Voltammetric Characterisation of Anticancer Drug Irinotecan
Samo za registrovane korisnike
2018
Autori
Jovanović-Novak, IvanaKomorsky-Lovrić, Šebojka
Lucić-Vrdoljak, Ana
Popović, Aleksandar R.
Neuberg, Marijana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH-dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1x10(-7)mol/L to 1.5x10(-6)mol/L and from 5x10(-9)mol/L to 1.2x10(-7)mol/L, if the accumulation time is 20s and 300s, respectively. The calculated limit of det...ection for irinotecan was found to be 8.7x10(-9)mol/L (if t(acc)=300s).
Ključne reči:
adsorptive stripping square-wave voltammetry / electroanalytical determination / irinotecan / redox mechanism / square-wave voltammetryIzvor:
Electroanalysis, 2018, 30, 2, 336-344Izdavač:
- Wiley-V C H Verlag Gmbh, Weinheim
Finansiranje / projekti:
- Croatian Ministry of Science, Technology, Education and Sport
DOI: 10.1002/elan.201700593
ISSN: 1040-0397
WoS: 000424874800020
Scopus: 2-s2.0-85038094929
Kolekcije
Institucija/grupa
Hemijski fakultet / Faculty of ChemistryTY - JOUR AU - Jovanović-Novak, Ivana AU - Komorsky-Lovrić, Šebojka AU - Lucić-Vrdoljak, Ana AU - Popović, Aleksandar R. AU - Neuberg, Marijana PY - 2018 UR - https://cherry.chem.bg.ac.rs/handle/123456789/2092 AB - Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH-dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1x10(-7)mol/L to 1.5x10(-6)mol/L and from 5x10(-9)mol/L to 1.2x10(-7)mol/L, if the accumulation time is 20s and 300s, respectively. The calculated limit of detection for irinotecan was found to be 8.7x10(-9)mol/L (if t(acc)=300s). PB - Wiley-V C H Verlag Gmbh, Weinheim T2 - Electroanalysis T1 - Voltammetric Characterisation of Anticancer Drug Irinotecan VL - 30 IS - 2 SP - 336 EP - 344 DO - 10.1002/elan.201700593 ER -
@article{ author = "Jovanović-Novak, Ivana and Komorsky-Lovrić, Šebojka and Lucić-Vrdoljak, Ana and Popović, Aleksandar R. and Neuberg, Marijana", year = "2018", abstract = "Electrochemical reduction of irinotecan was investigated on a static mercury drop electrode using square-wave voltammetry. The mechanism of irinotecan electroreduction is a complex, pH-dependent, quasireversible process and includes the transfer of two electrons and two protons. In acidic medium, the first electron transfer reaction is followed by the chemical reaction, and the product of this chemical reaction undergoes further electrochemical reduction at more negative potentials. Both irinotecan and the product of its reduction adsorb on the mercury electrode surface. Based on the adsorptive character of irinotecan, a new adsorptive stripping square-wave voltammetric method for its electroanalytical determination has been proposed. The voltammetric response could be used to determine irinotecan in the concentration range from 1x10(-7)mol/L to 1.5x10(-6)mol/L and from 5x10(-9)mol/L to 1.2x10(-7)mol/L, if the accumulation time is 20s and 300s, respectively. The calculated limit of detection for irinotecan was found to be 8.7x10(-9)mol/L (if t(acc)=300s).", publisher = "Wiley-V C H Verlag Gmbh, Weinheim", journal = "Electroanalysis", title = "Voltammetric Characterisation of Anticancer Drug Irinotecan", volume = "30", number = "2", pages = "336-344", doi = "10.1002/elan.201700593" }
Jovanović-Novak, I., Komorsky-Lovrić, Š., Lucić-Vrdoljak, A., Popović, A. R.,& Neuberg, M.. (2018). Voltammetric Characterisation of Anticancer Drug Irinotecan. in Electroanalysis Wiley-V C H Verlag Gmbh, Weinheim., 30(2), 336-344. https://doi.org/10.1002/elan.201700593
Jovanović-Novak I, Komorsky-Lovrić Š, Lucić-Vrdoljak A, Popović AR, Neuberg M. Voltammetric Characterisation of Anticancer Drug Irinotecan. in Electroanalysis. 2018;30(2):336-344. doi:10.1002/elan.201700593 .
Jovanović-Novak, Ivana, Komorsky-Lovrić, Šebojka, Lucić-Vrdoljak, Ana, Popović, Aleksandar R., Neuberg, Marijana, "Voltammetric Characterisation of Anticancer Drug Irinotecan" in Electroanalysis, 30, no. 2 (2018):336-344, https://doi.org/10.1002/elan.201700593 . .