research (BR or ON)-172008)
- Department of Defense Chemical Biological Defense Program through Defense Threat Reduction Agency (DTRA)
Napomena:
- Supplementary material: http://cherry.chem.bg.ac.rs/handle/123456789/3339
DOI: 10.1021/acsinfecdis.5b00028
ISSN: 2373-8227
PubMed: 27622742
WoS: 000368463600005
Scopus: 2-s2.0-84969135965
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Selaković, Života AU - Soloveva, Veronica AU - Gharaibeh, Dima N. AU - Wells, Jay AU - Šegan, Sandra B. AU - Panchal, Rekha G. AU - Šolaja, Bogdan A. PY - 2015 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2035 AB - Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics. PB - Amer Chemical Soc, Washington T2 - ACS INFECTIOUS DISEASES T1 - Anti-Ebola Activity of Diazachrysene Small Molecules VL - 1 IS - 6 SP - 264 EP - 271 DO - 10.1021/acsinfecdis.5b00028 ER -
@article{ author = "Selaković, Života and Soloveva, Veronica and Gharaibeh, Dima N. and Wells, Jay and Šegan, Sandra B. and Panchal, Rekha G. and Šolaja, Bogdan A.", year = "2015", abstract = "Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0.70 mu M) and are significantly less lipophilic than their predecessors. The three most potent diazachrysene antivirals do not exhibit any toxicity in vivo and protected 70-90% of the mice at 10 mg/kg following EBOV challenge. Together, these studies suggest that diazachrysenes are a promising class of compounds for hit to lead optimization and as potential Ebola therapeutics.", publisher = "Amer Chemical Soc, Washington", journal = "ACS INFECTIOUS DISEASES", title = "Anti-Ebola Activity of Diazachrysene Small Molecules", volume = "1", number = "6", pages = "264-271", doi = "10.1021/acsinfecdis.5b00028" }
Selaković, Ž., Soloveva, V., Gharaibeh, D. N., Wells, J., Šegan, S. B., Panchal, R. G.,& Šolaja, B. A.. (2015). Anti-Ebola Activity of Diazachrysene Small Molecules. in ACS INFECTIOUS DISEASES Amer Chemical Soc, Washington., 1(6), 264-271. https://doi.org/10.1021/acsinfecdis.5b00028
Selaković Ž, Soloveva V, Gharaibeh DN, Wells J, Šegan SB, Panchal RG, Šolaja BA. Anti-Ebola Activity of Diazachrysene Small Molecules. in ACS INFECTIOUS DISEASES. 2015;1(6):264-271. doi:10.1021/acsinfecdis.5b00028 .
Selaković, Života, Soloveva, Veronica, Gharaibeh, Dima N., Wells, Jay, Šegan, Sandra B., Panchal, Rekha G., Šolaja, Bogdan A., "Anti-Ebola Activity of Diazachrysene Small Molecules" in ACS INFECTIOUS DISEASES, 1, no. 6 (2015):264-271, https://doi.org/10.1021/acsinfecdis.5b00028 . .