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Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH
dc.creator | Korać, Jelena | |
dc.creator | Stanković, Dalibor | |
dc.creator | Stanić, Marina | |
dc.creator | Bajuk-Bogdanović, Danica | |
dc.creator | Žižić, Milan | |
dc.creator | Pristov-Bogdanović, Jelena | |
dc.creator | Grgurić-Šipka, Sanja | |
dc.creator | Popović-Bijelić, Ana | |
dc.creator | Spasojević, Ivan | |
dc.date.accessioned | 2018-11-22T00:43:24Z | |
dc.date.available | 2018-11-22T00:43:24Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://cherry.chem.bg.ac.rs/handle/123456789/2097 | |
dc.description.abstract | Coordinate and redox interactions of epinephrine (Epi) with iron at physiological pH are essential for understanding two very different phenomena - the detrimental effects of chronic stress on the cardiovascular system and the cross-linking of catecholamine-rich biopolymers and frameworks. Here we show that Epi and Fe3+ form stable high-spin complexes in the 1:1 or 3:1 stoichiometry, depending on the Epi/Fe3+ concentration ratio (low or high). Oxygen atoms on the catechol ring represent the sites of coordinate bond formation within physiologically relevant bidentate 1:1 complex. Redox properties of Epi are slightly impacted by Fe3+. On the other hand, Epi and Fe2+ form a complex that acts as a strong reducing agent, which leads to the production of hydrogen peroxide via O-2 reduction, and to a facilitated formation of the Epi-Fe3+ complexes. Epi is not oxidized in this process, i.e. Fe2+ is not an electron shuttle, but the electron donor. Epi-catalyzed oxidation of Fe2+ represents a plausible chemical basis of stress-related damage to heart cells. In addition, our results support the previous findings on the interactions of catecholamine moieties in polymers with iron and provide a novel strategy for improving the efficiency of cross-linking. | en |
dc.publisher | Nature Publishing Group, London | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173017/RS// | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/621375/EU// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.title | Coordinate and redox interactions of epinephrine with ferric and ferrous iron at physiological pH | en |
dc.type | article | |
dc.rights.license | BY | |
dcterms.abstract | Станковић, Далибор; Гргурић-Шипка, Сања; Поповиц-Бијелиц, Aна; Зизиц, Милан; Бајук-Богдановиц, Даница; Корац, Јелена; Пристов, Јелена Богдановиц; Спасојевиц, Иван; Станиц, Марина; | |
dc.citation.volume | 8 | |
dc.identifier.wos | 000425934200018 | |
dc.identifier.doi | 10.1038/s41598-018-21940-7 | |
dc.citation.other | 8(1): 3530 | |
dc.citation.rank | M21 | |
dc.identifier.pmid | 29476145 | |
dc.description.other | Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3040] | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85042549576 | |
dc.identifier.fulltext | https://cherry.chem.bg.ac.rs/bitstream/id/9115/2095.pdf |