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dc.creatorŽivković, Marija
dc.creatorKljun, Jakob
dc.creatorIlić-Tomić, Tatjana
dc.creatorPavić, Aleksandar
dc.creatorVeselinovic, A.
dc.creatorManojlović, Dragan D.
dc.creatorNikodinović-Runić, Jasmina
dc.creatorTurel, Iztok
dc.date.accessioned2018-11-22T00:42:59Z
dc.date.available2018-11-22T00:42:59Z
dc.date.issued2018
dc.identifier.issn2052-1553
dc.identifier.urihttp://cherry.chem.bg.ac.rs/handle/123456789/2071
dc.description.abstractThe anticancer potential of sixteen platinum(II) complexes with general formulae [PtCl(hq)(S-dmso)] (1a-8a) and [PtCl(hq)(pta)] (1b-8b) (where hq is 5-chloro-7-iodo-8-quinolinol (clioquinol; cqH) (1a, 1b), 8-hydroxy-5-nitroquinoline (nitroxoline; nxH) (2a, 2b), 5,7-dichloro-8-quinolinol (3a, 3b), 5,7-diiodo-8-quinolinol (4a, 4b), 5,7-dibromo-8-quinolinol (5a, 5b), 5,7-dichloro-8-hydroxy-2-methyl-quinoline (6a, 6b), 8-hydroxyquinoline (7a, 7b) and 8-quinolinethiol (8a, 8b); dmso is dimethyl sulfoxide and pta is 1,3,5triaza- 7-phosphaadamantane) was determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and A549) and embryotoxicity assay in a zebrafish model. Interactions with double stranded DNA through in vitro assay and a molecular docking study were examined. All complexes, except 6a, exhibited a high cytotoxic effect on MRC5 cells at a concentration of 10 mu g mL(-1) while 1b, 5a, 6a and 3b showed selective toxicity towards carcinoma cell lines. In general, pta-based complexes (series b) were more toxic according to the results of a MTT screen and the LC50 values obtained in zebrafish (Danio rerio) assay; they also induced higher oxidative stress in this model. Successful cellular uptake of complexes was shown by the ICP-MS methodology. The binding propensity of the complex with DNA obtained in in silico studies can be correlated with those from the experimental investigation. Compounds with the highest binding potential, according to the interaction energy value, were 1b, 3b, 6b and 5b. From observations of the DNA interaction ability and of the in silico assessment, no apparent DNA fragmentation was observed either on DNA extracted from the treated cancer cell line or from the zebrafish embryos.en
dc.publisherRoyal Soc Chemistry, Cambridge
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172036/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173048/RS//
dc.relationbilateral Slovenian-Serbian project [BI-RS/16-17-024]
dc.relationSlovenian Research Agency [P1-0175, Z1-6735]
dc.relationErasmus Mundus Action 2 Project Basileus V
dc.rightsopenAccess
dc.sourceINORGANIC CHEMISTRY FRONTIERS
dc.titleA new class of platinum(II) complexes with the phosphine ligand pta which show potent anticancer activityen
dc.typearticle
dc.rights.licenseBY
dcterms.abstractМанојловић, Драган; Зивковиц, М. Д.; Павиц, A.; Кљун, Ј.; Илиц-Томиц, Т.; Турел, И.; Веселиновиц, A.; Никодиновић-Рунић, Јасмина;
dc.citation.volume5
dc.citation.issue1
dc.citation.spage39
dc.citation.epage53
dc.identifier.wos000422862800003
dc.identifier.doi10.1039/c7qi00299h
dc.citation.other5(1): 39-53
dc.citation.rankaM21
dc.description.otherSupplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3144]
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85040815907
dc.identifier.fulltexthttp://cherry.chem.bg.ac.rs/bitstream/id/9091/2069.pdf
dc.identifier.rcubKon_3402


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